薛华丹团队主要研究方向是腹盆部影像诊断及肿瘤分子影像领域。

l  胰腺疾病临床影像学研究方向

    薛华丹团队在胰腺相关研究主要集中在新型CT成像技术及多参数MRI对胰岛素瘤进行精确诊断、术前定位优化胰腺相关疾病及胰胆管成像磁共振扫描序列，胰腺癌鉴别诊断及预后判断等方面。候选人带领团队组成员发表胰腺相关SCI文章19篇，累计影响因子：55.003（2019IF）。其中于2020年毕业博士生何铭以CT影像组学在胰腺癌术后复发评估中的应用研究完成毕业论文，在校期间以第一作者发表SCI文章3篇，中文核心期刊文章4篇，参加北美放射学年会教育展板1篇，欧洲放射学年会口头报告4篇，国际磁共振年会口头报告2篇、壁报1篇，参加国内学术会议包括中华放射学年会、腹部学组年会、ASMRM等口头发言6篇。先后获得2019 ISMRM “Magna Cum Laude Merit”、2019 ACAR“ACAR 2019 TOP 20”奖、2020年ECR “Invest in the Youth”奖。

l  多层螺旋CT新技术研究方向

    薛华丹带领学生团队对灌注CT的使用和优化进行了一系列研究，发表SCI文章6篇，作为团队重要参与者获得了中华医学奖一等奖（排名第5）、江苏省科技进步奖一等奖（排名第5）等重要的省部级及以上科研奖项。其中八年制毕业生朱亮发表4篇，发现灌注CT+常规CT的组合对于胰岛素瘤检出的准确性为90%以上，并分析了胰岛素瘤不同的强化方式。于2017年毕业硕士生李平以胰腺低剂量灌注CT的相关研究完成毕业论文。在校期间共发表中文核心期刊1篇，曾于国际大会Asian Oceanian Congress of Radiology（AOCR）做纸质壁报、国内中华放射学学术大会做口头发言。毕业后1年内将毕业论文相关内容发表于SCI期刊上。转博生李娟在课题组前人研究的基础上，研究使用灌注CT替代常规增强CT在胰岛素瘤诊断可行性，在保证胰岛素瘤诊断的前提下，进一步降低辐射剂量、对比剂用量、缩短检查时间，相关论文发表于Q1区SCI期刊上。

l  全身弥散加权成像方向

    薛华丹团队于2006年在国际上率先开展了用于恶性肿瘤全身评估的磁共振全身弥散加权成像的序列设计。带领硕士研究生张海波（2015年毕业）创新性地利用单层动态匀场（integrated shimming，iShim）技术突破了全身DWI在结构复杂区域成像技术瓶颈，推动了全身弥散加权成像技术在肿瘤全身影像学评价中的应用，相应研究论著以“本期亮点”形式刊登于放射学国际顶尖杂志《Investigative Radiology》，并获主编Val M.Runge高度赞誉，评价其为“杰出的论著”，并“体现了诊断影像学领域最前沿进展”。在此基础上，联合培养血液科张路博士发现肿瘤基线期全身骨髓扩散加权成像参数ADCmean值是其无进展生存期（HR=4.664）和总生存期（HR =14.130）的独立危险因素，相关研究于2020年发表于Q1区SCI杂志《European radiology》。

l  肿瘤分子影像学研究方向

    薛华丹创建了北京协和医院放射科分子影像实验室，开展了大量动物模型水平的磁性纳米颗粒淋巴结磁共振成像，找到了磁性纳米颗粒诊断淋巴结转移假阳性及假阴性的原因。利用纳米铁颗粒进行分子靶标，进而靶向肿瘤成像的体内及体外研究；提出了磁共振兼容的光学成像设备与磁共振仪相融合的多模态成像的设备创新构想。于2020年毕业博士研究生孙婷研究方向为分子影像学，以PD-L1对三阴性乳腺癌小鼠术中成像及术后预防复发和转移的实验研究完成毕业论文，在读期间以第一作者发表SCI文章2篇，以共同作者发表SCI文章6篇，参加世界分子影像大会及2018中国放射学年会各一次，获得世界分子影像大会2018 Student Travel Stipend Award。于2020年转博研究生张文佳研究方向为分子影像学，在读期间利用临床已批准的免疫调节胸腺五肽和近红外吲哚菁绿联合制备超分子纳米纤维，用于胰腺肿瘤的局部光热免疫治疗研究，有效抑制肿瘤生长和消除肿瘤转移，从而提高疗效改善预后。相关研究成果以共同第一作者身份被材料类顶刊Adv Mater（2019IF：27.398，Q1区）接收并在线发表。

