(1) 天津市多元投入基金项目面上项目，21JCYBJC00960，Glypican-3靶向纳米金材料用于增强肝癌光热-免疫治疗研究，2021.10-2024.9，10万元，项目负责人，在研；

(2) 国家自然科学基金面上项目，32071342，表面仿生修饰的黑磷给药系统用于肿瘤的多模态成像与治疗及其机制研究，2021.01-2024.12，16.8万元，参加单位负责人，在研；

(3) 中国医学科学院医学与健康科技创新工程重大协同创新项目，2021-I2M-1-065，重症二尖瓣返流的介入综合治疗关键技术和器械研发（子任务：开发生物活性的心肌修复水凝胶），2021.01-2024.12，负责经费：160万元，子任务负责人，在研；

(4) 横向项目，纳米金材料对消化道肿瘤的光热治疗研究，2020.12-2022.12，16.5万元，项目负责人，结题；

(5) 南开大学药物化学生物学国家重点实验室开放基金，2020019，功能化纳米金星在肿瘤光热-免疫联合治疗中的应用研究，2020.01-2021.12，5万元，项目负责人，结题；

(6) 天津市自然科学基金青年项目，18JCQNJC14500，聚合物前药纳米给药系统在肿瘤联合治疗中的应用研究，2018.04-2021.03，6万元，项目负责人，结题；

(7) 国家自然科学基金青年项目，21604095，肝癌胚胎抗原Glypican-3纳米疫苗递送系统的设计及其在肝癌免疫治疗中的应用，2017.01-2019.12，20万元，项目负责人，结题；

(8) 中国医学科学院医学与健康科技创新工程协同创新团队项目，2017-I2M-3-022，新型疫苗佐剂关键技术平台建立及应用研究（子任务：天然多糖纳米佐剂在肿瘤免疫治疗中的应用），2017.01-2020.12，负责经费：149万元，子任务负责人，结题；

(9) 中国医学科学院科研院所基本科研业务费，2016RC310021，纳米递送系统在癌症光动力学治疗联合化疗中的应用，2016.03-2016.12，3万元，项目负责人，结题；

(10) 南开大学功能高分子材料教育部重点实验室开放基金，201606，海藻酸钠纳米粒子在疫苗递送中的应用，2016.06-2017.06，2万元，项目负责人，结题；

(11) 中国博士后科学基金第58批面上项目，2015M580066，pH敏感性聚合物胶束在肝癌化疗联合给药中的应用，2015.11-2017.11，8万元，项目负责人，结题。

科研论文：

(1) Li Xiaomin, Yu Licheng, Zhang Chuangnian*, Niu Xiaoyan, Sun Mengjie, Yan Zichao, Wang Wei, Yuan Zhi*. Tumor acid microenvironment-activated self-targeting & splitting gold nanoassembly for tumor chemo-radiotherapy. Bioactive Materials. 2022, 7: 377-388. (IF: 16.874, 中科院一区)

(2) Feng Zujian, Li Qinghua, Li Shuangyang, Zhang Yushan, Liu Xiang, Zhang Chuangnian*, Dong Anjie, Kong Deling, Wang Weiwei*, Huang Pingsheng*. Flexible and Zwitterionic Fluorinated Hydrogel Scaffold with High Fluorine Content for Noninvasive 19F Magnetic Resonance Imaging under Ultrahigh Scanning Resolution. Advanced Healthcare Materials. 2022, 2201894. DOI: 10.1002/adhm.202201894. (IF: 11.092, 中科院一区)

(3) Zhang Chuangnian#, Shi Gaona#, Zhang Ju, Song Huijuan, Niu Jinfeng, Shi Shengbin, Huang Pingsheng, Wang Yanming, Wang Weiwei, Li Chen*, Kong Deling*. Targeted antigen delivery to dendritic cell via functionalized alginate nanoparticles for cancer immunotherapy. Journal of Controlled Release. 2017, 256: 170-181. (IF: 11.467, 中科院一区)

(4) Pei Mengyue, Liang Jiayi, Zhang Chao, Wang Xiaoli*, Zhang Changnian*, Ma Guilei, Sun Hunfan. Chitosan/calcium phosphates nanosheet as a vaccine carrier for effective cross-presentation of exogenous antigens. Carbohydrate Polymers. 2019, 224: 115172. (IF: 10.723, 中科院一区)

(5) Li Huiyang, Liang Xiaoyu, Chen Youlu, Liu Kaijing, Fu Xue, Zhang Chuangnian*, Wang Xiaoli, Yang Jing*. Synergy of antioxidant and M2 polarization in polyphenol-modified konjac glucomannan dressing for remodeling wound healing microenvironment. Bioengineering & Translational Medicine. 2022, e10398. DOI: 10.1002/btm2.10398. (IF: 10.684, 中科院二区)

