1.     中组部，第4批万人计划青年拔尖人才项目，主持

2.     国家自然科学基金委员会，面上项目，假性激酶TRIB3促进非霍奇金氏淋巴瘤发生发展的作用和机制在研，主持

3.     中国医学科学院医学与健康科技创新工程，“特殊药物（小檗碱）对心脑血管疾病的防治与分子基础”子项目，在研，子项目主持

4.     国家自然科学基金委员会，青年项目，TRB3调节PML-RARα介导急性粒细胞性白血病的作用和机制，结题，主持

5.     中央级公益性科研院所基本科研业务专项，TRB3调节上皮-间叶转化和肿瘤干细胞样性状的机制研究，结题，主持

6.     中央级公益性科研院所基本科研业务专项（团队项目），基于ULK1激酶的活性位点、下游通路及靶向抑制剂研究，参与。

7.     国家自然科学基金青年项目，基于MDM2-p53结构的新型小分子抑制剂LJ1019的结构优化及抗肿瘤活性研究，参与。

发表论文情况

1.     Li K#, Wang F#, Yang ZN#, Cui B, Li PP, Li ZY, Hu ZW* and Zhu HH*. PML-RARa interaction with TRIB3 impedes PPARg/RXR function and triggers dyslipidemia in acute promyelocytic leukemia. Theranostics. 2020 (Accepted, IF=8.579, First author)

2.     Zhu HH*, Yang MC, Wang F, Li K* and Zhang SZ*. Identification of a novel NUP98-RARA fusion transcript as the 14th variant of acute promyelocytic leukemia. American Journal of Hematology. 2020 (Accepted, IF=6.973, Corresponding author).

3.     Xue ST#, Li K#, Gao Y, Zhao LY, Gao Y, Yi H, Jiang JD*, and Li ZR*. The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target. Autophagy, 2020 Jan 27:1-15. doi: 10.1080/15548627.2019.1709762. (IF=11.1, Co-first author)

4.     Li K, Zhang TT, Hu ZW*. Metformin Reduces TRIB3 Expression and Restores Autophagy Flux: An Alternative Antitumor Action. Autophagy. 2018 Jul 20:1-2. (IF=11.1, First author)

5.     Li K, Zhang TT, Wang F, Cui B, Zhao CX, Yu JJ, Lv XX, Zhang XW, Yang ZN, Huang B, Li X, Hua F, Hu ZW*. Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression. Oncogene. 2018 Jul 20: 1-2. (IF=7.519, First author)

6.   Li K#, Wang F#, Cao WB, Lv XX, Hua F, Cui B, Yu JJ, Zhang XW, Shang S, Liu SS, Yu JM, Han MZ, Huang B, Zhang TT, Li X, Jiang JD, Hu ZW*. TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARa and Inhibition of p53-Mediated Senescence. Cancer Cell, 2017, 31: 697-710. (IF=27.407, First author)

7.   B Cui#, X Cao, W Zou, Y Wan, N Wang, Y Wang, P Li, F Hua, Y Liu, XW Zhang, K Li, XX Lv, B Huang, ZW Hu. Regulation of immune-related diseases by multiple factors: A meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine on Tumor Immunology. Acta Pharmaceutica Sinica B 2017;7(4):532–540 (IF=6.014)

8.   Li K, Wang F, Hu ZW*. Targeting TRIB3 and PML-RARα interaction against APL. Oncotarget. 2017, 8: 52012-52013. (IF=5.168, First author)

9.   Li K, Wang F, Hu ZW*. Targeting pseudokinase TRIB3 brings about a new therapeutic option for acute promyelocytic leukemia. Mol Cell Oncol. 2017, 4: e1337547. (First author)

10.   Li K, Hu ZW*. The real role of pseudokinase: linking diabetes to cancers. Cancer Med. 2016, 5: 1647-1649. (IF=3.362,  (IF=5.168, First author)

11.   Hua F#, Li K#, Yu JJ#, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW*. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun.2015, 13;6:7951. (#contributing equally, IF=12.353, Co-first author)

12.   Li K, Lv XX, Hua F, Lin H, Sun W, Cao WB, Fu XM, Xie J, Yu JJ, Li Z, Liu H, Han MZ and Hu ZW*. Targeting acute myeloid leukemia with a proapoptotic peptide conjugated to a Toll-like receptor 2-mediated cell-penetrating peptide. Intl J Cancer. 2014; 134:692-702. (IF=7.36, First author)

13.   Li K, Hua F, Lv XX, Yu JJ, Hu ZW*, Establishment and application of TLR2 receptor-based cell screening model. Acta Pharm Sin. 2013, 48: 694-699. (First author)

14.    Zhang XW#, Zhou JC#, Peng D, Hua F, Li K, Yu JJ, Lv XX, Cui B, Liu SS, Yu JM, Wang F, Jin CC, Yang ZN, Zhao CX, Hou XY, Huang B, Hu ZW*. Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation. Autophagy, 2019 1-15. (IF=11.1)

