主持的主要科研项目：

        1、番荔枝内酯防治肿瘤的关键科学问题及纳米靶向制剂成药性研究，国家自然科学基金-广东联合基金重点项目，2015.1-2018.12

        2、基于树枝状聚合物的新型纳米给药系统, 中国医学科学院院所长基金，2009.1-2010.12

        3、仿脂质体的可控制备和形成机理研究，北京市自然基金，2009.1-2010.12

        4、新型纳米给药系统及靶向给药纳米技术平台，科技部国际合作专项，2008.1-2012.12

        5、基于树枝状聚合物的新型脂质体纳米粒（仿脂质体），国家自然科学基金面上项目，2008.1-2012.12

        6、肝靶向长循环干扰素的制备，国家自然科学基金青年基金，2007.1-2009.12

参与的主要科研项目

        1、“中药资源可持续利用关键技术和新药开发”（子任务“难溶性药物给药技术及新药研发”）， 中国医学科学院医学与健康科技创新工程重大项目, 2016.9-2020.12

        2、结核病治疗新技术研究，重大传染病专项，2012.1-2015.12

        3、创新药物研究开发技术平台建设(中国医学科学院)，“重大新药创制”科技重大专项，2009.9-2014.12

        近年来在Bioconjugate Chemistry、Journal of Biomedical Nanotechnology、Soft matter、Colloids and Surfaces B、International Journal of Pharmaceutics、Journal of materials chemistry等杂志上发表SCI论文50余篇，发表中文论文50余篇，申请专利10项（其中PCT专利4项），授权9项；参编专著2部。

近期论文)：

1. Tiantian Huang#, Yian Wang# , Yiping Shen, Hui Ao, Yifei Guo, Meihua Han, Xiangtao Wang*. Preparation of High Drug-Loading Celastrol Nanosuspensions and Their Anti-Breast Cancer Activities in Vitro and in Vivo. Sci.Rep., 2020 Jun 1;10(1):8851.  doi: 10.1038/s41598-020-65773-9.  

2. Hui Ao#, Yijing Li#, Haowen Li, Yian Wang, Meihua Han, Yifei Guo, Rongxing Shi*, Feng Yue and Xiangtao Wang*. Preparation of hydroxy genkwanin nanosuspensionsand their enhanced antitumor efficacy against breast cancer, Drug Delivery, 27:1, 816-824

3. Haowen Li#, Biao Liu#, Hui Ao, Jingxin Fu, Yian Wang, Yue Feng, Yifei Guo and Xiangtao Wang*. Soybean lecithin stabilizes disulfiram nanosuspensions with a high drug-loading content: remarkably improved antitumor efficacy. Journal of Nanobiotechnology, 2020, 18:4

4. Yian Wang#, Tiantian Huang#, Haowen Li, Jingxin Fu, Hui Ao, Likang Lu, Meihua Han, Yifei Guo, Feng Yue, Xiangtao Wang*. Hydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer. Drug delivery, 2020(27):1, 228-237.

5. Yifei Guo, Ting Wang, Hanhong Qiu, Meihua Han, Zhengqi Dong⁎, Xiangtao Wang⁎, Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy. European Journal of Pharmaceutics and Biopharmaceutics 134 (2019) 178–184.

6. Runqi Yu, Yuan Zou, Biao Liu，Yifei Guo, Xiangtao Wang⁎, Meihua Han⁎. Surface modification of pH-sensitive honokiol nanoparticles based on dopamine coating for targeted therapy of breast cancer. Colloids and Surfaces B: Biointerfaces 177 (2019) 1–10.

7. Dongdong Bi, Lei Zhao, Haowen Li, Yifei Guo, Xiangtao Wang⁎, Meihua Han⁎. A comparative study of polydopamine modified and conventional chemical synthesis method in doxorubicin liposomes form the aspect of tumor targeted therapy. International Journal of Pharmaceutics 559 (2019) 76–85.

8. Lei. Zhao#, Dongdong. Bi#, Xiaoyu. Qi, Yifei. Guo, Xiangtao. Wang* and Meihua. Han* Polydopamine-Based Surface Modification of Paclitaxel Nanoparticles for Osteosarcoma Targeted Therapy. Nanotechnology. 2019 Jun 21;30(25):255101.

9. Dongdong Bi , Lei Zhao, Runqi Yu, Haowen Li, Yifei Guo, Xiangtao Wang* and Meihua Han*. Surface modification of doxorubicin-loaded nanoparticles based on polydopamine with pH-sensitive property for tumor targeting therapy. Drug Delivery, 2018, 25(1):564-575. (IF=6.402)

10. Yifei Guo, Shuang Zhao, Hanhong Qiu, Ting Wang, Yanna Zhao, Meihua Han, Zhengqi Dong*, and Xiangtao Wang*. The Shape of Nanoparticles as a Design Parameter to Improve Docetaxel Antitumor Efficacy. Bioconjugate Chemistry, 2018, 29, 1302-1311.

11. Haowen Li, Yijing Li, Hui Ao, Dongdong Bi, Meihua Han, Yifei Guo, Xiangtao Wang*. Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in Hela tumour-bearing mice. Drug Delivery, 2018 , 25 (1) :880-887.

