独立承担科研项目

1.   国家自然科学基金面上项目，81970621，通过基因敲除小鼠和斑马鱼模型探究ASK3缺失对血压昼夜节律和足细胞功能的影响

2.   中央高水平医院临床科研业务费资助项目，2022-PUMCH-B-020，血液净化治疗在疑难危重疾病中的应用研究

3.  国家自然科学基金青年项目，81100545，降低过度活跃的交感神经活性对 慢性肾脏病的时间生物学作用

4.  北京市科委，D131100004713007，慢性肾脏病早期诊断与进展评估模型的建立与验证

5.  新疆科技部，科技支疆项目，2017E0266，牙周微生物多样性及牙周干预对墨玉县维吾尔族人群高血压进程及预后的影响

6.  教育部，留学回国人员科研启动基金，限制性饮食对小鼠血压和肾脏生理昼夜节律 的重新调定

7.  北京协和医院青年基金，肾脏生物钟对血压昼夜节律和肾脏生理节律的调定

 临床注册研究（研究者发起）

a)  比较环孢素联合利妥昔单抗与利妥昔单抗单药治疗原发性膜性肾病有效性的开放性、多中心、随机对照研究（NCT04743739 2020-12）

b)  抗CD20单克隆抗体在原发性肾病综合征中维持缓解疗效的观察性队列研究

c)  ROXAKI罗沙司他减少冠脉搭桥术后急性肾损伤发生的随机、双盲、对照研究（NCT05010460 2021-8）

d)  超滤液吸附治疗轻链型多发性骨髓瘤急性肾损伤临床研究（2022-6 NCT05429515） 

参与项目

1.  国家科技支撑计划（科技部）：CKD并发症防治的关键技术2011BAI10B2，2012-1—2015-12

2.  国家科技支撑计划（教育部）：农村慢性病控制关键技术集成与应用示范研究2012BAJ18B03，2012-1—2015-12

3.  卫生部行业基金：前瞻性、随机、开放、对照、单中心临床研究评价低蛋白饮食结合复方α酮酸延缓慢性肾病进展的疗效2011-201

4.  北京市科委项目“优化、整合、推广适宜的CKD早期诊断方法”D09050704310901，2009-2012

5.  宁夏回族自治区科技部：CKD—MBD分期分级强化治疗的临床研究2018BFG02010，2018-2021

6.  国家重点研发计划项目（项目编号2020YFC0861000）重型及危重型新型冠状病毒肺炎标准化临床数据库建立及治疗方案真实世界研究

7.  中国医学科学研创新工程：基于人工智能和移动平台建立代谢性肾病高危风险预警管理模型及应用

发表论文节选:

1.   Xia P, Wen Y, Duan Y, Su H,Cao W, Xiao M, Ma J, Zhou Y, Chen G, Jiang W, Wu H, Hu Y, Xu S, Cai H, Liu Z,Zhou X, Du B, Wang J, Li T, Yan X, Chen L, Liang Z, Zhang S, Zhang C, Qin Y*,Wang G, Li X. Clinicopathological Features and Outcomes of Acute Kidney Injuryin Critically Ill COVID-19 with Prolonged Disease Course:A RetrospectiveCohort. J Am Soc Nephrol. 2020 Sep;31(9):2205-2221. (SCI IF 10.121)

2.  Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, Chen H, Ding X, ZhaoH,Zhang H, Wang C, Zhao J, Sun X, Tian R, Wu W, Wu D, Ma J, Chen Y, Zhang D,Xie J, Yan X, Zhou X, Liu Z, Wang J, Du B, Qin Y, Gao P, Qin X, Xu Y,Zhang W, Li T, Zhang F, Zhao Y, Li Y, Zhang S. Coagulopathy andAntiphospholipid Antibodies in Patients with Covid-19. N Engl J Med. 2020Apr 23;382(17): e38. (SCIIF 91.245)

3.   Xiao M, Zhang Y, Zhang S,Qin X, Xia P, Cao W, Jiang W, Chen H, Ding X, Zhao H, Zhang H, Wang C, Zhao J,Sun X, Tian R, Wu W, Wu D, Ma J, Chen Y, Zhang D, Xie J, Yan X, Zhou X, Liu Z,Wang J, Du B, Qin Y, Gao P, Lu M, Hou X, Wu X, Zhu H, Xu Y, Zhang W, LiT, Zhang F, Zhao Y, Li Y, Zhang S. Brief Report: Anti-phospholipid antibodiesin critically ill patients with Coronavirus Disease 2019(COVID-19). ArthritisRheumatol. 2020 Jun 30:10.1002/art.41425. (SCI IF10.995)

