作为项目负责人主持在研国家自然科学基金面上项目1项、北京市自然科学基金面上项目1项；临床前新药开发项目2项。

炎症与免疫药理学及其创新药物发现

主要研究方向：

1. 呼吸疾病（哮喘、COPD等）炎症免疫调控机制与新靶点发现及其创新药研究

2. 免疫介导的再生障碍性贫血病理机制及其靶点与新药发现研究

3. 多成分多靶点组分中药的开发及其在慢性复杂性疾病中的作用机制研究

近5年内发表的主要研究论文

1. Pei Ma#, ShuyiLi#, Hui Yang, Jiqiao Yuan, Ziqian Zhang, Xuyu Li, Nan Fang, MingbaoLin* and Qi Hou*. Comparative RNA‐Seq transcriptome analysis on pulmonary inflammation in a mouse modelof asthma-COPD overlap syndrome. Frontiers in Cell and Developmental Biology.2021，doi:10.3389/fcell.2021.628957.

2. Shuyi Li, Hui Yang,Jiqiao Yuan, Ziqian Zhang, Xuyu Li, Nan Fang, Mingbao Lin*, QiHou*. Syk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 BlocksAirway Inflammation of Asthma–COPD Overlap in vivo and in vitro. Journal ofInflammation Research. 2021，14：2173-2185.

3. Yasi Ding#,Weibin Tang#, Fei Pei#, Lixia Fu, Pei Ma, Jinye Bai, MingbaoLin*, Yunbao Liu*, Qi Hou*. Brusatol Derivative - 34 AttenuatesAllergic Airway Inflammation via Inhibition of the Syk Pathway. Frontiers inPharmacology. 2021, doi: 10.3389/fphar.2021.587417.

4. Hui Yang# ,WeiSun#,Yan-nan Fan, Shu-yi Li, Ji-qiao Yuan, Zi-qian Zhang, Xu-yu Li, Ming-baoLin* , and Qi Hou*. Perilla Leaf Extract Attenuates Asthma Airway Inflammationby Blocking the Syk Pathway. Mediators of Inflammation. 2021，2021：6611219.

5. Hui Yang,Wei Sun, PeiMa,Chunsuo Yao,Yannan Fan,Shuyi Li,Jiqiao Yuan,Xuyu Li, Mingbao Lin*,Qi Hou*.Multiple Components Rapidly Screened from Perilla Leaves Attenuate AsthmaAirway Inflammation by Synergistic Targeting on Syk. Journal of Inflammation Research.2020:13 897–911.

6. Pei Ma, Lifeng Yue, HuiYang, Yannan Fan, Jinye Bai, Shuyi Li, Jiqiao Yuan, Ziqian Zhang, Chunsuo Yao, MingbaoLin*, Qi Hou*. hondroprotective and anti-inflammatory effects ofamurensin H by regulating TLR4/Syk/NF-κB signals. J Cell Mol Med. 2020;24:1958–1968

7. Yannan Fan, Ziqian Zhang,Chunsuo Yao, Jinye Bai, Hui Yang, Pei Ma, Yiyao Fan, Shuyi Li, Jiqiao Yuan, MingbaoLin* and Qi Hou*. Amurensin H, a derivative from resveratrol,ameliorates lipopolysaccharide / cigarette smoke‐induced airway inflammation by blocking the Syk/NF-κB pathway.Frontiers in Pharmacology. 2019, 10: 1157.

8. Hui Yang#,Jing Guan#, Pei Ma, Yannan Fan, Jinye Bai, Shuyi Li, JiqiaoYuan,Yecheng Jin, Mingbao Lin#*, Jianmin Zhang*, and Qi Hou*.Beneficial Effects of Qingzixiaoban Granule on Henoch–Sch¨onlein Purpura Nephritis Mice through Inhibiting Immune ComplexDeposition and Th2 Immunodeviation. ECAM. 2019: 3050248.

9. Lixia Fu#,Jing Guan#, Yujia Zhang#, Pei Ma#, YuanyuanZhuang, Jinye Bai, Yasi Ding, Qi Hou, Wan Gong, Mingbao Lin*, WenshengZheng*, Jianmin Zhang*. Tulobuterol patch alleviates allergic asthmic inflammationby blockade of Syk and NF-κB activation in mice. Oncotarget. 2018, 9(15): 12154-12163.

10. Yuanyuan Zhuang#,Jiabao Liu#, Pei Ma#, Jinye Bai, Yasi Ding, Hui Yang,Yannan Fan, Mingbao Lin*, Shuai Li* & Qi Hou*. Tamarixinin A alleviatesjoint destruction of rheumatoid arthritis by blockade of MAPK and NF-κB activation. Frontiers inPharmacology. 2017, 8: 538.doi:10.3389/fphar.2017.00538.

11. Jin-Qian Yu#,Ming-BaoLin#, An-Jun Deng**, Qi Hou, Zhi-Hui Zhang, Shao-Peng Yuan,Ren-Tao Jiang, Hai-Lin Qin*. Phytochemistry. 2017, 138 (2017):152-162.

12. Pei Ma#,Ya-Si Ding#, Ling-Ling Xuan#, Lin Wang, Ji Shi, Jin-YeBai, Ming-BaoLin*, Wen-Sheng Zheng* & Qi Hou*. Anti-inflammatory effect of aresveratrol derivative 3,4,5-trimethoxy-4′,5′-dihydroxytrans-stilbene(WL-09-5) via ROS-mediated NF-κB pathway. Journal of Asian Natural Products Research. 2016, 18(10):1004-1013.

13. 张梓倩，李姝仪，袁继巧，杨慧，范燕楠，白金叶，马培，林明宝*，侯琦*。免疫介导再生障碍性贫血小鼠模型制备条件的实验比较研究，中国药理学通报. 2020，36（8）：1178-1183.

14. 傅丽霞，张宇佳，庄媛媛，关晶，白金叶，侯琦，郑稳生，林明宝*，张建民*.妥洛特罗体内外非特异性抗炎作用研究.中国药房. 2016，27（13）：1763-176。