15.     P Liu, HY Bao, CC Jin, JC Zhou, F Hua, K Li, XX Lv, XX Lv, B Cui, ZW Hu, XW Zhang*. Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin‐Induced Heart Failure Through Resolution of Toll‐Like Receptor 2–Mediated Myocardial Inflammation. J AM HEART ASSOC, 2019 8 (20), e012338 (IF=4.66)

16.     Liu SS#, Lv XX#, Liu C, Qi J, Li YX, Wei XP, Li K, Hua F, Cui B, Zhang XW, Yu JJ, Yu JM, Wang F, Shang S, Zhao CX, Hou XY, Yao ZG, Li PP, Li X, Huang B, Hu ZW*. Targeting C/EBPβ Degradation Reduces Lung Fibrosis by Disturbing the GSK-3β/A20 Interaction in Macrophages. Immunity, 2019, 51, 1-13. (IF=21.522)

17.     Hua F#, Shang S#, Yang YW, Zhang HZ, Xu TL, Yu JJ, Zhou DD, Cui B, Li K, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Zhang C, Huang B, Hu ZW*. TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology, 2019,156(3):708-721. (IF=19.8)

18.     B Cui, PA Eyers, LL Dobens, NS Tan, PD Mace, WA Link, E Kiss-Toth, K Li...ZW Hu#. Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer. Acta Pharmaceutica Sinica B 2019;9(2):443–454. (IF=5.808)

19.   Lv XX, Liu SS, Li K, Cui B, Liu C, Hu ZW*. Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice. Oncotarget. 2017, 8: 74720-74735. (IF=5.168)

20.   Xie J, Yun JP, Yang YN, Hua F, Zhang XW, Lin H, Lv XX, Li K, Zhang PC*, Hu ZW*. A novel ECG analog 4-(S)-(2,4,6-trimethylthiobenzyl)- epigallocatechin gallate selectively induces apoptosis of B16-F10 melanoma via activation of autophagy and ROS. Sci Rep. 2017, 7: 42194. (IF=4.259)

21.   Wang HQ, Li K, Ma LL, Wu S, Hu J, Yan HY, Jiang JD, Li YH. Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy. VIROL J. 2017, 14 (1):2-2 (IF=2.139)

22.   Zhang XW, Mi S, Li Z, Zhou JC, Xie J, Hua F, Li K, Cui B, Lv XX, Yu JJ, Hu ZW. Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes. Oncotarget. 2017, 8: 9922-9934. (IF=5.168)

23.   DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, Li K,... Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2016 12 (1), 1-222. (IF=11.1)

24.   Hua F, Li K, Yu JJ, Hu ZW*. The TRIB3-SQSTM1 interaction mediates metabolic stress-promoted tumorigenesis and progression via suppressing autophagic and proteasomal degradation. Autophagy. 2015, 11: 1929-31. (IF=8.593)

25.   Liu H, Mi S, Li Z, Lv XX, Li K, Hua F, Hu ZW*, SB216763, a selective small molecule inhibitor of glycogen synthase kinase-3, improves bleomycin-induced pulmonary fibrosis via activating autophagy. Acta Pharm Sin B. 2013, 3: 226-233.

26.   Lv XX, Wang XX, Li K, Wang ZY, Li Z, Lv Q, Fu XM and Hu ZW*, Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013, 8: e68631. (IF=2.806)

27.   Lin H, Yan J, Wang ZY, Hua F, Yu JJ, Sun W, Li K, Liu H, Yang HZ, Lv Q, Xue JF, Hu ZW*, Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesisi and progression in Toll-like receptor 2-deficient mice. Hepatology. 2013, 57: 171-182. (IF=13.246)

申请专利

1.     “一种与人源TLR2特异性结合的多肽，其制备方法和用途”，中国，发明专利，专利申请号：CN201310113133.5。

2.     “与TRB3蛋白特异性结合的多肽，其筛选方法、鉴定和用途”，中国，发明专利，专利申请号：CN201310206907.9。

3.     “与TRB3蛋白特异性结合的多肽，其筛选方法、鉴定和用途”，国际，发明专利，专利申请号：PCT/CN2014/092516。

4.     一种多肽及其在制备治疗和预防肿瘤的药物中的应用, 中国，发明专利，专利申请号，CN201610921217。

5.     一种多肽及其在制备治疗和/或预防肿瘤的药物中的应用，中国，发明专利，专利，CN201610402144。

6.     一种多肽或其衍生物在预防和/或治疗高血压性心肌肥厚中的应用，CN201610262690。

7.     一种多肽及其衍生物在制备抗肺纤维化药物中的应用，ZL201410826820.6。

发表学术专著

1.     胡卓伟，吕晓希，李珂，自噬与呼吸系统疾病，p301-321，自噬——生物学与疾病（第二版），科学出版社，中国。

2.     胡卓伟，花芳，李珂，免疫信号与自噬调控，p176-197，自噬——生物学与疾病（第二版），科学出版社，中国。