1. 团队视频：https://mp.weixin.qq.com/s/6Q-Rh5SGzAQkV_tSPWpAJg

1、2019 国家自然科学基金委员会 灵芝环装RNA23316以竞争性内源RNA方式结合milRNA117调控鲨烯环氧酶影响三萜类化合物合成的机制研究 56万 国家自然科学基金面上项目

2、2019 中华人民共和国科学技术部“一带一路”国家传统草药数据库与共享平台建设” 50万 “一带一路”国家传统草药品种本底整理及数据库建设

3、2016 中国医学科学院 本草基因组协同创新团队 120万 中国医学科学院医学与健康科技创新工程-协同创新团队项目

4、2016 微塞特(北京)科技有限公司 微塞(WS)临床诊断流程的建立与优化研究 企业横向项目 111.6万

5、2014 国家自然科学基金委员会 灵芝长非编码RNA 对三萜类化合物合成的调控作用和机理研究 16万 国家自然科学基金面上项目

6、2014 北京市自然科学基金 中药材GGT身份溯源系统构建关键技术研究 18万 北京市自然科学基金面上项目

7、2006 香港大学教育资助委员会UGC Identification and characterization of chromosomal functional domains in completely sequenced genomes 79.8万港币 General Research Fund （GRF）

8、2010 中国医学科学院 药用真菌和药用植 物基因组结构与功能解析 118万 中国医学科学院协和学者特聘教授经费

一、获奖

1、2014年，中华中医药学会科学技术一等奖：中草药DNA条形码生物鉴定体系（201401-03 ZY-32-R-08）

2、2015年，教育部科学技术进步一等奖：中草药DNA条形码生物鉴定体系（2014-204）

二、代表性研究论文

 1.         Zhou Y, Wu M, Zhu H, Shao J, Liu C, Cui Y: Identificationof LincRNA from Dermatophagoides farinae (Acari: Pyroglyphidae) for PotentialAllergen-Related Targets. Geneticsand molecular biology 2020, 43(1):e20190243.

2.         Zhou Q, Li J, Jiang M, Wang L, Liu C, Wang Y: The complete chloroplast genome ofAristolochia kwangsiensi. MitochondrialDNA Part B 2020, 5(2):1184-1185.

3.         Wang L, Zhang H, Wu X, Wang Z, Fang W, Jiang M, Chen H,Huang L, Liu C: Phylogeneticrelationships of Atractylodes lancea, A. chinensis and A. macrocephala,revealed by complete plastome and nuclear gene sequences. PLoS One 2020, 15(1):e0227610.

4.         Sun X, Li L, Pei J, Liu C, Huang LF: Metabolome and transcriptome profiling reveals quality variation andunderlying regulation of three ecotypes for Cistanche deserticola. Plant molecular biology 2020, 102(3):253-269.

5.         Shao J, Wang L, Liu Y, Qi Q, Wang B, Lu S, Liu C: Identification of milRNAs and their targetgenes in Ganoderma lucidum by high-throughput sequencing and degradome analysis.Fungal Genetics and Biology 2020, 136:103313.

6.         Liu J, Jiang M, Wang L, Huang L, Chen H, Liu C: The complete chloroplast genome sequence ofthe medicinal plant Siegesbeckia orientalis L., the first in the genusSiegesbeckia. Mitochondrial DNA PartB 2020, 5(1):145-146.

7.         Chen H, Jiang M, Wang L, You J, Liu C: Complete plastome of Leucanthemum maximum, the first in genusLeucanthemum. Mitochondrial DNA PartB 2020, 5(1):19-20.

8.         吴茜, 姜梅, 陈海梅, 王立强, 黄林芳, 刘昶: 旋覆花、湖北旋覆花和线叶旋覆花的叶绿体基因组比较分析和系统发育研究. 药学学报 2020, 55(05):1042-1049.

9.         Zhou Q, Pei J, Poon J, Lau AY, Zhang L, Wang Y, Liu C, HuangL: Worldwide research trends onaristolochic acids (1957-2017): Suggestions for researchers. PLoS One 2019, 14(5):e0216135.