在研项目：

 已结题项目：

在研项目：

 已结题项目：

研究成果

薛华丹主任医师主要研究方向是消化系统及女性生殖系统的CT及MRI影像诊断，开发国内外先进影像学技术，带头开展了多项极有意义的临床科研工作，并将其转化为临床常规，为院内、院际间的多学科合作建设工作做出了重要贡献。

1.发表文章：以第一作者及通讯作者发表 SCI 文章共47篇，累计影响因子158.552；以第一作者及通讯作者发表中文文章64篇。

2.获奖情况：科研奖项：曾获得“国家科技进步奖”、“华夏医学科技奖”、“中华医学科技奖”、“RSNA大会展板优秀奖”等多个国内外重要科研奖项。

教学奖项：曾获得“北京市高等学校青年教学名师奖”、“北京协和医院优秀教育工作者”、“北京协和医院优秀教师”等多个教学奖项。

3.承担基金项目：作为课题负责人先后承担17项基金项目，累及基金439.5万元（科研项目14项，教学项目3项）；作为课题参与人参加的科研项目10项（科研项目6项，教学项目4项）。

4.出版专著：作为主编及副主编出版专著10本（其中一本待出版），作为编者出版专著8本。

5.专利及软件著作权：已取得6项专利授权（3项实用新型专利，3项发明专利）；

已取得两项计算机软件著作权：CT卵巢癌病灶随访评估系统V1.0（排名第3）；CT卵巢癌病灶标记系统V1.0（排名第4）。

以第一作者及通讯作者发表 SCI 文章如下：

第一作者(含并列第一作者)：

1.      Xue H, Jin Z.Theappropriate position of radiology in COVID-19 diagnosis and treatment-currentstatus and opinion from China. Chin J Acad Radiol,2020: 1-3（第一作者）

2.      Fan L, Li D, Xue H, Zhang L, Liu Z, Zhang B, Zhang L,Yang W, Xie B, Duan X, Hu X, Cheng K, Peng L, Yu N, Song L, Chen H, Sui X,Zheng N, Liu S, Jin Z.Progress and prospect on imaging diagnosis of COVID-19.Chin J Acad Radiol,2020: 1-10（并列一作）

3.      Liu JJ, Xue HD, Liu W, Yan J, Pan WD, Li B, Xu K, WangY, Li P, Xiao Y, Jin ZY.CTcolonography with spectral filtration and advanced modeled iterativereconstruction in the third-generation dual-source CT: image quality, radiationdose and performance in clinical utility.Acad Radiol,2020: S1076-6332(20)30186-0（并列一作）

4.      Zhu L, Xue HD, Zhang W, Wang Q, Tan B, Lai YM, ZhengWY, Asbach P, Hamm B, Denecke T, Jin ZY.Pancreaticobiliary involvement intreated type 1 autoimmune pancreatitis: Imaging pattern and risk factors fordisease relapse. Eur J Radiol,2019,120: 108673 (并列一作)

5.     Zhu L, Xue H, Sun Z, Qian T, Weiland E, Kuehn B,Asbach P, Hamm B, Jin Z.Modified breath-hold compressed-sensing 3D MRcholangiopancreatography with a small field-of-view and high resolutionacquisition: Clinical feasibility in biliary and pancreatic disorders. J MagnReson Imaging,2018,48 (5): 1389-1399（并列一作）（2020 IF: 3.954）

