左起：王慧敏、张忆一、邓虹、张卫奇、刘润萌、高梦涵

1，北京市科技新星计划

2，北京市科技新星计划交叉学科合作课题

3，协和青年基金

4，医学分子生物学国家重点实验室自主课题

5，中国医学科学院创新工程分任务

发表论文 (*通讯作者，#第一作者) 

1.    W Zhang*, B Du, M Gao, CH Tung*. A hybridnanogel to preserve lysosome integrity for fluorescence imaging. ACS Nano.2021, 15, 16442.

2.    H Wang, H Deng, M Gao, W Zhang*.Self-assembled nanogels based on ionic gelation of natural polysaccharides for drugdelivery. Frontiers in Bioengineering and Biotechnology. 2021, 9,703559.

3.    M Gao, H Deng, W Zhang*.Hyaluronan based multifunctional nano-carriers for combination cancer therapy. Current Topics in Medicinal Chemistry. 2021, 21, 126.

4.    D Yan#, H Wei#,X Lai, Y Ge, S Xu, J Meng, T Wen, J Liu, W Zhang*, J Wang*, H Xu*.Co-delivery of homoharringtonine and doxorubicin boosts therapeutic efficacy ofrefractory acute myeloid leukemia.Journal of Controlled Release. 2020,327, 766.

5.    W Zhang#, B Han#, X Lai, C Xiao, SXu, X Meng, Z Li, J Meng, T Wen, X Yang, J Liu, H Xu. Stiffness of cationizedgelatin nanoparticles is a key factor determining RNAi efficiency in myeloidleukemia cells. Chemical Communications.2020, 56, 1255.

6.    W Zhang, CH Tung. Lysosome enlargement enhanced photochemotherapy using amultifunctional nanogel. ACS AppliedMaterials & Interfaces. 2018,10, 4343.

7.    W Zhang, CH Tung. Redox-responsive cisplatin nanogel for anticancer drugdelivery. Chemical Communications, 2018, 54, 8367.

8.    W Zhang, CH Tung. Real-time visualization of lysosome destruction using aphotosensitive toluidine blue nanogel. Chemistry-AEuropean Journal. 2018, 24,2089.

9.    W Zhang#, X Meng#, H Liu, L Xie, JLiu, H Xu. Ratio of polycations and serum is a crucial index determining theRNAi efficiency of polyplexes. ACS AppliedMaterials & Interfaces. 2017,9, 43529.

10.  W Zhang, CH Tung. Sequence-independentDNA nanogel as a potential drug carrier. MacromolecularRapid Communications. 2017, 38,1700366.

11.  W Zhang, CH Tung. Cisplatin cross-linkedmultifunctional nanodrugplexes for combination therapy. ACS Applied Materials & Interfaces. 2017, 9, 854.

12.  W Zhang, Z Zhang, CH Tung, Beyondchemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loadednanogels. Chemical Communications. 2017, 53, 779.

13.  W Zhang#, J Liu#, Y Tabata, J Meng, H Xu. The effect of serum inculture on RNAi efficacy through modulation of polyplexes size. Biomaterials, 2014, 35, 567.

14.  W Zhang, Y Ji, X Wu, H Xu. Traffickingof gold nanorods in breast cancer cells: uptake, lysosome maturation andelimination. ACS Applied Materials & Interfaces,2013, 5, 9856.

15.  W Zhang, Y Ji, J Meng, X Wu, H Xu.Probing the behaviors of gold nanorods in metastatic breast cancer cells basedon UV-vis-NIR absorption spectroscopy. PLoS One, 2012, 7, e31957.

16.  W Zhang#, J Meng#, Y Ji, X Li, H Kong, X Wu, H Xu. Inhibitingmetastasis of breast cancer cells in vitro using gold nanorod-siRNA deliverysystem, Nanoscale, 2011, 3, 3923.

17.  X Cheng#, W Zhang#, Y Ji, J Meng, HGuo, J Liu, X Wu, H Xu. Revealing silver cytotoxicity using Au Nanorods/Ag shellnanostructures: disrupting cell membrane and causing apoptosis through oxidativedamage, RSC Advances, 2013, 3, 2296.

18.  W Zhang, H Xu. Tailoring the RNAiefficiency of polyplexes. Bioengineered.2014, 5, 152.

19.  S Xu, M Zhang, X Fang, J Meng, H Xing,  D Yan, J Liu, Y Yang, T Wen, W Zhang, JWang, C Wang, H Xu. A novel CD123-targeted therapeutic peptide loaded bymicellar delivery system combats refractory acute myeloid leukemia. Journalof Hematology & Oncology. 2021, 14, 193.

