个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
张园园博士，中国医学科学院肿瘤医院分子肿瘤学国家重点实验室研究员，课题组长，北京协和医学院博士生导师。2020年博士毕业于北京大学生命科学学院&生物医学前沿创新中心（BIOPIC），师从国际著名生物信息学家、中国科学院院士张泽民教授。后在北京大学前沿交叉学科研究院/北大-清华生命科学联合中心（CLS）从事博士后研究，随后赴美国麻省理工学院-哈佛大学博德研究所（Broad Institute of MIT and Harvard）、美国德克萨斯大学MD安德森癌症研究中心(MD Anderson Cancer Center)进行博士后研究工作。2024年1月被人才引进到医科院肿瘤医院工作。
张园园博士近年来主要从事肿瘤微环境的单细胞功能与组学技术应用研究，包括系统性地解析肿瘤浸润T细胞的特征及动态关系，揭示化疗及免疫治疗策略的潜在作用机理。先后发表SCI论文18篇，总引用 > 6000次，研究成果以第一作者（含共同）发表在Cell （2017）、Nature（2018）、Nature Medicine（2018）、Genome Biology (2019)、Cancer Cell (2021) 等杂志上，与合作导师张泽民教授受邀在Cellular & Molecular Immunology（2020）杂志对领域进行综述和展望，获得同行高度认可，引用 > 1200次。成果荣获2017年Cell出版社中国年度论文、2017年度中国生命科学十大进展、2018年度中国生物信息学十大进展、2020年度北京市科学技术奖自然科学奖一等奖。张园园博士同时担任Frontiers in Immunology专刊主编（Main editor）。
课题组围绕癌症发生和发展的分子机理、肿瘤微环境重塑以及免疫治疗的分子机制展开研究，系统整合临床患者和小鼠模型，利用单细胞时空多组学测序、功能基因组学、CRISPR/Cas9等技术手段探究癌细胞表型可塑性及免疫逃逸的具体机制，期待通过对肿瘤微环境的关键组分和动态过程的深入理解，探索肿瘤发生、进展和转移的机制、免疫疗法的响应及抵抗机制，促进肿瘤新药物、新疗法的研发。
中国医学科学院医学与健康科技创新工程-医学健康领军科技人才养募专项，在研，主持
国家自然科学基金重大研究计划, 在研, 参与
上传附件
支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg上传附件
支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg上传附件
支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg中国医学科学院医学与健康科技创新工程-医学健康领军科技人才养募专项，在研，主持
国家自然科学基金重大研究计划, 在研, 参与
· Yuanyuan Zhang#, Hongyan Chen#, Hongnan Mo#, Xueda Hu#, Ranran Gao, Yahui Zhao, Baolin Liu, Lijuan Niu, Xiaoying Sun, Xiao Yu, Yong Wang, Qing Chang, Tongyang Gong, Xiuwen Guan, Ting Hu, Tianyi Qian, Binghe Xu*, Fei Ma*, Zemin Zhang*, Zhihua Liu*. Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer. Cancer Cell 39 (12):1578-1593.e8 (2021).
· Yuanyuan Zhang*, Zemin Zhang*. The history and advances in cancer immunotherapy: tumor-infiltrating immune cells characterization and their therapeutic implications. Cellular & Molecular Immunology 17, 807-821 (2020).
· Yuanyuan Zhang, Liangtao Zheng, Lei Zhang, Xueda Hu, Xianwen Ren, Zemin Zhang*. Deep single-cell RNA sequencing data of individual T cells from treatment-naïve colorectal cancer patients. Scientific Data 6, 131 (2019).
· Xinyi Guo#, Yuanyuan Zhang#, Liangtao Zheng#, Chunhong Zheng#, Jintao Song#, Qiming Zhang, Boxi Kang, Zhouzerui Liu, Liang Jin, Rui Xing, Ranran Gao, Lei Zhang, Minghui Dong, Xueda Hu, Xianwen Ren , Dennis Kirchhoff, Helge Gottfried Roider, Tiansheng Yan*, Zemin Zhang *. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Nature Medicine 24, 978-985 (2018).
