目前团队：

助理研究员2名，主管技师1名；

硕士研究生3名，博士研究生4名。

已毕业：

硕士毕业生5名，博士毕业生3名；其中有 1人次获得国家奖学金，2人次获得一等奖学金，多人次二等或三等奖学金。

1.中国医学科学院医学与健康科技创新工程：肿瘤关键代谢靶点的鉴定及其功能研究

2.国家自然科学基金面上项目：苹果酸酶调控肿瘤细胞命运的分子机制研究

3.中华人民共和国人力资源与社会保障部项目：肺癌中的代谢异常及其调控机制

4.海外高层次人才引进计划-青年项目

5.科技部重点研发：“环境应激和营养失衡所致获得性形状及其代际传递机制”

国家自然科学基金

科技部国家重点研发计划

人社部留学人员资助项目

医科院创新工程

(1) Chen Taiqi#,Xie Siyi#, Cheng Jie, Zhao Qiao, Wu Hong*, Jiang Peng*,Du Wenjing*. AKT1 phosphorylation of cytoplasmic ME2 induces a metabolicswitch to glycolysis for tumorigenesis. Nature Communications.2024, Jan 23;15(1):686.

(2) Luo Ya#,Qi Xianmei#, Zhang Zhenxi#, Zhang Jiawei, Shu Ting, LiXiaoran, Hu Huiyuan, Li Jinqiu, Tang Qihao, Zhou Yitian, Li Bolun, WangMingyao, Fan Tianfei, Guo Wenjun, Liu Ying, Zhang Jin, Yang Peiran, Gao Ran,Yan Chen, Xing Yanjiang*, Du Wenjing*, Wang Jing* and Wang Chen.Inactivation of malic enzyme 1 in endothelial cells alleviates pulmonaryhypertension.  Circulation,2024, Apr 23;149(17):1354-1371.

(3) Yang Yanting#,Zhang Zhenxi#, Li Wei#, Si Yufan, Li Li, Du Wenjing*.αKG-driven RNA polymerase II transcription of cyclin D1 licenses malic enzyme 2to promote cell-cycle progression. Cell Reports, 2023, Jul25;42(7):112770.

(4) Li Wei#,Kou Junjie#, Zhang Zhenxi, Li Haoyue, Li Li, Du Wenjing*.Cellular redox homeostasis maintained by malic enzyme 2 is essential forMYC-driven T-cell lymphomagenesis. PNAS, 2023, Jun6;120(23):e2217869120.

(5) Yang Yanting,Zhang Zhenxi, Li Wei, Li Li, Zhou Ying, Du Wenjing*. ME2 PromotesHepatocellular Carcinoma Cell Migration through Pyruvate. Metabolites,2023 Apr 10;13(4):540.

(6) YaoPengbo, Zhang Zhenxi, Liu Hongchao, Jiang Peng, Li Wei, Du Wenjing*. p53protects against alcoholic fatty liver disease via ALDH2 inhibition. EMBOJournal, 2023 Apr 17;42(8):e112304.

(7) YaoPengbo#, Chen Taiqi#, Jiang Peng, Li Li, Du Wenjing*.Functional skewing of TRIM21-SIRT5 interplay dictates IL-1β production inDSS-induced colitis. EMBO Reports, 2022 Jun 30:e54391.

(8) ZhaoMengjia#, Yao Pengbo#, Mao Youxiang#, Wujinjun#, Wang Weihua, Geng Chenhui, Cheng Jie, Du Wenjing*,Jiang Peng*. Malic enzyme 2 maintains protein stability of mutant p53 through2-hydrooxyglutarate. Nature Metabolism, 2022 Feb;4(2):225-238

(9) ZhangZhenxi, Du Wenjing*. Malic enzyme 2 as a therapeutic target for cancer:comments on 'Malic enzyme 2 maintains protein stability of mutant p53 through2-hydroxyglutarate'. J Mol Cell Biol, 2022 Jul 27;14(4):mjac024.

(10) Li Wei#, Kou Junjie#,Qin Junying#, Li Li, Zhang Zhenxi, Pan Ying, Xue Yi*, Du Wenjing*.NADPH levels affect cellular epigenetic state by inhibiting HDAC3-Ncor complex.Nature Metabolism, 2021, 3(1):75-89

(11) Career pathways, part 6. White JP*, DuWenjing*. Nature Metabolism. 2021 Oct;3(10):1277-1279.

(12) Sun Huishan#, Li Li#,Li Wei#, Yang Fan, Zhang Zhenxi, Liu Zizhao, Du Wenjing*. p53transcriptionally regulates SQLE to repress cholesterol synthesis and tumorgrowth. EMBO reports, 2021, Oct5;22(10):e52537.

(13) Yang Fan#; Kou Junjie#; Li Wei; DuWenjing*; MYC Enhances Cholesterol Biosynthesis and Supports Cell ProliferationThrough SQLE. Frontiers in Cell and Developmental Biology, 2021,9.

(14) Zhang Zhenxi, Su Jingyu, Li Li*, DuWenjing*. Identification of precise therapeutic targets and characteristicprognostic genes based on immune gene characteristics in uveal melanoma. Frontiersin Cell and Developmental Biology, 2021, doi: 10.3389/fcell.2021.666462

(15) Zhao Mengjia, Jiang Peng, Du Wenjing*. MYC retards cancer cell migrationthrough suppressing fibronectin expression. Science Bulletin, 2019, 64(11): 715-717. 

(16) Li Le#, Li Lijia#,Li Wei, Chen Taiqi, Bin Zou, Zhao Lina, Wang Huili, Wang Xueying, Xu Lina, LiuXiaohui, Wang Dong, Li Bo, Mak Tak W, DuWenjing*, Yang Xiaolu*, Jiang Peng*. TAp73-inducedphosphofructokinase-1 transcription promotes the Warburg effect and enhancescell proliferation. Nature Communications, 2018, 9(1): 4683-4683. 

(17) Yao Pengbo#, Sun Huishan, XuChang, Chen Taiqi, Zou Bing, Jiang Peng*, Du Wenjing*. Evidence for adirect cross-talk between malic enzyme and the pentose phosphate pathway viastructural interactions. J Biol Chem, 2017, 292(41): 17113-17120.

(18) Du Wenjing#, JiangPeng#, Mancuso Anthony, Stonestrom Aaron, Brewer Michael D, MinnAndy J, Mak Tak W, Wu Mian*, Yang Xiaolu*. TAp73 enhances the pentose phosphatepathway and supports cell proliferation. Nature Cell Biology,2013, 15(8): 991-1000.

(19) Jiang Peng#, Du Wenjing#,Mancuso Anthony, Wellen Kathryn E, Yang Xiaolu*. Reciprocal regulation of p53and malic enzymes modulates metabolism and senescence. Nature,2013, 493(7434): 689-693.

(20) Jiang Peng#, Du Wenjing#,Wang Xingwu, Mancuso Anthony, Gao Xiang, Wu Mian*, Yang Xiaolu*. p53 regulatesbiosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. NatureCell Biology, 2011, 13(3): 310-316.

(21) Du Wenjing#, JiangPeng#, Li Nan, Mei Yide, Wang Xingwu, Wen Longping, Yang Xiaolu*,Wu Mian*. Suppression of p53 activity by Siva1. Cell Death Differ, 2009, 16(11): 1493-1504.