导师风采
申国安
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个人信息

Personal Information

  • 副研究员
  • 导师类别:硕士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:药用植物研究所
  • 所属专业: 中药学
  • 邮箱 : gashen@implad.ac.cn
  • 工作电话 : 010-57833172

个人简介

Personal Profile

申国安,男,出生于1973年3月3日,籍贯河南省遂平县。副研究员,目前在中国医学科学院药用植物研究所,鉴定中心工作。

1992-1996年,在河南职业技术师院获得农学学士学位。1996-1999年,在西北农林科技大学获得作物遗传育种专业硕士学位。1999-2003年,在复旦大学获得遗传学专业博士学位。

2003-2005年,在上海交通大学,农业与生物学院,生物技术研发中心,从事博士后研究,主要研究内容为银杏次生代谢产物的生物合成途径。2006-2008年,在美国诺贝基金会(Noble Foundation)作为研究助理, 进行植物病毒生态与多样性研究。2008-2011年,在美国诺贝基金会(Noble Foundation),作为博士后,进行植物次生代谢调控研究。

本人常期从事植物分子生物学研究,主要研究兴趣为药用植物次生代谢产物的生物合成通途经解析。特别是植物类黄酮和萜类次生代谢产物生物合成途径的分子生物学解析,以及代谢产物对植物发育、抗病、抗虫等性状的调控机理研究。在银杏、大豆、百脉根、羽扇豆和水稻类黄酮和萜类次生代谢产物生物合成途径研究中取得多个重要研究成果。在银杏、百脉根、水稻和大豆中鉴定了多个重要的黄酮糖基转移酶基因,在大豆、羽扇豆和百脉根中首次鉴定到多个类黄酮异戊烯基转移酶基因,这些研究结果发表在高水平国际期刊。

作为参加人参与完成多项国家级课题,主持国家自然科学基金面上项目一项,承担企业研发课题三项。参与编写论著2项。发表论文72篇,其中SCI论文50多篇。


  • 研究方向Research Directions
药用植物次生代谢合成生物学;,药用植物发育生物学,合成生物学
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
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科研项目

国家自然科学基金面上项目“水稻黄酮醇糖基转移酶基因OsFUGT1调控种子活力的分子机制研究”(2016.1-2019.1),课题负责人。


研究成果

发表文章列表

1.    Liu J, Xia Y, Jiang W, Shen G, Pang Y. LaPT2 Gene Encodes aFlavonoid Prenyltransferase in White Lupin. Front Plant Sci. 2021 Jun11;12:673337. doi: 10.3389/fpls.2021.673337. PMID: 34177989; PMCID: PMC8226212.

2.    潘俊倩,李小明,杨倩茹,落艳娇,申国安,徐超群,魏升华,郭宝林*. 不同光强处理下拟巫山淫羊藿生物学性状和淫羊藿苷类黄酮的变化. 中国现代中药,2021,23(1):89-93. doi:10.13313/j.issn.1673-4890.20200204005

3.    李小明, 潘俊倩, 落艳娇, 杨倩茹, 徐超群, 申国安, 魏升华*, 郭宝林*. 不同光强下光质对拟巫山淫羊藿生长发育和淫羊藿苷类黄酮含量的影响[J]. 中国中药杂志,2020, 45 (11):2502-2508. doi:10.19540/j.cnki.cjcmm.20200329.113

4.    Su X, Xia Y, Jiang W, Shen G, Pang Y. GbMYBR1 from Ginkgobiloba represses phenylpropanoid biosynthesis and trichome development inArabidopsis. Planta. 2020 Sep 29;252(4):68. doi: 10.1007/s00425-020-03476-1.PMID: 32990805; PMCID: PMC7524859.

5.    Li XM, Pan JQ, Luo YJ, Yang QR, Xu CQ, Shen GA, Wei SH, GuoBL. [Effects of light quality on growth and icariin flavonoid content ofEpimedium pseudowushanense under different light intensity]. Zhongguo Zhong YaoZa Zhi. 2020 Jun;45(11):2502-2508. Chinese. doi: 10.19540/j.cnki.cjcmm.20200329.113.PMID: 32627481.

6.    Lixin Duan, Aimin Ma, Xianbin Meng, Guo-an Shen, Xiaoquan Qi. (2020) QPMASS: A parallel peak alignmentand quantification software for the analysis of large-scale gaschromatographymass spectrometry (GC-MS)-based metabolomics datasets. Journal ofChromatography A, 1620: 460999.

