主要研究课题：

1.  科技创新2030重大项目（主持）：疑难罕见病人工智能辅助诊断技术研究与临床应用，2022ZD0116000，1800万，2022.12-2025.11

2.  北京协和医院中央高水平医院临床科研专项专科提升项目（主持）：疑难罕见肾脏病分子病理临床应用转化研究，2022-PUMCH-B-019,210万，2022.10-2025.09

3.  北京协和医院中央高水平医院临床科研专项重大攻关计划（子课题负责人）：罕见病诊疗新技术研发及转化研究，2022-PUMCH-D-002,600万，2022.10-2025.09

4.  国家自然科学基金（主持）：ALDH2调节有氧糖酵解在急性肾损伤管球反馈机制中的时空组学研究，82170709，55万，2022.01-2025.12（面上）

5.  中国医学科学院创新工程项目（子课题负责人）:中国罕见病的精准诊疗研究，CIMFS 2021-I2M-1-003,1000万，2021.10-2025.12

6.  中华医学基金会OC项目(Co-PI)：基于人工智能技术建立慢性肾脏病妊娠的疾病预测模型和临床决策支持系统，#21-422，48.36万，2022.01-2024.12

7.  国家自然科学基金（主持）：肾脏Npt调节线粒体磷稳态和管球反馈参与药物相关范可尼综合征的机制研究，81970607，55万，2020.01-2023.12（面上）

8.  首都卫生发展科研专项（主持）：建立罕见遗传性肾小管间质病临床诊疗策略，CFH 2020-2-4018，39万，2020.07-2023.06

9. 北京市自然科学基金-海淀原始创新联合基金（主持）：精准治疗Gitelman综合征疗效研究，L202035，28万， 2020.12-2023.12

10.中国医学科学院医学与健康科技创新工程,临床与转化医学研究基金重点项目（主持）：基于人工智能和移动平台建立代谢性肾病高危风险预警管理模型及应用，CIFMS 2020-I2M-C&T-A-001，100万,2020.12-2022.11

11.宁夏回族自治区重点研发计划（对外科技合作专项）东西部合作项目：跨区域多学科合作慢性肾脏病矿物质及骨代谢异常一体化诊疗策略建立及临床应用（课题负责人）2018BFG02010, 474万，2018.06-2021.05

12. Baxter’s Global Scientific Review Council 2017 Renal PD Grant Program: The efficacy and outcomesof automated peritoneal dialysis in acute kidney injury: a multi-center randomizedcontrolled clinical trial. $ 119,450.00 USD, about 750,000 RMB,  2018.6-2021.5

13.国家自然科学基金（主持）：A1AR保护糖尿病肾小管微环境平衡的非管球反馈机制，81470937, 73万, 2015.01-2018.12（面上）

14.国家自然科学基金（主持）：肾脏巨噬细胞COX-2依赖的表型分化在肾性高血压管球对话中的作用81641024，10万，2017.1-12（应急管理项目）

15.国家自然科学基金（主持）：尿酸导致管球反馈失衡在高血压肾损害中不同于文献的分子机制，81170674，70万，2012.1-2015.12（面上）

16.国家自然科学基金（主持）：维生素D调节肾脏球旁器分泌肾素不同于文献的近距离反馈机制，30971369，32万，2010.1-2012.12（面上）

17.国家自然科学基金（主持）：血管紧张素调节肾素分泌近距离直接反馈机制，30770861，25万，2008.1-2010.12（面上）

18.首都临床特色应用研究（主持）：遗传性失盐性肾病临床分型的建立和验证，Z171100001017196，24万，2017.2-2020.9

19.中国医学科学院协和学者特聘教授，53万，2015.11-2018.10

20.中国医学科学院创新工程项目（子课题负责人）： 医学大数据信息采集和分析评价，CIFMS 2016-I2M-2-004, 200万，2016.1-2021.3（子课题经费）