4.  Ai S, Liu J, Ma G, Ye W, Hu R, Zhang S, Fan X, Liu B,Miao Q, Qin Y, Li X.Endocarditis-associated rapidly progressive glomerulonephritis mimicking vasculitis: a diagnostic and treatment challenge. Ann Med. 2022 Dec;54(1):754-763.doi: 10.1080/07853890.2022.2046288.(SCI IF 5.348)

5.  Ai S, Liu X, Chen G, Zhang Y, Bai X, Qin Y, Miao Q, LiX. Characteristics and Diagnostic Challenge of Antineutrophil CytoplasmicAntibody Positive Infective Endocarditis. Am J Med. 2022 Nov;135(11):1371-1377.doi:10.1016/j.amjmed.2022.06.015. Epub 2022 Jul 9. PMID: 35820459. (SCI IF 5.928) 

6.   Ai S, Ma G, Liu J, Bai X,Hu R, Fan X, Miao Q, Qin Y*, Li X. Infective Endocarditis-AssociatedPurpura and Glomerulonephritis Mimicking IgA Vasculitis: A Diagnostic Pitfall.Am J Med. 2021 Dec;134(12):1539-1545.(SCI IF 5.928)

7.   Chen Z, Li J, Shi X, Wang Y, Xia P, Ye W, Ye W, Qin Y,Li H, Li M, Li X, Wen Y, Chen L. Clinicopathological characteristics andlong-term prognosis of monoclonal immunoglobulin light chain associated Fanconisyndrome. Ther Adv Hematol.2021 Jan 30;12:2040620720983127. (SCI IF 7.167)

8.   Yang L, Xia P, Zhou Y, Cui Q, Chen G, Zheng K, Qin Y,Li X. Characteristics and risk factors for Pneumocystis jirovecii pneumonia inpatients with idiopathic membranous nephropathy. Eur J Clin Microbiol InfectDis. 2021 Nov;40(11):2305-2314. (SCI IF 3.267)

9.   Liu Y, Xia P, Cao W, Liu Z,Ma J, Zheng K, Chen L, Li X, Qin Y*, Li X. Divergence between serumcreatine and cystatin C in estimating glomerular filtration rate of criticallyill COVID-19 patients. RenFail. 2021 Dec;43(1):1104-1114(SCI IF 2.606)

10.  Chen G, Ma J, Xia P, Hu Y,Liu Z, Zhou X, Li T, Yan X, Chen L, Li X, Qin Y*, Zhang S. Absorbingfilter AN69 surface treatment in critically ill COVID-19 patients: asingle-center experience. RenFail. 2021 Dec;43(1):1492-1495. (SCI IF 2.606)

11.  Ma J, Xia P, Zhou Y, Liu Z,Zhou X, Wang J, Li T, Yan X, Chen L, Zhang S, Qin Y*, Li X. Potentialeffect of blood purification therapy in reducing cytokine storm as a latecomplication of critically ill COVID-19. Clin Immunol. 2020 May;214:108408.(SCIIF 3.368)

12.  Chen G, Zhou Y, Ma J, XiaP, Qin Y*, Li X. Is there a role for blood purification therapiestargeting cytokine storm syndrome in critically severe COVID-19 patients? RenFail. 2020 Nov;42(1):483-488. (SCI IF 2.606)

13.  Chen P, Zhang R, Mou L, LiX, Qin Y*, Li X. An impaired hepatic clock system effects lipidmetabolism in rats with nephropathy. Int J Mol Med. 2018 Nov;42(5):2720-2736. (SCIIF 3.098)

14.  Liu Y, Zhang B, Ma J, WangH, Fan X, Zheng K, Chen L, Li X, Qin Y*, Li L, Li X. Double-filtrationplasmapheresis combined with immunosuppressive treatment for severe pemphigus:10 years' experience of asingle center in China. J Clin Apher. 2021 Feb;36(1):20-27(SCI IF 2.474)

15. Chen P, Yang Q, Li X, QinY*. Potential association between elevated serum human epididymis protein 4and renal fibrosis: A systemic review and meta-analysis. Medicine (Baltimore).2017 Sep;96(36): e7824. (SCI IF 1.552)

