承担、参与并完成过多项国家及省部级科研项目及课题，包括国家高技术研究发展计划（863）、国家重点基础研究发展计划（973）、国家支撑计划、国家自然科学基金、国家精准医学研究计划、以及卫生部行业专项、北京市重大技术专项等课题。

目前承担项目，主要和以下方面有关：1. 外周血循环肿瘤细胞检测方法及技术的建立；2.外周血循环肿瘤细胞检测应用于早期恶性肿瘤辅助诊断；3. 外血循环肿瘤细胞的细胞及分子生物学特征以及其免疫逃逸机理。

研究成果均发表于国际肿瘤学相关刊物。参与编写《癌前病变和癌前疾病》以及《实用临床肿瘤学》等专著。曾获中国人民解放军科技进步二等奖和北京市科技进步二等奖。

1     Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes SimplexVirus Type 2 Encoding an Antibody Against Programmed Cell Death 1. Zhu Y, Hu X,Feng L, Yang Z, Zhou L, Duan X, Cheng S, Zhang W, Liu B, Zhang K*. Mol TherOncolytics. 2019 Oct 23;15:201-213. doi: 10.1016/j.omto.2019.10.003.eCollection 2019 Dec 20

2       Wen L, Guo L, Zhang W, Li Y, Jiang W, Di X, Ma J, Feng L, Zhang K*,Shou J*. Cooperation Between the Inflammation and Coagulation Systems Promotesthe Survival of Circulating Tumor Cells in Renal Cell Carcinoma Patients. FrontOncol. 2019, 17; 9: 504.

3       Guo L, Chen G, Zhang W, Zhou L, Xiao T, Di X, Wang Y, Feng L,Zhang K*. A high-risk luminal A dominant breast cancer subtype with increasedmobility. Breast Cancer Res Treat. 2019 Jun;175(2):459-472.

4       Wang Y, Guo L, Feng L, Zhang W, Xiao T, Di X, Chen G, Zhang K*.Single nucleotide variant profiles of viable single circulating tumour cellsreveal CTC behaviours in breast cancer. Oncol Rep. 2018 May;39(5):2147-2159.

5       Li P, Zhang L, Yu X, Tong R, Di X, Mao Y, Gao Y, Zhang K*, Feng L*,Cheng S*. Proliferation genes in lung development associated with the prognosisof lung adenocarcinoma but not squamous cell carcinoma. Cancer Sci. 2018Feb;109(2):308-316. 

6       Cao B, Luo L, Feng L, Ma S, Chen T, Ren Y, Zha X, ChengS, Zhang K*, Chen C*. A network-based predictive gene-expression signature for adjuvantchemotherapy benefit in stage II colorectal cancer. BMC Cancer. 2017 Dec13;17(1):844.

7       Feng L, Qian H, Yu X, Liu K, Xiao T, Zhang C, Kuang M,Cheng S, Li X, Wan J, Zhang K*. Heterogeneity of tumor-infiltrating lymphocytesascribed to local immune status rather than neoantigens by multi-omics analysisof glioblastoma multiforme. Sci Rep. 2017 Jul 31;7(1):6968. doi:10.1038/s41598-017-05538-z.

8       Zhang B, Feng L, Guo H, Li H, Wang Y, Zhang K*, Yu X*,Cheng S*. Villi-specific Gene Expression Reveals Novel Prognostic Biomarkers inMultiple Human Cancers. J Cancer. 2017 Aug 23; 8(14):2793-2801. doi:10.7150/jca.19787. eCollection 2017.

9       Kuang M*, Cheng J*, Zhang C*, Feng L*, Xu X, Zhang Y, ZuM, Cui J, Yu H, Zhang K*, Yang A, Cheng S. A novel signature for stratifyingthe molecular heterogeneity of the tissue-infiltrating T-cell receptorrepertoire reflects gastric cancer prognosis. Sci Rep. 2017 Aug 10;7(1):7762.doi: 10.1038/s41598-017-08289-z.

