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近些年围绕免疫学的重大科学问题“抗病毒免疫反应启动及消退的新型调控分子及其作用机制”,从非编码RNA和蛋白质两个方面探索病原体触发的天然免疫信号通路的调控机制,原创性地发现了数个新型免疫分子及其重要机制。
以第一或通讯作者身份发表SCI论文19篇,累计影响因子160分(3篇20分以上),累计引用约500余次。作为共同第一作者在Cell,Nature Immunol(2篇),PNAS和 Clinical cancer research 等杂志发表SCI论文;作为共同通讯作者在PNAS, Journal of Autoimmnity, Cell Mol Immunol,Cell Reports等杂志发表SCI论文。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg承担国家重大科学研究计划(973计划,子课题负责人)、卫生部行业专项(子课题负责人)、国家科技重大专项(2项,子课题负责人)和国家自然基金(3项,负责人)等多项国家级研究项目。
1. RNF138 inhibits lateinflammatory gene transcription through degradation of SMARCC1 of the SWI/SNFcomplex. Wei Liu, Ziqiao Wang, Shuo Liu, Xuan Zhang, Xuetao Cao*, Minghong Jiang*. CellRep. 2023 Feb 15;42(2):112097.
2. Cheng Wang, WenkaiZhou, Yin Liu, Yue Xu, Xuan Zhang, Chengyu Jiang, Minghong Jiang*, Xuetao Cao*. Nuclear translocation of RIG-I promotes cellular apoptosis. JAutoimmun. 2022 Jun;130:102840.
3. Wenkai Zhou, Jiaming Wang, Xin Wang, Bingjing Wang, Zhehui Zhao, Jie Fu,Yan Wang, Xuan Zhang, Ping Zhu, MinghongJiang*, Xuetao Cao*. Degradation of HDAC10 by autophagy promotesIRF3-mediated antiviral innate immune responses. Sci Signal. 2022 Dec20;15(765):eabo4356.
4. XiaoqiSong, Shuo Liu, Wendie Wang, Zhongfei Ma, Xuetao Cao, Minghong Jiang*.E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting anddegrading TLR3 in murine cells. Cell Mol Immunol. 2020Aug;17(8):865-874.
5. Wei Liu , Ziqiao Wang , Lun Liu , Zongheng Yang , ShuoLiu , Zhongfei Ma , Yin Liu , Yuanwu Ma , Lianfeng Zhang , Xuan Zhang , MinghongJiang*, Xuetao Cao*. LncRNA Malat1 inhibitionof TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity. Proc Natl Acad Sci USA. 2020. 117(38): 23695-23706.
6. Hongyu Lin#,Minghong Jiang#, Lun Liu, Zongheng Yang,Zhongfei Ma, Shuo Liu, Yuanwu Ma, Lianfeng Zhang, Xuetao Cao. The longnoncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innateimmune response. Nat Immunol. 2019Jul;20(7):812-823.
7. Minghong Jiang#, Zongheng Yang#, Hongyu Lin,Jun Zhu, Lun Liu, Wendie Wang, Shuo Liu, Wei Liu, Yuanwu Ma, Lianfeng Zhang,Xuetao Cao*. Self-Recognition of anInducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response. Cell.2018 May 3;173(4):906-919.e13.
8. Shuo Liu#, Minghong Jiang#,Wendie Wang, Wei Liu, Xiaoqi Song, Zhongfei Ma, Shikun Zhang, Lun Liu, Yin Liu,Xuetao Cao*. Nuclear RNF2 inhibits interferon function by promoting K33-linkedSTAT1 disassociation from DNA. NatImmunol. 2018, 19(1):41-52.
9. Wendie Wang#, MinghongJiang#, Shuo Liu, Shikun Zhang, Wei Liu, Yuanwu Ma, LianfengZhang, Jiyan Zhang, Xuetao Cao*. RNF122 suppresses antiviral type I interferonproduction by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci USA. 2016 Aug23;113(34):9581-6.
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