6.       Chen Y, Zhang X, Xue H,Zhu Y, Wang Y, Li Y, Zhang Z, Jin Z.Head and neck angiography at 70 kVp with athird-generation dual-source CT system in patients: comparison with 100 kVp.Neuroradiology,2017,59 (11): 1071-1081（并列一作）（2020 IF: 2.238）

7.      Sun H, Hou XY, Xue HD, Li XG,Jin ZY, Qian JM, Yu JC, Zhu HD.Dual-source dual-energy CT angiography withvirtual non-enhanced images and iodine map for active gastrointestinalbleeding: image quality, radiation dose and diagnostic performance. Eur JRadiol,2015,84 (5): 884-891（并列一作）（2020 IF:2.687）

8.      Xue H, Ren C, Yang J, Sun Z,Li S, Jin Z, Shen K, Zhou W.Histogram analysis of apparent diffusioncoefficient for the assessment of local aggressiveness of cervical cancer. ArchGynecol Obstet,2014,290 (2): 341-348（并列一作）（2020 IF: 2.283）

9.      Sun H, Xue HD, Wang YN, QianJM, Yu JC, Zhu F, Zhu HD, Jin ZY, Li XG.Dual-source dual-energy computedtomography angiography for active gastrointestinal bleeding: a preliminary study.Clin Radiol,2013,68 (2): 139-147（并列一作）（2020 IF: 2.118）

10.   Xue HD, Liu W, Xiao Y, Sun H,Wang X, Lei J, Jin ZY.Pancreatic and peri-pancreatic lesions mimic pancreaticislet cell tumor in multidetector computed tomography. Chin Med J(Engl),2011,124 (11): 1720-1725 （2020 IF: 1.585）

11.    Lei J, Xue HD, Li Z, LiS, Jin ZY.Possible pathological basis for false diagnoses of lymph nodes byUSPIO-enhanced MRI in rabbits. J Magn Reson Imaging,2010,31 (6): 1428-1434（并列一作）（2020 IF: 3.954）

12.    Xue HD, Roubidoux MA.Anintroduction to the status of radiology education in a leading Chinese medicalschool: Comparison to a leading US medical school. Med Teach,2010,32 (10): 868 （2020 IF: 2.654）

通讯作者（含并列通讯）：

1.      He M, Xue HD,et al.Application ofcompressed sensing 3D MR cholangiopancreatography(CS-MRCP)with contact-free physiologicalmonitoring(CFPM) for pancreaticobiliary disorders. Acad Radiol, 2020(2020 IF:2.488)[高1] 

2.      Yuan Li, Chengyu Lin, etal., Non-invasive Differentiation of Endometrial Adenocarcinoma from BenignLesions in the Uterus by Utilization of APT-weighted MRI, Molecular Imaging andBiology, 2020

3.      Zhang L, Wang Q, Wu X, Zhao A, Feng J, Zhang H, Cao X, Li S,Cai H, Sun Z, Duan M, Zhu T, Zhang W, Jin Z, Zhou D, Xue H, Li J.Baseline bonemarrow ADC value of diffusion-weighted MRI: a potential independent predictorfor progression and death in patients with newly diagnosed multiple myeloma.Eur Radiol,2020: [s2] （2020IF：4.101）

4.      Li SK, Zhang WJ, Xue HD, Xing RR, Yan XH.Tumormicroenvironment-oriented adaptive nanodrugs based on peptide self-assembly.Chemical Science,2020,11 (33): 8644-8656（2020IF：9.346）

5.       Wang Y,He YL, Yuan L, Yu JC, Xue HD, Jin ZY.Typical and atypical pelvic MRIcharacteristics of Mayer-Rokitansky-Kuster-Hauser syndrome: a comprehensiveanalysis of 201 patients. European Radiology,2020,30 (7): 4014-4022（2020 IF: 4.101）