21.首都临床特色应用研究（主持）：遗传性失盐性肾病诊疗体系的建立，Z121107001012139，22.5万，2012.6-2015.5

22.外国文教专家聘请计划重点外专引智项目（主持）：建立高血压水盐代谢与肾脏病理生理研究平台，9万，2012.1-2012.12

23.外国文教专家聘请计划重点外专引智项目（主持）：高血压水盐代谢与肾脏病理生理研究平台滚动，9万，2013.1-2013.12

国家及北京市大学生创新基金：指导老师（PI）

1.施潇潇，2013年，炎症及血流动力学调节在恶性高血压肾微血管损伤中作用

2.黄宝延，2013年，血液透析高血压患者自我管理干预的效果研究

3.周梦宇，2014年，Thl 7/Treg细胞失衡在原发性干燥综合征合并膜性肾病发病机制中的作用

4.梅燕青，2014年，腺苷l型受体基因敲除小鼠上建模探究腺苷及腺苷1型受体在心肌损害中发挥的作用

5.蒋兰萍，2014年，国家教育部博士交换培养计划（芝加哥大学）

6.王婧，2015年，异位生发中心在干燥综合征合并近端肾小管损伤中的作用

7.徐鲁斌，2015年，Connexin40与恶性高血压肾素调控的关系

8.郎珈馨，2015年，经典瞬时电位通道和血管周细胞在恶性高血压肾脏微血管病变中意义

9.朱晨，黄宝延，2016年，基于微信平台的腹膜透析患者高血压自我管理的干预效果研究

10.彭晓艳，2016年，NCC参与高血压发生的炎症反应机制研究

11.李阳，2016年，氨甲酰化白蛋白预测腹膜透析患者预后研究

12.马莹，2016年，铁调素在腹透相关性腹膜炎中的保护机制的研究

13.赵彧墨，2017年，SGLT2抑制剂对近端肾小管尿酸代谢的影响与机制

14.田东丽，2017年，巨噬细胞参与肥胖相关肾病蛋白尿形成的炎性反应机制

15.赵冰彬，2018年，蛋白质负荷试验评估Gitelman综合征患者肾脏储备功能

16.徐鲁斌，中国博士后科学基金面上资助:MAP17调控SGLT2参与家族性肾性糖尿发病机制初探

17.林敏，2019年，DKK3 在恶性高血压肾间质纤维化中的作用机制

18.尹欢欢，2019年，肠道菌群通过ILC3介导抗GBM病发病机制的研究

19.陈敏婷，2022年，犬尿氨酸通路在顺铂肾损伤铁死亡的保护机制初探

20.陈欣，2022年中央高校基本科研业务费：SDC-1对 ANCA 血管炎血栓风险的预测价值研究

专著:

1.  Christopher S. Wilcox, MIchael Choi, Liming Chen, Mark S.Segal, Winfred W. Williams, Handbook of Nephrology and Hypertension,SeventhEdition,ISBN: 9781975165727, LWW,2022.12（副主编）

2.  张抒扬，赵玉沛，黄尚志，崔丽英，陈丽萌等，《罕见病学》，ISBN：9787117305723，人民卫生出版社，2020.10（副主编）

3.  陈江华，王子明，魏强，陈丽萌等，《泌尿系统与疾病》（第2版），ISBN：9787117325745，人民卫生出版社，2022.2（副主编）

4.  陈丽萌，胡昭等，《慢性肾脏病继发性甲状旁腺功能亢进症临床实践》，ISBN：9787117304481，人民卫生出版社，2020.9（主编）

5.  张抒扬，陈丽萌等，《中国第一批罕见病目录释义》，ISBN：9787117275798，人民卫生出版社，2018.10.1 （副主编）

6.  张抒扬，陈丽萌等，《罕见病诊疗指南》（2019版），ISBN：9787117286688，人民卫生出版社，2019.10.1（副主编）

7.  李雪梅，陈丽萌等，《美国肾脏基金会肾脏病学，第6版》，ISBN：9787565920608，北京大学医学出版社，2019.12.1（副主译）

代表性论文：

1.      Zhang L, Peng X, Zhao B, Xia P, Wen Y, Ye W, Li X,Li X, Ye W*, Cheng H, Chen L*. Clinicopathological features of Gitelmansyndrome with proteinuria and renal dysfunction. Nephron. 2023 Feb 20. doi:10.1159/000529775（co-corresponding author）

