1. 科技部，国家重点研发计划“干细胞研究与器官修复”，2021YFA1101603，用于特定适应症治疗的间充质干细胞药物有效性分子标志物的研究，2021-12至2026-06，396万元，在研，课题负责人

2. 科技部，国家重点研发计划“干细胞及转化研究”，2019YFA0110803，靶向血液系统的离体基因治疗研究，2019-09至2023-12，663万元，结题，研究骨干（排名第三）

3. 国家自然科学基金委员会，重大项目，81890992，白血病形成及其在药物作用下的细胞异质性研究，2019-01至2023-12，392万元，结题，研究骨干（排名第三）

4. 中国医学科学院中央级公益性科研院所基本科研业务费青年医学人才奖励项目，2018RC310019,利用CRISPR/Cas9文库筛选技术和多组学测序 技术探索儿童急性髓系白血病复发耐药机制，2018.10-2019.09，50万元，结题，主持

5. 国家自然科学基金面上，81770175，PDGFRB重排协同IKZF1突变在Ph-like ALL发生及耐药中作用机制的研究, 2018.01-2021.12, 53万元，结题，主持

6. 北京协和医学院“中央高校基本科研业务费”，3332018190，AGGF1-PDGFRB在Ph-like B-ALL发生及TKI耐药中作用和机制的研究（滚动项目）, 2018.01-2018.12, 25万元，结题，主持

7. 北京协和医学院“协和青年基金”，3332016091，AGGF1-PDGFRB在Ph-like B-ALL发生及TKI耐药中作用和机制的研究, 2016.04-2018.03, 15万元，结题，主持

8. 国家自然科学基金青年项目，81400137，组蛋白甲基化复合物PRC2在ETP T-ALL中作用的研究，2015/01-2017/12，23万元，结题，主持

1. Jingliao Zhang#*, Yongjuan Duan#, Peng Wu#, Yanxia Chang#, Yue Wang,Tianyuan Hu, Chao Liu, Xiaoyan Chen, Suyu Zong, Xiaoli Chen, Yangping Wu,Linlin Jin, Yang Lan, Xiaoming Liu, Xuelian Cheng, Feng Ding, Tianyu Li,Xiaojuan Chen, Ye Guo, Yumei Chen, Wenyu Yang, Li Zhang, Yao Zou, Tao Cheng,Xiao-Fan Zhu*, Yingchi Zhang*. Clonal evolution dissection reveals highMSI2 level promotes chemo-resistance in T-cell acute lymphoblastic leukemia.Blood. 2024 Jan 25;143(4):320-335. (IF: 20.30)

2. Jiapei Yuan*, Jingliao Zhang*, Beibei Zhao, Fang Liu, TianfengLiu, Yongjuan Duan, Yumei Chen, Xiaojuan Chen, Yao Zou, Li Zhang, Ye Guo, WenyuYang, Yang Yang, Jun Wei#, Xiaofan Zhu#, Yingchi Zhang#. Single-celltranscriptomic analysis of the immune microenvironment in pediatric acuteleukemia. Cancer Letters, 2024 Aug 1:596:217018. (IF: 9.10)

3. Jingliao Zhang#, Tianfeng Liu#, Yongjuan Duan#, Yanxia Chang#,Lixian Chang, Chao Liu, Xiaoyan Chen, Xuelian Cheng, Tianyu Li, Wenyu Yang,Xiaojuan Chen, Ye Guo, Yumei Chen, Yao Zou, Li Zhang, XiaofanZhu*, YingchiZhang*. Single-cell analysis highlights a population of Th17-polarized CD4+naïve T cells showing IL6/JAK3/STAT3 activation in pediatric severe aplasticanemia. J Autoimmun. 2023 Apr:136:103026. (IF: 12.80)

