1.     国家自然科学基金面上项目，肝损伤过程中新型细胞死亡方式的鉴定和机制，31970687，2020/01-2023/12，58万，在研，主持。

2.     科技部重点研发计划，重要实质性脏器的细胞更替和调控机制，2019YFA0801501，2020/01-2024/12，237万，在研，骨干。

3.     科技部重点研发计划，多能干细胞自我更新与定向分化的细胞周期调控，2016YFA0100502, 2016/01-2020/12，244万，在研，骨干。

4.     国家自然科学基金优秀青年科学基金项目，31522038，转分化，2016/01-2018/12，130万，已结题，主持。

5.      国家自然科学基金面上项目，31571509，肝再生过程中细胞外基质对肝脏结构重建的时空调控机制，2016/01-2019/12，65万，已结题，主持。

1.建立了将皮肤成纤维细胞诱导直接转分化为肝脏细胞的方法，并通过细胞移植治疗肝衰竭动物。首次实现哺乳动物成体细胞跨胚层转分化，首次实现转分化细胞的体内功能。（2011年中国十大科学进展）。

2. 构建了基于转分化肝细胞的生物人工肝生命支持系统，并开展十多例肝衰竭病人的临床治疗研究（2018年上海市自然科学一等奖）。

3.构建3D生物打印肝脏，首次实现3D生物打印肝脏的体内功能，并通过体内移植治疗肝衰竭动物。

4.建立基于CRISPR的体内基因精确修复、体内基因激活、体内RNA沉默技术，并应用于肝脏疾病动物模型的治疗。

5.发现慢性肝损伤后肝再生的关键调控因子IGF-2及其作用机制。

6. 建立了全新的小RNA测序方法CPA-seq，可以检测携带末端修饰和碱基修饰的小RNA，并发现了大量新的小RNA类型。

发表论文：

2022年

1.    Yuan, Y. #, Wang, C. #,Zhuang, X. #, Lin, S., # Luo, M. #, Deng, W.,Zhou, J., Liu, L., Mao, L., Peng, W., Chen, J., Wang, Q., Shu, Y.*, Xue, Y.*, Huang,P.* PIM1 promotes hepatic conversion by suppressing reprogramming-inducedferroptosis and cell cycle arrest. Nature Communications, 2022, 13 (1), 1-19. （IF: 17.69; Featured Article）

- Faculty of 1000推荐

2.    Li, Z., Wang, H., Zhu, J., Nan, N., Lin, Y.,Zhuang, X., Li, L., Zhang, Y.*, Huang, P.*, Inhibition ofTWEAK/Tnfrsf12a axis protects against acute liver failure by suppressingRIPK1-dependent apoptosis. Cell Death Discovery, 2022, 8, 328. （IF: 7.109; Citation: 3）

2021年

1. Xie F., SunL., Pang Y., Xu G., Jin B., Xu H., Lu X., Xu Y., Du S., Wang Y., Feng S., SangX., Zhong S., Wang X., Sun W., Zhao H., Zhang H., Yang H.*, Huang P.*,Mao Y.*, Three-dimensional Bio-printing of primary human hepatocellularcarcinoma for personalized medicine. Biomaterials,2021,265:120416 (IF:15.304; Citation: 51)

2. Yang, H.#, Sun, L.#,Pang, Y.#, Hu, D.#, Xu, H., Mao, S., Peng, W., Wang, Y.,Xu, Y., Zheng, Y., Du, S., Zhao, H., Chi, T., Lu, X., Sang, X., Zhong, S.,Wang, X., Zhang, H., Huang, P.*, Sun, W.*, Mao, Y.*, Three-dimensionalbioprinted hepatorganoids prolong survival of mice with liver failure, GUT,2021, 70(3):567-574. (IF:31.793; Citation: 78)

- 入选ESI高被引论文

3. Wang, H.#, Huang R.#, Li L.#,Zhu, J., Li, Z., Peng C., Zhuang, X., Lin, H., Shi, S.*, Huang, P.*, CPA-seqreveals small ncRNAs with methylated nucleosides and diverse termini, Cell Discovery, 2021, 7(1):1-16. (IF:38.079; Citation: 16)

2020年

1. He,B.#, Peng, W.#, Huang, J.#, Zhang, H., Zhou,Y., Yang, X., Liu J., Li, Z., Xu, C., Xue M., Yang, H.*, Huang, P.*,Modulation of metabolic functions through Cas13d-mediated gene knockdown inliver, Protein Cell, 2020; 11(7):518–524 (IF:14.870;  Citation: 49)

2019年

1. Huang, P., Sun, L., Zhang,L., Hui, L.Conversion of Fibroblasts to Hepatocytes In Vitro, Hepatic Stem Cells,Humana Press, New York, NY, 2019. (Book Chapter; Citation: 5)

2018年

1. Zhou, H.#, Liu, J.#, Zhou, C.#, Gao, N.#, Rao, Z.#, Li, H.#, Hu, X., Li, C., Yao, X., Shen, X., Sun, Y., Wei, Y., Liu, F.,Ying, W., Zhang, J., Tang, C., Zhang, X., Xu, H., Shi, L., Cheng, L., Huang, P.*, Yang, H.* In vivosimultaneous transcriptional activation of multiple genes in the brain usingCRISPR-dCas9-activator transgenic mice. Nature Neuroscience, 2018: 21,440-446. (IF: 21.126;  Citation: 213)

