1.  “ARID1A在食管鳞状细胞癌中泛素化与去泛素化调控机制及其抑癌功能研究”国家自然科学基金面上项目（81972570），2020-2023，57万元，负责人；

2.  “细胞稳态破坏导致肿瘤发生的分子机制” 科技部重点研发计划慢病专项（2016YFC1302100），2016-2020，1065万元，项目负责人；

3.  “KLF家族及其相互作用蛋白在乳腺癌变中的作用” 国家自然科学基金重点国际合作项目（81420108025），2015-2019，300万元，负责人；

4.  “组蛋白和DNA甲基化对参与乳腺癌侵袭转移miRNAs的调节”，国家自然科学基金国际合作与交流项目（81461148025），2014-2017，200万元，负责人；

5.  “食管癌的转化医学研究”教育部创新团队发展计划（IRT13006），2014-2016，300万元，负责人；

6.  “KLF4的调控机制及在肿瘤发生发展中的功能研究”国家自然科学基金重点项目（81130043），2012-2016，260万元，负责人；

7.   “细胞微环境在肿瘤的发生发展及侵袭转移中的作用及机制”973项目“恶性肿瘤发生、发展的细胞表观遗传机制”子课题（2011CB504205），2011-2015，260万元，子课题负责人；

8.  “DNA代谢和损伤应答相关蛋白在肿瘤个体化诊治中的应用研究” 国家重点基础研究发展计划项目“DNA损伤修复相关蛋白在基因组稳定性维持和肿瘤发生发展中的机制研究”（2013CB911004）, 2013-2017, 155万元，分课题负责人；

9.   “上皮间质转换过程中microRNA的功能及机制研究”，国家自然科学基金重大研究计划“细胞重编程的表观遗传学机制”培育项目（91019009），2011-2013，60万元，负责人；

10.  “食管癌全基因组关联分析和药物基因组学研究”，863重点项目（2009AA022706），2009-2011，254万元，副组长；

11.  “恶性肿瘤的系统生物研究”国家重点基础研究发展规划项目（973）“多基因复杂性状疾病的系统生物学研究”子课题（2004CB518604），2005-2009，169万元，子课题负责人，已完成；

12.  “食管癌病因及发病机制的研究”，863课题（2006AA02Z467），2006-2008，100万元，分课题负责人，已完成；

13.  “食管癌变的分子机理研究”国家杰出青年基金（30425027），2005—2008，140万元，负责，已完成；

14.  “miRNA在食管癌及肝癌发生发展中的转录组研究”重大科技计划“以细胞为单元的人类基因转录组与蛋白质组的关联性研究”子课题（2006CB910407），2006-2010，100万元，子课题负责人；

15.  “C1orf10在食管癌中的功能及调控研究”国家自然科学基金（30772525），2008—2010，30万元，负责，已完成；

16.  “S100A14在食管癌中的功能及调控机制研究”国家自然科学基金（30671167），2007—2009，30万元，负责，已完成；

17.  “S100A8/S100A9在食管鳞癌中的作用及机理研究”教育部高校博士学科点基金（20040023038），2005—2007， 6万元，负责，已完成；

18.   “人不同种类细胞基因表达谱的获取及数据库的建立与应用”国家高技术研究发展计划（863）课题（2001AA231041），2001-2005，100万元，负责，已完成；

19.  “食管癌发生发展过程中的基因表达谱研究”国家重点基础研究发展规划项目（973）“疾病基因组学理论和技术体系的建立”子课题（G1998051021），1999—2003,195万元，负责，已完成；

20.  “食管癌与细胞分化”教育部跨世纪优秀人才培养计划基金，2004-2006，30万元，负责，已完成；

21.  “一个新的食管癌相关基因的功能研究”北京市科技合同项目（H020220020310），2002-2004，15万元，负责，已完成；

22.   “食管癌基因表达的生物信息学分析” 国家自然科学基金课题（30170519），2002-2004，18万元，负责，已完成；

23.  “食管癌发生发展过程中的基因表达谱研究”国家自然科学基金重大课题“中华民族基因组的结构与功能研究”子课题（39993420），1999—2002, 28万元，负责，已完成；