6.       He M,Xu J, Sun ZY, Wang XQ, Wang JZ, Feng F, Xue HD, Jin ZY.Prospective Comparisonof Reduced Field-of-View (rFOV) and Full FOV (fFOV) Diffusion-Weighted Imaging(DWI) in the Assessment of Insulinoma: Image Quality and Lesion Detection.Academic Radiology,2020,27 (11): 1572-1579（2020 IF: 2.488）

7.       Li J,Chen XY, Xu K, Zhu L, He M, Sun T, Zhang WJ, Flohr TG, Jin ZY, Xue HD.Detectionof insulinoma: one-stop pancreatic perfusion CT with calculated mean temporalimages can replace the combination of bi-phasic plus perfusion scan. EuropeanRadiology,2020,30 (8): 4164-4174（2020 IF: 4.101）

8.       Sun T,Zhang WJ, Li Y, Jin ZY, Du Y, Tian J, Xue HD.Combination Immunotherapy withCytotoxic T-Lymphocyte-Associated Antigen-4 and Programmed Death Protein-1Inhibitors Prevents Postoperative Breast Tumor Recurrence and Metastasis.Molecular Cancer Therapeutics,2020,19 (3): 802-811（2020 IF: 5.615）

9.       DangHD, Chen Y, Zhang ZH, Shi XH, Chen XM, Zhu XL, Hou B, Xing HQ, Xue HD, Jin ZY.Applicationof integrated positron emission tomography/magnetic resonance imaging inevaluating the prognostic factors of head and neck squamous cell carcinoma withpositron emission tomography, diffusion-weighted imaging, dynamic contrastenhancement and combined model. Dentomaxillofacial Radiology,2020,49(5):20190488（2020 IF: 1.796）

10.    ZhangDM, Xie YT, Wang YN, Guo N, Wang Y, Jin ZY, Xue HD.Initial Clinical Experienceof Virtual Monoenergetic Imaging Improves Stent Visualization in LowerExtremity Run-Off CT Angiography by Dual-Layer Spectral Detector CT. AcademicRadiology,2020,27 (6): 825-832 （2020 IF: 2.488）

11.    Qi YF,He YL, Lin CY, Wang XQ, Zhou HL, Yuan L, Li Y, Xiang Y, Xue HD, Jin ZY.Diffusion-weightedimaging of cervical cancer: Feasibility of ultra-high b-value at 3T.European Journal of Radiology,2020,124: 108779（2020 IF: 2.687）

12.   He YL, Li Y, Lin CY, Qi YF, Wang XQ, Zhou HL, Yang JJ, XiangY, Xue HD, Jin ZY.Three-dimensional turbo-spin-echo amide protontransfer-weighted mri for cervical cancer: A preliminary study. Journal ofMagnetic Resonance Imaging,2019,50 (4): 1318-1325(2020 IF：3.954)

13.    ChengSH, Liu D, Hou B, Hu Y, Huo L, Xing HQ, Jin ZY, Xue HD.PET -MR Imaging and MRTexture Analysis in the Diagnosis of Pancreatic Cysts: A ProspectivePreliminary Study. Academic Radiology,2020,27 (7): 996-1005（2020 IF: 2.488）

14.    He M,Xu J, Sun ZY, Wang ST, Zhu L, Wang XQ, Wang JZ, Feng F, Xue HD, JinZY.Comparison and evaluation of the efficacy of compressed SENSE (CS) andgradient- and spin-echo (GRASE) in breath-hold (BH) magnetic resonancecholangiopancreatography (MRCP). Journal of Magnetic Resonance Imaging,2020,51(3): 824-832 (2020 IF：3.954)

15.    He M,Liu ZY, Lin YS, Wan JZ, Li J, Xu K, Wang Y, Jin ZY, Tian J, XueHD.Differentiation of atypical non-functional pancreatic neuroendocrine tumorand pancreatic ductal adenocarcinoma using CT based radiomics. European Journalof Radiology,2019,117: 102-111（2020 IF: 2.687）

16.   Li P,Deng WL, Xue HD, Xu K, Zhu L, Li J, Sun ZY, Jin ZY.Weight-adaptedultra-low-dose pancreatic perfusion CT: radiation dose, image quality, andperfusion parameters. Abdominal Radiology,2019,44 (6): 2196-2204（2020IF：2.429）

