“国家重点研发计划—政府间国际科技创新合作重点专项”

—PGM3 抑制剂作为胰腺导管腺癌创新疗法的临床前评估（药代负责人）

代表性论文（第一作者/通讯作者）

1.  Manman Zhao, Jiaqi Mi, Baolian Wang, Qiong Xiao, Yulin Tian, JinpingHu*, Yan Li*. Insights into the metabolic characteristics ofaminopropanediol analogues of SYLs as S1P1 modulators: from structure tometabolism. European Journal of Pharmaceutical Sciences 158 (2021) 105608

2.  Jinping Hu ,Jie Zhou, Yanhong Sun, HuixinTan, Fenghe Wang, Shuainan Liu, Bailing Xu, YanLi,Zhufang Shen*.Quantitative determination of Cpd118, A novelFBPase inhibitor, in dog plasma by HPLC–MS/MS. Bioanalysis(2021) 13(11),865–873.

3.   Minwan Hu1, Yang Li1, Feng You, Jie Bai, XiaoqingFan, Shengyu Zhao, Yanhong Sun, Baolian Wang*, Jinping Hu*, Yan Li. Comparisonand identification of metabolic profiling of bicyclol in rats, dogs and humansin vitro and in vivo. European Journal of Pharmaceutical Sciences154 (2020):105518

4.   Qiong Xiao1, Minwan Hu1, Si Chen, Zeyu Shi, JinpingHu*, Ping Xie*, Dali Yin*.Design and synthesis of analogues of thesphingosine-1-phosphate receptor 1 agonist IMMH001 with improvedphosphorylation rate in human blood. Bioorganic & Medicinal Chemistry 28(2020) 115722

5.   Xiaoqing Fan, Jie Bai, Minwan Hu, Yanxia Xu , Shengyu Zhao, Yanhong Sun,Baolian Wang, Jinping Hu*, Yan Li. Drug interaction study of flavonoidstoward OATP1B1 and their 3D structure activity relationship analysis forpredicting hepatoprotective effects. Toxicology, 2020, 437:152445  

6.   Jie Bai, Li Li, Shengyu Zhao, Xiaoqing Fan, Jie Zhang, Minwan Hu, YonghuiChen, Yanhong Sun, Baolian Wang, Jing Jin, Xiaojian Wang, Dan Zhang, JinpingHu*, Yan Li. Heterotropic activation of flavonoids on cytochrome P4503A4: A case example of alleviating dronedarone-induced cytotoxicity. Toxicology Letters, 2020, 319: 187-196.

7.   Xiao Q, Hu M, Chen S,  Tang Y, Shi Z, Jin J, Hu J*, Xie P*,Yin D*. Design and synthesis ofselective sphingosine-1-phosphate receptor 1 agonists with increasedphosphorylation rates. Acta Pharmaceutica Sinica B, 2020, 10: 1134-1142.

8.   Shengyu Zhao, Rubing Wang, Jie Bai., Xiaoqing Fan, Minwan Hu, BaolianWang, Jinping Hu*, Yan Li. Simultaneous determination of a promisinganti-brain tumor agent CAT3 and its two major metabolites in mouse plasma andbrain by a LC-MS/MS method. J Pharm Biomed Anal, 2020, 181: 113106.

9.   Xiao Q, Hu M, Chen S, Jin J, Li L, Hu J*, Xie P*,Yin D*.S1P1-selective agonist prodrug IMMH002 is phosphorylated in rats to form anS-configured enantiomer: Synthesis, verification, and biological activity ofthe in vivo active metabolite. Bioorganic & Medicinal Chemistry Letters,2020, 30: 127141.

10.   Jie Bai, Shengyu Zhao, Xiaoqing Fan, Yonghui Chen, Xiaowen Zou, MinwanHu, Baolian Wang, Jing Jin, Xiaojian Wang, Jinping Hu*, Dan Zhang*, YanLi. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo:Food/herb-drug interactions and structure-activity relationships. Toxicologyand Applied Pharmacology, 2019, 369: 49-59

11.   Xiaoqing Fan, Jie Bai, Shengyu Zhao, Minwan Hu,Yanhong Sun, BaolianWang,Ming Ji, Jing Jin, Xiaojian Wang, Jinping Hu*,Yan Li. Evaluation ofinhibitory effects of flavonoids on breast cancer resistance protein (BCRP):From library screening to biological evaluation to structure-activityrelationship[J]. Toxicology in Vitro, 2019, 61: 104642.

12.  Jiaqi Mi, Manman Zhao, Shu Yang, Yufei Jia, Yan Wang, Baolian Wang, JingJin, Xiaojian Wang, Qiong Xiao, Jinping Hu*, Yan Li*. Identification ofcytochrome P450 isoforms involved in the metabolism of Syl930, a selectiveS1PR1 agonist acting as a potential therapeutic agent for autoimmuneencephalitis. Drug Metabolism and Pharmacokinetics. 2017; 32(1):53-60

13.  Jiaqi Mi, Manman Zhao, Shu Yang, Shuang Yang, Jing Jin, Xiaojian Wang,Qiong Xiao, Jinping Hu*, Yan Li* Pharmacokinetics of H002, a novelS1PR1 modulator, and its metabolites in rat blood using liquidchromatography–tandem mass spectrometry.  Acta Pharmaceutica Sinica B. 2016;6(6):576–583

14.   Manman Zhao, Jiaqi Mi, Dan Li, Xin Liu, Shuang Yang, Baolian Wang, LiSheng, Xiaojian Wang, Jing Jin, Jinping Hu*, Yan Li* Quantitativedetermination of2-amino-2-(2-(4′-(2-propyloxazol-4-yl)-[1,1-biphenyl]-4-yl)ethyl)propane-1,3-dioland its active phosphorylated metabolite in ratblood by LC–MS/MS andapplication to PK/PD analysis. Anal Bioanal Chem (2015)407:7511–7516

15.   Hu J, Sheng L, Li L, Zhou X, XieF, D'Agostino J, Li Y, Ding X. Essential Role of the Cytochrome P450 EnzymeCYP2A5 in Olfactory Mucosal Toxicity of Naphthalene. DrugMetab Dispos. 2014 Jan; 42(1):23-7.

16.   Hu J, You F, Yang S, Li Y.Quantitative determination of Lx2-32 C, a novel taxane derivative, in ratplasma by liquid chromatography–tandem mass spectrometry. Journal ofPharmaceutical and Biomedical Analysis. 88:483-488,2014

17.  Jin J1, Hu J1, Zhou W, Wang X, Xiao Q, XueN, Yin D*, Chen X*. Development of a selective S1P1 receptor agonist, Syl930,as a potential therapeutic agent for autoimmune encephalitis. BiochemPharmacol. 2014Jul 1; 90(1):50-61.