- 入选ESI高被引论文

2.Yao, X., Wang, X., Liu, J., Shi, L., Huang,P.*, Yang, H.*, CRISPR/Cas9-mediated targeted integration in vivo using ahomology-mediated end joining-based strategy. Journal of visualized experiments, 2018(133). (Google Scholar Citation: 19)

3.Wang, L.#, Zhou, Y.#, Dai, J.#,Jiang, S.#, Lu, Y., Sun, M., Gong,J.*, Huang, P.*, Yao, Y.*2-Thiophene ethylamine modified hyaluronic acid with its application onhepatocytes culture, Materials Science and Engineering:C,2018; 88. (Google Scholar Citation: 29)

4. Huang, P.*, Chen, Q., Generation ofHepatocytes by Transdifferentiation, Stem Cells and Cancer in Hepatology,edited by Yun-Wen Zheng, Elsevier, 2018 (Book Chapter)

2017年

1.Liu, J.#, Hu, X.#, Chen, J.#,Li, X., Wang, L., Wang, B., Peng, W., Yang, C., Li, Z., Chen, Y., Wang, Y., Li,C., Li, X., Yan, F., Wang, Y., Shang, C., Wang, X., Chen, T.*, Huang, P.* Pericentral hepatocytesproduce insulin-like growth factor-2 to promote liver regeneration duringselected injuries in mice. Hepatology, 2017; 66(6), 2002-2015. (IF: 14.079; Citation: 23)

- Faculty of 1000推荐

2.Yao, X.#, Wang, X.#, Liu, J.#,Hu, X., Shi, L., Shen, X., Ying, W., Sun, X., Wang, X., Huang, P.*, Yang, H.* CRISPR/Cas9-mediated precise targetedintegration in vivo using a double cut donor with short homology arms. EBioMedicine.2017; 20, 19-26. (Citation: 74)

3.Yao, X.#, Wang, X.#, Hu, X.#,Liu, X.#, Liu, J., Zhou, H., Shen,X., Wei, Y., Huang, Z., Ying, W., Wang, Y., Nie, Y., Zhang, C., Li, S., Cheng,L., Wang, Q., Wu, Y., Huang, P.,Sun, Q.*, Shi, L.*, Yang, H.* Homology-mediated end joining-based targetedintegration using CRISPR/Cas9. Cell Research, 2017; 27:801-814. (Citation: 254)

4. Yan, S.#,Li, X.#, Dai, J., Wang, Y., Wang,B., Lu, Y., Shi, J., Huang, P.,Gong, J.*, Yao, Y.* Electrospinning of PVA/sericin nanofiber and the effect onepithelial-mesenchymal transition of A549 cells. Mater Sci Eng C Mater Biol Appl,2017; 79: 436-444. (Citation: 29)

2016年

1. Huang, P., Li, B., Zheng, Y., Role ofstem cells in the gastrointestinal tract and in the development of cancer. StemCells in Toxicology and Medicine, edited by Sahu SC, John Wiley &Sons, 2016 (Book Chapter)

2.Shi, X.#, Gao, Y.#, Yan, Y.#,Ma, H.#, Sun, L.#, Huang,P.#,Ni, X., Zhang, L., Zhao, X., Ren, H., Hu, D., Zhou, Y., Tian, F., Ji, Y.,Cheng, X., Pan, G.*, Ding, Y.*, Hui, L.*, Improved survival of porcine acuteliver failure by a bioartificial liver device implanted with induced humanfunctional hepatocytes. Cell Research, 2016; 26:206-216. (Citation: 119)

3. Pu, W., Zhang, H., Huang, X., Tian, X.,He, L., Wang, Y., Zhang, L., Liu, Q., Li, Y., Li, Y., Zhao, H., Liu, K., Lu,J., Zhou, Y., Huang, P., Nie, Y.,Yan, Y., Hui, L., Lui, K., Zhou, B. Mfsd2a+ hepatocytes repopulate the liverduring injury and regeneration. Nature Communications, 2016; 7,13369. (Citation: 82)

2014年

1. Huang, P.#, Zhang, L.#, Gao, Y.#,He, Z.#, Yao, D., Wu, Z., Cen, J.,Chen, X., Liu, C., Hu, Y., Lai, D., Hu, Z., Chen, L., Zhang, Y., Ma, X., Pan,G., Wang, X., Hui, L. Direct reprogramming of human fibroblasts to functionaland expandable hepatocytes. Cell Stem Cell, 2014; 14(3):370–84. (Citation: 520)

- Cell Stem Cell发表评论. 

- Faculty of 1000推荐.

- 入选美国细胞出版社“2014中国年度论文”.

2011年

 1. Huang, P., He, Z., Ji, S., Sun,H., Xiang, D., Liu, C., Hu, Y., Wang, X., and Hui, L.* Induction of functionalhepatocyte-like cells from mouse fibroblasts by defined factors. Nature,2011; 475(7356):386-9. (Citation: 932)

- Cell Stem Cell, Hepatology等学术期刊发表评论.

- Cell, Nature News, NatureBiotechnology等学术期刊和媒体报道.

- Faculty of 1000推荐.

- 入选科技部评选的“2011年中国十大科学进展”.

- 入选ESI高被引论文

2010年 

1. Huang, P., Han, J.*, and Hui, L.*MAPK signaling in inflammation-associated cancer development. ProteinCell, 2010; 1, 218-226. (Google Scholar Citation: 239)

#co-firstauthor;  * corresponding author