陈实平：女，副教授（返聘），

董红燕：女，主管技师（返聘），

韩睿钦：男，研究助理，

刘艾洁：女，实验助理，

陈  冉，女，博士研究生，

王  菲，女，博士研究生，

于晓芹，女，硕士研究生，

张文静，女，硕士研究生，

目前承担在研项目

1．     “十三五”国家重点研发专项：干细胞移植的分子免疫调控机理，骨干；

2．    国家重点研发计划：免疫对配子发生和胚胎发育的影响，子课题负责人；

3．    中国医学科学院医学创新工程项目：组织干细胞衰老关键分子机理及干预研究，子课题负责人；

4．    中国医学科学院医学“一带一路”科技先导专项：感染与免疫相关的不孕不育机制研究；主持。

已结题项目

1.     国家重点研发(2015CB943001)，长非编码RNA在精子发生中的功能及机制，2015/01-2019/12，100万元，骨干。

2.     国家自然科学基金面上项目，31371518，睾丸免疫环境与睾丸炎的调节机理，2014/01-2017/12，80万元，主持。

3.     国家自然基金国际（地区）合作项目，31261160491，TAM受体酪氨酸激酶在血睾屏障及睾丸天然免疫中的功能，2013/01-2016/12，80万元，主持。

4.     国家自然科学基金面上项目，31171445，TLR及TAM受体调节睾丸免疫反应的机理，2012/01-2015/12，55万元，主持。

5.     国家自然科学基金面上项目，30971459，Tyro3 RTKs调节Sertoli细胞功能及精子形态变化的机理，2010/01-2012/12，33万元，主持。

6.     国家支撑计划，2008BAI54B0406，生物制品生产用细胞基质安全性研究，2009/01-2010/12，60万元，子课题负责人.

7.     973计划课题(2007CB94750),小鼠雄性生殖细胞分化的关键基因研究，2007/09-2011/08，130万元，子课题负责人。

8.     973计划课题，2006CB504001，精子发生、成熟与凋亡，2006/01-2010/12，140万元，子课题负责人。

9.     国家自然科学基金面上项目，30570678，哺乳动物精子发生关键调节基因的研究，2006/01-2008/12，25万元，主持。

10.  国家自然科学基金面上项目，30470878，细胞染色质浓缩关键调节蛋白/基因的功能研究，2005/01-2007/12，21万元，主持。

11.  973计划课题，(G1999055901），精子发生及基因表达调控，2000/04-2005/03，110万元，子课题负责人。

目前承担研究项目

1．     “十三五”国家重点研发专项：干细胞移植的分子免疫调控机理；

2．    国家重点研发计划：免疫对配子发生和胚胎发育的影响；

3．    中国医学科学院医学创新工程项目：组织干细胞衰老关键分子机理及干预研究；

4．    中国医学科学院医学“一带一路”科技先导专项：感染与免疫相关的不孕不育机制研究；

5.       国家自然科学基金：腮腺炎病毒诱导睾丸炎及其导致男性不育的机制。

近期发表论文

1.    XiaoqinYu, Ran Chen, Fei Wang, Weihua Liu, WenjingZhang, Maolei Gong, Han Wu, Aijie Liu, RuiqinHan, Yongmei Chen and Daishu Han*. Pattern RecognitionReceptor-initiated Innate Immune Responses in mouse Prostatic Epithelial Cells.Biol Reprod. 2021; doi: 10.1093/biolre/ioab076.

2.   Wu H and Daishu Han*. Mumps Orchitis: C;inical Aspects and Mechanisms. Front.Immunol. 2021; 12:582946.

2．Ran Chen, Wenjing Zhang, Maolei Gong, Fei Wang, Han Wu,Weihua Liu, Yunxiao Gao, Baoxing Liu, Song Chen, Wei Lu, Xiaoqin Yu, Aijie Liu,Ruiqin Han, Yongmei Chen and Daishu Han*.Characterization of an Antiviral Factor Against Mumps Viral Infection in HumanSeminal Plasma. Front. Immunol. 2021; 12:580454.

3．Fei Wang, Ran Chen, Qian Jiang, HanWu, Maolei Gong, Weihua Liu, Xiaoqin Yu, Wenjing Zhang, Ruiqin Han, Aijie Liu,Yongmei Chen, Daishu Han*.Roles of sialic acid, AXL and MER receptor tyrosine kinases in mumps virusinfection of mouse Sertoli and Leydig cells. Front. Microbiol. 2020; 11:1292.