2.     Li J, Shi X, Chen Z, Xu J, Zhao R, Liu Y, Wen Y, Chen L*. Aldehydedehydrogenase 2 alleviates mitochondrial dysfunction by promotingPGC-1α-mediated biogenesis in acute kidney injury. Cell Death Dis. 2023 Jan20;14(1):45. (corresponding author)

3.      Zheng H#, Wang H#, Zhou Z, Cai H, Liang J, Qin Y,Xia P*, Chen L*.End Stage Renal Failure Patients With Hemophilia Treated WithPeritoneal Dialysis: A Case Series. Kidney Int Rep. 2022 Sep 30;7(12):2639-2646.(co-corresponding author)

4.     Liu Y#, Zhang GM#, Peng X, Li X, Sun H*, Chen L*. Diffusion kurtosisimaging as an imaging biomarker for predicting prognosis in chronic kidneydisease patients. Nephrol Dial Transplant. 2022 Jul 26;37(8):1451-1460. (co-corresponding author)

5.     Ma Y, Lin J, Xia P, Zheng H, Cheng X, Ji P, Wu W, Hou L, Wang L, Zhu G, QiuL*, Zheng Y*, Chen L*. Comparison of the profiles of patients defined byage-adapted and fixed threshold CKD criteria: a nationwide, cross-sectionalstudy. Clin Kidney J. 2022 Aug 25;15(12):2312-2321. （corresponding author）

6.     Zhang Z, Zhang X, Gui Y, Wang X, Tong A, Yu S, Li M, Zheng K, Qin Y, Xia P,Chen L*, Renal arteriovenous fistula complicated with malignanthypertension: a case report. J Hypertens. 2022 Oct 1;40(10):2076-2080 (corresponding author).

7.      Ma T, Zhang L, Chen L*. The SubcellularLocalization of RRAGD. J Am Soc Nephrol. 2022 May;33(5):1046-1048. (corresponding author)

8.     He X, Wen Y, Hu R, Wu H, Ye W, Yue C, Qin Y, Xia P, Chen L*, Interstitialnephritis without glomerulonephritis in ANCA-associated vasculitis: a caseseries and literature review. Clin Rheumatol. 2022 Nov;41(11):3551-3563 (co-corresponding author).

9.     You R, Heyang Z, Ma Y, Xia P, Zheng H, Lin J, Ji P, Chen L*. Identificationof biomarkers, immune infiltration landscape, and treatment targets ofischemia-reperfusion acute kidney injury at an early stage by bioinformatics methods.Hereditas. 2022 Jun 4;159(1):24.(corresponding author)

10.   Tang X#, Zheng H#, Wang H, Xia P, Wang Y, Zhao X,Zhou Z, Qiu L, Li X, Chen L*. Optimal targets of chronic kidneydisease-mineral and bone disorder markers for Chinese patients with maintenanceperitoneal dialysis: a single-center retrospective cohort study. Ren Fail. 2022Dec;44(1):336-345. (corresponding author)

11.   Lin J#, Zheng H#, Xia P#, Cheng X, Wu W, Li Y, MaC, Zhu G, Xu T, Zheng Y, Qiu L*, Chen L*. Long-term ambient PM2.5exposure associated with cardiovascular risk factors in Chinese less educatedpopulation. BMC Public Health. 2021 Dec 10;21(1):2241.（co-corresponding author）

12.   Jiang L#, Peng X#, Zhao B, Zhang L, Xu L, Li X, NieM*, Chen L*. Frequent SLC12A3 mutations in Chinese Gitelman syndrome patients:structure and function disorder. Endocr Connect. 2021 Dec 1:EC-21-0262.R2.（co-corresponding author）

13.   Lang J, Shi X, Ma Y, Zou L, Fei Y, Chen L*.Primary Sjögren's syndrome with minimal change disease: case series and literaturereview. Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):226-227.（corresponding author）