· Fenglin Liu#, Yuanyuan Zhang#, Lei Zhang, Ziyi Li, Qiao Fang, Ranran Gao, Zemin Zhang*. Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data. Genome Biology 20, 242 (2019)
· Lei Zhang#, Xin Yu#, Liangtao Zheng#, Yuanyuan Zhang#, Yansen Li, Qiao Fang, Ranran Gao, Boxi Kang, Qiming Zhang, Julie Y. Huang, Hiroyasu Konno, Xinyi Guo, Yingjiang Ye, Songyuan Gao, Shan Wang, Xueda Hu, Xianwen Ren, Zhanlong Shen*, Wenjun Ouyang*, Zemin Zhang*. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature 564, 268-272 (2018)
· Chunhong Zheng#, Liangtao Zheng#, Jae-Kwang Yoo#, Huahu Guo#, Yuanyuan Zhang#, Xinyi Guo#, Boxi Kang, Ruozhen Hu, Julie Y. Huang, Qiming Zhang, Zhouzerui Liu, Minghui Dong, Xueda Hu, Wenjun Ouyang*, Jirun Peng*, Zemin Zhang*. Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing. Cell 169, 1342-1356.e16 (2017).
· Fuduan Peng#, Ruiping Wang#, Yuanyuan Zhang#, Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo*, Yunyan Gu*. Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma. Molecular Cancer 1, 98 (2017).
· Baolin Liu, Yuanyuan Zhang, Dongfang Wang, Xueda Hu, Zemin Zhang*. Single-cell meta-analysis reveals temporal dynamics of tumor-reactive T cells following immune-checkpoint blockade. Nature Cancer (2022).
· Fuduan Peng, Yuanyuan Zhang, Ruiping Wang, Wenbin Zhou, Zhangxiang Zhao, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Hongwei Wang, Chenguang Wang, Zheng Guo*, Yunyan Gu*. Identification of differentially expressed miRNAs in individual breast cancer patient and application in personalized medicine. Oncogenesis 5, e194 (2016).
· Xianwen Ren#, Lei Zhang#, Yuanyuan Zhang, Ziyi Li, Nathan Siemers, Zemin Zhang*. Insights Gained from Single-Cell Analysis of Immune Cells in the Tumor Microenvironment. Annual Review of Immunology 39, 583-609 (2021).
· Hui Hong#, Shun Yao#, Yuanyuan Zhang, Yi Ye, Cheng Li, Liang Hu, Yihua Sun, Hsin-Yi Huang*, Hongbin Ji*. In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor. PLoS Genetics 16(11), e1009168 (2020).
· Sofia Battaglia#, Kevin Dong#, Jingyi Wu#, Zeyu Chen, Fadi J. Najm, Yuanyuan Zhang, Molly M. Moore, Vivian Hecht, Noam Shoresh, Bradley E. Bernstein*. Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements. Nature Genetics 54, 1504–1513 (2022).
· Baolin Liu#, Xueda Hu#, Kaichao Feng#, Ranran Gao, Zhiqiang Xue, Sujie Zhang, Yuanyuan Zhang, Emily Corse, Yi Hu, Weidong Han*, Zemin Zhang*. Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Nature Cancer 3, 108–121 (2022).
· Yunyan Gu#*, Pengfei Li#, Fuduan Peng#, Mengmeng Zhang, Yuanyuan Zhang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Hongwei Wang, Chenguang Wang, Zheng Guo*. Autophagy-related prognostic signature for breast cancer. Molecular Carcinogenesis 55, 292-9 (2016).
· Yunyan Gu#*, Mengmeng Zhang#, Fuduan Peng, Lei Fang, Yuanyuan Zhang, Haihai Liang, Wenbin Zhou, Lu Ao, Zheng Guo*. The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2. Oncotarget 6, 2397-406 (2015).
· Yunyan Gu#*, Ruiping Wang#, Yue Han, Wenbin Zhou, Zhangxiang Zhao, Tingting Chen, Yuanyuan Zhang, Fuduan Peng, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Da Yang, Zheng Guo*. A landscape of synthetic viable interactions in cancer. Briefings in Bioinformatics 19, 644-655 (2017).
文件上传中...
