主持或参加多项科研项目(课题):

1. 北京市人力资源和社会保障局，2017A03, 2018年北京市百千万人才工程。

2. 科技部重点研发计划项目，2017YFA0103500子课题。

3. 北京市科技计划，Z151100003915080。

4. 国家重点基础研究发展计划(973计划)，2014CB850000。

5. 中组部第十批 “千人计划” 青年项目。

发表文章 

1. Zhiwei Lu, Yuhua Xie, Huanwei Huang, Kaiju Jiang, Bin Zhou, Fengchao Wang, Ting Chen. Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells. eLife,2020.

2. Fei Li, Zhiwei Lu, Wenbo Wu, Nannan Qian, Fengchao Wang & Ting Chen.Optogenetic gene editing in regional skin.Cell Research, 2019.

3. Zhou Yu, Kaiju Jiang, Zijian Xu, Huanwei Huang, Nannan Qian, Zhiwei Lu, Daoming Chen, Ruonan Di, Tianyi Yuan, Zhenhai Du, Wei Xie, Xiaoling Lu, Huawei Li, Renjie Chai, Yong Yang, Bing Zhu, Tetsuo Kunieda,Fengchao Wang, Ting Chen. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration. Cell Stem Cell,2018. 

(featured article with cover, highlight comment article in the same issue).

4. Sabrina Mai-Yi Fan, Yi-Ting Chang, Chih-Lung Chen, Wei-Hung Wang, Ming-Kai Pan, Wen-Pin Chen, Wen-Yen Huang, Zijian Xu, Hai-En Huang, Ting Chen, Maksim V. Plikus, Shih-Kuo Chen, andSung-Jan Lin. External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway. PNAS,2018.

5. Minh Binh Nguyen, Idan Cohen, Vinod Kumar, Zijian Xu, Carmit Bar, Katherine L. Dauber-Decker, Pai-Chi Tsai, Pauline Marangoni, Ophir D. Klein, Ya-Chieh Hsu, Ting Chen, Marja L. Mikkola & Elena Ezhkova. FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun,2018.

6. Wenbo Wu, Zhiwei Lu, Fei Li, Wenjie Wang, Nannan Qian, Jinzhi Duan, Yu Zhang, Fengchao Wang,and Ting Chen. Efficient in vivo gene editing using ribonucleoproteins in skin stem cells of recessive dystrophic epidermolysis bullosa mouse model. PNAS,2017.

7. Lingjuan He, Yan Li, Yi Li, Wenjuan Pu, Xiuzhen Huang, Xueying Tian, Yue Wang, Hui Zhang, Qiaozhen Liu, Libo Zhang, Huan Zhao, Juan Tang, Hongbin Ji, Dongqing Cai, Zhibo Han, Zhongchao Han, Yu Nie, Shengshou Hu, Qing-Dong Wang, Ruilin Sun, Jian Fei, Fengchao Wang, Ting Chen, Yan Yan, Hefeng Huang, William T Pu & Bin Zhou. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med,2017.

8. Hui Zhang, Xiuzhen Huang, Kuo Liu, Juan Tang, Lingjuan He, Wenjuan Pu, Qiaozhen Liu, Yan Li, Xueying Tian, Yue Wang, Libo Zhang, Ying Yu, Hongyan Wang, Ronggui Hu, Fengchao Wang, Ting Chen, Qingdong Wang, Zengyong Qiao, Li Zhang, Kathy O. Lui, Bin Zhou. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Research,2017.

9. Lingjuan He, Xiuzhen Huang, Onur Kanisicak, Yi Li, Yue Wang, Yan Li, Wenjuan Pu, Qiaozhen Liu, Hui Zhang, Xueying Tian, Huan Zhao, Xiuxiu Liu, Shaohua Zhang, Yu Nie, Shengshou Hu, Xiang Miao, Qing-Dong Wang, Fengchao Wang, Ting Chen, Qingbo Xu, Kathy O. Lui, Jeffery D. Molkentin, and Bin Zhou. Preexisting endothelial cells mediate cardiac neovascularization after injury. JCI,2017.