7.    Yixin Zhang, Xiang Liu, Yu Yao, Yanjiao Luo, Qianru Yang,Cheng Zhang, Xu Chaoqun, Fengmei Suo, Guoan Shen*, Baolin Guo* (2020) The completechloroplast genome of Epimedium pudingense (Berberidaceae), a narrowlydistributed plant species in China. Mitochondrial DNA Part B, 5:3, 2631-2633.

8.    Xiaoming Li, Tianrong Xu, Yu Yao, Qianru Yang, Chaoqun Xu,Fengmei Suo, Cheng Zhang, Guoan Shen, Baolin Guo, Xiang Liu & Shenghua Wei(2020) The complete chloroplast genome of Epimedium enshiense B. L. Guo etHsiao (Berberidaceae), Mitochondrial DNA Part B, 5:3, 2045-2046.

9.    Guoan Shen, Xiang Liu, Congfen He, Yu Yao,Qianru Yang,Yanjiao Luo, Cheng Zhang, Chaoqun Xu, Fengmei Suo, Baolin Guo*. The complete chloroplastgenome of Epimedium rhizomatosum (Berberidaceae), an endemic plant species toChina. Mitochondrial DNA Part B, 2020, 5(2):1886–1887.

10.  FENG-MEI SUO, XIANG LIU,CHENG ZHANG, GUO-AN SHENG*, BAO-LIN GUO*. The complete chloroplast genome ofEpimedium elachyphyllum Stearn (Berberidaceae), an endangered species endemicto China. Mitochondrial DNA Part B-Resources.2020,5(1):1027-1028.

11.  Chunmei Wen, Xiang Liu, YuYao, Yanjiao Luo, Ting Liu, Qianru Yang, Baolin Guo, Chaoqun Xu, Fengmei Suo,Guoan Shen & Fei Ge (2020) The complete chloroplast genome of Epimediummikinorii Stearn. (Berberidaceae), Mitochondrial DNA Part B, 5:1, 806-807.

12.  Yanjiao Luo, Xiang Liu,Yao Yu, Qianru Yang, Baolin Guo, Chaoqun Xu, Fengmei Suo, Cheng Zhang, GuoanShen , Anjia Chen .The complete chloroplast genome of Epimediumqingchengshanense G. Y. Zhong et B. L. Guo (Berberidaceae), an endangeredspecies endemic to China, Mitochondrial DNA Part B, 2020, 5(1): 796-797

13.  Ting Liu,Xiang Liu,YanjiaoLuo,Yu Yao,Chunmei Wen,Qianru Yang,Guoan Shen,Baolin Guo. The completechloroplast genome of Epimedium wushanense T. S. Ying. (Berberidaceae), atraditional Chinese medicinal herb. Mitochondrial DNA Part B, 2020,5(1):817-818.

14.  Yue zhang, Xiang Liu,Cheng Zhang, Baolin Guo, Chaoqun Xu, Guoan Shen, Lijuan Zhang . The completechloroplast genome of Epimedium tianmenshanense (Berberidaceae). MitochondrialDNA Part B, 2020, 5(1):1007-1008

15.  Yuanyue Wang, Xiang Liu,Cheng Zhang, Chaoqun Xu, Fengmei Suo, Guoan Shen, Baolin Guo. The completechloroplast genome of Epimedium xichangense Y. J. Zhang (Berberidaceae).Mitochondrial DNA Part B, 2020, 5(1):1035-1037

16.  Qianru Yang, Xiang Liu,Cheng Zhang, Yu Yao, Yanjiao Luo, Guoan Shen*, Baolin Guo*. The completechloroplast genome of Epimedium davidii Franch. (Berberidaceae). MitochondrialDNA Part B, 2020, 5(1): 445-446.

17.  Yu Yao, Xiang Liu, QianruYang, Yanjiao Luo, Cheng Zhang, Chaoqun Xu, Fengmei Suo, Guoan Shen*, BaolinGuo*. The complete chloroplast genome of Epimedium brevicornu (Berberidaceae),a traditional Chinese medicinal herb. Mitochondrial DNA Part B, 2020, 5(1):887-888.

18.  Xiang Liu, Qianru Yang,Cheng Zhang, Guoan Shen & Baolin Guo.The complete chloroplast genome ofEpimedium sagittatum (Sieb. et Zucc.) Maxim. (Berberidaceae),a traditionalChinese herb. Mitochondrial DNA Part B Resources,2019, 4(2)2572

19.  Yang Q, Pan J, Shen G, GuoB. Yellow light promotes the growth and accumulation of bioactive flavonoids inEpimedium pseudowushanense. J Photochem Photobiol B. 2019 Aug;197:111550. doi:10.1016/j.jphotobiol.2019.111550. Epub 2019 Jul 5. PMID: 31330424.