10.       Wang L, Zhang H, Jiang M, Chen H, Huang L, Liu C: Complete plastome sequence of Iodescirrhosa Turcz., the first in the Icacinaceae, comparative genomic analyses andpossible split of Idoes species in response to climate changes. PeerJ 2019, 7:e6663.

11.       Sun X, Wang YP, Liu C, Huang LF: Molecular identification of Taihangia rupestris Yu et Li, an endangeredspecies endemic to China. SouthAfrican Journal of Botany 2019, 124:173-177.

12.       Shi L, Chen H, Jiang M, Wang L, Wu X, Huang L, Liu C: CPGAVAS2, an integrated plastome sequenceannotator and analyzer. Nucleic acidsresearch 2019, 47.

13.       Shao J, Wang L, Liu X, Yang M, Chen H, Wu B, Liu C: Identification and characterization ofcircular RNAs in Ganoderma lucidum. ScientificReports 2019, 9(1):16522.

14.       杨俏俏, 姜梅, 王立强, 陈海梅, 刘昶, 黄林芳: 药食两用藠头叶绿体基因组解析、比较基因组学及系统发育研究. 药学学报 2019, 54(1):189-197.

15.       Jiang M, Chen H, He S, Wang L, Chen AJ, Liu C: Sequencing, Characterization, andComparative Analyses of the Plastome of Caragana rosea var. rosea. International Journal of Molecular Sciences 2018,19(5):1419.

16.       Chen H, Shao J, Zhang H, Jiang M, Huang L, Zhang Z, Yang D, HeM, Ronaghi M, Luo X: Sequencing andAnalysis of Strobilanthes cusia (Nees) Kuntze Chloroplast Genome Revealed theRare Simultaneous Contraction and Expansion of the Inverted Repeat Region inAngiosperm. Frontiers in PlantScience 2018, 9.

17.       张慧, 何帅兵, 孔繁德, 陈海梅, 唐泰山, 徐淑菲, 苗丽, 刘昶: 益母草叶绿体基因组序列与系统进化位置分析.中医药信息 2018(4).

18.       Yang D, Shao J, Hu R, Chen H, Xie P, Liu C: Angiotensin II promotes the anticoagulanteffects of rivaroxaban via angiotensin type 2 receptor signaling in mice. Sci Rep 2017, 7(1):369.

19.       Wu B, Chen H, Shao J, Zhang H, Wu K, Liu C: Identification of Symmetrical RNA EditingEvents in the Mitochondria of Salvia miltiorrhiza by Strand-specific RNASequencing. Scientific Reports 2017,7:42250.

20.       Wang XC, Chen H, Yang D, Liu C: Diversity of mitochondrial plastid DNAs (MTPTs) in seed plants. Mitochondrial Dna Part A Dna MappingSequencing & Analysis 2017, 29(4):1.

21.       Shao J, Chen H, Yang D, Jiang M, Zhang H, Wu B, Li J, Yuan L,Liu C: Genome-wide Identification andCharacterization of Natural Antisense Transcripts by Strand-specific RNASequencing in Ganoderma lucidum. SciRep 2017, 7(1):5711.

22.       Pan J, Chen H, Guo B, Liu C: Understanding the molecular mechanisms underlying the effects of lightintensity on flavonoid production by RNA-seq analysis in Epimediumpseudowushanense B.L.Guo. Plos One 2017,12(8):e0182348.

23.       Yang D, Chen H, Zeng X, Xie P, Wang X, Liu C: Macrophage CGI-58 Attenuates InflammatoryResponsiveness via Promotion of PPARgamma Signaling. Cellular physiology and biochemistry : international journal ofexperimental cellular physiology, biochemistry, and pharmacology 2016, 38(2):696-713.

24.       Wang XC, Shao J, Liu C: Thecomplete mitochondrial genome of the medicinal fungus Ganoderma applanatum(Polyporales, Basidiomycota). MitochondrialDna A Dna Mapp Seq Anal 2016, 27(4):2813-2814.

