个人信息
Personal Information
- 教授
- 导师类别：博士生导师
- 性别： 女
- 学历：博士研究生
- 学位：博士
联系方式
Contact Information
- 所属院系：系统医学研究所 ( 苏州 )
- 所属专业： 细胞生物学
- 邮箱 : hesudan2018@163.com
- 工作电话 : 0512-62875015
个人简介
Personal Profile
何苏丹，中国医学科学院&北京协和医学院苏州系统医学研究所研究员，博士生导师，国家优秀青年基金和教育部长江学者奖励计划青年学者获得者。主要从事细胞死亡机制以及相关疾病的发病机理研究。作为第一作者或通讯作者的论文发表于国际重要学术期刊Cell、PNAS、Nature Immunology、Nature Communications、Journal of Virology和Biomaterials等，获专利授权3项。论文他引2000余次。作为项目负责人承担多项国家级和省级科研项目，包括国家自然科学基金重点项目和面上项目， 国家优秀青年科学基金、 江苏省杰出青年科学基金， 霍英东青年教师基金，江苏省自然科学基金面上项目等，作为课题负责人承担国家重点研发计划子课题，入选教育部长江学者奖励计划青年学者、江苏省双创团队、 江苏省六大人才高峰， 333高层次人才培养工程，荣获江苏省青年科技奖和苏州市十佳魅力科技人物。
团队成员包括2位副研、2位博士后、2位科研助理和5名研究生。
作为项目负责人承担多项国家级和省部级科研项目，包括国家自然科学基金重点、优秀青年基金项目和面上项目、 江苏省杰出青年科学基金， 霍英东青年教师基金、 江苏省六大人才高峰，以及作为课题负责人承担国家重点研发计划子课题等。
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支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg作为项目负责人承担多项国家级和省部级科研项目，包括国家自然科学基金重点、优秀青年基金项目和面上项目、 江苏省杰出青年科学基金， 霍英东青年教师基金、 江苏省六大人才高峰，以及作为课题负责人承担国家重点研发计划子课题等。
近年来在阐明程序性细胞死亡的分子机制以及生理学意义等方面取得了重要成果，作为第一作者或通讯作者论文发表于国际重要学术期刊Cell、PNAS、Nature Communications和 Journal of Virology等，获专利授权3项。
代表性论文 (*通讯作者)：
1. Zhao C, Zhou Y,Ran Q, Yao Y, Zhang H, Ju J, Yang T, Zhang W, Yu X*, He S*. MicroRNA-381-3pFunctions as a Dual Suppressor of Apoptosis and Necroptosis and PromotesProliferation of Renal Cancer Cells. FrontCell Dev Biol. 2020;8:290.
2. Yang C, Ran Q,Zhou Y, Liu S, Zhao C, Yu X, Zhu F, Ji Y, Du Q, Yang T, Zhang W, He S*.Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activationof the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis. Apoptosis. 2020;25(5-6):441-455.
3. Zhu F, Wang Y,Du Q, Ge W, Li Z, Wang X, Fu C, Luo L, Tian S, Ma H, Zheng J*, Zhang Y,Sun X, He S*, Zhang X*. Structural optimization ofaminopyrimidine-based CXCR4 antagonists. Eur J Med Chem. 2020;187:111914.
4. Hou J, Ju J, Zhang Z, Zhao C, Li Z, Zheng J,Sheng T, Zhang H, Hu L, Yu X, Zhang W, Li Y, Wu M, Ma H*, Zhang X*, He S*.Discoveryof potent necroptosis inhibitors targeting RIPK1 kinase activity for thetreatment of inflammatory disorder and cancer metastasis. Cell Death Dis. 2019；24;10(7):493.
5. He S*, Wang X*. RIP kinases as modulators of inflammation andimmunity. Nat Immunol. 2018;19(9):912-922.
6. Chen Q, Zhang H,Wu M, Wang Q, Luo L, Ma H*, Zhang X*, He S*. Discoveryof a potent hedgehog pathway inhibitor capable of activating caspase8-dependentapoptosis. J Pharmacol Sci. 2018 ;137(3):256-264.
7. Ma H, Chen Q, Zhu F, Zheng J, Li J, Zhang H,Chen S, Xing H, Luo L, Zheng LT, He S*,Zhang X*. Discoveryand characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor. Eur J Med Chem. 2018;149:110-121.
8. Yang C, Li J, YuL, Zhang Z, Xu F, Jiang L, Zhou X*, He S*. Regulation of RIP3 by the transcription factor Sp1 and theepigenetic regulator UHRF1 modulates cancer cell necroptosis. Cell Death Dis.2017;8(10):e3084.
9. Cao Z, Peng F,Hu Z, Chu B, Zhong Y, Su Y*, He S*, He Y*.In vitro cellular behaviors andtoxicity assays of small-sized fluorescent silicon nanoparticles. Nanoscale. 2017;9 (22):7602-7611.