20. 田景,金华, 申国安*,郭宝林*,姜志海,李砾,杨相波. 6-BA及尿素对拟巫山淫羊藿根芽形成的影响[J]. 中国现代中药, 2019, 21(1):71-75. doi:10.13313/j.issn.1673-4890.20180813002

21.  Liu J, Jiang W, Xia Y,Wang X, Shen G*, Pang Y*.(2018). Genistein-specific G6DT gene for the inducible production of wighteonein Lotus japonicus. Plant Cell Physiol. 59(1):128-141. (IF= 4.760)

22.  Su X, Wang W, Xia T, GaoL, Shen G, Pang Y. Characterization of a heat responsive UDP: Flavonoidglucosyltransferase gene in tea plant (Camellia sinensis). PLoS One. 2018 Nov26;13(11):e0207212. doi: 10.1371/journal.pone.0207212. PMID: 30475819; PMCID:PMC6261043.

23.  Yin Q, Shen G (co-first author), Di S, Fan C,Chang Z, Pang Y*. (2017). Genome-wide identification and functionalcharacterization of UDP-glucosyltransferase genes involved in flavonoidbiosynthesis in Glycine max. Plant Cell Physiol.  58(9):1558-1572. (IF= 4.760)

24.  Su X, Shen G*, Di S, Dixon RA, Pang Y*. (2017). Characterizationof UGT716A1 as a multi-substrate UDP:flavonoid glucosyltransferase gene in Ginkgo biloba. Front Plant Sci. 8:2085. doi: 10.3389.(IF= 4.298)

25.  Yin Q, Shen G, Chang Z, Tang Y, Gao H,Pang Y*. (2017). Involvement of three putative glucosyltransferases from theUGT72 family in flavonol glucoside/rhamnoside biosynthesis in Lotus japonicus seeds. J Exp Bot. 68(3):597-612. (IF= 5.830)

26. Li B, Cui G, Shen G, Zhan Z, Huang L, Chen J,Qi X. (2017). Targeted mutagenesis in the medicinal plant Salvia miltiorrhiza. Sci Rep. 7:43320. (IF= 4.259)

27. Okpala NE, Duan L, Shen G, Zhang G, Qi X. (2017). Identification of putativemetabolic biomarker underlying cooked rice elongation. Plant Omics. 10 (3):164-168.

28. Okpala NE, Duan L, Shen G, Zhang G, Qi X. (2017).Comparisons of cooking and eating qualities of two indica rice cultivars. J Rice Res. 5:2.

29. Duan L, Molnár I, Snyder JH,Shen G, Qi X. (2016).Discrimination and quantification of true biological signals in metabolomicsanalysis based on liquid Chromatography-Mass Spectrometry. Mol Plant. 9(8):1217-20. (IF= 8.827)

30. Xu H, Song J, Luo H, ZhangY, Li Q, Zhu Y, Xu J, Li Y, Song C, Wang B, Sun W, Shen G, Zhang X, Qian J, Ji A, Xu Z, Luo X, He L, Li C, SunC, Yan H, Cui G, Li X, Li X, Wei J, Liu J, Wang Y, Hayward A, Nelson D, Ning Z,Peters RJ, Qi X, Chen S. (2016). Analysis of the genome sequence of themedicinal plant Salvia miltiorrhiza. Mol Plant. 9(6):949-52. (IF= 8.827)

31. Shen, G., Duan, L., Qi, X. (2015). Plantmetabolome data mining and databases. ChineseBulletin of Life Sciences. 27(8):31-35.(inChinese)

32. Cui G, Duan L, Jin B, QianJ, Xue Z, Shen G, Snyder JH,Song J, Chen S, Huang L, Peters RJ, Qi X. (2015). Functional divergence of diterpenesyntheses in the medicinal plant Salviamiltiorrhiza. Plant Physiol. 169(3):1607-18. (IF= 6.456)

33.  Qiu, J., Gao, F.H., Shen, G. (co-first author), Li,C.H., Han, X.Y., Zhao, Q., Zhao, D.X., Hua, X.J., Pang, Y.Z. (2013). Metabolicengineering of the phenylpropanoid pathway enhances the antioxidant capacity ofSaussurea involucrata. Plos One. 8(8): e70665. (IF= 2.806)

34.  Pang Y, Cheng X, HuhmanDV, Ma J, Peel GJ, Yonekura-Sakakibara K, Saito K, Shen G, Sumner LW, Tang Y, Wen J, Yun J, Dixon RA. (2013).Medicagoglucosyltransferase UGT72L1: potential roles in proanthocyanidin biosynthesis. Planta.238(1):139-54. (IF= 3.361)