4. Yingchi Zhang#,Shicheng Wang#, Jingliao Zhang#, Chao Liu#, Xinqi Li, Wenbo Guo, Yongjuan Duan,Xiaoyan Chen, Suyu Zong, Jiarui Zheng, Yixuan W u, Xiaoli Chen, Xuelian Cheng,Yanxia Chang, Yue Wang, Feng Ding, Wenyu Yang, Xiaojuan Chen, Ye Guo, Li Zhang,Yumei Chen, Yao Zou, Xiaofan Zhu*, Jin Gu*, Tao Cheng*. Elucidating Minimal ResidualDisease of Pediatric B cell Acute Lymphoblastic leukemia by Single CellAnalysis. Nature Cell Biology, 2022 Feb;24(2):242-252. (IF: 21.30)

5. Riguo Fang#, Jingliao Zhang#, Huihui Yang, Jia Shi, Huimin Zeng,Xiaofan Zhu, Dong Wei, Pengfei Yuan, Tao Cheng*, Yingchi Zhang*. Highlyefficient gene editing and single cell analysis of hematopoieticstem/progenitor cells from X-linked sideroblastic anemia patients. SignalTransduct Target Ther. 2021 Jul 2;6(1):248. (IF: 39.30)

6. Benshang Li#, Samuel W. Brady#, Xiaotu Ma#, Shuhong Shen#, YingchiZhang#, Yongjin Li#, Karol Szlachta, Li Dong, Yu Liu, Fan Yang, NinglingWang, Diane A. Flasch, Matthew A. Myers, Heather L. Mulder, Lixia Ding, YanlingLiu, Liqing Tian, Kohei Hagiwara, Ke Xu, Xin Zhou, Edgar Sioson, Tianyi Wang,Liu Yang, Jie Zhao, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, Jiaoyang Cai,Hui-Ying Sun, Ting-Nien Lin, Lijuan Du, Hui Li, Michael Rusch, Michael N.Edmonson, John Easton, Xiaofan Zhu, Jingliao Zhang, Cheng Cheng, Benjamin J.Raphael, Jingyan Tang, James R. Downing, Ludmil B. Alexandrov, Bin-Bing S.Zhou*, Ching-Hon Pui*, Jun J. Yang*, Jinghui Zhang*. Therapy-induced mutationsdrive the genomic landscape of relapsed acute lymphoblastic leukemia , Blood,2020, 135(1): 41-55. (IF: 20.30)

7. Jingliao Zhang#, Yingchi Zhang#*, Man Zhang, Chao Liu,Xiaoming Liu, Jie Yin, Peng Wu, Xiaojuan Chen, Wenyu Yang, Li Zhang, Ye Guo,Yao Zou, Yumei Chen, Youjia Cao, Tao Cheng*, Xiaofan Zhu*. FLT3 pathway is apotential therapeutic target for PRC2 mutated T cell acute lymphoblasticleukemia. Blood. 2018 Dec 6;132(23):2520-2524. (IF: 20.30)

8. Yingchi Zhang#, Yufeng Gao#, Hui Zhang#, Jingliao Zhang,Fuhong He, Aleš Hnízda, Maoxiang Qian, Xiaoming Liu, Yoshihiro Gocho, Ching-HonPui, Tao Cheng, Qianfei Wang, Jun J. Yang*, Xiaofan Zhu*, Xin Liu*. PDGFRBmutation and tyrosine kinase inhibitor resistance in Ph-like acutelymphoblastic leukemia. Blood. 2018 May 17;131(20):2256-2261. (IF: 20.30)

9. Yingchi Zhang#, Jingliao Zhang#, Wenbin An#, Yang Wan,Shihui Ma, Jie Yin, Xichuan Li, Jie Gao, Weiping Yuan, Ye Guo, James DouglasEngel, Lihong Shi*, Tao Cheng*, Xiaofan Zhu*. Intron 1 GATA site enhances ALAS2expression indispensably during erythroid differentiation. Nucleic Acids Res.2017 Jan 25;45(2):657-671. (IF: 14.90)