10. Hou J, Zhang Z,Huang Q, Yan J, Zhang X, Yu X, Tan G, Zheng C, Xu F*, He S*. Antiviralactivity of PHA767491 against human herpes simplex virus in vitro and in vivo. BMC Infect Dis. 2017 Mar 20;17(1):217.
11. Yu X, HeS*. GSDME as anexecutioner of chemotherapy-induced cell death. Sci China Life Sci. 2017 Nov;60(11):1291-1294.
12. Hu Z, Song B, XuL, Zhong Y, Peng F, Ji X, Zhu F, Yang C, Zhou J, Su Y, Chen S, He Y*, HeS*. Aqueous synthesized quantum dots interfere with the NF-κB pathwayand confer anti-tumor, anti-viral and anti-inflammatory effects. Biomaterials 2016;108:187-196.
13. Yang C, He S*. Heat shockprotein 90 regulates necroptosis by modulating multiple signaling effectors. Cell Death Dis 2016;3;7:e2126.
14. He S*, Huang S, ShenZ*. Biomarkers for the detection of necroptosis. Cell Mol LifeSci 2016;73(11-12):2177-81.
15. Dong T, Li C, Wang X, Dian L, Zhang X, Li L,Chen S, Cao R, Li L, Huang N, He S*, Lei X*. Ainsliadimer A selectively inhibits IKKa/b by covalentlybinding a conserved cysteine. NatCommun 2015; 27;6:6522.
16. Yu X, Li Y, Chen Q, Su C, Zhang Z, Yang C, HuZ, Hou J, Zhou J, Gong L, Jiang X, Zheng C*, He S*. Herpessimplex virus Type 1 (HSV-1) and HSV-2 mediate species specific modulations ofprogrammed necrosis through the viral ribonucleotide reductase large subunit R1. J Virol 2015;90(2):1088-95.
17. Wang X, Li Y, Liu S, Yu X, Li L, Shi C, He W,Li J, Xu L, Hu Z, Yu L, Yang Z, Chen Q, Ge L, Zhang Z, Zhou B, Jiang X, Chen S,He S*. Direct activation of RIP3/MLKL-dependent necrosisby herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense.Proc Natl Acad Sci USA 2014;111(43):15438-43.
18. Wang H, Jiang X, Wang X, Wei X, Zhu Y, Sun B,Su Y, He S*, He Y*. A hairpin DNA-assisted silicon/silverbased surface enhanced raman scattering platform for ultrahighly sensitive andspecific discrimination of deafness mutations in a real system. Anal Chem 2014;86:7368-76.
19. He S*, Liang Y, ShaoF, Wang X*. Toll-like receptors activate programmed necrosis in macrophagesthrough a receptor-interacting kinase-3 mediated pathway. Proc Natl Acad Sci USA 2011;108:20054-59.
20. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X*. Receptor interacting protein kinase-3determines cellular necrotic response to TNF-alpha. Cell 2009; 137:1100-1111.
21. Liu S, Wang X, Li Y, Xu L, Yu X, Ge L, Li J,Zhu Y*, He S*. Necroptosis MediatesTNF-Induced Toxicity of Hippocampal Neurons. BioMed research international 2014, 2014:290182.
22. Yu X, He S*. The interplaybetween human herpes simplex virus infection and the apoptosis and necroptosiscell death pathways. VirolJ 2016;6;13(1):77.
23. Zhang Y, ZhangJ, Yan R, Tian J, Zhang Y, Zhang J, Chen M, Cui Q, Zhao L, Hu R, Jiang M, Li Z,Ruan C, He S, Dai K*. Receptor-interactingprotein kinase 3 promotes platelet activation and thrombosis. Proc Natl Acad Sci USA 2017; 114(11):2964-2969.
24. Liu K, Jian Y,Sun X, Yang C, Gao Z, Zhang Z, Liu X, Li Y, Xu J, Jing Y, Mitani S, He S,Yang C*. Negative regulation ofphosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. JCell Biol. 2016;212(2):181-98.
25. Sun L, Wang H, Wang Z, He S,Chen S, Liao D, Wang L, Yan J, Liu W, Lei X*, Wang X*.Mixed lineage kinasedomain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012;148:213-227.
26. Cheng J, Zhu Y, He S, Liu Y,Chen J, Han B, Petrillo M, Wrzeszczynski K, Yang S, Dai P, Zhai S, Han D, ZhangM, Li W, Liu X, Li H, Chen ZY, Yuan H*. Functional mutation of SMAC/DIABLO,Encoding a Mitochondrial Pro-apoptotic Protein, Causes Human ProgressiveHearing Loss DFNA64. Am J Hum Genet2011;89:56-66.
