郑月宏教授带领团队，依托北京协和医院是全国疑难重症诊治中心及疑难重症及罕见病国家重点实验室的优势已初步搭建医疗全景数据中台与专病数据库，初步构建专病智能辅助诊疗系统、多中心智能科研协同管理平台以及云阅片与影像标注平台。与北京航空航天大学生物与医学工程学院合作，已建立血流仿真高性能工作站，用于血管建模及血流模拟计算。已初步建立血流仿真整合模型，成功模拟小样本主动脉手术后血管重塑和血流流场的变化。已初步建立主动脉疾病全景云平台数据库，整合病历资料、检验数据和影像信息。

    郑月宏教授长期从事主动脉瘤相关基础研究，发现炎症反应、蛋白代谢、巨噬细胞自噬等腹主动脉瘤形成中的关键调节机制。已开展基因组、转录组、蛋白质组、微生物组学和代谢组学等多系统组学研究，在主动脉疾病标志物筛选和治疗新靶点预测方面完成大量工作，成果发表在 Circulation，Frontiers in Physiology 等主流期刊并获批多项发明专利。已摸索出将高通量测序平台产生的生物大数据和海量的医院病历文档、生化检验、病理学和影像学等数字化信息的有效整合方案。

      项目组首次创立改良腹膜后入路和改良 Crawford 血管重建术治疗 主动脉疾病;率先建立主动脉疾病全腔内治疗体系;并应用动物模型对脊髓缺血和肾缺血损伤进行深入研究。应用血流仿真模型评估不同手术入路和血管重建方式对动脉阻断、 吻合角度等的影响，并对主动脉疾病经典开放术式和 IV 型主动脉疾病手术入 路进行改良。建立包含平行支架、开窗支架等复杂技术的主动脉疾病全腔内治疗。

     项目组目前发表 SCI 40 余篇，获专利 20 余项，项目负责 人主编/副主编专著 4 本，获国自然/北自然科学基金 5 项，获中华医学科技奖、 华夏医学科技奖 2 项，多次获北京协和医院医疗成果奖。

l   2019.01-2023.12 国家自然科学基金（重大项目），热物理调控新方法在靶病灶诊疗过程中的临床转化应用，项目编号518908942，分课题负责人

l  2021-01-2024-12 国家自然科学基金（面上项目），KIF9缺失介导的巨噬细胞重编程在腹主动脉瘤形成中的作用及分子机制研究，项目编号82070492，主持

l 2018.01-2021.12 国家自然科学基金 ，趋化因子受体CXCR2促进腹主动脉瘤发生的病理生理机制研究，项目编号81770481，主持

1. Ji L, Chen S, Gu G, Zhou J, Wang W, Ren J, Wu J, Yang D, Zheng Y.Exploration of Crucial Mediators for Carotid Atherosclerosis Pathogenesis Through Integration of Microbiome, Metabolome, and Transcriptome. Front Physiol. 2021 May 24;12:645212. eCollection 2021. 论著，IF3.367.

2. Chen S, Ji L, Chen M, Yang D, Zhou J, Zheng Y.Weighted miRNA co-expression network reveals potential roles of apoptosis related pathways and crucial genes in thoracic aortic aneurysm. J Thorac Dis. 2021 May;13(5):2776-2789. 论著， IF2.045.

3. Ji L, Zheng Y.Letter by Ji and Zheng Regarding Article, "Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis". "Circulation. 2021 May 11;143(19):e917-e918. LETTER，IF23.6.

4. Wu J, Wang W, Chen Z, Xu F, Zheng Y.Proteomics applications in biomarker discovery and pathogenesis for abdominal aortic aneurysm"Expert Rev Proteomics

. 2021 May 4;1-10. Online ahead of print."综述, IF 3.614.

5. Gu G, Wu X, Ji L, Liu Z, Li F, Liu B, Liu C, Ye W, Chen Y, Shao J, Zeng R, Song X, Guan H, Zheng Y.Proposed modification to the Shamblin's classification of carotid body tumors: A single-center retrospective experience of 116 tumors. Eur J Surg Oncol

. 2021 Mar 20;S0748-7983(21)00389-9. 论著, IF3.959.

6. Chuxiang Lei, Dan Yang , Wenlin Chen, Haoxuan Kan, Fang Xu, Hui Zhang, Wei Wang , Lei Ji, Yuehong Zheng.The potential role of chemotaxis and the complement system in the formation and progression of thoracic aortic aneurysms inferred from the weighted gene coexpression network analysis. J Transl Med. 2021 Feb 2;19(1):49. 论著, IF 4.124.

7. Siliang Chen, Dan Yang, Bao Liu, Yuexin Chen, We Ye, Mengyin Chen, Yuehong Zheng. Identification of crucial genes mediating abdominal aortic aneurysm pathogenesis based on gene expression profiling of perivascular adipose tissue by WGCNA. Ann Transl Med. 2021 Jan;9(1):52.论著,IF3.297.