4．Wu H,Jiang X, Gao Y, Liu W, Wang F, Gong M, Chen R, Yu X, Zhang W, Gao B,Song C*, Daishu Han*. Mumps virus infection disruptsblood-testis barrier through the induction of TNF-α in Sertoli cells. FASEB J.2019; 33:12528-12540.

5．WeihuaLiu, Fei Wang, Xiaoqin Yu, Han Wu, Maolei Gong, Ran Chen, Wenjing Zhang, RuiqinHan, Aijie Liu, Yongmei Chen, Daishu Han*. Damaged male germ cellsinduce epididymitis in mice. Asian J Andrology. 2019Nov 1; 21:1-9 doi: 10.4103/aja.aja_116_19.

6．Gong M,Wang F, Liu W, Chen R, Wu H, Zhang W, Yu X, Han R, Liu A, Chen Y, Daishu Han*. Pattern recognition receptor-mediated innate immune responses inseminal vesicle epithelial cell and their impacts on cellular function. Biologyof Reproduction. 2019; 101, 733-747.

7． Wang F, Liu W, Jiang Q, Gong M, Chen R, Wu H, Han R, Chen Y, Han D*.Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumornecrosis factor alpha. Biol Reprod.  2019 Mar 1; 100(3):849-861.

8． LiuW, Han R, Wu H, Han D*. Viral threat to male fertility. Andrologia. 2018Dec;50(11):e13140. doi: 10.1111/and.13140. Invited review.

9． JiangQ, Wang F, Shi L, Zhao X, Gong M, Liu W, Song C, Li Q, Chen Y, Wu H, Han D*. C-X-C motif chemokine ligand 10produced by mouse Sertoli cells in response to mumps virus infection inducesmale germ cell apoptosis. Cell Death Dis.2017 Oct 26;8(10):e3146.

10．Su L, Cheng YC, Lee WM,Zhang M, Yang F, Zhao B, Han D, LiuY, Hu D. Abcb1a andAbcb1b genes function differentially in blood-testis barrier dynamics in therat. Cell Death Dis. 2017 Sep 7;8(9):e3038.

11．Yan K, Feng D, Liang J,Wang Q, Deng L, Zhang X, Ling B, Han D*. Cytosolic DNA sensor-initiated innateimmune responses in mouse ovarian granulosa cells. Reproduction.2017 Jun;153(6):821-834.

12．王菲，韩代书*。感染与免疫相关的男性不育。2017，中国科学：生命科学，47 (2):1-10.

13．Wu H, Zhao X, Wang F,Jiang Q, Shi L, Gong M, Liu W, Gao B, Song C, Li Q, Chen Y, Han D*. Mouse Testicular Cell Type-SpecificAntiviral Response against Mumps Virus Replication. Front Immunol. 2017 Feb 10;8:117.

14．Ma W, Li S, Ma S, Jia L,Zhang F, Zhang Y, Zhang J, Wong G, Zhang S, Lu X, Liu M, Yan J, Li W, Qin C, Han D, Qin C, Wang N, Li X, Gao GF. Zika Virus Causes Testis Damage andLeads to Male Infertility in Mice. Cell.2016 Dec 1;167(6):1511-1524.

15．Wang Q, Wu H, Cheng L,Yan K, Shi L, Zhao X, Jiang Q, Wang F, Chen Y, Li Q, Han D*. Mumps virus induces innate immuneresponses in mouse ovarian granulosa cells through the activation of Toll-likereceptor 2 and retinoic acid-inducible gene I. MolCell Endocrinol. 2016 Nov 15; 436:183-94.

16．Cheng L, Chen Q, Zhu W,Wu H, Wang Q, Shi L, Zhao X, Han D*. Toll-like Receptors 4 and 5Cooperatively Initiate the Innate Immune Responses to Uropathogenic Escherichiacoli Infection in Mouse Epididymal Epithelial Cells. Biol Reprod. 2016 Mar;94(3):58.

17．Li N, Mruk DD, Mok KW,Li MW, Wong CK, Lee WM, Han D,Silvestrini B, Cheng CY. Connexin 43reboots meiosis and reseals blood-testis barrier following toxicant-mediatedaspermatogenesis and barrier disruption. FASEB J.2016 Apr; 30(4):1436-52.

