国家重点研发计划课题：食管癌演进及治疗过程中肿瘤微环境异质性组成及其变化规律研究，2021.12-2024.11，主持；

国家自然科学基金面上项目：超级增强子调控的致癌基因驱动食管癌发生发展的机制研究，2023.01-2026.12，主持；

国家自然科学基金面上项目：先锋转录因子GATA3介导雄激素受体驱动食管鳞癌发生的机制研究，2021.01-2024.12，主持；

国家自然科学基金面上项目：S100A14在上皮间质转化、肿瘤微环境和肿瘤干细胞调节中的作用及机制研究，2015.01-2018.12,主持；

国家自然科学基金面上项目：LncRNAs通过调控ER转录程序介导芳香化酶抑制剂耐药的分子机制研究，2017.01-2020.12，主持；

国家重点实验室青年骨干创新项目：S100A14对上皮间质转化、肿瘤微环境和肿瘤干细胞调节的研究，2015.11-2016.11，主持；

中国医学科学院医学与健康科技创新工程协同创新团队项目：基于液体活检的乳腺癌复发耐药机制及其临床应用研究，2017.01-2020.12，任务负责人；

中国医学科学院中央级公益性科研院所基本科研业务费：恶性肿瘤与微生物组学，2019.12-2022.12，任务负责人；

代表性论文 (#first author; *corresponding author)

1.     Zhang Y#,Chen H#, Mo H#, Hu X#, Gao R,Zhao Y, Liu B, Niu L, Sun X, Yu X, Wang Y, Chang Q, Gong T, Guan X, Hu T, Qian T,Xu B*, Ma F*, Zhang Z*, Liu Z*. Single-cell analyses reveal key immunecell subsets associated with response to PD-L1 blockade in triple negativebreast cancer. Cancer Cell. 2021; 39(12).

2.     Huang F#, Chen H#, ZhuX, Gong T, Li X, Hankey W, Wang H, Chen Z*, Wang Q*, Liu Z*. The oncogenomicfunction of androgen receptor in esophageal squamous cell carcinoma is directedby GATA3. Cell Res. 2021.31(3): 362-365. 

3.     Zhu X,Zhang Y, Luo Q, Wu X, Huang F, Shu T, Wan Y, Chen H*, Liu Z*.The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizingBIP. Singal Transduct Target Ther. 2021; 6(1): 264. 

4.     Yuan J#,Jiang Q#, Gong T#, Fan D#, Zhang J, Chen F,Zhu X, Wang X, Qiao Y, Chen H*, Liu Z*, Su J*.Lossof grand histone H3 lysine 27 trimethylation domains mediated transcriptionalactivation in esophageal squamous cell carcinoma. NPJ Genome Med. 2021; 6(1): 65. 

5.     Bao S, Hu T, Liu J, Su J, Sun J, Ming Y, Li J, WuN, Chen H*, Zhou M*. Genomic instability-derived plasmaextracellular vesicle-microRNA signature as a minimally invasive predictor ofrisk and unfavorable prognosis in breast cancer. J Nanobiotechnology.2021, 19(1):22.

6.     Cui Y,# Chen H,# XiR,# Cui H,# Zhao Y,# Yan T,# Xu En,#Lu X, Huang F, Kong P, Li Y, Zhu X, Wang J, Zhu W, Wang J, Ma Y, Zhou Y, Guo S,Zhang L, Liu Y, Wang B, Xi Y, Sun R, Yu X, Zhai Y, Wang F, Yang J, Yang B, ChengC, Liu J, Song B, Li H, Wang Y, Zhang Y, Cheng X, Zhan Q*, Li Y*, Liu Z*. WholeGenome Sequencing of 508 Patients Identifies Key Molecular Features Associatedwith Poor Prognosis in Esophageal Squamous Cell Carcinoma. Cell Res. 2020, 30(10): 902-913.

7.     Li X, Wang M, Gong T, Lei X, Ding F, Chen H*, Liu Z*. AS100A14-CCL2/CXCL5 signaling axis drives breast cancer metastasis. Theranostics.2020. 10(13):5687-5703.

8.     Ma J, Zhan Y, Xu Z, Li Y, Luo A, Ding F, Cao X, Chen H*, Liu Z*. ZEB1 inducedmiR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophagealsquamous cell carcinoma. Cancer Lett.2017, 398:37-45.

9.     Xu C#, ChenH*, Wang X, Gao J, Che Y, Li Y, Ding F, Luo A, Zhang S, Liu Z*. S100A14, a Member of theEF-hand Calcium-binding Proteins, Is Overexpressed in Breast Cancer and Acts asa Modulator of HER2 Signaling. J Biol Chem. 2014. 289: 827-837.

10.     Chen H#, Yuan Y, Zhang C, Luo A,Ding F, Ma J, Yang S, Tian Y, Tong T, Zhan Q, Liu Z*. Involvementof S100A14 protein in cell invasion by affecting expression and function ofmatrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation.J Biol Chem 2012. 287: 17109-17119. (IF:4.773)

11.     Chen H#, Ma J, Sunkel B,Luo A, Ding F, Li Y, He H, Zhang S, Xu C, Jin Q, Wang Q, Liu Z*. S100A14 is anovel modulator of terminal differentiation of esophageal squamous cellcarcinoma. Mol Cancer Res. 2013,11:1542-1553. (IF=4.353)

12.     Chen H#, Yu D, Luo A, Tan W, Zhang C, Zhao Z, Yang M, Liu J, Lin D*, Liu Z*.Functional role of S100A14 geneticvariants and their association with esophageal squamous cell carcinoma. CancerRes, 2009, 69(8):3451-3457. (IF=7.514).