“复杂天然活性化合物的合成与新药先导物发现研究”， 中国医学科学院医学与健康科技创新工程协同创新团队，首席科学家，（2016-I2M-3-009 ，2016.09-2020.12）， 1900万元

1.      JunminDong, Xuan Pan, Ying Yang, Guangyan Zhang, Zhiyan Xiao, Zhanzhu Liu *, Design,synthesis and biological evaluation of exiguamine A analogues as IDO1inhibitors, EuropeanJournal of Medicinal Chemistry, 2021, 223, 113631

2.       Xuan Pan, Rui Yu, Zhanzhu Liu*, An improved total synthesis ofgriseofamine A, Tetrahedron Letters, 2021, 67, 152894

3.      Xiangran Lu, Xuan Pan, Baohe Guan and Zhanzhu Liu*, Design, synthesis and cytotoxicity of novel hexacyclicsaframycinecteinascidin analogs, Organic& Biomolecular Chemistry, 2020, 18,237-249.

4.      HuanY, Pan X, Peng J, Jia C, Sun S, Bai G, Wang X, ZhouT, Li R, Liu S, Li C, Liu Q, Liu Z*, Shen Z*. A novel specific PPARγ modulator YR4-42ameliorates hyperglycemia and dyslipidemia and hepatic steatosis indiet-induced obese mice. Diabetes Obesity & Metabolism, 2019, 00, 2553–2563.

5.      Xuan Pan, Zhanzhu Liu*, Total synthesis and antibacterial activity evaluation of griseofamine A and 16-epi-griseofamine A, Organic Letters, 2019,21, 2393-2396

6.      Xuan Pan, Yantao Ma, ZhanzhuLiu*, A Concise Synthesis of (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines by Aryne induced [2,3] Stevens Rearrangement of 1,2,3,4-Tetrahydroisoquinolines,Organic& Biomolecular Chemistry, 2018,16, 7393-7399

7.      ZhaozhuSun, Tian Zhou, Xuan Pan, Ying Yang, Yi Huan, Zhiyan Xiao, Zhufang Shen*, Zhanzhu Liu*, Design, synthesis and biological evaluation ofa series of novel GPR40 agonists containing nitrogen heterocyclic rings, Bioorganic& Medicinal Chemistry Letters, 2018,28, 3050-3056

8.      Enming Du, Xuan Pan, Baohe Guanand Zhanzhu Liu*, Asymmetric synthesis of highly functionalized tyrosine derivativesfor the construction of bistetrahydroisoquinoline alkaloids, TetrahedronLetters, 2018, 59, 3029-3032

9.      Xuan Pan, Zhanzhu Liu*, Synthesisof 3-Aryl-3-benzazepines via Aryne [1,2] Stevens Rearrangement of1,2,3,4-Tetrahydroisoquinolines, Organic Chemistry Frontiers, 2018, 5, 1798-1810

10.      Xuan Pan, Lulu Tao, Ming Ji,Xiaoguang Chen, Zhanzhu Liu*, Synthesis and cytotoxicity of novelimidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A, Bioorganic & Medicinal Chemistry Letters,2018, 28, 866-868

11.      Xiangran Lu, Xuan Pan, YingYang, Ming Ji, Xiaoguang Chen, Zhiyan Xiao, Zhanzhu Liu*, Synthesis andcytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carboline moieties, European Journal of Medicinal Chemistry, 2017, 135, 260-269

12.      Lulu Tao, Xuan Pan**, Ming Ji, Xiaoguang Chen, ZhanzhuLiu*, Efficient synthesis and cytotoxicity of novel microtubule-stabilizing agent ceratamine A analogues, Tetrahedron, 2017, 73, 2159-2171

 13.  Liang Li, Xuan Pan, Baohe Guan and Zhanzhu Liu*, Stereoselective total synthesis of (±)-parthenolide and(±)-7-epi-parthenolide, Tetrahedron,2016, 72, 4346-4354

 14.   Xuan Pan, Yi Huan, Zhufang Shen, Zhanzhu Liu*, Synthesis and biological evaluation of novel tetrahydroisoquinoline-C-aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes, European Journal of Medicinal Chemistry, 2016, 114, 89-100