18．Chen Q, Deng T, Han D*. Testicular immunoregulation andspermatogenesis. Semin Cell Dev Biol. 2016Jan 21. pii: S1084-9521(16)30019-2. Invited review.

19．Wu H, Shi L, Wang Q,Cheng L, Zhao X, Chen Q, Jiang Q, Feng M, Li Q, Han D*. Mumps virus-induced innate immuneresponses in mouse Sertoli and Leydig cells. SciRep. 2016 Jan 18;6:19507.

20．Deng T, Chen Q, Han D*. The roles of TAM receptor tyrosinekinases in the mammalian testis and immunoprivileged sites. Front Biosci (Landmark Ed).2016 Jan 1;21:316-27. Invited review.

21．Yan K, Cheng L, Liu P,Liu Z, Zhao S, Zhu W, Wang Q, Wu H, HanD*.Polyinosinic-Polycytidylic AcidPerturbs Ovarian Functions Through Toll-Like Receptor 3-Mediated Tumor NecrosisFactor A Production in Female Mice. Biol Reprod.2015 Jul;93(1):11.

22．Li N, Mruk DD, Wong CK,Lee WM, Han D, Cheng CY. Actin-bundling protein plastin 3 is aregulator of ectoplasmic specialization dynamics during spermatogenesis in therat testis. FASEB J. 2015Sep;29(9):3788-805.

23．Li N, Mruk DD, Wong CK, Han D, Lee WM, Cheng CY. Formin 1 Regulates EctoplasmicSpecialization in the Rat Testis Through Its Actin Nucleation and BundlingActivity. Endocrinology. 2015 Aug;156(8):2969-83.

24．Zhu W, Zhao S, Liu Z,Cheng L, Wang Q, Yan K, Chen Q, Wu H, HanD*.Pattern recognitionreceptor-initiated innate antiviral responses in mouse epididymal epithelialcells. J Immunol. 2015 May 15;194(10):4825-35.

25．Liu Z, Zhao S, Chen Q,Yan K, Liu P, Li N, Cheng CY, Lee WM, HanD*.Roles of Toll-like receptors 2 and 4in mediating experimental autoimmune orchitis induction in mice. Biol Reprod. 2015 Mar;92(3):63.

26．Yu L, Liu P, Liu Z, ZhuW, Yan K, Chen Q, Han D*. p204-mediated innate antiviralresponses in mouse adipose cells and their effects on cell functions. Immunol Cell Biol. 2015 Feb;93(2):147-57.

27．Li N, Liu Z, Zhang Y,Chen Q, Liu P, Cheng CY, Lee WM, Chen Y, HanD*.Mice lacking Axl and Mer tyrosinekinase receptors are susceptible to experimental autoimmune orchitis induction.Immunol Cell Biol. 2015Mar;93(3):311-20.

28．Zhao S, Zhu W, Xue S, Han D*. Testicular defense systems: immune privilege andinnate immunity. Invited review. Cell Mol Immunol. 2014, 11:428–437.

29．Zhu W, Liu P, Yu L, Chen Q, Liu Z, Yan K, Lee WM,Cheng CY, Han D*. p204-initiated innate antiviralresponse in mouse Leydig cells. Biol Reprod. 2014, 91(1):8.

30．Qian X, Mruk DD, ChengYH, Tang EI, Han D, Lee WM, Wong EW,Cheng CY. Actin bindingproteins, spermatid transport and spermiation. SeminCell Dev Biol. 2014 Jun;30:75-85. Review.

31．Xiao X, Mruk DD, WongEW, Lee WM, Han D, Wong CK, ChengCY. Differentialeffects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking eventsat the Sertoli cell blood-testis barrier: an in vitro study. Am J Physiol Endocrinol Metab. 2014, 307(7):E553-62.

32．Chen Q, Zhu W, Liu Z, Yan K, Zhao S, Han D*. Toll-like receptor 11-initiatedinnate immune response in male mouse germ cells. Biol Reprod. 2014,90(2):38.

33．Yan K, Liu P, Liu Z, Zhao S, Cheng L, Han D*. Polyinosinic-Polycytidylic acid initiates ovarianinnate antiviral response and inhibits steroidogenesis in female mice. BiolReprod. 2014. 90(1):11.