14.   You R#, Zheng H#, Xu L, Ma T, Chen G, Xia P, Fan X,Ji P, Wang L, Chen L*. Decreased urinary uromodulin is potentiallyassociated with acute kidney injury: a systematic review and meta-analysis. JIntensive Care. 2021 Nov 15;9(1):70.（corresponding author）

15.   Tian D#, Li J#, Zou L, Lin M, Shi X, Hu Y, Lang J,Xu L, Ye W, Li X, Chen L*. Adenosine A1 Receptor Deficiency AggravatesExtracellular Matrix Accumulation in Diabetic Nephropathy through Disturbanceof Peritubular Microenvironment. J Diabetes Res. 2021 Oct 11; 2021:5584871（corresponding author）

16.   You R, Chen L, Xu L, Zhang D, Li H, Shi X, Zheng Y,Chen L*. High Level of Uromodulin Increases the Risk of Hypertension: AMendelian Randomization Study. Front Cardiovasc Med. 2021 Sep 1;8:736001. （corresponding author）

17.   Ma T#, Jia H#, Ji P, Heyang Z, Chen L*. Identification of the candidate lncRNA biomarkers foracute kidney injury: a systematic review and meta-analysis. Expert Rev Mol Diagn.2021;21(1):77-89. (corresponding author)

18.   Chen Z#, Li J#, Shi X#, Wang Y, Xia P, Ye W, Ye W,Qin Y, Li H, Li M, Li X, Wen Y*, Chen L* Clinicopathological Characteristics and Long-termPrognosis of Monoclonal Immunoglobulin LightChain Associated Fanconi Syndrome. Ther Adv Hematol, 2021;12: 1–12. (co-corresponding author)

19.   Zhang G#, Liu Y#, Sun H*, Xu L, Sun J, An J, ZhouH, Liu Y, Chen L*, Jin Z*. Textureanalysis based on quantitative magnetic resonance imaging to assess kidney function:a preliminary study. Quant Imaging Med Surg 2021;11(4):1256-1270.  (co-corresponding author)

20.   Zhao B#, Zhang L#, Ji P, Lin J, Han J, Li J, ZhouZ, Wang H, Qiu L, Hong X*, Williams W*, ChenL*. Bridging "Office-Based Care" With the "Virtual PracticeCare Model": Evolving Care for Chronic Kidney Disease Patients in theCOVID-19 Pandemic-And Beyond. Front Med (Lausanne). 2020;7:568201 (co-corresponding author)

21.   Shi X, Chen Z, Wang J, Wen Y, Zou L,Fei Y, Ye W, Qin Y, Li H, Li M, Li X, Zhang F, Li X, Chen L*. Primary Sjӧgren’s Syndrome with Renal Fanconi Syndrome:Good Responses to Treatment with Glucocorticoids. Semin ArthritisRheum. 2020;50(6):1326-1332. ( corresponding author)

22.   Xia P#, Zhang L#, Zou M, Zhang T, Li R,Shi X, Wang J, Qin Y, Li X, Li J, Chen L*.Acute Kidney Injury Caused by TAFRO Syndrome in a Chinese Patient: Efficacy ofLong-Term Corticosteroids Combined with Bortezomib and Cyclophosphamide. KidneyBlood Press Res. 2020;1-7. (corresponding author)

23.   Wang D#, Yu S#, Zou Y#, ZhangY, Qiu L*, Chen L*. Distribution of free 25OHD in elderlypopulation based on LC-MS/MS. J Steroid Biochem Mol Biol.2020;200:105672. (co-corresponding author)

24.   Zhang L#, Peng X#, Zhao B, Zhu Z, WangY, Tian D, Yan Z, Yao L, Liu J, Qiu L, Xing X, Chen L*.Clinical and laboratory features offemale Gitelman syndrome and the pregnancy outcomes in a Chinese cohort.Nephrology (Carlton). 2020;25(10):749-757 (corresponding author)

25.   Wang Y#, Li Y#, Wang H, Ma Y, Ma D,Tian D, Liu B, Zhou Z, Yang W, Li X, Cui J, Chen L*.Early-start andconventional-start peritoneal dialysis: a Chinese cohort study on outcome.RenFail. 2020,42(1):305-313. (corresponding author)

