创新工程-医学健康领军科技人才养募专项项目，2024-2029，500万，主持

创新工程-医学健康领军科技人才养募专项项目，2024-2029，500万，主持

代表性论文：

1. Chen, Y.; Craven, GB; Kamber RA; Cuesta, A.; Zhersh, S.; Moroz YS;Bassik MC; Taunton, J. Direct mapping of ligandable tyrosines and lysines incells with chiral sulfonyl fluoride probes. Nat. Chem. 2023.15(11),1616-1625. 

https://www.nature.com/articles/s41557-023-01281-3

2.  Chen,Y.; Liu, Y.; Lan, T.;Qin, W.; Zhu, Y.; Qin, K.; Gao, J.; Wang, H.; Hou, X.; Chen, N.; FriedmannAngeli, J. P.; Conrad, M.; Wang,C., Quantitative Profiling of Protein Carbonylations in Ferroptosis by  an Aniline-Derived Probe. J. Am. Chem. Soc. 2018,140(13), 4712-4720. (This  paper was selected as ACS Editor’s Choice and JACS Spotlights) 

https://pubmed.ncbi.nlm.nih.gov/29569437/

3. Li,X.#; Xiong, X.#; Zhang, M.#; Wang, K.#; Chen,Y.#; Zhou, J.; Mao, Y.; Lv, J.; Yi, D.; Chen, X. W.;Wang, C. ; Qian, S. B.; Yi, C., Base-Resolution  Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded  Transcripts. Mol. Cell  2017, 68 (5), 993–1005. (# Equal Contribution) 

https://pubmed.ncbi.nlm.nih.gov/29107537/

4. Chen, Y.; Cong, Y.; Quan, B.; Lan, T.; Chu, X.; Ye, Z.;Hou, X.; Wang, C.,Chemoproteomic profiling of targets of lipid-derived electrophiles by  bioorthogonal aminooxy probe. Redox Biol. 2017, 12, 712-718. 

https://pubmed.ncbi.nlm.nih.gov/28411555/

5. Chen, Y. #; Quan, B. #; Li, Y. #; Liu Y.; Qin, W.; Wang, C., Quantitative profiling of  PTM stiochiometry by resolvable mass tags. RSC Chem. Biol. 2022, 3(11), 1320-1324. (# Equal Contribution)

https://pubmed.ncbi.nlm.nih.gov/36349223/

6.  Chen, Y.; Qin, W.; Li, Z.; Guo, Z.; Liu, Y.; Lan, T.; Wang, C., Site-specific  chemoproteomic profiling of targets of glyoxal. Future Med. Chem. 2019, 11 (23), 2979-2987. 

https://pubmed.ncbi.nlm.nih.gov/31663776/

7. Chen, Y.; Liu, Y.; Hou, X.; Ye, Z.; Wang, C.,Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein.Chem. Res. Toxicol. 2019, 32 (3),467-473. 

https://pubmed.ncbi.nlm.nih.gov/30604966/

8. Chen, Y. #; Qin, W. #; Wang, C., Functional proteomics driven by chemical and computational approaches. Chin. J. Chem. 2022, 40, 628-634. (# Equal Contribution) 

https://onlinelibrary.wiley.com/doi/abs/10.1002/cjoc.202100785

9. Chen, Y.; Wang, C., Profiling of Protein Carbonylations in Ferroptosis by  Chemical Proteomics. Methods Mol.Biol. 2022, 2543, 141-153.

https://pubmed.ncbi.nlm.nih.gov/36087265/

10.Chen,Y.; Qin, W.; Wang, C., Chemoproteomic profiling of  protein modifications by lipid-derived electrophiles. Curr. Opin. Chem. Biol. 2016, 30, 37-45. 

https://pubmed.ncbi.nlm.nih.gov/26625013/

11.Chen, C. #; Chen, Y. #; Lu, J. #; Chen,Z.; Wang, C.; Pi, R., Acrolein-conjugated proteomics in brains of adult C57BL/6  mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice. Toxicol. Lett. 2021, 344, 11–17. (# Equal Contribution) 

https://pubmed.ncbi.nlm.nih.gov/33675918/

12.Dubiella,C.; Pinch, B. J.; Koikawa, K.; Zaidman, D.; Poon, E.; Manz, T. D.; Nabet, B.;He, S.; Resnick, E.; Rogel, A.; Langer, E. M.; Daniel, C. J.; Seo, H. S.; Chen,Y.; Adelmant, G.; Sharifzadeh, S.; Ficarro, S. B.; Jamin, Y.; Martins daCosta, B.; Zimmerman, M. W.; Lian, X.; Kibe, S.; Kozono, S.; Doctor, Z. M.;Browne, C. M.; Yang, A.; Stoler-Barak, L.; Shah, R. B.; Vangos, N. E.; Geffken,E. A.; Oren, R.; Koide, E.; Sidi, S.; Shulman, Z.; Wang, C.; Marto, J. A.;Dhe-Paganon, S.; Look, T.; Zhou, X. Z.; Lu, K. P.; Sears, R. C.; Chesler, L.;Gray, N. S.; London, N., Sulfopin is a covalent inhibitor of Pin1 that blocks  Myc-driven tumors in vivo. Nat. Chem.Biol. 2021, 17 (9), 954-963. 

https://pubmed.ncbi.nlm.nih.gov/33972797/

13.Qin, W.; Zhang, Y.; Tang, H.; Liu, D.; Chen, Y.; Liu, Y.; Wang,C., Chemoproteomic profiling of itaconation by bioorthogonal probes in  inflammatory macrophages. J. Am. Chem. Soc. 2020, 142 (25), 10894-10898. 

https://pubmed.ncbi.nlm.nih.gov/32496768/

14.Qin, W.; Qin, K.;Zhang, Y.; Jia, W.; Chen, Y.; Cheng, B.; Peng, L.; Chen, N.; Liu, Y.;Zhou, W.; Wang, YL.; Chen, X.; Wang, C., S-glycosylation-based cysteine  profiling reveals regulation of glycolysis by itaconate. Nat. Chem. Biol. 2019, 15 (10), 983-991.

https://pubmed.ncbi.nlm.nih.gov/31332308/

15.Qin, W.; Lv,P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.; Chen, X.,Quantitative Time-resolved Chemoproteomics Reveals that Stable O-GlcNAc Regulates  Box C/D snoRNP Biogenesis. Proc. Natl. Acad. Sci. USA 2017, 114 (33), E6749-e6758. 

https://pubmed.ncbi.nlm.nih.gov/28760965/

专利：

1.  王初，陈影，羰基化蛋白质的鉴定，ZL 2018 1 0200763.9（授权）。