1. 国家级青年人才项目

2. 国家自然科学基金面上项目，狼毒大戟中蓖麻烯型二萜从简单环状骨架向复杂环状骨架的转化过程及其代谢工程菌的建立，

3.国家自然科学基金面上项目， 基于自组织特征映射神经网络和合成生物学技术鉴定和表征狼毒大戟中松香烷型二萜生物合成途径的细胞色素P450酶

4. 广东省重点领域研发计划“岭南中医药现代化”重点专项

5. 广东省珠江人才计划本土创新团队项目

主要聚焦植物源的多环萜烯、黄酮和苯丙素类化合物，构建高效异源生物合成体系并研究关键酶的催化机制。在国内外，首次建立水飞蓟素药效成分群、檀香挥发油成分群等中药药效成分的“从头”生物合成方法；利用量子化学计算揭示以类吉马烯合成酶的催化机制。

代表性论文：

1.      JiazengYang, Jincai Liang, Lei Shao, Lihong Liu, Ke Gao, Junliang Zhang, Zhenjiao Sun,Wendong Xu, Pengcheng, Lin, Rongmin Yu, JiachenZi*. Green production of silybin and isosilybin by merging metabolicengineering approaches and enzymatic catalysis. Metab. Eng. 2020, 59:44-52.

2.      WenlongZha, Tianyue An, Ting Li, Jianxun Zhu, Ke Gao, Zhenjiao Sun, Wendong Xu,Pengcheng Lin, Jiachen Zi*.Reconstruction of the Biosynthetic Pathway of Santalols under Control of theGAL Regulatory System in Yeast ACS Synth. Biol. 2020, 9(2):449-456.

3.      FanZhang, Tianyue An, Xiaowen Tang, JiachenZi*, Hai-Bin Luo*, and Ruibo Wu*. Enzyme Promiscuity versus Fidelity in twoSesquiterpene Cyclases (TEAS versus ATAS). ACS Catal. 2020, 10: 1470–1484.

4.      JianxunZhu, Lihong Liu, Maobo Wu, Guiyang Xia, Pengcheng Lin, and Jiachen Zi*. Characterization of a Sesquiterpene SynthaseCatalyzing Formationof Cedrol and Two Diastereoisomers of Tricho-Acorenol from Euphorbia fischeriana. J.Nat. Prod. 2021, 84, 1780−1786

5.      TianyueAn, Linsheng Li, Ying Lin, Fanqi Zeng, Pengcheng Lin, Jiachen Zi*. Characterization of guaiene synthases from Stellera chamaejasme L. flowers andtheir application in de novo production of (-)-rotundone in yeast. J.Agric. Food Chem., 2020, 68(10): 3214-3219.

6.      JiajianHuang, Wenlong Zha, Tianyue An, Hua Dong, Ying Huang, Dong Wang, Rongmin Yu,Lixin Duan, Xueli Zhang, Reuben J. Peters*, Zhubo Dai*, Jiachen Zi*.Identification of RoCYP01 (CYP716A155) enables construction of engineered yeastfor high-yield production of betulinic acid , Appl. Microbiol. Biotechnol.2019, 103(17): 7029-7039.

7.      JianChen, Xiaona Fan, Jianhua Zhu, Liyan Song, Zhiwei Li, Fei Lin, Rongmin Yu*,Hanhong Xu*, Jiachen Zi*. Limonoidsfrom seeds of Azadirachta indica A.Juss. and their cytotoxic activity. Acta Pharm. Sin. B 2018, 8(4):639-644.

8.      TianyueAn, Wenlong Zha, Jiachen Zi*. BiotechnologicalProduction of Betulinic Acid and Derivatives and Their Applications. Appl.Microbiol. Biotechnol. 2020, 104(8): 3339-3348.

9.      Jiachen Zi, Yuki Matsuba, Young J. Hong,Alana J. Jackson, Dean J. Tantillo, Eran Pichersky and Reuben J. Peters.Biosynthesis of lycosantalonol, a cis-prenyl derived diterpenoid. J.Am. Chem. Soc., 2014, 136: 16951-16953.

10.      Jiachen Zi, Sibongile Mafu, and Reuben J.Peters. To Gibberellins and Beyond! Surveying the Evolution of (Di)terpenoidMetabolism. Annu. Rev. Plant Biol., 2014, 65, 259-286.