(6) Tang Jianghai, Chen Xuanjin, Shi Hang, Zhang, Mingming, Zhou Zhimin, Zhang Chuangnian*, Ke Tingyu, Kong Deling, Li Chen*. Prebiotic inulin nanocoating for pancreatic islet surface engineering. Biomaterials Science. 2023, 11(4): 1470-1485. (IF: 7.590, 中科院二区)

(7) Pei Mengyue, Li Huiyang, Zhu Yingwei*, Lu Jian, Zhang Chuangnian*. In vitro evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy. Biomaterials Science. 2022, 10(11): 2865-2876. (IF: 7.590, 中科院二区)

(8) Qu Yue, Shi Hang, Liu Mohan, Zhang Mingming, Wang Hai, Pang Liyun, Zhang Chuangnian*, Kong Deling, Li, Chen*. In Vivo Insulin Peptide Autoantigen Delivery by Mannosylated Sodium Alginate Nanoparticles Delayed but Could Not Prevent the Onset of Type 1 Diabetes in Nonobese Diabetic Mice. Molecular Pharmaceutics. 2021, 18(4): 1806-1818. (IF: 5.364, 中科院二区)

(9) Zhang Chuangnian#, Dong Ying#, Gao Jing, Wang Xiaoli*, Jiang Yanjun*. Radial porous SiO2 nanoflowers potentiate the effect of antigen/adjuvant in antitumor immunotherapy. Frontiers of Chemical Science and Engineering. 2021, 15(5): 1296-1311. (IF: 4.803, 中科院二区)

(10) Pei Mengyue, Xu Rong, Zhang Chuangnian*, Wang Xiaoli, Li Chen, Hu Yunzhang*. Mannose-functionalized antigen nanoparticles for targeted dendritic cells, accelerated endosomal escape and enhanced MHC-I antigen presentation. Colloids and Surfaces B: Biointerfaces. 2021, 197: 111378. (IF: 5.999, 中科院二区)

(11) Zhang Xiaolei#, Zhang Chuangnian#, Cheng Mingbo, Zhang Yahui, Wang Wei, Yuan Zhi*. Dual pH-responsive “charge-reversal like” gold nanoparticles to enhance tumor retention for chemo-radiotherapy. Nano Research. 2019, 12(11): 2815-2826. (IF: 10.269, 中科院一区)

(12) Zhang Chuangnian#, Zhang Jimin#, Qin Yibo, Song Huijuan, Huang Pingsheng, Wang Weiwei, Wang Chun, Li Chen, Wang Yanming*, Kong Deling*. Co-delivery of doxorubicin and pheophorbide A by pluronic F127 micelles for chemo-photodynamic combination therapy of melanoma. Journal of Materials Chemistry B. 2018, 6(20): 3305-3314. (IF: 7.571, 中科院二区)

(13) Qin Yibo, Yang Pengxiang, Shi Shengbin, Sun Hongfan, Zhang Chuangnian*, Kong Deling*. Redox-sensitive Alginate Prodrug Nanoparticles for Tumor Photodynamic Therapy. Acta Polymerica Sinica. 2018, 7: 909-916. (IF: 2.272, 中科院三区)

(14) Zhang Chuangnian, Shi Gaona, Zhang Ju, Niu Jinfeng, Huang Pingsheng, Wang Zhihong, Wang Yanming, Wang Weiwei, Li Chen*, Kong Deling*. Redox- and light-responsive alginate nanoparticles as effective drug carriers for combinational anticancer therapy. Nanoscale. 2017, 9(9): 3304-3314. (IF: 8.307, 中科院二区)

(15) Zhang Chuangnian#, Zhang Ju#, Shi Gaona, Song Huijuan, Shi Shengbin, Zhang Xiuyuan, Huang Pingsheng, Wang Zhihong, Wang Weiwei, Wang Chun*, Kong Deling*, Li Chen. A Light Responsive Nanoparticle-Based Delivery System Using Pheophorbide A Graft Polyethylenimine for Dendritic Cell-Based Cancer Immunotherapy. Molecular Pharmaceutics. 2017, 14(5): 1760-1770. (IF: 5.364, 中科院二区)

(16) Shi Gaona#, Zhang Chuangnian#, Xu Rong, Niu Jinfeng, Song Huijuan, Zhang Xiuyuan, Wang Weiwei, Wang Yanming, Li Chen*, Wei Xiaoqing*, Kong Deling*. Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine. Biomaterials. 2017, 113: 191-202. (IF: 15.304, 中科院一区)

(17) Zhang Chuangnian, Wang Wei, Liu Tong, Wu Yukun, Guo Hua, Wang Ping, Tian Qin, Wang Yongming, Yuan Zhi*. Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy. Biomaterials. 2012, 33(7): 2187-2196. (IF: 15.304, 中科院一区)

