近五年承担了1项国家重大新药创制品种项目，3项国家自然科学基金项目，参与了多项国家传染病重大专项和国家重大新药创制平台建设。

近三年研究成果

1.Tang K, Zhang X, Guo Y*.Identification of the dietary supplement capsaicin as an inhibitor of Lassavirus entry. ActaPharm Sin B, 2020,10(5):789-798.

2.Zhang X, Tang K, Guo Y*.The antifungal isavuconazoleinhibits the entry of lassavirus by targeting the stable signal peptide-GP2 subunit interface of lassavirus glycoprotein. AntiviralRes. 2020,174:104701.

3.Xu C, Xin Y,Chen M, Ba M, Guo Q,Zhu C, Guo Y*,Shi J*  Discovery, synthesis, andoptimization of an N-alkoxy indolylacetamideagainst HIV-1 carrying NNRTI-resistant mutations from the Isatis indigoticaroot. EurJ Med Chem. 2020 Mar 1;189:112071.

4.Zhang X, Yan F, Tang K, Chen Q, Guo J, Zhu W, He S, Banadyga L, Qiu X*, GuoY*  Identification of a clinical compoundlosmapimod thatblocks Lassa virus entry. Antiviral Res. 2019 167:68-77.

5.Tang K, He S, Zhang X, Guo J,Chen Q, Yan F, Banadyga L,Zhu W, Qiu X*, Guo Y*. Tangeretin, anextract from Citrus peels, blocks cellular entry of arenaviruses thatcause viral hemorrhagic fever. AntiviralRes, 2018, 160:87-93.

6.Chen Q, Tang K, Zhang X, Chen P, Guo Y*. Establishment of pseudovirusinfection mouse models for in vivo pharmacodynamics evaluation of filovirusentry inhibitors. ActaPharm Sin B, 2018, 8(2):200-208.

7.Liu X, Chen P, Li X, Ba M, Jiao X*, Guo Y*, Xie P. Design, synthesis and biological evaluation of substituted (+)-SG-1derivatives as novel anti-HIV agents. Bioorganic& Medicinal Chemistry Letters, 2018, 28: 1699–1703.

8.Guo JM, BaMY, Yang Y, Yao CS, Yu M, Shi JG, GuoY*. Discovery of a semi-synthesized cyclolignan as a potent HIV-1 non-nucleoside reversetranscriptase inhibitor JAsian Nat Prod Res. 2019Jan;21(1):76-85.

9. Chen Q, Tang K, Guo Y*.Discovery of Sclareol and Sclareolide as FilovirusEntry Inhibitors. J Asian Nat Prod Res.2020,22(5):464-473.

10.张晓雨，唐克，郭家梅，陈勍，郭颖*  沙粒病毒进入抑制剂体外药效学评价模型的建立，药学学报，2018，53(5):735-742.

11.唐克，张晓雨，陈勍，郭颖*  沙粒病毒进入宿主细胞阻断剂3,4,6,7,4’-五甲氧基黄酮的发现及机制研究，药学学报，2019，54(5):838-845.

12.陈勍，陈盼盼，莘一婧，唐克，张晓雨，郭颖*  新属种丝状病毒勐腊病毒进入模型的建立及阻断剂研究，药学学报，2019，54(9):1612-1619.

13.唐克，张晓雨，王丽丽，陈勍，郭颖*  尼帕病毒进入抑制剂体外药效学评价模型的建立，中国新药杂志。2020，29(8):914-921.

14.获授权专利8项，申请专利3项。