8. Bo Sun, Fangda Li , Song Lai , Xu Zhang , Hongxia Wang , Yuan Li , Wei Wang , Yuexin Chen , Bao Liu , Yuehong Zheng.Inhibition of CXCR2 alleviates the development of abdominal aortic aneurysm in Apo E-/- mice"Acta Cir Bras. 2021 Feb 15;36(1):e360105. 论著, IF 0.974.

9. Mengyin Chen, Siliang Chen, Dan Yang, Jiawei Zhou, Bao Liu, Yuexin Chen, Wei Ye, Hui Zhang, Lei Ji, Yuehong Zheng.Weighted Gene Co-expression Network Analysis Identifies Crucial Genes Mediating Progression of Carotid Plaque. Front Physiol. 2021 Feb 5;12:601952.论著, IF 3.367. 

10. Yuan Li , Dan Yang , Yuehong Zheng.Challenges of applying circulating biomarkers for abdominal aortic aneurysm progression. Exp Biol Med (Maywood) . 2021 Feb 27;1535370221992530. 综述, IF 3.139.

11. Ting Xie, Liangying Yin, Dan Guo, Zixin Zhang, Yuexin Chen, Bao Liu, Wei Wang, Yuehong Zheng. The potential role of plasma fibroblast growth factor 21 as a diagnostic biomarker for abdominal aortic aneurysm presence and development. Life Sci. 2021 Mar 10;274:119346.论著, IF3.647.

12. Siliang Chen, Dan Yang, Bao Liu, Lei Wang, Yuexin Chen, Wei Ye, Changwei Liu, Leng Ni, Xiaobo Zhang, Yuehong Zheng.Identification and validation of key genes mediating intracranial aneurysm rupture by weighted correlation network analysis. Ann Transl Med. 2020 Nov;8(21):1407. 论著IF 3.297.

13. Si Chen, Zhonghuang Xu, Hongju Liu, Yuelun Zhang, Jiao Zhang, Yuexin Chen, Yuehong Zheng, Yuguang Huang.Perioperative patient-controlled regional analgesia versus patient-controlled intravenous analgesia for patients with critical limb ischaemia: a study protocol for a randomised controlled trial. BMJ Open. 2020 Oct 8;10(10):e037879. 论著,IF 2.496.

14. Xu Zhang , Fangda Li , Wei Wang , Lei Ji , Bo Sun , Xue Xiao , Xiaoxiao Wang , Yuexin Chen , Bao Liu , Wei Ye , Cui Tian , Hongxia Wang , Yuehong Zheng.Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.Biochem Biophys Res Commun . 2020 Oct 2;S0006-291X(20)31829-5. 论著. IF 2.985.

15 Lei C, Yang D, Chen S, Chen W, Sun X, Wu X, Chen M, Li Y, Zheng Y.Patterns of immune infiltration in stable and raptured abdominal aortic aneurysms: A gene-expression-based retrospective study.Gene. 2020 Dec 15;762:145056.论著,IF 2.984.

16. Zhang H, Yang D, Chen S, Li F, Cui L, Liu Z, Shao J, Chen Y, Liu B, Zheng Y.Identification of potential proteases for abdominal aortic aneurysm by weighted gene coexpression network analysisGenome. 2020 Nov;63(11):561-575. 论著, IF 2.037.

17.Chen S, Yang D, Liu Z, Li F, Liu B, Chen Y, Ye W, Zheng Y.Crucial Gene Identification in Carotid Atherosclerosis Based on Peripheral Blood Mononuclear Cell (PBMC) Data by Weighted (Gene) Correlation Network Analysis (WGCNA).Med Sci Monit. 2020 Mar 11;26:e921692. 论著, IF 1.98.

18. Guangchao Gu, Jinping Liu , Yanze Lv , Hui Huang , Fangda Li, Mengyin Chen, Yuexin Chen, Jiang Shao, Bao Liu, Changwei Liu, Xiaodong Zhang , Yuehong Zheng Costoclavicular ligament as a novel cause of venous thoracic outlet syndrome: from anatomic study to clinical application"Surg Radiol Anat. 2020 Aug;42(8):865-870. 论著, IF 1.092.

19. Gu G, Wang Y, Liu B, Chen Y, Shao J, Li F, Wu X, Cui L, Lu X, Liu C, Guan H, Gao Z, Feng G, Zheng Y.Distinct features of malignant carotid body tumors and surgical techniques for challengeable lesions: a case series of 11 patients.2020Mar;277(3):853-861.论著,IF1.75.

20. Li FD, Nie H, Tian C, Wang HX, Sun BH, Ren HL, Zhang X, Liao PZ, Liu D, Li HH, Zheng YH.Ablation and Inhibition of the Immunoproteasome Catalytic Subunit LMP7 Attenuate Experimental Abdominal Aortic Aneurysm Formation in Mice.J Immunol4.718. 2019 Feb 15;202(4):1176-1185.论著, IF 4.718.

21, Yuan Li , Dan Yang , Bo Sun, Xu Zhang, Fangda Li, Zhili Liu, Yuehong Zheng Discovery of crucial aytokines associated with abdominal aortic aneurysm by protein array analysis. Exp Biol Med (Maywood). 2019 Dec;244(18):1648-1657.论著, IF3.005.