(18) Zhang Chuangnian, Wang Ping, Lai Quanyong, Zhang Qian, Zhang Yue, Wu Yukun, Liu Tong, Wang Wei, Yuan Zhi*. Qualitative and quantitative evaluation of glycyrrhetinic acid modified alginate liver targeting drug delivery system. Acta Polymerica Sinica. 2011, 8(8): 817-823. (IF: 2.272, 中科院三区)

(19) Tian Qin#, Zhang Chuangnian#, Wang Xiuhua, Wang Wei, Huang Wei, Cha Ruitao, Wang Chunhong, Yuan Zhi*, Liu Min, Wan Haiying, Tang Hua*. Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles for liver-targeted delivery. Biomaterials. 2010, 31(17): 4748-4756. (IF: 15.304, 中科院一区)

(20) Zhang Chuangnian, Wang Wei, Wang Chunhong, Tian Qin, Huang Wei, Yuan Zhi*, Chen Xuesi. Cytotoxicity of liver targeted drug-loaded alginate nanoparticles. Science in China Series B-Chemistry. 2009, 52(9): 1382-1387.

(21) 张闯年, 王蔚, 王春红, 田秦, 黄微, 袁直*, 陈学思. 肝靶向海藻酸钠载药纳米粒的细胞毒性研究. 中国科学(B辑:化学). 2009, 39(9): 943-949.

授权发明专利：

(1) 张闯年; 王晓莉; 孔德领; 孙洪范; 裴萌月; 徐蓉. 一种应用于肝癌免疫治疗的抗原和佐剂共递送纳米疫苗. 授权公告日：2022.3.21. 授权公告号：CN110585426B.

(2) 张闯年; 王晓莉; 孔德领; 孙洪范; 裴萌月; 徐蓉. 一种应用于肝癌免疫治疗的抗原和佐剂共递送纳米疫苗的制备方法. 授权公告日：2022.3.21. 授权公告号：CN110585425B.

(3) 冯祖建; 王伟伟; 黄平升; 张闯年. 可生物降解紫外光固化医用粘合剂及其制备方法和应用. 授权公告日：2022.12.13. 授权公告号：CN114558166B.

(4) 王晓莉; 张闯年; 杨菁; 徐蓉; 柳凯静. 基于纳米颗粒的活细胞表面改造方法及其使用的纳米颗粒. 授权公告日：2022.12.06. 授权公告号：CN112807289B. 

(5) 王晓莉; 张闯年; 姜艳军; 马桂蕾; 董莹. 一种载有纳米颗粒的微米颗粒疫苗载体的制备方法. 授权公告日：2022.10.14. 授权公告号：CN110025777B.

(6) 王晓莉; 张闯年; 裴萌月; 梁佳怡; 徐蓉; 马桂蕾; 孙洪范. 一种片状磷酸钙疫苗佐剂及其制备方法. 授权公告日：2022.07.26. 授权公告号：CN109908339B.

(7) 王伟伟; 刘文帅; 冯祖建; 黄平升; 孔德领; 张闯年. 一种抗菌糖肽水凝胶的制备方法. 授权公告日：2022.06.10. 授权公告号：CN113214507B. 

(8) 李宸; 张闯年; 张明明; 周志敏. 醛基化菊糖及其制备方法和应用. 授权公告日：2022.03.15. 授权公告号：CN112661870B.

(9) 宋会娟; 王伟伟; 张闯年; 黄平升; 孔德领. 共组装表位疫苗及其应用. 授权公告日：2022.03.01. 授权公告号：CN110339352B.

(10) 刘文帅; 王伟伟; 孔德领; 黄平升; 张闯年. 一种兼具抗菌修复性能的纳米凝胶及其制备方法与应用. 授权公告日：2021.08.24. 授权公告号：CN111234163B.

(11) Zhi Yuan; Wei Huang; Qin Tian; Chuangnian Zhang; Liang Han; Tong Liu; Yue Zhang; Yue Chen. Glycyrrhetinic acid-mediated nanoparticles of hepatic targeted drug delivery system, process for preparing the same and use thereof. Date of Patent: Nov. 3, 2015, Patent No.: US 9,173,852 B2.

(12) 袁直; 王蔚; 田秦; 王秀华; 黄微; 张闯年. 一种壳聚糖基肝靶向纳米粒子给药系统及其制备方法. 授权公告日：2012.05.23. 授权公告号：CN101642573B.

(13) 袁直; 田秦; 张闯年; 黄微; 贺晓婷; 刘通; 张跃; 陈跃. 甘草次酸－聚乙二醇/壳聚糖肝靶向复合给药系统及制备方法. 授权公告日：2010.09.15. 授权公告号：CN101254308B.

(14) 袁直; 黄微; 张闯年; 田秦; 韩亮; 刘通; 张跃; 陈跃. 纳米肝靶向两亲性嵌段共聚物给药系统及制备方法. 授权公告日：2010.06.02. 授权公告号：CN101249266B.