24.  “食管癌发生发展过程中大规模基因表达的生物信息学分析”首都二四八工程重大创新工程（生物医药领域）资助项目（H010210030113），2001—2002，20万元，负责，已完成；

25.  “食管癌发生发展过程中的基因表达谱研究”,2000年度教育部优秀青年教师资助计划，9万元，负责，已完成；

26.  “维甲酸特异激活基因RA28编码蛋白质的结构与功能研究”，国家自然科学基金（39700168），1998-2000, 10万元，负责，已完成。

发表文章：

1.      Cui Y#, ChenH#, Xi R#, Cui H#, Zhao Y#, Xu E#, Yan T, Lu X, Huang F, Kong P, Li Y, Zhu X,Wang J, Zhu W, Wang J, Ma Y, Zhou Y, Guo S, Zhang L, Liu Y, Wang B, Xi Y, SunR, Yu X, Zhai Y, Wang F, Yang J, Yang B, Cheng C, Liu J, Song B, Li H, Wang Y,Zhang Y, Cheng X, Zhan Q*, Li Y*, Liu Z*.Whole genome sequencing of 508 patients identifies key molecular features associatedwith poor prognosis in esophageal squamous cell carcinoma. Cell Research. 2020. doi: 10.1038/s41422-020-0333-6.

2.      Zhou Z#; Zhou H#; Ponzoni L, Luo A, Zhu R, He M, Huang Y,Guan KL, Bahar I, Liu Z*, Wan Y*.EIF3H orchestrates Hippo pathway-mediated oncogenesis via catalytic control ofYAP stability. Cancer Research. 2020,doi: 10.1158/0008-5472.

3.      Luo Q, Wu X, Liu Z*. Remodeling of the ARID1A tumor suppressor. Cancer Letters. Available online 29 July2020. https://doi.org/10.1016/j.canlet.2020.07.026

4.      Li X#, Wang M#, Gong T, Lei X, Hu T, Tian M, Ding F, Ma F, ChenH*, Liu Z*. A S100A14-CCL2/CXCL5signaling axis drives breast cancer metastasis. Theranostics. 2020,10(13):5687-5703.

5.      Luo Q, Wu X, Chang W, Zhao P, Zhu X, Chen H, Nan Y, Luo A,Zhou X, Su D, Jiao W, Liu Z*. ARID1Ahypermethylation disrupts transcriptional homeostasis to promote squamous cellcarcinoma progression. Cancer Research.2020, 80:406-417.

6.      YuF, Li K, Li S, Liu J, Zhang Y, Zhou M, Zhao H, Chen H, Wu N, Liu Z*, Su J*. CFEA:a cell-free epigenome atlas in human diseases. Nucleic Acids Res. 2020, 48(D1),D40-D44.

7.      Luo Q, Wu X, Nan Y, Chang W, Zhao P, Zhang Y, Su D, Liu Z*. TRIM32/USP11 balances ARID1Astability and the oncogenic/tumor-suppressive status of squamous cellcarcinoma. Cell Reports. 2020,30:98-111.

8.      WuX, Luo Q, Zhao P, Chang W, Wang Y, Shu T, Ding F, Li B, Liu Z*. JOSD1 inhibits mitochondrial apoptotic signaling todrive acquired chemoresistance in gynaecological cancer by stabilizing MCL1. Cell Death Differ. 2020, 27:55-70.

9.      Huang F, Ma G, Zhou X, ZhuX, Yu X, Ding F, Cao X, Liu Z,∗.Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppressinvasion and metastasis in esophageal squamous cell carcinoma. Cancer Lett, 2020, 479:100-111.

10.   Wu X, Luo Q, Liu Z*. Ubiquitination and deubiquitinationof MCL1 in cancer: deciphering chemoresistance mechanisms and providingpotential therapeutic options. Cell Death & Disease. 2020,11(7):556.