34．Yu L, Yan K, Liu P, Li N, Liu Z, Zhu W, Chen Y, Han D*. Pattern recognition receptor-initiated innateantiviral response in mouse adipose cells. Immunol Cell Biol.  2014,92(2):105-15. 

35．朱伟伟 赵树涛 薛社普 韩代书*。睾丸免疫豁免与天然免疫。科学通报。2014, 59:2652-2662.

36．Yu W, Zheng H, Lin W,Tajima A, Zhang Y, Zhang X, Zhang H, Wu J, HanD, Rahman NA, Korach KS, Gao GF, Inoue I, Li X. Estrogen promotes Leydig cellengulfment by macrophages in male infertility. JClin Invest. 2014 Jun; 124(6):2709-21.

37．Zhu W, Chen Q, Yan K, Liu Z, Li N, Zhang X, Yu L,Chen Y, Han D*. RIG-I-like receptors mediate innate antiviralresponse in mouse testis. Mol Endocrinol. 2013, 27(9):1455-67.

38．Qi N, Liu P, Zhang Y, Wu H, Chen Y, Han D*. Development of a spontaneous liver diseaseresembling autoimmune hepatitis in mice lacking tyro3, axl and mer receptortyrosine kinases. PLoS One. 2013, 8(6):e66604.

39．Chen B, Xue Z, Yang G,Shi B, Yang B, Yan Y, Wang X, Han D,Huang Y, Dong W. Akt-signalintegration is involved in the differentiation of embryonal carcinoma cells.PLoS One. 2013 Jun 6;8(6):e64877.

40．Zhang Y, Li N, Chen Q, Yan K, Liu Z, Zhang X, LiuP, Chen Y, Han D*. Breakdown of immune homeostasis in the testis ofmice lacking Tyro3, Axl and Mer receptor tyrosine kinases. Immunol Cell Biol.2013, 91(6):416-26.

41．Yan K, Zhu W, Yu L, Li N, Zhang X, Liu P, Chen Q,Chen Y, Han D*. Toll-like receptor 3 and RIG-I-like receptoractivation induces innate antiviral responses in mouse ovarian granulosa cells.Mol Cell Endocrinol. 2013, 372(1-2):73-85.

42．Zhang X, Wang T, Deng T, Xiong W, Lui P, Li N, ChenY, Han D*. Damaged spermatogenic cells induce inflammatorygene expression in mouse Sertoli cells through the activation of Toll-likereceptors 2 and 4. Mol Cell Endocrinol. 2013, 365(2):162-73.

43．Deng T, Feng X, Liu P, Yan K, Chen Y, Han D*. Toll-like receptor 3 activation differentiallyregulates phagocytosis of bacteria and apoptotic neutrophils by mouseperitoneal macrophages. Immunol Cell Biol. 2013, 91(1):52-9.

44．Li N, Wang T, HanD*. Structural, cellular and molecular aspects ofimmune privilege in the testis. Front Immunol. 2012, 3:152. Invited review.

45．Wang T, Zhang X, Chen Q, Deng T, Zhang Y, Li N,Shang T, Chen Y, Han D*. Toll-like receptor 3-initiated antiviralresponses in mouse male germ cells in vitro. Biol Reprod. 2012, 86(4):106.

46．Deng T, Zhang Y, Chen Q, Yan K, Han D*. Toll-like receptor-mediated inhibition of Gas6and ProS expression facilitates inflammatory cytokine production in mousemacrophages. Immunology. 2012, 135(1):40-50.

47．Tingting Deng, Yue Zhang,Qiaoyuan Chen, Keqin Yan, Daishu Han*. Toll-like receptor-mediatedinhibition of Gas6 and ProS expression facilitates inflammatory cytokineproduction in mouse macrophages. Immunology, 2011, 135:40-50.

48．Xueying Feng, TingtingDeng, Yue Zhang, Shaobo Su, Chiju Wei, DaishuHan*. Lipopolysaccharide inhibits macrophage phagocytosisof apoptotic neutrophils by regulating the production of tumour necrosis factor and growth arrest-specific gene 6.Immunology, 2011, 132(2):287-95.