20.  SK Lee, MS Han, W Zhang, CH Tung. Multilayered activatablenanoprobe for ultra-bright tumor imaging. MacromolecularBioscience. 2019, 19, 1900260.

21.  B Du, W Zhang, CH Tung. A multiresponsive nanohybrid to enhancethe lysosomal delivery of oxygen and photosensitizers. Chemistry–A European Journal.2019, 25, 12801.

22.  H Guo, H Kommidi, UB Maachani, JC Voronina, W Zhang, RS Magge,J Ivanidze, AP Wu, MM Souweidane, O Aras, R Ting. An [18F]-positron emitting fluorophoreallows safe evaluation of small molecule distribution in the CSF, CSF Fistulas,and CNS device placement. Molecular Pharmaceutics.2019, 16, 3636.

23.  H Guo, H Kommidi, Y Vedvyas, JE McCloskey, W Zhang, N Chen, FNurili, AP Wu , HB Sayman, O Akin, EA Rodriguez, O Aras, MM Jin, R Ting. A fluorescent,[18F]-positron-emittingagent for imaging prostate-specific membrane antigen allows genetic reportingin adoptively transferred, genetically modified cells. ACS Chemical Biology. 2019,14, 1449.

24.  B Du, W Zhang, CH Tung. Layer-by-layer construction of anoxygen-generating photo-responsive nanomedicine for enhanced photothermal andphotodynamic combination therapy. ChemicalCommunications. 2019, 55, 5926.

25.  TS Lee, Y Kim, W Zhang, IH Song, CH Tung. Facile metabolicglycan labeling strategy for exosome tracking. Biochim Biophys Acta. 2018,1862, 1091.

26.  W Ma, J Liu, J Xie, X Zhang , H Zhou, H Yao, W Zhang, D Guo,L Zhu, L Xiao, D Wu, H Xu, S Chen, Y Zhao. Modulating the growth and imatinibsensitivity of chronic myeloid leukemia stem/progenitor cells withpullulan/microRNA nanoparticles in vitro. Journalof Biomedical Nanotechnology. 2015,11, 1961.

27.  J Meng, Y Ji, J Liu, X cheng, H Guo, W Zhang, X Wu, H Xu.Using gold nanorods core/silver shell nanostructures as model material to probebiodistribution and toxic effects of silver nanoparticles in mice, Nanotoxicology, 2014, 8, 686.

28.  J Meng, X Cheng, Jian Liu, W Zhang,X Li, H Kong, H Xu. Effects of long and shortcarboxylated or aminated multiwalled carbon nanotubes on blood coagulation. PLoS One, 2012, 7, e38995.

29.  M Yang, J Meng, X Cheng, J Lei, H Guo, W Zhang, H Kong, H Xu.Multiwalled carbon nanotubes interact with macrophages and influence tumorprogression and metastasis. Theranostics,2012, 2, 258.

30.  J Meng, M Yang, F Jia, H Kong, W Zhang, C Wang, J Xing, S Xie,H Xu. Subcutaneous injection of water-soluble multi-walled carbon nanotubes intumor-bearing mice boosts the host immune activity. Nanotechnology, 2010, 21,145104.

邓虹，博士，助理研究员。2007年江西师范大学化学学士，2012年于中国科学院化学研究所获博士学位。2012-2020年于中国科学院化学研究所任助理研究员。2020年加入中国医学科学院基础医学研究所任助理研究员。主要研究领域为肿瘤光动力治疗，迄今已在Journal of Medicinal Chemistry、Journal of Biomedical Nanotechnology和 Dyes and Pigments 等期刊发表论文10余篇，申请中国专利3项。

张忆一，博士，助理研究员。 2021年1月博士毕业于北京科技大学化学专业，同年9月加入中国医学科学院基础医学研究所任助理研究员。主要研究方向为纳米药物载体与光热治疗应用，迄今已在Nano Today, Advanced Healthcare Materials和Analytica Chimica Acta等期刊发表论文10余篇。

高梦涵，博士研究生，2019年本科毕业于中央民族大学生物科学专业

王慧敏，硕士研究生，2020年本科毕业于中国海洋大学药学专业

刘润萌，硕士研究生，2021年本科毕业于四川大学药学专业