课题组现有研究员1人，副研究员3人， 助理研究员3人， 在校博士生5人，硕士生12人（含联合培养），形成了以博士为主，老中青结合，结构配置合理的研究梯队，围绕天然药物化学学科开展中药药效物质基础研究，形成了稳定的研究方向

主持的主要课题：

1.      国家科技重大专项“重大新药创制”十三五项目：中药组分资源库

2.      国家科技重大专项“重大新药创制”十三五项目：分子复方的发现技术-基于代谢组学的分子复方的发现技术

3.      国家发改委中药标准化行动计划：中药质量标准库建设—化学成分库 

4.      国家科技重大专项“重大新药创制”以GPCRβ1/β2AR为靶标的中药活性筛选及创新中药发现子课题

5.      国家科技重大专项“重大新药创制”中药候选药物“抗哮喘中药甘参平喘胶囊的开发研究”

6.      国家科技重大专项“重大新药创制”“创新药物研究开发技术平台建设”项目，任务：中药分析及质量控制研究平台

7.      国家科技重大专项“重大新药创制”项目：面向新药发现的数字化中药化学成分库

8.      国家自然科学基金：基于“肠道菌群-肠-脑”轴 研究柴胡疏肝散抗抑郁机制及药效成分

9.      国家自然科学基金：基于宿主和肠道菌群代谢特征的心可舒心肌保护组分配伍研究

10    国家自然科学基金：基于代谢网络调控和肠吸收的柴胡疏肝散组方配伍研究

11.   国家自然科学基金：基于代谢网络的心可舒防治冠心病物质基础和作用机制研究

12.   国家自然科学基金项目：基于代谢组学的"柴胡疏肝散"抗抑郁作用效应物质基础研究

13.   中国医学科学院医学与健康科技创新工程协同创新团队

主要成就：

1. 完成了花椒等30余种中草药活性成分的系统研究，并开展了常用中药标准品及质量评价研究。 

2.  建立了基于NMR和LC-MS代谢组学技术挖掘中药复方中活性成分的研究思路和方法，在经典方剂柴胡疏肝散、中成药心可舒及医院制剂地五养肝方等复方制剂的效应成分及指标性成分阐释上取得了显著成绩。

3. 针对中药和民族药样品资源，创建了国家级资源共享平台-“国家中药化合物库”，处于国际领先地位。

发表学术论文227篇，其中SCI收载论文126篇。申请发明专利16项，授权7项。

代表性论文：

  [1] Tian D, Yang Y, Yu M, Han ZZ, Wei M, Zhang HW, Jia HM*,Zou ZM*. Anti-inflammatory chemical constituents of Flos Chrysanthemi Indicidetermined by UPLC-MS/MS integrated with network pharmacology. Food Funct. 202011(7):6340-6351

  [2] Wang MH, Zhang XY, Tan XM, Niu SB, Sun BD, Yu M, Ding G*, Zou ZM*. ChetocochliodinsA-I, Epipoly (thiodioxopiperazines) from Chaetomium cochliodes. J Nat Prod.2020；24;83(4):805-813

 [3]  Song B, Li LY, Shang H, Liu Y, Yu M, Ding G*, Zou ZM*. Trematosphones A and B, Two Unique Dimeric Structures fromthe Desert Plant Endophytic Fungus Trematosphaeria terricola. Org Lett. 2019; 21(7):2139-2142.

 [4]  Chen JH, Zhang T, Zhang QB, Liu Y, Li LY, Si JG, Zou ZM*, Hua HM*.Isobutylhydroxyamides from Sichuan Pepper and Their Protective Activity on PC12Cells Damaged by Corticosterone. J AgricFood Chem. 2018;66(13):3408-3416.

 [5]  Sun L, Jia H, Ma L, Yu M, Yang Y, Liu Y, Zhang H, Zou Z*. Metabolicprofiling of hypoxia/reoxygenation injury in H9c2 cells reveals the accumulationof phytosphingosine and the vital role of Dan-Shen in Xin-Ke-Shu.Phytomedicine. 2018;49:83-94.