12. Yifei Guo,*,† Ting Wang,†,‡ Shuang Zhao,† Meihua Han,† Zhengqi Dong,† Xiangtao Wang,*,† and Yanhong Wang‡. Amphiphilic Hybrid Dendritic-Linear Molecules as Nanocarriers for Shape-Dependent Antitumor Drug Delivery. Molecular Pharmaceutics, 2018, 15(7):2665-2673. 

13. Meihua Han, †a Xiaoyu Qi,†ab Dongdong Bi, †a Yijing Li,a Yifei Guo, a Xiangtao Wang*a and Li Feng*. Administration of raloxifene hydrochloride nanosuspensions partially attenuates bone loss in ovariectomized mice. RSC Adv., 2018, 8, 23748-23756.

14. Yifei Guo, Ting Wang, Shuang Zhao, Hanhong Qiu, Meihua Han, Zhengqi Dong*, XiangtaoWang*. Effect of alkyl chain on cellular uptake and antitumor activity of hydroxycamptothecin nanoparticles based on amphiphilic linear molecules. Eur J Pharm Sci. 2018 Nov 1;124:266-272. 

15. Yifei Guo,  Yanna Zhao,  Ting Wang, Ran Li,  Meihua Han,  Zhengqi Dong, Chunyan Zhu* and Xiangtao Wang*. Hydroxycamptothecin Nanorods Prepared by Fluorescently Labeled Oligoethylene Glycols (OEG) Codendrimer: Antitumor Efficacy In Vitro and In Vivo. Bioconjugate Chem. 2017, 28, 390-399. \

16. Yifei Guo, Yanna Zhao, Ting Wang, Shuang Zhao, Hanhong Qiu, Meihua Han, Xiangtao Wang*. Honokiol Nanoparticles Stabilized by Oligoethylene Glycols Codendrimer: In Vitro and In Vivo Investigation. Journal of material chemistry B, 2017, 5, 697-706. 

17. Yifei Guo, Chunying Hao, Xiangkang Wang, Yanna Zhao, Meihua Han, Mincan Wang*, Xiangtao Wang*. Well-defined Podophyllotoxin Polyprodrug Brush: Preparation via RAFT Polymerization and Evaluation as Drug Carrier. Polymer chemistry, 2017, 8, 901–909.

18. Jingyi Hong, Yingying Liu, Yao Xiao, Xiaofeng Yang, Wenjing Su, Mingzhu Zhang, Yonghong Liao, Haixue Kuang*and Xiangtao Wang*. High drug payload curcumin nanosuspensions stabilized by mPEG-DSPE and SPC: in vitro and in vivo evaluation. Drug Delivery, 2017 Nov; 24(1):109-120.

19. Linjie Yang，Jingyi hong，Jing Di，Yifei guo，Meihua han，Meifeng liu*，Xiangtao Wang*.10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, 2017:12, 3681–3695.

20. Jung Kwon Oh*, Depannita Biswas, So Young An, Yijing Li, and Xiangtao Wang. Intracellular delivery colloidally-stable core-crosslinked triblock copolymer micelles with glutathioneresponsive enhanced drug release for cancer therapy. Mol. Pharmaceutics, 2017, 14(8):2518-2528.   IF=4.342

21. Jingyi Hong, Zhonghao Sun, Yijing Li, Yifei Guo, Yonghong Liao, Meifeng Liu* and Xiangtao Wang*. Folate modified annonaceous acetogenins (ACGs) nanosuspensions and their improved anti-tumor efficacy. International Journal of Nanomedicine 2017:12 5053–5067.  

22. Yijing Li, Jingyi Hong, Haowen Li, Xiaoyu Qi, Yifei Guo, Meihua Han, Xiangtao Wang*. Genkwanin nanosuspensions: a novel and potential antitumor drug in breast carcinoma therapy. Drug Delivery, 2017, 24(1):1491-1500.

23. Guoxuan Sun, Pedro Ernesto de Resende, Paul Stapleton, Martyna Kuta, Xiangtao Wang, Shozeb Haider, Min Yang*. Regioselective glycosylation of novobiocin alters activity, Carbohydrate Research 452 (2017) 116-121.

近期授权专利

1．韩美华，王向涛，于鑫. 一种和厚朴酚纳米粒及其制备方法，专利号ZL201410001498.3 

2. 韩美华，王向涛. 一种20（S）-原人参二醇纳米粒及其制备方法，专利号ZL201410009584.9

3. 王向涛，邸静，洪靖怡，刘营营.一种槲皮素纳米粒及其制备方法，专利号ZL201510359739.6 

4. 王向涛，杨晓凤，韩美华，郭一飞. 一种喜树碱类药物的纳米晶及其制备方法。专利号ZL201610195547.0 （授权公告日，2019年9月24日，CN106466296B）

5. 王向涛，张明珠，韩美华，郭一飞. 一种雷公藤红素纳米混悬剂及其制备方法，专利号ZL201610886793.0   （授权公告日，2019年9月24日，CN106309364B）

6. 王向涛，洪靖怡，李艳红，李怡静. 一种番荔素类药物的纳米混悬剂及制备方法，专利号ZL201610367608.7（授权公告日，2019年11月12日，授权公告号CN106420604B）

7. 王向涛，洪靖怡，刘营营. 一种基于环糊精和磷脂为载体的番荔枝总内酯纳米粒及其制备方法和应用，专利号ZL201610330947.8（授权公告日，2019年12月6日，授权公告号CN106389385B）