11.   Luo Q, Wu X, Chang W, Zhao P, Nan Y, Zhu X, Katz J, Su D,Liu Z*. ARID1A prevents squamouscell carcinoma initiation and chemoresistance by antagonizingpRb/E2F1/c-Myc-mediated cancer stemness. CellDeath & Differentiation. 2019 Dec 12. DOI: 10.1038/s41418-019-0475-6.

12.   Zhang J, Luo A, Huang F, Gong T, Liu Z*. SERPINE2 promotes esophageal squamous cell carcinomametastasis by activating BMP4. Cancer Lett. 2019, 469:390-398.

13.   He H, Wu Z, Li S, Chen K, Wang D, Zou H, Chen H, Li Y, Liu Z*, Qu C*. TRAF7 enhances ubiquitin-degradation of KLF4 to promotehepatocellular carcinoma progression. Cancer Lett. 2019, 469:380-389.

14.   Wu X, Luo Q, Zhao P, Chang W, Wang Y, Shu T, DingF, Li B, Liu Z*. MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovariancancer. Proc Natl Acad Sci USA. 2019, 116(8):2961-2966. 

15.   Zou H, Chen H, Zhou Z, Wan Y*, Liu Z*. ATXN3 promotes breast cancermetastasis by deubiquitinating KLF4. Cancer Lett. 2019, 467:19-28.

16.   WangL & Liu Z*. Keeping aclean research environment: Addressing research misconduct and improvingscientific integrity in China. Cancer Lett. 2019, 464:1-4.

17.   Luo A, Zhou X, Shi X, Zhao Y, Men Y, Chang X, Chen H, Ding F, LiY, Su D, Xiao Z*, Hui Z*, Liu Z*.Exosome-derived miR-339-5p mediates radiosensitivity by targeting Cdc25A inlocally advanced esophageal squamous cell carcinoma. Oncogene. 2019,38(25):4990-5006. 

18.   Li L, Zhou H, Zhu R, Liu Z*. USP26 promotes esophageal squamous cell carcinomametastasis through stabilizing Snail. Cancer Lett. 2019, 448:52-60.

19.   Zhou H, Liu Y, Zhu R, DingF, Cao X, Lin D, Liu Z*. OTUB1promotes esophageal squamous cell carcinoma metastasis through modulating Snailstability. Oncogene. 2018, 37:3356-3368.

20.   Liu Y, Zhou H, Zhu R, Ding F, Li Y, Cao X, Liu Z*. SPSB3 targets SNAIL for degradation in GSK-3βphosphorylation-dependent manner and regulates metastasis.Oncogene. 2018,37:768-776.

21.   Luo Q, Wu X, Zhang Y, Shu T, Ding F, Chen H, Zhao P, Chang W,Zhu X, LiuZ*. ARID1A ablation leads to Multiple DrugResistance in ovarian cancer via transcriptional activation of MRP2.Cancer Lett.2018, 427:9-17.

22.   ZhuR, Liu Y, Zhou H, Li L, Li Y, Ding F, Cao X, Liu Z*. Deubiquitinating enzyme PSMD14 promotes tumor metastasis throughstabilizing SNAIL in human esophageal squamous cell carcinoma. Cancer Lett. 2018,418:125-134.

23.   Shu T, Li Y, Wu X, Li B*, LiuZ*. Down-regulation of HECTD3 by HER2 inhibition makes serousovarian cancer cells sensitive to platinum treatment. Cancer Lett. 2017, 411:65-73.

24.   Li Y*, Wu X, Li L, Liu Y, Xu C, Su D, Liu Z*. The E3 ligase HECTD3 promotes esophageal squamous cellcarcinoma (ESCC) growth and cell survival through targeting and inhibitingcaspase-9 activation. Cancer Lett. 2017,404:30430-5.