35.  Shen, G., Huhman, D., Lei, Z., Synder, J., Lloyd, S. andDixon, R.A. (2012). Characterization of anisoflavonoid-specific prenyltransferase from Lupinus albus. PlantPhysiology. 159(1):70-80.(IF= 6.456)

36.  Pang Y, Cheng XF, HuhmanDV, Ma J, Peel GJ, Yonekura-Sakakibara K, Saito K, Shen, G., Sumner LW, Tang Y, Wen J, Yun J, Dixon RA. (2013).Medicago glucosyltransferase UGT72L1: potential roles in proanthocyanidinbiosynthesis. Planta. 238(1):139-54. (IF= 3.361)

37.  Thapa V, Melcher U, WileyGB, Doust A, Palmer MW, Roewe K, Roe BA, ShenG, Roossinck MJ, Wang YM, Kamath N. (2012). Detection of members of theSecoviridae in the Tallgrass Prairie Preserve, Osage County, Oklahoma, USA. Virus Res. 167(1):34-42. (IF= 2.628)

38.  Thapa, V., Melcher. U.,Wiley, G. B. Q, Doust, A., Palmer, M. W., Roewe, K., Roe, B.A., Shen, G., Roossinck, M.J., Wang,Y.M., Kamath, N. (2012). Detection of members of the Secoviridae in the Tallgrass Prairie Preserve, Osage County,Oklahoma, USA. Virus Research. 167(1):34-42. (IF= 2.628)

39.  Stobbe AH, Melcher U,Palmer MW, Roossinck MJ, Shen G. Co-divergence and host-switching in theevolution of tobamoviruses. J Gen Virol. 2012 Feb;93(Pt 2):408-418. doi:10.1099/vir.0.034280-0. Epub 2011 Nov 2. PMID: 22049092.

40.  Roossinck, M.J., Saha, P.,Wiley, G.B., Quan, J., White, J.D., Lai, H., Chavarri´A, F., Shen, G. and Roe, B.A. (2010). Ecogenomics: using massively parallelpyrosequencing to understand virus ecology. Molecular Ecology. 19 (Suppl. 1) 1–8. (IF= 6.086)

41.  Chen, Y., Wang, A., Zhao,L., Shen, G., Cui, L. andTang, K. (2009). Expression of thymosinα1 concatemer in transgenic tomato (Solanum lycopersicum)fruits. Biotechnology and AppliedBiochemistry. 52, 303-312. (IF= 1.413)

42.  Chen Y, Wang A, Zhao L,Shen G, Cui L, Tang K. Expression of thymosin alpha1 concatemer in transgenictomato (Solanum lycopersicum) fruits. Biotechnol Appl Biochem. 2009 Apr;52(Pt4):303-12. doi: 10.1042/BA20080054. PMID: 18752465.

43.  Chen Y, Zhao L, Shen G,Cui L, Ren W, Zhang H, Qian H, Tang K. Expression and analysis of thymosinalpha1 concatemer in Escherichia coli. Biotechnol Appl Biochem. 2008 Jan;49(Pt1):51-6. doi: 10.1042/BA20070055. PMID: 17523920.

44.  Shen, G., Pang, Y., Wu, W., Deng, Z., Zhao, L., Cao, Y., Sun, X., Tang,K. (2006). Molecular cloning andcharacterization of a novel tissue-specific flavanone 3-hydroxylase cDNA from Ginkgo biloba. Bioscience Reports. 26 (1): 19-29. (IF= 2.906)

45.  Shen, G., Pang, Y., Wu, W., Zhao, L., Zhao, Sun, X., Tang, K. (2006). Cloning and characterization of aroot-specific expressing gene encoding 3-hydroxy-3-methylglutaryl coenzyme Areductase from Ginkgo biloba. Mol Biol Rep. 33(2)117-127. (IF= 1.828)

46.  Shen, G., Pang, Y., Wu, W., Liu X., Zhao, L., Tan, F., Sun, X.and Tang, K. (2006). Isolation and characterizationof a novel tissue-specific anthocyanidin reductase gene from Ginkgo biloba. Journal of Plant Physiology 163(2):224-227.(IF= 3.121)

47.  Wu W, Pang Y, Shen GA, LuJ, Lin J, Wang J, Sun X, Tang K. (2006). Molecular cloning, characterizationand expression of a novel trehalose-6-phosphate synthase homologue from Ginkgo biloba. J Biochem Mol Biol. 39(2):158-66.