16. Fan S, Xiao M, Qin Y, LiT, Xu Y, Zhang D, Chen Y, Xie J, Li Y, Yan X,Zhu Y, Peng B, Cui L, Zhang S,Guan H. Neurological Manifestations in Critically Ill Patients With COVID-19: ARetrospective Study. Front Neurol. 2020 Jul 10;11:806. (SCI IF 2.889)

17. Zhou Y, Ren Q, Hu R,Zheng K, Qin Y, Li X. Does HIF-PHI increased risk of gastrointestinalhemorrhage in patients with renal anemia: a review of cases reported to theU.S. Food and drug administration adverse event reporting system. Ren Fail. 2021Dec;43(1):1170-1171. (SCI IF 2.606)

18. Chen G, Ning LJ, QinY, Zhao B, Mei D, Li XM. Acute kidney injury following the use of differentproton pump inhibitor regimens: A real-world analysis of post-marketingsurveillance data. JGastroenterol Hepatol. 2021 Jan;36(1):156-162.

19. Zhang W, Zhao Y, ZhangF, Wang Q, Li T, Liu Z, Wang J, Qin Y, Zhang X, Yan X, Zeng X, Zhang S.The use of anti-inflammatory drugs in the treatment of people with severecoronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologistsfrom China. Clin Immunol. 2020 May;214:108393. (SCI IF 3.368)

20. Chen G, Zhou Y, Xia J,Yao J, Zheng K, Qin Y, Li X. When the COVID-19 pandemic changed thefollow-up landscape of chronic kidney disease: a survey of real-worldnephrology practice. Ren Fail. 2020 Nov;42(1):733-739. (SCI IF 2.606)

21. Chen G, Qin Y,Fan QQ, Zhao B, Mei D, Li XM. Renal adverse effects following the use ofdifferent immune checkpoint inhibitor regimens: A real-worldpharmacoepidemiology study of post-marketing surveillance data. Cancer Med.2020 Jul 27. doi: 10.1002/cam4.3198. Epub ahead of print. PMID: 32720449.(SCI IF 3.491)

22.  Chen G, Ning LJ, Qin Y, Zhao B, Mei D, Li XM. Acute kidneyinjury following the use of different proton pump inhibitor regimens: Areal-world analysis of post-marketing surveillance data. J GastroenterolHepatol. 2020 Jun 15. doi: 10.1111/jgh.15151. Epub ahead of print. PMID:32542684.(SCI IF 2.005)

23.  Qian H, Gao P, TianR, Yang X, Guo F, Li T, Liu Z, Wang J, Zhou X, Qin Y,Chang L, Song Y,Yan X, Wu W, Zhang S. Myocardial Injury on Admission as a Risk in CriticallyIll COVID-19 Patients: A Retrospective in-ICU Study. J Cardiothorac VascAnesth. 2021 Mar;35(3):846-853. (SCI IF 2.628)

24.  Gao P, Wu W, Tian R,Yan X, Qian H, Guo F, Li T, Liu Z, Wang J, Zhou X, QinY, Zhao D, Bian X,Lin X, Zhang S. Association between tachyarrhythmia and mortality in a cohortof critically ill patients with coronavirus disease 2019(COVID-19). Ann TranslMed. (SCIIF 3.932)

25.  Ding X, Chen H, ZhaoH, Zhang H, He H, Cheng W, Wang C, Jiang W, Ma J, Qin Y，Liu Z, Wang J,Yan X, Li T, Zhou X, Long Y, Zhang S. ECCO2R in 12 COVID-19 ARDS Patients WithExtremely Low Compliance and Refractory Hypercapnia.Front Med (Lausanne). 2021Jul 8;8:654658. (SCI IF 5.091)

26. Tian R, Wu W, Wang C, Pang H, Zhang Z, Xu H, Luo Q,Gao P, Shi J, Li W, Qian H, Guo F, Li T, Liu Z, Wang J, Zhou X, Qin Y,Yan X, Zhang S. Clinical characteristics and survival analysis in critical andnon-critical patients with COVID-19 in Wuhan, China: a single-centerretrospective case control study. Sci Rep. 2020 Oct 16;10(1):17524. (SCI IF 4.379)

27. Isenberg JS, Qin Y（共同第一作者）, Maxhimer JB, Sipes JM, Despres D,Schnermann J, Frazier WA, Roberts DD. Thrombospondin-1 and CD47 regulate bloodpressure and cardiac responses to vasoactive stress. Matrix Biol.2009;28(2):110-9. (SCI IF 3.558)