17.   ChengSH, Cheng YJ, Jin ZY, Xue HD.Unresectable pancreatic ductal adenocarcinoma:Role of CT quantitative imaging biomarkers for predicting outcomes of patientstreated with chemotherapy. European Journal of Radiology,2019,113: 188-197（2020IF：2.687）

18.   He YL,Ding N, Qi YF, Li Y, Xiang Y, Qian TY, Liu H, Lin CY, Yuan L, Zhou HL, Jin ZY,Xue HD.Visualising the boundary sharpness of uterine zonal structures usinghigh-resolution T2-weighted images during the menstrual cycle.Clinical Radiology,2019,74 (1): 81.e19-81.e24（2020IF：2.118）

19.   ZhangGM, Sun H, Shi B, Xu M, Xue HD, Jin ZY.Uric acid versus non-uric acid urinarystones: differentiation with single energy CT texture analysis. ClinicalRadiology,2018,73 (9): 792-799（2020 IF：2.118）

20.   Zhu L,Sun ZY, Xue HD, Liu D, Qian TY, Asbach P, Jin ZY.Patient-adapted respiratorytraining: Effect on navigator-triggered 3D MRCP in painful pancreatobiliarydisorders. Magnetic Resonance Imaging,2018,45: 43-50（2020IF：2.053）

21.   Du Y,Liang X, Li Y, Sun T, Jin Z, Xue H, Tian J.Nuclear and Fluorescent LabeledPD-1-Liposome-DOX-(64)Cu/IRDye800CW Allows Improved Breast Tumor TargetedImaging and Therapy. Mol Pharm,2017,14 (11): 3978-3986 (2020 IF: 4.321)

22.   Zhu L,Xue HD, Sun ZY, Li P, Qian TY, Xing XP, Li NS, Zhao YP, Wu WM, JinZY.Prospective Comparison of Biphasic Contrast-Enhanced CT, Volume PerfusionCT, and 3 Tesla MRI With Diffusion-Weighted Imaging for Insulinoma Detection.Journal of Magnetic Resonance Imaging,2017,46 (6): 1648-1655 （2020 IF: 3.954）

23.   Zhu L,Wu WM, Xue HD, Liu W, Wang X, Sun H, Li P, Zhao YP, Jin ZY.Sporadic insulinomason volume perfusion CT: dynamic enhancement patterns and timing of optimal tumour-parenchymacontrast. European Radiology,2017,27 (8): 3491-3498（2020 IF: 4.101）

24.   Zhu L,Xue HD, Liu W, Wang X, Sui X, Wang Q, Zhang DM, Li P, Jin ZY.Enhancingpancreatic mass with normal serum CA19-9: key MDCT features to characterizepancreatic neuroendocrine tumours from its mimics. Radiologia Medica,2017,122(5): 337-344（2020 IF: 2.00）

25.   Zhu L,Xue HD, Sun H, Wang X, Wu WM, Jin ZY, Zhao YP.Insulinoma Detection With MDCT:Is There a Role for Whole-Pancreas Perfusion? American Journal ofRoentgenology,2017,208 (2): 306-314（2020 IF: 3.013）

26.   ZhangGM, Shi B, Sun H, Xue HD, Wang Y, Liang JX, Xu K, Wang M, Wang M, Xu M, JinZY.High-pitch low-dose abdominopelvic CT with tin-filtration technique fordetecting urinary stones. Abdominal Radiology,2017,42 (8): 2127-2134（2020IF：2.429）

27.   ZhangGM, Shi B, Sun H, Jin ZY, Xue HD.Differentiating pheochromocytoma fromlipid-poor adrenocortical adenoma by CT texture analysis: feasibility study.Abdominal Radiology,2017,42 (9): 2305-2313（2020IF：2.429）

28.   ZhangGMY, Sun H, Shi B, Jin ZY, Xue HD.Quantitative CT texture analysis forevaluating histologic grade of urothelial carcinoma. AbdominalRadiology,2017,42 (2): 561-568（2020IF：2.429）