25.       Wang B, Chen H, Ma H, Zhang H, Lei W, Wu W, Shao J, Jiang M,Jia Z: Complete plastid genome ofAstragalus membranaceus (Fisch.) Bunge var. membranaceus. Mitochondrial DNA 2016, 1(1):517-519.

26.       Liu Y, Li X, Xie C, Luo X, Bao Y, Wu B, Hu Y, Zhong Z, Liu C,Li M: Prevention Effects and PossibleMolecular Mechanism of Mulberry Leaf Extract and its Formulation on Rats withInsulin-Insensitivity. Plos One 2016,11(4):e0152728.

27.       Lei W, Ni D, Wang Y, Shao J, Wang X, Yang D, Wang J, Chen H,Liu C: Intraspecific and heteroplasmicvariations, gene losses and inversions in the chloroplast genome of Astragalusmembranaceus. Scientific Reports 2016,6:21669.

28.       Zhang J, Chen H, Wu K, Liu C: Transcriptome-wide identification of genes related to fatty acidbiosynthesis in the medicinal plant Salviamiltiorrhiza. Plant Omics Journal2015, 8(2):148-158.

29.       Wang XC, Wu K, Chen H, Shao J, Zhang N, Chen X, Lan J, Liu C: The complete mitochondrial genome of thewhite-rot fungus Ganoderma meredithiae (Polyporales, Basidiomycota). Mitochondrial DNA 2015:1-2.

30.       Wang XC, Shao J, Liu C: Thecomplete mitochondrial genome of the medicinal fungus Ganoderma applanatum(Polyporales, Basidiomycota). MitochondrialDNA 2015:1-2.

31.       Wang XC, Liu C, Huang L, Bengtsson-Palme J, Chen H, Zhang JH,Cai D, Li JQ: ITS1: a DNA barcode betterthan ITS2 in eukaryotes? Mol EcolResour 2015, 15(3):573-586.

32.       Kües U, Nelson DR, Liu C, Yu G-J, Zhang J, Li J, Wang X-C, SunH: Genome analysis of medicinalGanoderma spp. with plant-pathogenic and saprotrophic life-styles. Phytochemistry 2015, 114:18-37.

33.       Lu S, Le S, Tan Y, Li M, Liu C, Zhang K, Huang J, Chen H, RaoX, Zhu J et al: Unlocking the mystery of the hard-to-sequence phage genome: PaP1methylome and bacterial immunity. BMCGenomics 2014, 15:803.

34.       Li J, Wu B, Xu J, Liu C: Genome-wideidentification and characterization of long intergenic non-coding RNAs in Ganoderma lucidum. PLoS One 2014, 9(6):e99442.

35.       Chen H, Zhang J, Yuan G, Liu C: Complex interplay among DNA modification, noncoding RNA expression andprotein-coding RNA expression in Salviamiltiorrhiza chloroplast genome. PLoSOne 2014, 9(6):e99314.

36.       Chen H, Wu B, Nelson DR, Wu K, Liu C: Computational Identification and Systematic Classification of NovelCytochrome P450 Genes in Salviamiltiorrhiza. PLoS One 2014, 9(12):e115149.

37.       Li J, Zhang J, Chen H, Chen X, Lan J, Liu C: Complete Mitochondrial Genome of theMedicinal Mushroom Ganoderma lucidum.PLoS One 2013, 8(8):e72038.

38.       Song J, Shi L, Li D, Sun Y, Niu Y, Chen Z, Luo H, Pang X, SunZ, Liu C et al: Extensive pyrosequencing reveals frequent intra-genomic variations ofinternal transcribed spacer regions of nuclear ribosomal DNA. PLoS One 2012, 7(8):e43971.

39.       Pang X, Liu C, Shi L, Liu R, Liang D, Li H, Cherny SS, Chen S:Utility of the trnH-psbA IntergenicSpacer Region and Its Combinations as Plant DNA Barcodes: A Meta-Analysis. PLoS One 2012, 7(11):e48833.

