何维/张建民课题组由何维教授和张建民教授共同领导。课题组主要研究领域为 T 细胞受体抗原识别、肿瘤免疫、抗感染免疫和老化免疫研究。长期从事γδT细胞生物学功能研究，近年发现肿瘤相关γδT细胞识别性新配体，并开展γδT细胞抗肿瘤的临床前与临床试验研究。同时，研究神经系统与免疫系统的对话机制，探讨神经系统和免疫系统之间相互作用、相互调节的生理机制以及神经免疫性疾病的发病机理、早期诊断生物标志及治疗性靶点。利用基因敲除和转基因小鼠模型，研究重大神经性疾病（如Alzheimer’s disease，Parkinson’s disease 和脑中风等）和免疫性疾病（如自身免疫性疾病等）的病理机制。运用高通量筛选技术寻找这类重大疾病的早期诊断生物标志和治疗性靶点。

课题组目前拥有2名教授、1名副研究员、1名副主任技师、1名助理研究员；在站博士后3名，在校硕士研究生4名，博士研究生5名。

课题组近年来主要科研项目

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课题组近年主要科研项目

      负责：

    参与：

课题组近年代表性论文

1)        Jia Yang, Qi Yang, Menghua Cai,Chao Li, Fei Gao, Huaishan Wang, Dongdong Wang, Yi Fu, Yu Zhou, Hui Chen, YuHu, Xuan Zhang, Wei He*, Jianmin Zhang*.ATPase Thorase Regulates Mitochondrial Quality Control and Pathogenesis ofNeurodegenerative Diseases. (Under revision on Neuron)

2)        Huaishan Wang, Fei Gao, Jia Yang, Yi Fu, YingchaoXue, Qi Yang, Menghua Cai, Xue Zhang, Yu Zhou, Kangle Zhai, Yu Hu, Hui Chen, Fang Liu, Yi Xu, Chao Ma, Wei He*and Jianmin Zhang*. TSPO/PBR Knockout Promotes Amyloid Pathology andNeuroinflammation by Affecting Microglia Phagocytosis.(Underrevision on Neurobiology of ageing)

3)        Yi Fu, Dongdong Wang, Huaishan Wang, Junwen Zhang, Hui Chen, Yu Hu, XuanZhang, Mingyao Ying, Wei He*, Jianmin Zhang*. TSPO deficiencyinduces mitochondrial dysfunction, leading to hypoxia, angiogenesis and agrowth-promoting metabolic shift towards glycolysis in glioblastoma. NeuroOncol. 2019 Sep 29. pii: noz183. doi: 10.1093/neuonc/noz183.

4)        Yuxia Li, Xinfeng Wang,Da Teng, Hui Chen, Maoshui Wang, Junjing Wang, Jianmin Zhang*, Wei He.Identification ofthe Ligands of TCRγδ by Screening the Immune Repertoire of γδT Cells fromPatients with Tuberculosis. Front. Immunol., 24 September 2019https://doi.org/10.3389/fimmu.2019.02282

5)        Menghua Cai, Yan Zhu,Zinan Li, Yu Zhou, Yu Hu, Hui Chen, Yun Liu *, Wei He * and Jianmin Zhang*.Profiling the Gene Expression and DNA Methylation in the Mouse Brain afterIschemic Preconditioning. Neuroscience. 406 (2019) 249–261

6)        Fei Gao, Jianmin Zhang *. Mitochondrialquality control and neurodegenerative diseases. Neuronal Signalling. (2018)https://doi.org/10.1042/NS20180062

7)        Yingchao Xue, XipingZhan, Shisheng Sun, Senthilkumar S. Karuppagounder, Shuli Xia, Valina L.Dawson, Ted M. Dawson, John Laterra, JianminZhang* and Mingyao Ying*. Synthetic mRNAs drive highly efficient iPSC celldifferentiation into dopaminergic neurons. StemCell Translational Medicine. 2018Nov 1. doi: 10.1002/sctm.18-0036

8)        Peng Dong, Xiangwu Ju,Yiwu Yan, Siya Zhang, Menghua Cai, Huaishan Wang, Hui Chen, Yu Hu, LianxianCui, Jianmin Zhang*, Wei He*. γδ Tcells provide protective function in highly pathogenic avian H5N1 influenza Avirus infection. 2018 Dec 4;9:2812. doi:10.3389/fimmu.2018.02812. eCollection 2018..