49．Song Chen, Chunhui Lai, Xiaoxiang Wu, Yaozheng Lu, Daishu Han, Weizhong Guo, Linchun Fu,Jean-Marie Andrieu and Wei Lu. Variability of bio-clinicalparameters in chinese-origin rhesus macaques infected with simianimmunodeficiency virus: a nonhuman primate AIDS model. PloS One, 20116(8):e23177.

50．Tao Wang, Xueying Feng, Daishu Han*.Mechanisms of testicular immune privilege. Frontiers in Biology, 2011, 6 (1):19-30. Invited review.

51．Tao Shang,Xiaoyan Zhang, Tao Wang, Bing Sun, Tingting Deng, Daishu Han*. Toll-like receptor-initiatedtesticular innate immune responses in mouse Leydig cells. Endocrinology, 2011,152:2827-2836.

52．Tingting Deng, Yue Zhang,Qiaoyuan Chen, Keqin Yan, Daishu Han*. Toll-like receptor-mediatedinhibition of Gas6 and ProS expression facilitates inflammatory cytokineproduction in mouse macrophages. Immunology, 2011, 135:40-50.

53．Bing Sun, Nan Qi, TaoShang, Hui Wu, Tingting Deng, and DaishuHan*. SertoliCell-Initiated Testicular Innate Immune Response through Toll-Like Receptor-3Activation Is Negatively Regulated by Tyro3, Axl, and Mer Receptors.Endocrinology, 2010, 151: 2886-28.

著作章节

1．    Han D*, Liu Z, Yan K. Immunology ofthe Testis and Privileged Sites. 2016, In: Ratcliffe M.J.H (Editor in Chief),Encyclopedia of Immunobiology, Vol. 5, pp. 46-53. Oxford: Academic Press.

2．    Deng T, Han D*.Testicular Immune Environment for Spermatogenesis. 2016, In: Gladys Robinson(Editor), Spermatogenesis: Molecular Mechanisms, Regulation and BiologicalPerspectives, pp. 71-100. Nova publishers.

3．    Jiang Q, Han D*.Infectious and immunological aspects of male infertility. 2017，In: Manuela Simoni and IlpoHuhtaniemi (Editor), Endocrinology of the Testis and Male Reproduction. pp1051-1067. Springer publishers.

4．     Wang F, Jiang Q, Han D*. Testicularimmunoregulation: The role of Tyro3, Axl, and Mer receptor tyrosine kinases andpattern recognition receptors. 2018; In: Yan C Cheng (Editor), Spermatogenesis:Biology and Clinical Implications. p51-61. Springer.

5．    Gong M, Han D*. Immune Environment in the Testis. 2018, In: Yan C Cheng (Editor), MolecularMechanisms in Spermatogenesis, Second Edition. Springer.

6．    Wang F, Chen R, Han D*. Innate immune defense in the male reproductive system and malefertility. 2019, In: SK, Saxena (Editor), Innate Immunity in Health andDisease. IntechOpen publishers.

7．    Wang F, Chen R, Han D*. Phagocytosis of Sertoli cells: a critical event forspermatogenesis. 2019, In: Male Reproductive Health, 10.5772/intechopen.86808.IntechOpen Publishers.

8．    Chen R, Wang F, Han D*. Immunological function of Leydig cells. 2020, In: Brono Solomon(Editor), Leydig cells: Structure, Functions and Clinical Aspects, p1-25. NovaScience Publishers.

9.    韩代书。第三章，精子发生与成熟。生殖生物学（杨增明等主编）2008，科学出版社。

10.    韩代书，陈咏梅。第五章：精子发生。生殖生物学（第二版）2019，科学出版社。

生殖系统具有特殊的免疫抑制环境，以保护生殖细胞不受免疫系统的损伤，但又容易受到微生物病原体的感染。微生物感染与生殖系统炎症是不孕不育的重要病因。

目前实验室研究男性生殖系统免疫环境的调节机制、以及微生物感染与炎症相关的男性不育。主要内容包括：睾丸与附睾免疫豁免环境保护精子发生的机制；微生物感染与自身免疫反应诱导睾丸炎、附睾炎、精囊炎及前列腺炎的机制；组织特异细胞天然免疫/抗病毒反应及其在诱发组织炎症中的作用；揭示生殖系统微生物感染与炎症破坏精子发生与功能、从而导致男性不育的机制。