25.   Zhou Z, Luo A, Shrivastava I, He M, Huang Y, Bahar I, Liu Z*, Wan Y*. Regulation of XIAP Turnover Reveals a Role for USP11 inPromotion of Tumorigenesis. EBioMedicine.2017, 15:48-61.

26.   ZhouH, Liu Y, Zhu R, Ding F, Wan Y, Liu Z*.FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 toproteasomal degradation. Oncogene, 2017,36:3312-3321.

27.  Ma J, Zhan Y, Xu Z, Li Y, Luo A, Ding F, CaoX, Chen H, Liu Z*. ZEB1 induced miR-99b/let-7e/miR-125a clusterpromotes invasion and metastasis in esophageal squamous cell carcinoma. Cancer Lett. 2017, 398:37-45.

28.   Xu Z, Zou L, Ma G, Wu X, Huang F, Feng T, Li S, Lin Q, He X, Liu Z*, Cao X*. Integrinβ1 is a critical effector in promoting metastasis and chemo-resistance ofesophageal squamous cell carcinoma. Am J Cancer Res. 2017, 7(3):531-542.

29.   ZhanY, Liang X, Li L, Wang B, Ding F, Li Y, Wang X, Zhan Q, Liu Z*. MicroRNA-548j Functions as a Metastasis Promoter inHuman Breast Cancer by Targeting Tensin1. MolecularOncology. 2016,10(6): 838-849.

30.   ZhaoY, Luo A, Li S, Zhang W, Chen H, Li Y, Ding F, Huang F, Liu Z*. ID1 inhibitsetoposide induced apoptosis in a c-Jun/c-Fos-dependent manner in humanesophageal cancer cells. J Biol Chem.2016, 291(13):6831-42.

31.   He H, Li S, Hong Y, Zou H, Chen H, Ding F, Wan Y, LiuZ*. Krupple-like factor 4 promotes esophageal squamous cell carcinomadifferentiation by up-regulating Keratin 13 expression. J Biol Chem. 2015, 290(21):13567-77.

32.   HeH, Ding F, Li S, Chen H, Liu Z*. Expressionof migfilin is increased in esophageal cancer and represses theAkt-β-catenin activation. Am J Cancer Res. 2014, 4(3):270-8.

33.   HeH, Li S, Chen H, Li L, Xu C, Ding F, Zhan Y, Ma J, Zhang S, Shi Y, Qu C, and Liu Z*. 12-O-tetrodecanoylphorbol-13-acetate promotes breast cancer cell motilityby increasing S100A14 level in a KLF4-dependent manner. J Biol Chem. 2014, 289(13):9089-99.

34.   Chen H, Xu C, Jin Q, Liu Z*. S100 protein family in human cancer. Am J Cancer Res. 2014, 4(2): 89-115.

35.   XuC, Chen H, Wang X, Gao J, Che Y, Li Y, Ding F, Luo A, Zhang S, Liu Z*. S100A14 isoverexpressed in breast cancer and acts as a modulator of HER2 signaling. JBiol Chem. 2014, 289(2):827-837.

36.   Chen H, Ma J, Sunkel B, Luo A, Ding F, Li Y,He H, Zhang S, Xu C, Jin Q, Wang Q, LiuZ*. S100A14 is a novel modulator of terminal differentiation ofesophageal squamous cell carcinoma. MolCancer Res. 2013, 11:1542-1553.

37.   ZhangX, Zhang B, Gao J, Wang X, Liu Z*: MiRNA-200b controlsanoikis by targeting Pin1 and is regulated by PEA3 and ELK-1. J Biol Chem.2013, 288: 32742-32752.

38.   LuoA, Chen H, Ding F, Ding F, Zhang Y, Wang M, Xiao Z*, Liu Z*. Small proline-rich repeatprotein 3 enhances the sensitivity ofesophageal cancer cells in response to DNA damage-induced apoptosis. Molecular Oncology. 2013, 7:955-967.

39.  Yang S, Li Y,Gao J, Zhang T, Li S, Luo A, Chen H, Ding F, Wang X, Liu Z*. MicroRNA-34 suppressed tumor invasion and metastasisby directly targeting Fra-1 in breast cancer. Oncogene, 2013, 32(36):4294-303.