40.       Liu C, Shi L, Zhu Y, Chen H, Zhang J, Lin X, Guan X: CpGAVAS, an integrated web server for theannotation, visualization, analysis, and GenBank submission of completelysequenced chloroplast genome sequences. BMCGenomics 2012, 13(1):715.

41.       Liu C, Shi L, Xu X, Li H, Xing H, Liang D, Jiang K, Pang X,Song J, Chen S: DNA barcode goestwo-dimensions: DNA QR code web server. PLoSOne 2012, 7(5):e35146.

42.       Liu C, Li J, Wang L, Wu F, Huang L, Xu Y, Ye J, Xiao B, MengF, Chen S et al: Analysis of tanshinone IIA induced cellular apoptosis in leukemia cellsby genome-wide expression profiling. BMCComplement Altern Med 2012, 12(1):5.

43.       Chen S, Xu J, Liu C, Zhu Y, Nelson DR, Zhou S, Li C, Wang L,Guo X, Sun Y et al: Genome sequence of the model medicinalmushroom Ganoderma lucidum. Nat Commun 2012, 3:913.

44.       李文涛, 刘昶, 王增绘, 杨默, 黄林芳, 陈士林: 基于中医治疗血液病方剂的中药组合规律数据挖掘. 中华中医药杂志 2012, 27(012):3096-3099.

45.       Liu C, Yu H, Chen SL: Frameworkfor Sustainable Use of Medicinal Plants in China. Plant Diversity and Resources 2011, 33(1):1-5.

46.       Liu C, Liang D, Gao T, Pang X, Song J, Yao H, Han J, Liu Z,Guan X, Jiang K et al: PTIGS-IdIt, a system for speciesidentification by DNA sequences of the psbA-trnH intergenic spacer region. BMC Bioinformatics 2011, 12 Suppl 13:S4.

47.       Yao H, Song J, Liu C, Luo K, Han J, Li Y, Pang X, Xu H, Zhu Y,Xiao P et al: Use of ITS2 region as the universal DNA barcode for plants and animals.PLoS One 2010, 5(10).

48.       Ma XY, Xie CX, Liu C, Song JY, Yao H, Luo K, Zhu YJ, Gao T,Pang XH, Qian J et al: Species identification of medicinalpteridophytes by a DNA barcode marker, the chloroplast psbA-trnH intergenicregion. Biol Pharm Bull 2010, 33(11):1919-1924.

49.       Liu C, Li J, Meng FY, Liang SX, Deng R, Li CK, Pong NH, LauCP, Cheng SW, Ye JY et al: Polysaccharides from the root of Angelicasinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway.BMC Complement Altern Med 2010, 10:79.

50.       Han JP, Song JY, Liu C, Chen J, Qian J, Zhu YJ, Shi LC, Yao H,Chen SL: Identification of Cistanchespecies (Orobanchaceae) based on sequences of the plastid psbA-trnH intergenicregion. Yao Xue Xue Bao 2010, 45(1):126-130.

51.       Han J, Liu C, Li M, Shi L, Song J, Yao H, Pang X, Chen S: Relationship between DNA barcoding andChemical Classification of Salvia Medicinal Herbs. Chinese Herbal Medicines 2010, 2(1):16-29.

52.       Gao T, Yao H, Song J, Liu C, Zhu Y, Ma X, Pang X, Xu H, ChenS: Identification of medicinal plants inthe family Fabaceae using a potential DNA barcode ITS2. J Ethnopharmacol 2010, 130(1):116-121.

53.       Chen S, Yao H, Han J, Liu C, Song J, Shi L, Zhu Y, Ma X, GaoT, Pang X et al: Validation of the ITS2 region as a novel DNA barcode for identifyingmedicinal plant species. PLoS One 2010,5(1):e8613.

54.       Yao H, Song JY, Ma XY, Liu C, Li Y, Xu HX, Han JP, Duan LS,Chen SL: Identification of Dendrobiumspecies by a candidate DNA barcode sequence: the chloroplast psbA-trnHintergenic region. Planta Med 2009,75(6):667-669.

