近年来，主持承担“重大新药创制”国家科技重大专项子课题、国家自然科学基金面上/青年基金、中国药学会-以岭生物医药创新基金和中央公益性科研院所基本科研业务费等项目，并作为主要研究人员参与了国家“十二五”和“十三五”重大新药创制专项课题、中国医学科学院创新工程重大协同创新项目及与企业合作的开发项目等多项课题。

代表性论文：

1. Shengnan Li#, Hui Liao#, Lijun Luo#, Bingxu Meng,Fengxin Zheng, Li Sheng, Hongyi Zhao, Yi Huan, Lei Lei, Jiayu Zhai, Kunlu Zhao, JinhongTian, TingWu, Gang Li,* Jianxin Pang,*Haihong Huang*. Proline-derivedquinoline formamide compounds as human urate transporter 1 inhibitors with potent uric acid-lowering activities. Eur. J. Med.Chem., 2024, 269, 116327.

2. 唐霞霞，李文艺，李鹏，王彬，陆宇，黄海洪*，李刚*. 2-芳基取代苯并硫代吡喃酮类化合物的设计、合成及其抗结核活性研究[J]. 药学学报, 2024, 59 (4): 987−996.

3. PengLi#,Kaijing Guo#,Lei Fu, Bin Wang, Baoxi Zhang, Ningbo Gong, Yang Lu, Chen Ma, Haihong Huang*,Yu Lu*, Gang Li*. Solubility-driven optimizationof benzothiopyranone salts leading to a preclinicalcandidate with improved pharmacokinetic properties and activity against Mycobacteriumtuberculosis. Eur. J. Med. Chem., 2023, 246, 114993.

4. Peng Li, Bin Wang, Xi Chen, Ziyun Lin, Gang Li*, YuLu*, Haihong Huang*. Design, synthesis and biological evaluation ofalkynyl-containing maleimide derivatives for the treatment of drug-resistanttuberculosis. Bioorg. Chem., 2023, 131, 106250.

5. Rongfei Qin#,Pengxu Wang#, Bin Wang, Lei Fu, Sarah M. Batt, Gurdyal S. Besra,Chengwei Wu, Yanan Wang, Haihong Huang*, Yu Lu*, Gang Li*, Identification ofthiophene-benzenesulfonamide derivatives for the treatment ofmultidrug-resistant tuberculosis, Eur. J. Med. Chem., 2022, 231, 114145.

6. Pengxu Wang∥, Sarah M. Batt∥, Bin Wang, Lei Fu, Rongfei Qin, Yu Lu, Gang Li*, Gurdyal S. Besra*, Haihong Huang*. Discovery ofnovel thiophene-arylamide derivatives as DprE1 inhibitors with potentantimycobacterial activities. J. Med. Chem., 2021, 64, 6241–6261.(Supplementary Cover)

7. Peng Li, Bin Wang, Lei Fu, Kaijing Guo, Chen Ma,Baolian Wang, Ziyun Lin, Gang Li*, Haihong Huang*, Yu Lu*. Identification of novel benzothiopyranones with ester andamide motifs derived from active metabolite as promising leads against Mycobacteriumtuberculosis. Eur. J. Med. Chem., 2021, 222, 113603.

8. Hui Chen, Bin Wang, Peng Li, Hong Yan, Gang Li*,Haihong Huang*, Yu Lu*. The optimization andcharacterization of functionalized sulfonamides derived from sulfaphenazoleagainst Mycobacterium tuberculosis with reduced CYP 2C9 inhibition. Bioorg.Med. Chem. Lett., 2021, 40, 127924.

9. Peng Li, Shengnan Li, Gang Li*, Haihong Huang*.Synthesis of 2-aryl-4H-thiochromen-4-one derivatives via across-coupling reaction. ACS Omega, 2021, 6, 14655−14663.

10. Gang Li#,Bingxu Meng#, Baokun Yuan, Yi Huan, Tian Zhou, Qian Jiang, Lei Lei,Li Sheng, Weiping Wang, Ningbo Gong, Yang Lu, Chen Ma, Yan Li, Zhufang Shen*,Haihong Huang*. The optimization of xanthine derivatives leading to HBK001hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur. J. Med. Chem., 2020, 188, 112017.

11. Hui Chen, Peng Li, Rongfei Qin, Hong Yan, Gang Li*,Haihong Huang*. DMAP catalyzed one-pot synthesis of quinazoline-2,4-diones from2-aminobenzamides and di-tert-butyl dicarbonate. ACS Omega, 2020,5, 9614−9623.

12. Peng Li, Yongqi Wu, Tingting Zhang, Chen Ma, ZiyunLin, Gang Li*, Haihong Huang*. An efficient and concise access to 2-amino-4H-benzothiopyran-4-onederivatives. Beilstein J. Org. Chem.,2019, 15, 703–709.

13. Peng Li, Bin Wang, Xinwei Zhang, Sarah M. Batt,Gurdyal S. Besra, Tingting Zhang, Chen Ma, Dongfeng Zhang, Ziyun Lin, Gang Li*,Haihong Huang*, Yu Lu*. Identification of novel benzothiopyranone compoundsagainst Mycobacterium tuberculosis through scaffold morphing frombenzothiazinones. Eur.J. Med. Chem., 2018, 160, 157-170.

14. Pengxu Wang, Yanan Wang, Ziyun Lin, Gang Li*, HaiHongHuang*. Facile and efficient synthesis of quinazoline-2,4(1H,3H)-dionesthrough sequential hydrogenation condensation. Synth. Commun., 2018,48(10), 1183-1189.

15. Gang Li#, Yi Huan#, BaokunYuan, Jin Wang, Qian Jiang, Ziyun Lin, Zhufang Shen*, Haihong Huang*. Discoveryof novel xanthine compounds targeting DPP-IV and GPR119 as anti-diabeticagents. Eur. J. Med. Chem., 2016,124, 103-116.

16. Gang Li1, Bao-Kun Yuan1,Wu Tang, Hong-Yi Zhao, Zi-Yun Lin, Hai-Hong Huang*, An improved and efficientsynthesis of the antibacterial agent torezolid, Chem. Pharm. Bull., 2015, 63, 143-146.

17. Gang Li, Li Li, Haihong Huang* and Dali Yin*. Ti (IV)-catalyzedcascade synthesis of tetrahydrofuro[3,2-d]oxazole from arene-1,4-diones. Org. Biomol. Chem., 2015, 13, 4418-4421.

18. Gang Li, Jin Wang, Baokun Yuan, Dongfeng Zhang, ZiyunLin, Peng Li, Haihong Huang*. Iron-catalyzed one-pot synthesis ofbenzimidazoles from 2-nitroanilines and benzylic alcohols. Tetrahedron Lett.,2013, 54, 6934-6936.

专利：

申请发明专利22项，其中PCT专利2项，获授权专利12项，转化专利7项。