40.   ZhouZ, Jing C, Zhang L, Takeo F, Kim H, Huang Y, Liu Z*, Wan Y*.Regulation of Rad17 turnover unveils an impact of Rad17-APC cascade in breastcarcinogenesis and treatment. J Biol Chem. 2013, 288(25):18134-45. 

41.   LiS, Zhou Q, He H, Zhao Y, Liu Z*.Peroxisome proliferator-activated γ agonists induce cell cycle arrest throughtranscriptional regulation of Krupple-like factor 4. J Biol Chem. 2013,288(6):4076-84.

42.   ChenH, Yuan Y, Zhang C, Luo A, Ding F, Ma J, Yang S, Tian Y, Tong T, Zhan Q, Liu Z*. Involvement of S100A14 protein in cell invasion byaffecting expression and function of matrix metalloproteinase (MMP)-2 viaP53-dependent transcriptional regulation. J Biol Chem. 2012, 287(21):17109-19.

43.   HeH, Ding F, Li Y, Luo A, Chen H, Wu C, LiuZ*. Migfilin regulates esophageal cancer cell motility throughpromoting GSK-3β mediated degradation of β-catenin. Mol Cancer Res. 2012, 10(3):273-281.

44.  Tian Y, Luo A, Cai Y, Su Q, Ding F, Chen H, Liu Z*. MicroRNA-10b promotes human esophageal cancer cell migration and invasionthrough KLF4. J Biol Chem.2010, 285(11):7986-7994.

45.   ZhouQ, Hong Y, Zhan Q, Shen Y, Liu Z*: A role for Krüppel-likefactor 4 in determining theoutcome of p53 response to DNA damage. CancerResearch,2009, 69(21):8284-8292.  

46.   Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao Z, Yang M, LiuJ, Lin D* , LiuZ*:  Functional role of S100A14genetic variants and their association with esophageal squamous cellcarcinoma. Cancer Research, 2009,69(8):3451-3457.

47.   Li C, Chen H, Ding F, Zhang Y, Luo A, Wang M, Liu Z*. A novel p53target gene, S100A9, induces p53-dependent cellular apoptosis and mediates p53apoptosis pathway. Biochem J. 2009, 422(2):363-372.

48.   WangY, Cao W, Yu Z, Liu Z*: Downregulation of amitochondria associated protein SLP-2 inhibits tumor cell motility,proliferation and enhances cell sensitivity to chemotherapeutic reagents. Cancer Biol & Therapy. 2009,8(17):1658-1665.

49.   ZhangW, Chen X, Luo A, Lin D, Tan W, Liu Z*: Genetic variants of C1orf10and risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Sci. 2009, 100(9):1695-1700.

50.   ZhangL, Ding F, Cao W, Liu Z, Liu W, Yu Z, Wu Y, LiW, Li Y, Liu Z*: Antisense Stomatin-like protein 2(SLP-2) showed decreased cell growth, tumorigenecity and cell adhesion in humanesophageal squamous cell carcinoma. ClinCancer Res, 2006, 12(5):1639-1646.

51.   YuX, Luo A, Zhou C, Ding F, Wu M, Zhan Q, Liu Z*:Differentiation-associated genes regulated by TPA-induced c-Jun expression viaa PKC/JNK pathway in KYSE450 cells. BiochemBiophys Res Commun, 2006, 342(1):286-292.

52.   ZhiH, Wang L, Zhang J, Zhou C, Ding F, Luo A, Wu M, Zhan Q, Liu Z*：Significanceof COX-2 expression in human esophageal squamous cell carcinoma. Carcinogenesis. 2006, 27(6):1214-1221.

53.   Hong Y, MiaoX, Zhang X, Ding F, Luo A, Guo Y, Tan W, Liu Z*, Lin D*: The Role of P53 and MDM2 Polymorphisms in Risk of Esophageal Squamous Cell Carcinoma. Cancer Res, 2005, 65(20):9582-9587.

