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张博，北京协和医院临床医学研究所独立PI，博士生导师，国家自然基金优秀青年基金获得者，中国医学科学院北京协和医学院准聘助理教授。博士毕业于北京大学（医学部）药学院-天然药物与仿生药物国家重点实验室（2011-2016），师从周德敏教授，主要研究方向为基于化学生物学的生物技术药物开发。2016年入职北京协和医院-医学科学研究中心，主要研究兴趣聚焦于利用化学生物学与合成生物学的交叉技术手段，开发以细胞因子和免疫细胞为主的新型生物技术药物，用于实现免疫稳态的精准调控策略和自身免疫病的靶向治疗。发表论文30余篇，近年代表性成果发表在Nature Biomedical Engineering，风湿病领域顶级期刊Annals of the Rheumatic Diseases, Cell Chemical Biology, Signal Transduction and Targeted Therapy, Acta Biomateriali等专业期刊，H-index 13， 申请和授权专利10余项。主持北京市科技新星、国自然面上、或作为科研骨干参与国家重大新药创制专项等多项研发计划。
主要研究方向包括：
1、基于合成生物学原理与技术手段，开发具有免疫调控功能的生物技术药物，对现有内源性分子进行基于临床需求的定向改造和人工设计
2、免疫稳态调控的基础研究
3、基因密码子拓展技术和非天然氨基酸介导的合成生物学基础和应用研究
招生方向： 蛋白质工程；细胞治疗；化学生物学
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支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg1. Bo Zhang#*; Jiaqi Sun#; Yeshuang Yuan#; Dezhong Ji#; Yeting Sun#; Yudong Liu; Shengjie Li; Xingxing Zhu; Xunyao Wu; Jin Hu; Qiu Xie; Ling Wu; Lulu Liu; Boyang Cheng; Yuanjie Zhang; Lingjuan Jiang; Lidan Zhao; Fei Yu; Wei Song; Min Wang; Yue Xu; Shiliang Ma; Yunyun Fei; Lihe Zhang; Demin Zhou*; Xuan Zhang*; Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity, Signal Transduction and Targeted Therapy, 2023, 8(1)
2. Yeting Sun; Yeshuang Yuan; Bo Zhang*; Xuan Zhang*; CARs: a new approach for the treatment of autoimmune diseases, SCIENCE CHINA Life Sciences, 2023, 66(4): 711-728
3. Bo Zhang#; Jiaqi Sun#; Yan Wang#; Dezhong Ji#; Yeshuang Yuan#; Shengjie Li; Yeting Sun; Yingqin Hou; Pengchong Li; Lidan Zhao; Fei Yu; Wenxiao Ma; Boyang Cheng; Ling Wu; Jin Hu; Min Wang; Wei Song; Xiaogang Li; Hao Li; Yunyun Fei; Hua Chen; Lihe Zhang; George C. Tsokos*; Demin Zhou*; Xuan Zhang*; Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells, Nature biomedical engineering, 2021, 5(11): 1288- 1305
4. Bo Zhang#; Yan Wang#; Yeshuang Yuan#; Jiaqi Sun; Lulu Liu; Dan Huang; Jin Hu; Min Wang; Shengjie Li; Wei Song; Hua Chen; Demin Zhou*; Xuan Zhang*; In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells, Annals of the Rheumatic Diseases, 2021, 80(2): 176-184
5. Bo Zhang#; Yan Wang#; Shenlong Huang#; Jiaqi Sun; Min Wang; Wenxiao Ma; YanboYou; Ling Wu; Jin Hu; Wei Song; Xudong Liu; Shengjie Li; Hua Chen; Guisheng Zhang; Lihe Zhang; Demin Zhou*; Lingjun Li*; Xuan Zhang*; Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator, Cell Chemical biology, 2021, 28(1): 60-69
6. Dezhong Ji#; Yuanjie Zhang#; Jiaqi Sun; Bo Zhang; Wenxiao Ma; Boyang Cheng; Xinchen Wang; Yuanhao Li; Yu Mu; Huan Xu; Qi Wang; Chuanling Zhang; Sulong Xiao; Lihe Zhang; Demin Zhou*; An engineered influenza virus to deliver antigens for lung cancer vaccination, Nature Biotechnology, 2023
7. Yuan-Yang Guo#, Bo Zhang#, Luying Wang, Shenlong Huang, Shilei Wang, Yanbo You, Gongming Zhu, Anlian Zhu, Mingwei Geng, Lingjun Li*, An efficient and easily-accessible ligand for Cu(I)-catalyzed azide-alkyne cycloaddition bioconjugatio, Chem Commun (Camb); 2020 Nov 19;56(92):14401-14403
8. Bo Zhang; Huan Xu; Jingxian Chen; Yongxiang Zheng; Yiming Wu; Longlong Si; Ling Wu; Chuanling Zhang; Gang Xia; Lihe Zhang; Demin Zhou*; Development of next generation of therapeutic IFN-a2b via genetic code, Acta Biomaterialia, 2015, Jun(19): 100-111
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