9)        Xue Zhang, Fei Gao, Dongdong Wang, Chao Li, Yi Fu, Wei He*, Jianmin Zhang*. Tau pathology in Parkinson’s disease. Front. Neurol., October 2, 2018;https://doi.org/10.3389/fneur.2018.00809

10)    Jianmin Zhang, Jia Yang, Huaishan Wang,Omar Sherbini, Matthew J. Keuss, George K. E. Umanah, Emily Ling-Lin Pai ,Zhikai Chi, Kaisa M. A. Paldanius, Wei He, Hong Wang, Shaida A. Andrabi, Ted M.Dawson, and Valina L. Dawson The AAA + ATPase Thorase is neuroprotective against ischemic injury. J Cereb Blood Flow Metab. 2018Jan 1:271678X18769770. doi: 10.1177/0271678X18769770

11)     Zinan Li, Siya Zhang,Ying Wan, Weiqing Wang, Yuli Zhu, Zhen Li, Yu Hu, Huaishan Wang, Hui Chen,Lianxian Cui, Xuan Zhang, Jianmin Zhang*, Wei He*. miR-146a Regulates the Positive SelectionDuring T Cell Development. Front Immunol.2018 Jan 23;8:2006. doi: 10.3389/fimmu.2017.02006

12)     Yuli Zhu, Siya Zhang, Zinan Li, Huaishan Wang, ZhenLi, Yu Hu, Hui Chen, Xuan Zhang, Lianxian Cui, Denian Ba, Jianmin Zhang*, Wei He*. MiR-125b-5p and miR-99a-5p regulate theactivation and cytotoxicity of gd T cells. CellMol Immunol. 2018 Feb 12. doi: 10.1038/cmi.2017.164

13)    Hui Chen, Mingjin Zou, Da Teng, YuHu, Jianmin Zhang*, Wei He1*.Profiling the pattern of the human T cell receptor γδ complementary determinant region 3 repertoire in patientswith lung carcinoma. Cell Mol Immunol.2018 Feb 5. doi: 10.1038/cmi.2017.157

14)     Fei Gao, Jia Yang, Chao Li, Huaishan Wang, Wei He*, Jianmin Zhang*. Mitophagy in Parkinson Disease: Pathogenic Roles and TherapeuticImplications. Front. Neurol., 2017;doi.org/10.3389/fneur.2017.00527

15)     Wen-Xiu Mo, Shan-ShanYin, Hua Chen, Chen Zhou, Jia-Xin Zhou, Li-Dan Zhao, Yun-Yun Fei, Hua-Xia Yang,Jing-Bo Gou, Yu-Jia Mao, Lin-Fang Huang, Wen-Jie Zheng, Wen Zhang, Jian-MinZhang, Wei He*, Xuan Zhang*. Chemotaxis of Vδ2 T cells to the jointscontributes to the pathogenesis of Rheumatoid Arthritis. Ann Rheum Dis. 2017 Dec;76(12):2075-2084. doi: 10.1136/annrheumdis-2016-211069

16)     Chen H, Zou M, Teng D, ZhangJ*, He W. Characterization of the diversity of T cell receptor γδcomplementary determinant region 3 in human peripheral blood by ImmuneRepertoire Sequencing. J Immunol Methods. 2017 Jan 31. pii:S0022-1759(16)30291-5. doi: 10.1016/j.jim.2017.01.009.

17)     Wang H, Zhai K, Xue Y, Yang J, Yang Q, Fu Y, Hu Y,Liu F, Wang W, Cui L, Chen H, Zhang J*,He W*. Global Deletion of TSPODoes Not Affect the Viability and Gene Expression Profile. PLoS One. 2016 Dec 1;11(12):e0167307. doi:10.1371/journal.pone.0167307

18)     Jianmin Zhang, Huaishan Wang, Omar Sherbini, Emily Ling-lin Pai,Sung-Ung Kang, Ji-Sun Kwon, Jia Yang, Wei He, Hong Wang, Stephen M. Eacker,Zhikai Chi, Xiaobo Mao, Jinchong Xu, Haisong Jiang, Shaida A. Andrabi, Ted M.Dawson, Valina L. Dawson. High Content Genome-Wide RNAi Screen Reveals CCR3 asa Key Mediator of Neuronal Cell Death. eNEURO.2016 Oct 7. DOI: 10.1523/ENEURO.0185-16.2016

课题组代表性专利

1.抗人转化生长因子β1的纳米抗体B3及其制备方法和应用。专利申请号：202010227938.2

2. 一种检测过敏原的新型蛋白质芯片。专利申请号：201710293500.2

3.肿瘤结合特异性γδTCR基因修饰的αβT细胞及其抑癌用途。专利申请号：201510846740.1

4.一种治疗老年性痴呆的中药组合物。2003， 专利证号 ZL03125124.2。

5.一种新型体外扩增γδ T细胞的方法。2003，专利证号 ZL02156725.5。

6.用于治疗和预防阿尔茨海默病的重组腺相关病毒基因疫苗及其用途。2003. 专利证号 ZL02154703.3。