28.  Liu LL, Qin Y, Cai JF, Wang HY, Tao JL, Li H, Chen LM, Li MX, Li XM, Li XW.Th17/Treg imbalance in adult patients with minimal change nephrotic syndrome.Clin Immunol. 2011;139(3):314-20. (SCIIF 3.932)

29.  Asada L, Qin Yan, Xuzhen Hu, Christoph E, Yuning Huang, Richard Chen, DianeMizel, Hua Zhou, Elizabeth CW, Jeffrey BK, J Schnermann, Peter Yuen and RobertA Star. Angiotensin II overcomes strain-dependent resistance of rapid CKDprogression in a new remnant kidney mouse model. Kidney International2010;78(11):1136-53 (SCI IF 6.193)

30.  Bauer EM, Qin Yan, Miller TW, Bandle RW, Csanyi G, Pagano PJ, Bauer PM,Schnermann J, Roberts DD, Isenberg JS. Thrombospondin-1 supports blood pressureby limiting eNOS activation and endothelialdependent vasorelaxation.Cardiovasc Res. 2010;88 (3): 471-481. (SCI IF 5.801)

31.  Oppermann M, Qin Y, Lai EY, Eisner C, Li L, Huang Y, Mizel D, Fryc J, Wilcox CS,Briggs J, Schnermann J, Castrop H. Enhanced tubuloglomerular feedback in micewith vascular overexpression of A1 adenosine receptors. Am J Physiol Renal Physiol.2009; 297(5): F1256-64. (SCI IF 3.89)

32.  Therrien JP, Kim SM, Terunuma A, Qin Yan, Tock CL, Pfützner W, OhyamaM, Schnermann J, Vogel JC. A gene therapy approach for long-term normalizationof blood pressure in hypertensive mice by ANP-secreting human skin grafts. ProcNatl Acad Sci U S A. 2010; 107(3):1178-83. （SCI IF 9.38）

33.  Kim SM, Theilig F, Qin Y, Cai T, Mizel D, Faulhaber-Walter R, Hirai H, Bachmann S,Briggs JP, Notkins AL, Schnermann J. Dense-core vesicle proteins IA-2 andIA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergicpathway. Am J Physiol Renal Physiol. 2009; 296(2):F382-9. (SCI IF 3.89)

34.  Kim SM, Huang Y, Qin Y, Mizel D, Schnermann J, Briggs JP. Persistence of circadianvariation in arterial blood pressure in beta1/beta2-adrenergicreceptor-deficient mice. Am J Physiol Regul Integr Comp Physiol.2008;294(5):R1427-34. (SCI IF 3.272)

35. Doi K,Asada L, Hu X, Sidransky KL, Qin Y,Eisner C, Schnermann J, Yuen PS, Star RA. Pre-existing renal disease promotessepsis-induced acute kidney injury and worsens outcome. Kidney Int.2008;74(8):1017-25. (SCI IF 6.41)

36. Chen G, Hu R, Wang Y,Zhao X, Xia J, Qin Y, Chen L, Li X. Recommendation from Peking Union MedicalCollege Hospital for urgent hemodialysis during the COVID-19 pandemic.Int Urol Nephrol. 2020 Jun 8:1–2.

37. Shi X, Chen Z, Wang J,Wen Y, Zou L, Fei Y, Ye W, Qin Y, Li H, Li M, Li X, Zhang F, Li X, Chen L.Primary Sjӧgren's syndrome with renal Fanconi syndrome: Good responsesto treatment with glucocorticoids. Semin Arthritis Rheum. 2020:S0049-0172(20)30093-7.

38. Chen G, Zhou Y, Zhang L,Wang Y, Hu RR, Zhao X, Song D, Xia JH, Qin Y, Chen LM, Li XM. Coreprinciples for infection prevention in hemodialysis centers during the COVID-19pandemic. Infect Control Hosp Epidemiol. 2020 Apr 6:1-2.

39. Xia P, Zhang L, Zou M,Zhang T, Li R, Shi X, Wang J, Qin Y, Li X, Li J, Chen L. Acute KidneyInjury Caused by TAFRO Syndrome in a Chinese Patient: Efficacy of Long-TermCorticosteroids Combined with Bortezomib and Cyclophosphamide. KidneyBlood Press Res. 2020;45(4):623-630.