54.   LiW, Ding F, Zhang L, Liu Z, Wu Y, Luo A, Wu M, Wang M, Zhan Q, Liu Z*:Overexpression of Stefin A in Human Esophageal Squamous Carcinoma CellsInhibits Tumor Cell Growth, Angiogenesis, Invasion and Metastasis. Clin Cancer Res, 2005, 11(24):8753-8762.

55.   ZhangJ, Zhi H, Zhou C, Ding F, Luo A, Zhang X, Sun Y, Wang X, Wu M, Liu Z*:Upregulation of Fibronectin in Oesophageal Squamous Cell Carcinoma isAssociated with Activation of Erk pathway. JPathol, 2005,207:402-409.

56.   LiuZ, Zhang L, Ding F, Li J, Guo M, Li W, Wang Y, Yu Z, Zhan Q, Wu M, Liu Z*: 5-aza-2’-deoxycytidine induces retinoic acid receptor-b2 demethylation and growth inhibition in esophagealsquamous carcinoma cells. CancerLett. 2005, 230(2):271-83.

57.   LiJ, Liu Z, Wang Y, Yu Z, Wang M, Zhan Q, LiuZ*: Allelic imbalance ofchromosome 1q in esophageal squamous cell carcinomas from China: a novel regionof allelic loss and significant association with differentiation. Cancer Lett. 2005, 220(2):221-230.

58.   ZhangJ, Zhi H, Ding F, Luo A, Liu Z*:Transglutaminase 3expression in C57BL/6J mouse embryo epidermis and the correlation with itsdifferentiation. Cell Research. 2005,15(2):105-110.

59.   LuoA, Kong J, Hu G, Liew C, Xiong M, Wang X, Ji J, Wang T, Zhi H, Wu M, Liu Z*: Discovery of Ca2+-relevantand differentiation associated genes down-regulated in esophageal squamous cellcarcinoma using cDNA microarray. Oncogene,2004, 23(6):1291-1299.

60.   JiJ, Zhao L, Wang X, Zhou C, Ding F, Wu M,Liu Z *: Differential Expression of S100Gene Family in Human Esophageal Squamous Cell Carcinoma. J Cancer Res Clin Oncol. 2004, 130(8):480-486.

61.   Zhi H, Zhang J, Hu G, Lu J, Wang X, Zhou C, Wu M, LiuZ*: The Deregulation of Arachidonic Acid Metabolism Related Genes in Human Esophageal Squamous CellCarcinoma. Int J Cancer. 2003,106,327-333.

62.   WangQ, Lu J, Yang C, Wang X, Cheng L, Hu G, Wu M, Liu Z*： CASK and Its Target Gene Reelin WereCo-upregulated in Human Esophageal Cancer. CancerLett. 2002, 179:71-77.

63.   ZhouJ, Wang H, Lu A, Hu G, Luo A, Ding F, Zhang J, Wang X, Wu M, Liu Z*: A Novel Gene NMES1Down-Regulated in Human Esophageal Squamous Cell Carcinoma. Int J Cancer. 2002,101,311-316.

64.   Zhao J, Wang M, Chen J, Luo A, Wang X, Wu M, Yin D,Liu Z*: The initial evaluation of non-peptidic small-molecule HDM2inhibitors based on p53-HDM2 complex structure. Cancer Lett.2002, 183(1):69-77.

65.   LuJ, Liu Z*, Xiong M, Wang Q,Wang X, Yang G, Zhao L, Qiu Z, Zhou C, Wu M: Gene Expression profile changes ininitiation and progression of squamous cell carcinoma of esophagus. Int J Cancer. 2001, 91:288-294.

66.   WangQ, Yang C, Zhou J, Wang X, Wu M, LiuZ*: Cloning and Characterization of EC45 Gene which Encoded HumanRibosomal Protein L15 and Overexpressed in Esophageal Cancer. Gene. 2001, 263(1-2):205-209.