10   Shi L, Zhang Y, Feng L, Wang L, Rong W, Wu F, Wu J, ZhangK*, Cheng S*. Multi-omics study revealing the complexity and spatialheterogeneity of tumor-infiltrating lymphocytes in primary liver carcinoma.Oncotarget. 2017 May 23;8(21):34844-34857.

11   Zhang C, Kuang M, Li M, Feng L, Zhang K*, Cheng S*. SMC4,which is essentially involved in lung development, is associated with lungadenocarcinoma progression. Sci Rep. 2016 Sep 30;6:34508.

12   Xu J*, Feng L*, Han Z*, Li Y*, Wu A, Shao T, Ding N, LiL, Deng W, Di X, Wang J, Zhang L, Li X, Zhang K*, Cheng S*. ExtensiveceRNA-ceRNA interaction networks mediated by miRNAs regulate development inmultiple rhesus tissues. Nucleic Acids Res.  2016 Nov 2;44(19):9438-9451. （IF 11.561）

13   Yu X, Feng L, Han Z, Wu B, Wang S, Xiao Y, Li F, Zhang L,Cao B, Di X, Lu D, Li X, Jiang W, Zhang K*, Cheng S*. Crosstalk of dynamicfunctional modules in lung development of rhesus macaques. Mol Biosyst. 2016Apr 22;12(4):1342-9. doi: 10.1039/c5mb00881f.

14   Zhang W, Bao L, Yang S, Qian Z, Dong M, Yin L, Zhao Q, GeK, Deng Z, Zhang J, Qi F, An Z, Yu Y, Wang Q, Wu R, Fan F, Zhang L, Chen X, NaY, Feng L, Liu L, Zhu Y, Qin T, Zhang S, Zhang Y, Zhang X, Wang J, Yi X, Zou L,Xin HW, Ditzel HJ, Gao H, Zhang K*, Liu B*, Cheng S*. Tumor-selectivereplication herpes simplex virus-based technology significantly improvesclinical detection and prognostication of viable circulating tumor cells. Oncotarget.2016 May 18. doi: 10.18632/oncotarget.9465.

15   An N, Yang X, Cheng S*, Wang G*, Zhang K*. Developmentalgenes significantly afflicted by aberrant promoter methylation and somaticmutation predict overall survival of late-stage colorectal cancer. ScientificReports. 2015, 5:18616.

16   Li F, Xiao Y, Huang F, Deng W, Zhao H, Shi X, Wang S, YuX, Zhang L, Han Z, Luo L, Zhu Q, Jiang W, Cheng S, Li X, Zhang K*.Spatiotemporal-specific lncRNAs in the brain, colon, liver and lung of macaqueduring development. Mol Biosyst. 2015 Oct 12.

17  An N, Shi X, Zhang Y, Lv N, Feng L, Di X, Han N, Wang G,Cheng S*, Zhang K* Discovery of a Novel Immune Gene Signature with ProfoundPrognostic Value in Colorectal Cancer: A Model of Cooperativity DisorientationCreated in the Process from Development to Cancer. PLoS One. 2015 Sep1;10(9):e0137171.

18  Feng L,Wang J, Cao B, Zhang Y, Wu B, Di X, Jiang W, An N, Lu D, Gao S, Zhao Y, Chen Z,Mao Y, Gao Y, Zhou D, Jen J, Liu X, Zhang Y, Li X, Zhang K*, He J*, Cheng S*.Gene expression profiling in human lung development: an abundant resource forlung adenocarcinoma prognosis. PLoS One.2014; 9(8): e105639.

19. YangL, Rong W, Xiao T, Zhang Y, Xu B, Liu Y, Wang L, Wu F, Qi J, Zhao X, Wang H,Han N, Guo S, Wu J*, Gao Y*, Cheng S*. Secretory/releasing proteome-basedidentification of plasma biomarkers in HBV-associated hepatocellular carcinoma.Sci China Life Sci. 2013 Jul;56(7):638-646. Li M, Ling B, Xiao T, Tan J, An N,Han N, Guo S, Cheng S, Zhang K*. Sp1 transcriptionally regulates BRK1expression in non-small cell lung cancer cells. Gene. 2014; 542 (2): 134-40.