55.       Yang M, Chan GC, Deng R, Ng MH, Cheng SW, Lau CP, Ye JY, WangL, Liu C: An herbal decoction of Radixastragali and Radix angelicae sinensis promotes hematopoiesis andthrombopoiesis. J Ethnopharmacol 2009,124(1):87-97.

56.       Song J, Yao H, Li Y, Li X, Lin Y, Liu C, Han J, Xie C, Chen S:Authentication of the familyPolygonaceae in Chinese pharmacopoeia by DNA barcoding technique. J Ethnopharmacol 2009, 124(3):434-439.

57.       Liu C, Wang L, Lancto CA, Abrahamsen MS: Characterization of a Cryptosporidium parvum protein that bindssingle-stranded G-strand telomeric DNA. MolBiochem Parasitol 2009, 165(2):132-141.

58.       Yang M, Ng MH, Li CK, Chan PK, Liu C, Ye JY, Chong BH: Thrombopoietin levels increased in patientswith severe acute respiratory syndrome. ThrombRes 2008, 122(4):473-477.

59.       Rong J, Tilton R, Shen J, Ng KM, Liu C, Tam PK, Lau AS, ChengYC: Genome-wide biological responsefingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables theselection of multiple marker genes as a potential metric for quality control.J Ethnopharmacol 2007, 113(1):35-44.

60.       Chen S, Yao H, Song J, Li XW, Liu C, Lu JW: Use of DNAbarcoding to identify Chinese medicinal materials. World Science and Technology/Modernization ofTraditional Chinese Medicine and Materia Medica 2007, 9(3).

61.       Liu C, Ghosh S, Searls DB, Saunders AM, Cossman J, Roses AD: Clusters of adjacent and similarlyexpressed genes across normal human tissues complicate comparativetranscriptomic discovery. OMICS 2005,9(4):351-363.

62.       Templeton TJ, Lancto CA, Vigdorovich V, Liu C, London NR,Hadsall KZ, Abrahamsen MS: The Cryptosporidiumoocyst wall protein is a member of a multigene family and has a homolog inToxoplasma. Infect Immun 2004, 72(2):980-987.

63.       Abrahamsen MS, Templeton TJ, Enomoto S, Abrahante JE, Zhu G,Lancto CA, Deng M, Liu C, Widmer G, Tzipori S et al: Complete genomesequence of the apicomplexan, Cryptosporidium parvum. Science 2004, 304(5669):441-445.

64.       Striepen B, White MW, Li C, Guerini MN, Malik SB, Logsdon JM,Jr., Liu C, Abrahamsen MS: Geneticcomplementation in apicomplexan parasites. Proc Natl Acad Sci U S A 2002, 99(9):6304-6309.

65.       Liu C, Vigdorovich V, Kapur V, Abrahamsen MS: A random survey of the Cryptosporidiumparvum genome. Infect Immun 1999,67(8):3960-3969.

66.       Liu C, Abrahamsen MS: Identificationof a putative telomeric repeat DNA binding factor of Cryptosporidium parvum.J Eukaryot Microbiol 1999, 46(5):50S-51S.

67.       Aiello AE, Xiao L, Limor JR, Liu C, Abrahamsen MS, Lal AA: Microsatellite analysis of the human andbovine genotypes of Cryptosporidium parvum. J Eukaryot Microbiol 1999, 46(5):46S-47S.

68.       Liu C, Schroeder AA, Kapur V, Abrahamsen MS: Telomeric sequences of Cryptosporidiumparvum. Mol Biochem Parasitol 1998,94(2):291-296.

69.       Liang F, Ren G, Chen Y, Liu C, Zhao G: Study on Fermentation of Bacillus thuringiensis subsp. Kenyae ken-Ag inFermentor of 10T. Acta ScientiarumNaturalium Universitatis NanKaiensis 1995, 31(2):28-32.