29.   Zhu L,Xue HD, Sun H, Wang X, He YL, Jin ZY, Zhao YP.Isoattenuating insulinomas atbiphasic contrast-enhanced CT: frequency, clinicopathologic features andperfusion characteristics. European Radiology,2016,26 (10): 3697-3705 （2020 IF: 4.101）

30.   Zhu L,Shi XH, Xue HD, Wu HW, Chen G, Sun H, He YL, Jin ZY, Liang ZY, Zhang ZL.CTImaging Biomarkers Predict Clinical Outcomes After Pancreatic Cancer Surgery.Medicine,2016,95 (5): 1-10（2020 IF: 1.552）

31.   ZhangHB, Xue HD, Alto S, Hui L, Kannengiesser S, Berthold K, Jin ZY.Integrated ShimmingImproves Lesion Detection in Whole-Body Diffusion-Weighted Examinations ofPatients With Plasma Disorder at 3 T. Investigative Radiology,2016,51 (5):297-305（2020 IF: 5.156）

32.    He YL, Ding N, Li Y, Li Z, Xiang Y, Jin ZY, Xue HD.Cyclicchanges of the junctional zone on 3 T MRI images in young and middle-agedfemales during the menstrual cycle. Clinical Radiology,2016,71 (4): 341-348（2020IF：2.118）

33.    He YL, Du XC, Ding N, Li Z, Zhou WX, Chen B, Jin ZY, Sun H,Zhu L, Xue HD.Spectrum of IgG4-related disease on multi-detector CT: a 5-yearstudy of a single medical center data. Abdominal Imaging,2015,40 (8): 3104-3116（2020IF：2.429）

34.   Wu HW,Zhu L, Zhang H, Shi XH, Zhang L, Wang WZ, Xue HD, Liang ZY.Coexpression of EGFRand CXCR4 Predicts Poor Prognosis in Resected Pancreatic Ductal Adenocarcinoma.Plos One,2015,10 (2): e0116803（并列通讯：梁志勇）（2020 IF: 2.740）

35.   He Y,Ding N, Li Y, Li Z, Xiang Y, Jin Z, Xue H.3-T diffusion tensorimaging (DTI) of normal uterus in young and middle-aged females during themenstrual cycle: evaluation of the cyclic changes of fractional anisotropy (FA)and apparent diffusion coefficient (ADC) values. British Journal ofRadiology,2015,88 (1049): 20150043（2020 IF: 2.196）

36.   Wang X,Xue HD, Jin ZY.Authors' reply to "Re: Quantitative hepatic CT perfusionmeasurement: comparison of Couinaud's hepatic segments with dual-source128-slice CT". European Journal of Radiology,2014,83 (5): 866-866（2020 IF: 2.687）

37.   Wang X,Xue HD, Jin ZY, Su BY, Li Z, Sun H, Chen Y, Liu W.Quantitative hepatic CTperfusion measurement: Comparison of Couinaud's hepatic segments withdual-source 128-slice CT. European Journal of Radiology,2013,82 (2): 220-226.（2020 IF: 2.687）

38.   Chen Y,Xue HD, Jin ZY, Zhang J, Sun H, Wang X, Zhang ZH, Zhang DM, Lu GM, Zhang ZQ,Schoepf UJ, Bucher AM, Wolla CD, Wang Y.128-SliceAcceletated-Pitch Dual Energy CT Angiography of the Head and Neck: Comparisonof Different Low Contrast Medium Volumes. Plos One,2013,8 (11): e80939（2020 IF: 2.740）

39.   He YL,Song W, Lei J, Li Z, Cao J, Huang S, Meng J, Xu HY, Jin ZY, Xue HD.Anti-CXCR4monoclonal antibody conjugated to ultrasmall superparamagnetic iron oxidenanoparticles in an application of MR molecular imaging of pancreatic cancercell lines. Acta Radiologica,2012,53 (9): 1049-1058 （2020 IF: 1.635）