26.   Chen G, Hu R, Wang Y, Zhao X, Zhou Y,Song D, Xia J, Qin Y, Chen L*, LiX*. Recommendation from Peking UnionMedical College Hospital for urgenthemodialysis during the COVID-19 pandemic. Int Urol Nephrol. 2020;52(9):1809-1810.(co-corresponding author)

27.   Tian D, Shi X, Zhao Y, Peng X, Zou L,Xu L, Ma Y, Wen Y, Faulhaber-Walter R, ChenL*. The effect of A1 adenosine receptor in diabetic megalin loss withcaspase-1/IL18 signaling. Diabetes Metab Syndr Obes. 2019;12:1583-1596.(corresponding author)

28.   Zhang S, Chen L, Zhang Z, Zhao Y. Orphan drug development in China:progress and challenges.Lancet. 2019,394(10204):1127-1128.

29.   Wu J, Li D, Li J, Yin YC，Li P, Qiu L*, Chen L*. Identification of microRNA-mRNAnetworks involved in cisplatin-induced renal tubular epithelial cells injury. EurJ Pharmacol. 2019;851:1-12 (co-corresponding author)

30.   Zhang G, Sun H*, Qian T, An J, Shi B,Zhou H, Liu Y, Peng X, Liu Y, Chen L*,Jin Z*.  Diffusion-weightedimaging of the kidney: comparison between simultaneous multi-slice andintegrated slice-by-slice shimming echo planar sequence. ClinRadiol. 2019;74(4):325.e1-325 (co-corresponding author)

31.   Zhao Y#, Xu L#, Tian D, Xia P, Zheng H,Wang L, Chen L*, Effects of sodium-glucose co-transporter2 (SGLT2) inhibitors on serum uric acid level: A meta-analysis of randomizedcontrolled trials, Diabetes Obes Metab,2018,20(2):458-462. (corresponding author)

32.   Peng X#, Zhao B#, Zhang L, Jiang L,Yuan T, Wang Y, Wang H, Ma J, Li N, Zheng K, Nie M, Li X, Xing X, Chen L*. Hydrochlorothiazide Test as a Tool inthe Diagnosis of Gitelman Syndrome in Chinese Patients. FrontEndocrinol (Lausanne). 2018;9:559. (corresponding author)

33.   Liu Y, Zhang GM, Peng X, Wen Y, Ye W,Zheng K, Li X, Sun H*, Chen L*. Diffusionalkurtosis imaging in assessing renal function and pathologyof IgA nephropathy: a preliminary clinical study. Clin Radiol.2018;73(9):818-826 (co-corresponding author)

34.   Huang B, Li Z*, Wang Y, Xia J, Shi T,Jiang J, Marie Nolan T., Li X, Nigwekar, Sagar U, Chen L*. Effectiveness of Self-management Support in MaintenanceHaemodialysis Patients with Hypertension: A Pilot Cluster Randomized ControlledTrial, Nephrology, 2018;23(8): 755-76330. (co-corresponding author)

35.   Wang Y, Qin Y, Fan X, Cai J, Ye W, XiaJ, Li M, Li X, Li X, Chen L*.Variability in Predialysis SystolicBlood Pressure and Long-Term Outcomes in Hemodialysis Patients. KidneyBlood Press Res. 2018;43(1):115-124.（corresponding author)

36.   Yang H, Wang J, Wen Y, Fei Y, Jiang M,Zhou M, Zhang W, Li H, Li X, Zhang F, Li X, Zhang X, Chen L*. Renal involvements in primary Sjögren’s syndrome: aretrospective study of 103 biopsy-proven cases from a single-center in China,Int J Rheum Dis. 2018,21(1):223-229. (corresponding author)

37.   Wang J#, Wen Y#，Zhou M，Shi X，JiangL，Li M, Yu Y*, Li X, Li X, Zhang W, LundquistAL, Chen L*; Ectopic Germinal Centerand Megalin Defect in Primary Sjogren Syndrome with Renal Fanconi Syndrome.ArthritisRes Ther. 2017;19(1):120. (co-corresponding author)

