主要科研领域与方向：将先进生物技术应用于临床医学与诊断，特别是临床分子诊断新技术的研究。主要领域包括对传染病大规模高通量、高灵敏快速筛查所需新技术的研究，以及适用于精准医学及个性化医疗临床检测所需的生物标记物（包括基因突变/SNP、基因表达、甲基化，CTC， cfDNA、蛋白质标记物，小分子代谢标记物等）的发现及其大规模高通量检测新技术的研究。课题组已研发出CLIP-PCR、MELPA等一系列独创检测新技术并已在临床实践中应用。

代表性论文：

● Pian H, Yang M, Sun X, Zheng Z*. Sandwich hybridization-based loop-mediated isothermal amplification (SHB-LAMP) for high-throughput detection of malaria RNA from asymptomatic infections. Sensors and Actuators B: Chemical. 2022, 365:131973.

●  Zhao YL, Zhao Y, Sun Y, Fan L, Wang D, Wang H, Sun X*, Zheng Z*. A direct, sensitive and high-throughput genus- and species-specifc molecular assay for large-scale malaria screening. Infectious Diseases of Poverty. 11, 25 (2022).

●  Liu D， Li W， Yang M， Qu  L， Pian H，Huang Y， Cheng M， Zheng Z*. Photothermal Mediated Rolling Circle Amplification Toward Specific and Direct In Situ mRNA Detection. Biosensors and Bioelectronics 2021, 192:113507-13.

● Dong Y, Huang Y, Fan C, Wang L, Zhang R, Li W, Guo Z*, Wang D*, Zheng Z*. GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma. Cell Death Dis. 2021 May 4;12(5):444. 

●  Lin Z，Li S, Sun X*，Zheng Z*, Yang J, Pian H, Tian P, Chen Q, Sun X, Ding C, Duan K, Chen H, Bee DY, Zhou H*. Effectiveness of joint 3 + 1 malaria strategy along China–Myanmar cross border areas. BMC Infectious Diseases. 2021， 21:1246-56.

● Tian, X, Zhou, J, Zhao, Y., Cheng, Z., Song, W., Sun, Y., Sun, X*., and Zheng, Z*.. High-throughput, Multiplex Genotyping Directly from Blood or Dried Blood Spot without DNA Extraction for the Screening of Multiple G6PD Gene Variants at Risk for Drug-induced Hemolysis, Journal of Molecular Diagnostics 2017, 19: 638-650.

●  Xu Y and Zheng Z*, Direct RNA detection without nucleic acid purification and PCR: Combining sandwich hybridization with signal amplification based on branched hybridization chain reaction. Biosensors and Bioelectronics. 2016, 79 : 593-599

●  Cheng Z, Wang D, Tian X, Sun Y, Sun X*, Xiao N*, Zheng Z*  Capture Ligation Probe-PCR (CLIP-PCR) for Molecular Screening, with Application to Active Malaria Surveillance for Elimination. Clin Chem. 2015, 61：821-8

●  Tian X, Chen D, Zhang R，Zhou J, Peng X，Yang X*, Zhang X*, Zheng Z*,  Quantitative survey of multiple CpGs from 5 genes identifies CpG methylation panel discriminating between high- and low-grade cervical intraepithelial neoplasia. Clinical Epigenetics. 2015, 7:4

●  Mu X*, Xin X, Fan C, Li X, Tian X*, Xu K, Zheng Z*. A paper-based skin patch for the diagnostic screening of cystic fibrosis. Chem Commun 2015, 51:5365.

●  Mu M*, Zhang L, Chang S, Cui W and Zheng Z*. Multiplex Microfluidic Paper-based Immunoassay for the Diagnosis of Hepatitis C Virus Infection, Analytical Chemistry, 2014, 86: 5338-5344.

●  Mu X, Liang Q*, Zhou J, Ren K, Hu P, Wang Y, Zheng Z*, Luo G*. “Oil-water biphasic parallel flow for the precise patterning of metals and cells”, Biomed Microdevices, 2014;16(2):245-53

●  Cheng, Z, Sun, X, Yang, Y, Wang, H and Zheng, Z* "A Novel, Sensitive Assay for High-Throughput Molecular Detection of Plasmodia for Active Screening of Malaria for Elimination" J. Clin. Microbio 2013. 51:125-130。

●  Ran R, Li L*, Wang M, Wang S, Zheng Z*, Lin PP. Determination of EGFR mutations in single cells microdissected from enriched lung tumor cells in peripheral blood. Anal Bioanal Chem. 2013;405(23):7377-82.

●  Zheng, Z*, Luo，Y., and McMaster, GK "Sensitive and Quantitative Measurement of Gene Expression Directly from Small Amount of Whole Blood". Clin Chem 2006, 52: 1294-302.

●  周南，李龙芸*，郑直*，李单青，崔巍，翁姗姗，王孟昭，王树兰，钟巍 “蝎形探针扩增阻滞突变系统检测肺癌患者血清与肿瘤组织中表皮生长因子受体基因突变”。《癌症进展》2011, 9(1)： 19-26.

●  管慧,李龙芸*,王孟昭,王树兰,韩如冰,钟巍,冉然,周京伟,郑直*.  晚期非小细胞肺癌患者使用EGFR-TKI治疗后长期生存的研究 [J]. 癌症进展. 2011, 9 (5)： 561-8.

●  张秀茹;陈迪;田晓怡;郑直* 抑癌基因甲基化位点定量检测在宫颈癌早期诊断中的意义探讨 《中华临床医师杂志（电子版）》2012年24期

●  杨丹丽，田晓怡，石伟先，郑直*  无需逆转录的高通量多重呼吸道病毒RNA检测技术的建立 《中国医学科学院学报》 2013年Vol. 35  (1): 24-28

●  徐瑶，郑直* 基于金属增强荧光的高通量碱基突变的筛查 基础医学与临床 2014 Vol. 34 (6): 797-801

●  由磊，赵烨，阚秀，李一林，王东民，张爱群，王红霞，刘颖，王丹丹，林平，郑直* 同步原位检测CTC多重瘤标蛋白表达与染色体异倍体的意义 《临床与实验病理学杂志》 2017 Vol.33(03): 297-302

专著章节

●  Zheng Z* and Cheng, Z. (2017). “Advances in Molecular Diagnosis of Malaria”. In: Gregory S. Makowski, editor: Advances in Clinical Chemistry. Vol 80, pp155-92. UK: Academic Press.

●  Xu, Y and Zheng Z*. (2018) . “Hybridization chain reaction for direct mRNA detection without nucleic acid purification”. In: Gaspar, Imre. (Ed), RNA Detection: Methods and Protocols. ISBN:978-1-4939-7212-8, Springer pp 187-196

●  Zheng, Z.(2008) "Genomic Approaches to Chronic Lymphocytic Leukemia". In : Moreau IB. ed.. Chronic Lymphocytic Leukemia: New Research. Hauppauge, NY: Nova Science Publishers. pp3-45. （See Google Book link here）

美国媒体报道 (点击标题）

●  American Association for Clinical Chemistry News Release, May 11, 2015: “New Malaria Test Could Lead to Global Eradication of the Disease”.

●  American Chemical Society News Release, May 21, 2014: “Paper-Based Diagnostics, Made with a Scrapbooking Tool, Could Curb Hepatitis C Pandemic”.（https://www.acs.org/content/acs/en/pressroom/presspacs/2014/acs-presspac-may-21-2014/paper-based-diagnostics-could-curb-hepatitis-c-pandemic.html）