10. Zhimiao Lin, Shuo Li, Cheng Feng, Shang Yang, Huijun Wang, Danhui Ma, Jing Zhang, Mengting Gou, Dingfang Bu, Tengjiang Zhang, Xiaohui Kong, Xintong Wang, Ofer Sarig, Yali Ren, Lanlan Dai, Hankui Liu, Jianguo Zhang, Fei Li, Yongyan Hu, Gilly Padalon-Brauch, Dan Vodo, Feng Zhou, Ting Chen, Haiteng Deng, Eli Sprecher, Yong Yang & Xu Tan. Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Nat Genet,2016.

11. Zijian Xu, Wenjie Wang, Kaiju Jiang, Zhou Yu, Huagnwei Huang, Fengchao Wang, Bin Zhou, Ting Chen. Embryonic attenuated Wnt/β-catenin signaling defines niche location and long-term stem cell fate in hair follicle. eLife,2015.

12. Zhili Deng, Xiaohua Lei, Xudong Zhang, Huishan Zhang, Shuang Liu, Qi Chen, Huimin Hu, Xinyue Wang, Lina Ning, Yujing Cao, Tongbiao Zhao, Jiaxi Zhou, Ting Chen, Enkui Duan. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration. J MOL CELL BIOL,2015.

13. Ting Chen,Evan Heller, Slobodan Beronja, Naoki Oshimori, Nicole Stokes & Elaine Fuchs. An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature,2012.

(Selected by Faculty of 1000 Biology)

14. Valentina Greco, Ting Chen, Michael Rendl, Markus Schober, H.Amalia Pasolli, Nicole Stokes, June dela Cruz-Racelis, Elaine Fuchs A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell,2009.

* Authors contributed equally

(Highlight Review in Cell Stem Cell, Selected by Faculty of 1000 Biology)

15. Ting Chen, Tara L. Muratore, Christine E. Schaner-Tooley, Jeffrey Shabanowitz, Donald F. Hunt& Ian G. Macara. N-terminal α-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Nat Cell Biol,2007.

(Highlight Review in Nature Cell Biology, Selected by Faculty of 1000 Biology)

16. Ting Chen, Amy M. Brownawell, and Ian G. Macara*. Nucleocytoplasmic Shuttling of JAZ, a New Cargo Protein for Exportin-5. Mol Cell Biol,2004.

Invited Review

1. Zhou Yu, Ting Chen. Regional differences. eLife,2017.

2. Elaine Fuchs, Ting Chen. A matter of life and death: self-renewal in stem cells. EMBO Rep,2013.

编纂书籍

Wenbo Wu, Ting Chen. Ribonucleoproteins Mediated Efficient In Vivo Gene Editing in Skin Stem Cells. Methods in Molecular Biology, 2018 .

皮肤是生物体对外界的第一道屏障，这个重要的器官有两大特质：1. 面对终其一生的磨损与消耗，皮肤有强大的再生功能，因此皮肤是为数不多的拥有成体干细胞的器官之一，是研究干细胞生物学及再生医学重要的模型。2.面对外界的损伤与入侵，皮肤里的免疫细胞起到重要的巡逻，报警，与抵御作用，也因此皮肤常见疾病经常跟免疫系统失调息息相关，对皮肤里免疫相关疾病的研究能对疾病治疗带来直接影响。我们实验室针对以上两个主要方向，利用小鼠模型进行了长期的探索与研究。针对干细胞功能的调控，我们主要研究微环境分泌的生长因子，小分子代谢产物，以及机械力感应离子通道开合是如何调控皮肤干细胞分化与存活的。对皮肤常见疾病的机制研究我们实验室建立了几种不同的小鼠疾病模型，模拟人体常见的自身免疫相关皮肤疾病如白癜风，银屑病等，结合体内小鼠遗传学实验/体外细胞与生化实验来研究疾病发生进展的分子机制，为疾病治疗带来新的方向。肤浅这个源自皮肤的形容词恰恰可以用来概括我们目前对皮肤生物学以及疾病的理解，也因此大部分皮肤相关的疾病仍处于易诊难治的状态。但是目前日新月异的强大生物学方法的涌现，结合我们整个领域对基础生物学知识的积累，注定接下来将是一个从量变到质变的阶段，机制研究的突破将为皮肤再生医学以及常见疾病治疗带来根本改变。