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田育林,博士,副研究员,硕士生导师。2010年本科毕业于沈阳药科大学基础药学理科基地班,2015年在北京协和医学院-中国医学科学院药物研究所取得药物化学博士学位,2015-2018年在纽约州立大学水牛城分校从事博士后研究,2018年进入中国医学科学院药物研究所工作,主要从事药物化学与化学生物学研究,具体包括:(1)新型肿瘤光诊疗探针的开发与应用。(2)基于生物正交反应的新型化学生物学工具的开发与应用。(3)基于结构的药物分子设计、合成与生物活性研究。近年来在J. Am. Chem. Soc., Org. Lett., Chem. Commun., Chin. Chem. Lett.等杂志发表论文30多篇,2020年获得北京市科技新星计划资助,2022年获得药物所“梁周黄于刘青年科技奖”三等奖。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg(1) 国家自然科学基金青年项目,基于分子探针与定量蛋白组学技术的抗肝炎药物双环醇的靶标鉴定研究,2020.01-2022.12, 主持
(2) 北京市科技新星计划, 生物正交化学驱动的Turn-on型荧光探针的构建及在蛋白质标记中的应用, 2020.09-2023.08, 主持
第一或通讯作者身份发表论文:
1. Yu Teng, Rongrong Zhang, Bingbing Yang, Hong Yang, Xiang Li,Dali Yin, Xinchi Feng *, Yulin Tian*, Bioorthogonally-ActivatedTetraphenylene-Tetrazine Aggregation-Induced Emission Fluorogenic Probes, J.Mater. Chem. B, 2022, 10, 8642–8649 (Inside Front Cover).
2. Yongcheng Wang‡, Yu Teng‡, Hong Yang, Xiang Li, Dali Yin, YulinTian*, Bioorthogonally applicable multicolor fluorogenic naphthalimide–tetrazine probes with aggregation-induced emission characters, Chem.Commun., 2022, 58, 949-952.(Back Cover)
3. Xiang Li‡, Hong Yang‡, Yu Teng, Yongcheng Wang, Dali Yin, Yulin Tian*, A general strategy for in situ assembly of light-up fluorophores via bioorthogonal Suzuki-Miyaura cross-coupling, Chin. Chem. Lett., 2022, 33, 4223-4228.
4. Yu Teng, Hong Yang, Xiang Li,Yongcheng Wang, Dali Yin, YulinTian*, A Bioorthogonal-Activated Fluorescence Turn-On Probe Based on Nitrone-Modified 1,8-Naphthalimide for Live-Cell Imaging, Chin.J. Chem., 2022, 40, 209-214.(Back Cover)
5. Yulin Tian*, Hong Yang, Xiang Li, Yongcheng Wang, Yu Teng, Dali Yin, Design of Nitroso-Modified Naphthylene-Based Fluorophores as Photoactivatable Bioorthogonal Turn-On Probes, Org. Lett., 2021, 23, 3782-3787.
6. Yulin Tian, Ming Fang, Qing Li*, Intracellular bioorthogonal labeling of glucagon receptor via tetrazine ligation, Bioorg. Med. Chem., 2021, 43, 116256.
7. HongYang, Yongcheng Wang, Xiang Li, Yu Teng, Yulin Tian*, A Dansyl Amide N-Oxide Fluorogenic Probe Based on aBioorthogonal Decaging Reaction, ChemistryOpen, 2021, 10, 1013-1019.
8. Xiang Li, Yongcheng Wang, Hong Yang, Dali Yin, Yulin Tian*, Design of Hydrazone-Modified 1,8-Naphthalimides as Fluorogenic Click Probes Based on Nitrile Imine-Alkyne Cycloaddition, Eur. J. Org. Chem., 2020, 4296–4300.(Cover Feature)
9. Yulin Tian*‡, Xiang Li‡, Dali Yin, Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling, Chem. Commun., 2019, 55, 12865-12868.
10. Yulin Tian, Qing Lin*, Fitness Factors for Bioorthogonal Chemical Probes, ACS Chem. Biol., 2019, 14, 2489−2496.
11. Yulin Tian, Huafei Zou, Peng An, Zhihong Zhou, Weijun Shen*, Qing Lin*, Design of stapled oxyntomodulin analogs containing functionalized biphenyl cross-linkers, Tetrahedron, 2019, 75, 286-295.
12. Yulin Tian, Qing Lin*, Recent Development of Photo-Cross-Linkers as Tools for Biomedical Research, Chimia, 2018, 72, 758-763.
13. Yulin Tian, Qing Lin,* Genetic encoding of 2-aryl-5-carboxytetrazole-based protein photo-cross-linkers, Chem. Commun., 2018, 54, 4449-4452.
14. Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu, Qing Lin*, Genetically encoded 2-aryl-5-carboxytetrazoles for site-selective protein photo-cross-linking, J. Am. Chem. Soc., 2017, 139, 6078–6081.
15. Yulin Tian, Xiaojian Wang*, Qiong Xiao, Chenbin Sun, Dali Yin*, Synthesis of dihydrobenzoheterocycles through Al(OTf)3-mediated cascade cyclization and ionic hydrogenation, J. Org. Chem., 2014, 79, 9678-9685.
16. Yulin Tian‡, Jing Jin‡, Xiaojian Wang*, Jinping Hu, Qiong Xiao, Wanqi Zhou, Xiaoguang Chen, Dali Yin*, Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design, Eur. J Med. Chem., 2014, 85, 1-15.
17. Yulin Tian, Jianguo Qi, Chenbin Sun, Dali Yin, Xiaojian Wang*, Qiong Xiao, One-pot synthesis of 4-methylisoquinolines via sequential Pd-catalyzed Heck reaction and intramolecular cyclization, Org. Biomol. Chem., 2013, 11, 7262-7266.
18. Yulin Tian, Jing Jin, Xiaojian Wang, Weijuan Han, Gang Li, Wanqi Zhou, Qiong Xiao, Jianguo Qi, Xiaoguang Chen, Dali Yin*, Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor, MedChemComm, 2013, 4, 1267-1274.
授权专利:
1. 艾托莫德的制备方法,陈思,石泽玉,肖琼,张翔,田育林,尹大力,中国发明专利,2022-06-21,专利号:ZL201811244306.6.
2. 一种艾托莫德的制备方法,陈思,石泽玉,肖琼,张翔,田育林,尹大力,中国发明专利,2022-06-21,专利号:ZL201811244290.9.
3. 普赛莫德的制备方法,石泽玉,陈思,肖琼,张翔,田育林,尹大力,中国发明专利,2022-06-21,专利号:ZL201811244302.8.
4. 一种普赛莫德的制备方法,石泽玉,陈思,肖琼,张翔,田育林,尹大力,中国发明专利,2022-07-19,专利号:ZL201811244291.3.
5. Oxyntomodulin analogs and methods of making and using same, Qing Lin, Avinash Muppidi, Weijun Shen, Huafei Zou, Peter Schultz, Yulin Tian, US Patent, 2018-04-03, No. US9931379B2.
6. 含五元芳杂环的氨基丙二醇类化合物、其制备方法及其医药用途,田育林,汪小涧,金晶,齐建国,周琬琪,陈晓光,尹大力,中国发明专利,2019-04-09, 专利号:ZL201410053130.1.
7. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途,齐建国,汪小涧,金晶,田育林,周琬琪,陈晓光,尹大力,中国发明专利,2018-10-30, 专利号:ZL201410053128.4.
2020年北京市科技新星
2022年中国医学科学院药物研究所“梁周黄于刘青年科技奖”三等奖
北京协和医学院研究生院招生办公室
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