 [6] Wang MH, Hu YC, Sun BD, Yu M1, Niu SB, Guo Z, Zhang XY, Zhang T,Ding G*, Zou ZM*. Highly Photosensitive Poly-Sulfur-Bridged Chetomin Analoguesfrom Chaetomium cochliodes. Org Lett.2018, 20(7):1806-1809

 [7] Chen L, Niu SB, Li L, Ding G*, Yu M, Zhang GS, Wang MH, Li LY,Zhang T, Jia HM, Zhang HW, Shang H, Liu XZ, Zou ZM*. Trichoderpyrone, a Unique Polyketide Hybrid with aCyclopentenone-Pyrone Skeleton from the Plant Endophytic Fungus Trichodermagamsii. J Nat Prod. 2017, 80(6):1944-1947

 [8] Yu M, Jia HM, Zhou C, Yang Y, Sun LL, Zou ZM*. Urinary and Fecal Metabonomics Study of the ProtectiveEffect of Chaihu-Shu-Gan-San on Antibiotic-Induced Gut Microbiota Dysbiosis inRats. Sci Rep. 2017, 7:46551

 [9] JiangT, Wang M, Li L, Si J, Song B, Zhou C, Yu M, Wang X, Zhang Y, Ding G *, Zou Z*. Overexpression of the GlobalRegulator LaeA in Chaetomium globosum Leads to the Biosynthesis ofChaetoglobosin Z. J Nat Prod. 2016, 79(10):2487-2494.

 [10] LiuYT, Zhou C, Jia HM, Chang X, Zou ZM*.Standardized Chinese Formula Xin-Ke-Shu inhibits the myocardium Ca(2+)overloading and metabolic alternations in isoproterenol-induced myocardialinfarction rats. Sci Rep. 2016, 6:30208.

 [11 ] JiaHM, Li Q, Zhou C, Yu M, Yang Y, Zhang HW, Ding G, Shang H, Zou ZM*. Chronic unpredictive mild stress leads to altered hepaticmetabolic profile and gene expression. SciRep. 2016, 6:23441.

 [12] Zhou C,Jia HM, Liu YT, Yu M, Chang X, Ba YM, Zou ZM*. Metabolismof Glycerophospholipid, Bile Acid and Retinol Are Correlated with the EarlyOutcomes of Autoimmune Hepatitis. Mol.BioSyst, 2016,12(5):1574-85

 [13] Yu M,Cui FX, Jia HM, Zhou C, Yang Y, Zhang HW, Ding G, Zou ZM*. Aberrant purine metabolism inallergic asthma revealed by plasma metabolomics. J Pharm Biomed Anal. 2016, 120:181-9.

 [14] Shang H,Tian Y, Luo J, Li LY, Tang YF* Zou ZM*,Rhodium(II)-catalyzed intramolecular annulation of 1-sulfonyl-1,2,3-triazoleswith indoles: facile synthesis of functionalized tetrahydro-β-carbolines, RSC Adv., 2016, 6, 30835-30839.

 [15] Zhang QB, Ding G, Zhang T, Si JG, Song B, Wang MH, Chen JH,Yu M, Gu YC, Zou ZM*. New furanopyridinealkaloids from the leaves of Glycosmis pentaphylla, Phytochemistry Letters, 2016, 18: 51-54

  [16] Zhang T, Si JG, Zhang QB, Ding G, Zou ZM*. New Highly Oxygenated Germacranolides from Carpesiumdivaricatum and their Cytotoxic Activity. SciRep. 2016, 6:27237.

  [17] Cheng WH, CaoB, Shang H, Niu C, Zhang LM, Zhang ZH, Tian DL, Zhang S, Chen H*, Zou ZM* .Synthesis and evaluation of novel podophyllotoxinderivatives as potential antitumor agents.Eur J Med Chem. 2014,85C:498-507.

  [18] Liu YT, Peng JB, Jia HM, Zhang HW, Ding G, Zou ZM*.  Urinary metabonomic evaluation of thetherapeutic effect of traditional Chinese medicine Xin-Ke-Shu againstatherosclerosis rabbits using UPLC-Q/TOF MS，Chemometricsand Intelligent Laboratory Systems，2014, 136: 104-114 

  [19] Liu YT, Jia HM, Chang X, Cheng WH, Zhao X, Ding G,Zhang HW, Cai DY, Zou ZM*. Metabolicpathways involved in Xin-Ke-Shu protecting against myocardial infarction inrats using ultra high-performance liquid chromatography coupled with quadrupoletime-of-flight mass spectrometry. J PharmBiomed Anal, 2014,90:35-44

  [20] Liu YT, PengJB, Jia HM, Cai DY, Zhang HW, Yu CY*,ZouZM*, UPLC-Q/TOF MS standardized Chinese Formula Xin-Ke-Shu for thetreatment of atherosclerosis in a rabbit model. Phytomedicine，2014, 21(11):1364-72