38.   Hao J, Li Y, Zhang X, Pang C, Wang Y,Nigwekar SU, Qiu L*, Chen L*. The prevalenceand mortality of hyponatremia is seriously underestimated in Chinese generalmedical patients: an observational retrospective study. BMC Nephrol.2017;18(1):328.（co-corresponding author）

39.   Peng X, Jiang L, Chen C, Qin Y, Yuan T,Wang O, Xing X, Li X, Nie M, Chen L*.Increased urinary prostaglandin E2 metabolite: a potential therapeutic targetof Gitelman syndrome. Plos one, 2017; 10;12(7):e0180811 (corresponding author)

40.   YuanT#, Jiang L#,Chen C, Peng X, Nie M,Xing X*, Li X, Chen L*.GlucoseTolerance and Insulin Responsiveness in Gitelman Syndrome Patients. EndocrineConnections. 2017;6(4):243-252.（co-orresponding author）

41.   Xu L, Li Y, Lang J, Xia P, Zhao X, WangL, Yu Y, Chen L*. Effects ofsodium-glucose co-transporter 2 (SGLT2) inhibition on renal function andalbuminuria in diabetic patients: a systematic reviw and metaanalysis. Peer J. 2017;5:e3405（corresponding author）

42.   Li Y, Xia P, Xu L, Wang Y, Chen L*.A Meta-Analysis on Prehypertension and Chronic Kidney Disease. PLoS One. 2016,11(6):e0156575.（corresponding author）

43.   Wang Y, Wang O, Li W, Ma L, Ping F, Chen L*, Nie M*. Variants inVitamin D Binding Protein Gene Are Associated With Gestational DiabetesMellitus. Medicine (Baltimore). 2015;94(40):e1693 (co-corresponding author)

44.   Jiang L, Peng X, Ma J, Yuan T, Qin Y,Wang O, Wang H, Wang Y, Chen G, Yue C, Chao Li, Nie M, Xing X, Li X, Lee X, Chen L*. Normomagnesemic Gitelman Syndrome Patients Exhibit aBetter Reaction to Thiazide than Hypomagnesemic Patients. Endocrine Practice.2015;21(9):1017-25 (Corresponding author)

45.   Chen L*, Faulhaber-Walter R, Wen Y, Huang Y, Mizel D, Chen M,Sequeira Lopez ML, Weinstein LS, Gomez RA, Briggs JP, Schnermann J. Renalfailure in mice with Gsalpha deletion in juxtaglomerular cells. Am J Nephrol.2010;32(1):83-94. (Corresponding author)

46.   Chen L, Kim SM, Eisner C, Oppermann M, Huang Y, Mizel D, Li L, ChenM, Sequeira Lopez ML, Weinstein LS, Gomez RA, Schnermann J, Briggs JP.Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent.J Am Soc Nephrol. 2010;21(6):986-92.

47.   Chen L, Kim SM, Oppermann M, Faulhaber-Walter R, Huang Y, Mizel D,Chen M, Lopez ML, Weinstein LS, Gomez RA, Briggs JP, Schnermann J. Regulationof renin in mice with Cre recombinase-mediated deletion of G protein Gsalpha injuxtaglomerular cells. Am J Physiol Renal Physiol. 2007;292(1):F27-37.

48.   Faulhaber-Walter R, Chen L, Oppermann M, Kim SM, Huang Y,Hiramatsu N, Mizel D, Kajiyama H, Zerfas P, Briggs JP, Kopp JB, Schnermann J.Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerularinjury. J Am Soc Nephrol. 2008;19(4):722-30.

49.   Kim SM, Chen L, Faulhaber-Walter R, Oppermann M, Huang Y, Mizel D, BriggsJP, Schnermann J. Regulation of renin secretion and expression in micedeficient in beta1- and beta2-adrenergic receptors. Hypertension. 2007;50(1):103-9.

50. 中国研究型医院学会罕见病分会,中国罕见病联盟,北京罕见病诊疗与保障学会,等.Gitelman综合征诊疗中国专家共识（2021版）.协和医学杂志，2021,12（6）：902-912.（共同通讯作者）