三、学术专著

《中药DNA条形码分子鉴定》 编委 人民卫生出版社 2012

《药用植物品质生物学》 编委 科学出版社 2019

《The Salvia miltiorrhiza Genome》 编委 SpringerNature，Switzerland 2019

《中药质量控制与分析》 编委 中国协和医科大学出版社 2020

四、软件著作权

1、软著登字第2048613号 DNA-Barcode HMM Identifier中药材真伪品鉴定系统［简称： DNA-Barcode HMM Identifier］V1.0 中国医学科学院药用植物研究所 2017SR463329 No.01906917 2017年8月22日

2、软著登字第2358238号 中药材GGT溯源软件系统V1.0 中国医学科学院药用植物研究所 2018SR029143 No.02242802 2018年1月12日

3、软著登字第2405389号 CPGAVAS植物叶绿体基因组注释专家系统[简称：CPGAVAS]V1.0 中国医学科学院药用植物研究所 2018SR076294 No.02299044 2018年1月31日

4、软著登字第2405394号 FUMGA真菌线粒体基因组注释专家系统[简称：MitoFungi]V0.2 中国医学科学院药用植物研究所 2018SR076299 No.02299045 2018年1月31日

5、软著登字第2405399号 trnh-psbA DNA条形码数据库及鉴定专家系统[]V1.0 中国医学科学院药用植物研究所 2018SR076304 No.02299046 2018年1月31日

6、软著登字第2405406号 QR-DNA条形码分析专家系统[简称：DNAQR]V1.0 中国医学科学院药用植物研究所 2018SR076311 No.02299047 2018年1月31日

7、软著登字第3420092号 基于区块链的中药材溯源软件系统V1.0 中国医学科学院药用植物研究所 2018SR1090997 No.03405747 2018年12月29日

8、软著登字第3425741号 基于区块链数据库的生物产品溯源系统V1.0 中国医学科学院药用植物研究所 2019SR0004984 No.03424344 2019年1月2日

9、软著登字第4817551号 CPGAVAS2质体序列注释与分析综合工具软件 中国医学科学院药用植物研究所 2019SR1396794 No.05061463 2019年12月19日

10、软著登字第4817557号 基于区款链和ORCID身份认证的DNA信息记录系统 中国医学科学院药用植物研究所 2019SR1396800 No.05061464 2019年12月19日

一、博士后

李建琴、陈海梅、王新存、张建辉、王立强

二、进修老师

雷万钧、吴茜

三、研究生

邵俊杰、张慧、姜梅、柳靖婷

四、联培研究生

云南中医药大学（裴亦菲）；福建农林大学（倪阳、岳静雯）；西南大学（李京凌、徐溢岑）；天津大学（杨合宇）

五、毕设实习生

2018：湘南学院（唐艳华、姚丽萍、周举军）；山西农业大学（孙琴琴、刘玉嫣）；烟台大学（李双智、李丹丹）；河南科技大学（仝艳）；成都中医药大学（周游）

2019：湘南学院（李宇宁、郑彧玥、刘洋、齐倩茹），North Carolina State University （Michelle Liu）

2020：湘南学院（陈卓尔、周俊臣、孙思慧、朱思琳）；Wake Forest University （白露）、东北农业大学（马冰欣）

2021：湘南学院（陈灏东、曾晶、李静、范榕俊）；西南大学（裴晓莹）

研究生培养内容包括：

1、“干”、“湿”实验技术。通过系统的科研训练，使学生掌握常规分子生物学实验技术，基因组测序、组装、注释、高通量数据分析等技术，linux操作、Python语言编程、R语言编程等计算机技术；

2、论文写作。开展文献计量学论文写作培训，系统综述与meta分析论文写作培训，SCI科研论文写作培训；

3、国际交流与合作。鼓励学生积极参与国际交流活动，开拓学术视野。提供参加国际学术会议、出国联合培养的机会；

4、教学技能。组织学生参与教学活动，积累教学经验；

5、英语学习。在课题组内构建英文科研交流环境，鼓励学生使用英文进行文献解读和工作汇报。