48.  Pang, Y., Shen, G., Wu, W., Bergès,T., Cardier, H., Sun, X., Tang, K. (2006).Molecular cloning, characterization and heterologous expression in Saccharomyces cerevisiae of a novelmevalonate disphosphate decarboxylase cDNA from Ginkgo biloba. PhysiologiaPlantarum, 127(1):19-27. (IF= 3.33)

49.  Pang,Y., Shen, G., Wu, W., Liu,X., Lin, J., Tan, F., Sun, X., Tang, K. (2005).Characterizationof genomic sequence and expression of chalcone synthase gene from Ginkgo biloba. Plant Science, 168:1525-1531. (IF= 3.437)

50.  Shen, G., Pang,Y., Wu W., Deng, Z., Liu, X., Lin, J., Li, Z., Sun, X., Tang, K. (2005). Molecular cloning, characterization and expression of a novelAsr gene from Ginkgo biloba. PlantPhysiology and Biochemistry. 43(9):836-843. (IF= 2.724)

51.  Shen, G., Pang, Y., Wu, W., Miao, Z., Qian, H., Zhao, L., Sun, X.,Tang, K. (2005). Molecular cloning,characterization and expression of a novel defensin gene from Ginkgo biloba. Journal of Plant Physiology. 162(10):1160-1168.(IF= 3.121)

52.  Lin, J., Zhou, X., Pang,Y., Gao, H., Fei, J., Shen, G.,Wang, J., Li, X., Sun, X., Tang, K. (2005)Cloning and characterization of an agglutinin gene from Arisaema lobatum. BioscienceReports. 25(5-6):345-62. (IF= 2.906)

53.  Pang, Y., Shen, G., Qi, H., Tan, F., Sun,X., Tang K. (2004). Transgenic tobaccoexpressing Zephyranthes candidaagglutinin showed enhanced resistance to aphids. Engineering in Life Sciences. 4: 155-159. (IF= 1.698)

54.  Pang, Y., Shen, G., Liu, C., Liu, X., Tan,F., Sun, X., Tang K. (2004). Molecular Cloningand sequence analysis of a novel chalcone synthase gene from Ginkgo biloba. DNA Sequence. 15(4): 283-290.

55.  Pang, Y., Yao, J., Shen, G., Qi, H., Tan, F., Sun,X., Tang K. (2004). Transgenic tobaccoexpressing Lycoris radiata agglutininshowed enhanced resistance to aphids. ActaBotanica Sinica. 46(7): 767-772.

56.  Mi LP, Wei C, Huang JS, DuXL, Qian XY, Li KG, Shen GA, Yang JS. [The cloning and expression of a novelrPDCD5 gene from rice]. Yi Chuan. 2004 Nov;26(6):893-7. Chinese. PMID:15640122.

57.  Pang, Y., Shen, G. (co-first author), Liao, Z., Yao, J., Fei, J., Tan, F., Tang, K. (2003). Cloning and characterisation of a novel lectingene from Zephyranthes Candida. DNA Sequence. 14(3):163-167.

58.  Shen, G., Pang, Y., Lin,C., Wei, C., Qian, X., Jiang, L., Du, X., Li, K., Yang, J. (2003).Cloning andCharacterisation of a novel Hsp100/Clp gene (osClpD) from Oryza sativa. DNA Sequence. 14(4): 285-293.

59.  Du XL, Wang D, Qian XY,Jiang LZ, Chun W, Li KG, Shen GA, Lin CF, Yang JS. cDNA cloning and expressionanalysis of the rice (Oryza sativa L.) RNase L inhibitor. DNA Seq. 2003Aug;14(4):295-301. doi: 10.1080/1085566031000141162. PMID: 14631652.

60.  Jiang, R.,Lin, C., Shen, G., Qian, M.,Wang, D., Du, X., Huang, J., Yang, J. (2002).Cloning ofthe rice cytoplasmic malic dehydrogenase gene (RcMDH) and itsexpression in E. coli. Journal of Fudan University. 41(1): 67-69. (In Chinese with English abstract).

61.  Shen, G., Wang, Z., Li, W., Dong, P., Liu, S., He, P. (2000).Analysis of the inheritance and combining ability of the canopy temperature inwheat. Journal of Northwest Sci-techUniversity of Agriculture and Forestry (natural science edition). 28(6):43-47. (In Chinese with English abstract).

62.  Shen, G., Wang, D., Qian, M., Jiang, R., Yang, J. (2002).Sequencing and preliminary analysis of genomic sequence of rice nmads1 gene. Journal of Fudan University. 41(1):109-112. (In Chinese with English abstract).


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