22. Chen S, Yang D, Lei C, Li Y, Sun X, Chen M, Wu X, Chen S, Yang D, Lei C, Li Y, Sun X, Chen M, Wu X, Zheng Y.Identification of crucial genes in abdominal aortic aneurysm by WGCNPeerJ .2019 Oct 8;7:e7873. 论著, IF2.353.

23.Gulidanna Shayan  Jiang Shao  Yuewei Wang  Loubin Si  Junyue Shen Yu Chen  Bao Liu  Yuehong ZhengManagement of cervical aortic arch complicated by multiple aneurysms.Interact Cardiovasc Thorac Surg. 2019 Mar 21;ivz087. 论著, IF 1.757.

24. Hao Nie· Hong‑Xia Wang· Cui Tian · Hua‑Liang Ren1 · Fang‑Da Li1 · Chao‑Yu Wang1 · Hui‑Hua Li3 · Yue‑Hong Zheng1Chemokine (C–X–C motif) receptor 2 blockade by SB265610 inhibited angiotensin II‑induced abdominal aortic aneurysm in Apo E−/− mice. Heart Vessels. 2019 May;34(5):875-882. 论著, IF2.185.

25. Liu D, Ren HL, Liu B, Shao J, Chen YX, Song XJ, Liu ZL, Chen Y, Li YJ, Liu CW, Zheng YH.Renal Function Preservation in Surgical Resection of Primary Inferior Vena Cava Leiomyosarcoma Involving the Renal Veins. Eur J Vasc Endovasc Surg. 2018 Feb;55(2):229-239.论著, IF3.642.

26.Fang-Da Li, Zhi-Gang Ji, Chang-Wei Liu, Jiang Shao, Yi Xie, and Yue-Hong ZhengOrthotopic renal autotransplantation for young-onset and medical treatment-requiring complex renovascular hypertension.J Renin Angiotensin Aldosterone Syst. Jul-Sep 2018;19(3):1470320318789861. 论著, IF1.197.

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28. Ren H, Li F, Tian C, Nie H, Wang L, Li HH, Zheng Y.Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E(-/-) Mice.Sci Rep. 2015 Oct 28;5:15730.论著, IF 5.578.

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1.     一种外科手术医疗器械  ZL 2018 2 1227879.3  实用新型专利

2.     一种手术显露装置          ZL 2018 2 1228298.6  实用新型专利

3.     一种药物球囊导管和球囊装置  ZL 2018 2 1243355.3  实用新型专利

4.     多功能手术示教系统      ZL 2018 2 1355426.9  实用新型专利

5.     顺血流导管          ZL 2018 2 1511358.0  实用新型专利

6.     生理盐水易开瓶盖          ZL 2018 2 1512828.5  实用新型专利

7.     高分子材料瓶盖  ZL 2018 2 1512871.1  实用新型专利

8.     腔内可控开孔导管          ZL 2018 2 1766678.0  实用新型专利

9.     反向分支的腹主动脉瘤覆膜支架          ZL 2018 2 1809201.6  实用新型专利

10.  血管腔内活检装置及活检系统  ZL 2019 2 0724559.7  实用新型专利

11.  手术信息采集与显示系统          ZL 2018 2 1355343.X  实用新型专利

12.  滤器回收装置      ZL 2019 2 0229936.X  实用新型专利

13.  下腔静脉滤器抓捕器      ZL 2019 2 0229937.4 实用新型专利

14.  多重防漏腹主动脉支架  ZL 2019 2 0229908.8  实用新型专利

15.  医用智能眼镜      ZL 2019 2 0840263.1 实用新型专利

16.  可变形支架          ZL 2019 2 0444408.6 实用新型专利

17.  可调硬度球囊      ZL 2019 2 0251411.6  实用新型专利

18.  用于血管介入手术的医疗装置  ZL 2019 2 0840259.5  实用新型专利

19.  可弯曲的吸引器头          ZL 2019 2 0730102.7  实用新型专利

20.  双功能外科辅助工具      ZL 2019 2 0730038.2  实用新型专利

21.  修复式血管支架  ZL 2019 2 0229880.8  实用新型专利

1.     复杂主动脉瘤的综合治疗与优化策略研究，省部级，2017，三等奖，中华医学科技奖 ，第四位      

2.     复杂主动脉瘤的优化综合治疗体系的建立，省部级，2017，二等奖，华夏医学科技奖 ，第四位      

3.     累及颈内动脉的头颈（颅底）病变外科技术体系，省部级，2017，三等奖，中华医学科技奖，第二位        

4.     累及颈内动脉的头颈（颅底）病变外科技术体系，省部级，2018，三等奖，华夏医学科技奖，第二位            

5.     协和胸腹主动脉瘤诊疗体系的建立和提升，院级，2018，二等奖，北京协和医院医疗成果奖，第一位

6.    协和胸腹主动脉瘤危重症杂交手术救治，院级，2019，三等奖，北京协和医院医疗成果奖，第一位