 15.   Enming Du, Wenfang Dong, Baohe Guan,Xuan Pan, Zheng Yan, Li Li, Nan Wang and Zhanzhu Liu, Asymmetric total synthesis of three stereoisomers of (–)-Renieramycin G and their cytotoxic activities, Tetrahedron, 2015, 71, 4296-4303

 16.   Xuan Pan, Zhanzhu Liu*, The preparation of novel chiral auxiliaries SAMIQ/RAMIQ and their application in the asymmetric Michael addition, Tetrahedron, 2014, 70, 4602-4610

 17.   Qiguo Feng, Lulu Tao, Zhanzhu Liu*, Total Synthesis of Microtubule-Stabilizing Agent Ceratamine A, The Journal of Organic Chemistry, 2013, 78, 12814-12818

 18.   Ju Guo, Wenfang Dong, Wei Liu, Zheng Yan, Nan Wang, Zhanzhu Liu*, Synthesis and cytotoxicity of 3-aryl acrylic amide derivatives of the simplified saframycin-ecteinascidin skeleton prepared from L-dopa, European Journal of Medicinal Chemistry, 2013, 62, 670-676.

 19.   Wei Liu, Xiangwei Liao, Wenfang Dong, Zheng Yan, Nan Wang, Zhanzhu Liu*,Total synthesis and cytotoxicity of (-)-jorumycin and its analogues, Tetrahedron, 2012, 68, 2759-2764.

 20.   Wenfang Dong, Wei Liu, Zheng Yan, Xiangwei Liao, Baohe Guan, Nan Wang,Zhanzhu Liu*, Asymmetric synthesis and cytotoxicity of (–)-saframycin Aanalogues, European Journal ofMedicinal Chemistry, 2012, 49,239-244

 21.   Wenfang Dong, Wei Liu, Xiangwei Liao, Baohe Guan, Shizhi Chen, Zhanzhu Liu*, Asymmetric total synthesis of (–)-saframycin A from L-tyrosine, The Journal of Organic Chemistry, 2011, 76,5363–5368

 22.   Wei Liu, Wenfang Dong, Xiangwei Liao, Zheng Yan, Baohe Guan, Nan Wang,Zhanzhu Liu* , Synthesis and cytotoxicity of (-)-renieramycin G analogues, Bioorganic& Medicinal Chemistry Letters, 2011, 21, 1419-1421

 23.   Wei Liu, Wen Fang Dong, Xiang Wei Liao, Bao He Guan, Zhan Zhu Liu*, Synthesisof an Isomer of the Renieramycin Skeleton from L-Tyrosine, Journal of Heterocyclic Chemistry, 2011, 48,414-418

 24.   Geng Xu, Zheng Yan, Nan Wang, Zhanzhu Liu*, Synthesis and cytotoxicity ofcis-dichloroplatinum (II) complexes of (1S, 3S) - 1, 2, 3, 4-tetrahydroisoquinolines, European Journal of Medicinal Chemistry, 2011, 46, 356-363

 25.   Ke Wang, Zhan-Zhu Liu*, Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study, European Journal of Medicinal Chemistry, 2010, 45, 4175-4179

 26.   Ke Wang, Xiang-Yan Li, Xiao-Guang Chen, Zhan-Zhu Liu*, Synthesis and antitumoractivity of bisindolylmaleimide and amino acid ester conjugates, Journal of Asian Natural Products Research,2010, 12, 36-42

 27.   Xiang Wei Liao, Wen Fang Dong, Wei Liu, Bao He Guan, Zhan Zhu Liu*, Total Synthesis of (-)-MY 336a from L-Tyrosine, Journal ofHeterocyclic Chemistry, 2010, 47,50-53

 28.   Ke Wang, Zhanzhu Liu*, Synthesis of Arcyriarubin A and Arcyriaflavin A via Cross-coupling of Indolylboronic Acid with Dibromomaleimides, Synthetic Communications, 2010, 40, 144 - 150

 29.   Xiang Wei Liao, Wei Liu, Wen Fang Dong, Bao He Guan, Shi Zhi Chen, and Zhan Zhu Liu *, Total Synthesis of (-)-Renieramycin G from L-Tyrosine, Tetrahedron, 2009, 65, 5709-5715

2019年度北京协和医学院优秀教师