40. Ye W, Zhuang J, Yu Y, LiH, Leng X, Qian J, Qin Y, Chen L, Li XM. Gender and chronic kidney disease inankylosing spondylitis: a single-center retrospectively study. BMCNephrol. 2019 Dec 9;20(1):457.

41. Ye W, Shu H, Wen Y, YeW, Li H, Qin Y, Chen L, Li X. Renal histopathology of prolonged acute kidneyinjury in HELLP syndrome: a case series and literature review. Int UrolNephrol. 2019;51(6):987-994.

42. Wang Y, Qin Y, Fan X,Cai J, Ye W, Xia J, Li M, Li X, Li X, Chen L. Variability in PredialysisSystolic Blood Pressure and Long-Term Outcomes in Hemodialysis Patients.Kidney Blood Press Res. 2018;43(1):115-124.

43. Jiang L, Peng X, Ma J,Yuan T, Qin Y, Wang O, Wang H, Wang Y, Chen G, Yue C, Li C, Nie M, Xing X, LiX, Lee X, Chen L. NORMOMAGNESEMIC GITELMAN SYNDROME PATIENTS EXHIBIT A STRONGERREACTION TO THIAZIDE THAN HYPOMAGNESEMIC PATIENTS.Endocr Pract.2015 Sep;21(9):1017-25.

44. Guo X, Qin Y, Zheng K,Gong M, Wu J, Shou W, Cheng X, Xia L, Xu E, Li X, QiuL. Improved glomerularfiltration rate estimation using new equations combinedwith standardizedcystatin C and creatinine in Chinese adult chronic kidney disease patients. ClinBiochem. 2014 Sep;47(13-14):1220-6.

45.    Jiang L, Chen C, Yuan T,Qin Y, Hu M, Li X, Xing X, Lee X, Nie M, Chen L.Clinical severity of Gitelmansyndrome determined by serum magnesium. Am J Nephrol.2014;39(4):357-66.

46. 陈沛沛; 牟利军; 张瑞雨; 李雪梅; 李学旺;秦岩*, 肾病大鼠血压昼夜节律紊乱伴随心脏局部生物钟系统破坏,中华肾脏病杂志, 33(5), 363-369,2017

47. 陈沛沛; 秦岩*; 李雪梅, 血小板反应蛋白1在肾脏疾病中的研究进展, 中华肾脏病杂志, 32(1),68-69, 2016

48. 陈沛沛; 秦岩*; 李雪梅, 尿外泌体在肾脏疾病的研究进展,中国医学科学院学报,38(4), 464-469, 2016

49. 王宝宝，武元，付强，弓孟春，石希敏，景红丽，李方，陈朝英，宋红梅，秦岩*，李雪梅。高效液相色谱法测定血清碘海醇浓度方法的建立和应用。基础医学与临床，2015(7)：963-967

50. 张瑞雨，牟利军，李雪梅，李学旺，秦岩*。肾脏局部生物钟系统与水盐排泄昼夜节律的时相一致性。中国医学科学院学报，2015，37（6）：698-704

专利：

1.  实用新型专利：新型透析器置换膜加热外套，专利号：ZL202220844764.9 发明人：李蕾 秦岩 陈丽萌 夏京华 授权日2022-8-23

2.  发明专利：一种肾小球肾炎的免疫荧光分类方法及装置，专利号ZL202011101137.8，发明人：陈丽萌；文煜冰；夏鹏；任菲；吕智龙；李雪梅；秦岩；授权日：2021-11-5

3.  实用新型专利：用于辅助记忆慢性肾脏病分期中降糖药使用规则的教具，专利号：ZL202120651567.X，发明人：陈罡；李雪梅；秦岩；陈丽萌；周央中。授权日：2021-11-16

4.  实用新型专利：妊娠期安全用药规则记忆教具，专利号：ZL202120651659.9 发明人：陈罡；李雪梅；秦岩；陈丽萌；周央中 授权日：2021-11-9

 获奖:

1.  2016年四川省科学技术进步奖三等奖：新型肾病早期监测试剂盒的研发和应用研究

2.  2015年欧洲肾脏病年会：优秀口头报告奖 Travel grant获得者

3.  2017年欧洲肾脏病年会：优秀口头报告奖 Travel grant获得者

4.  2019年国际血液分离学会年会：获得优秀口头报告奖

5.  2020年、2022年北京协和医院院级优秀教师

6.  2021年国家卫生健康委直属机关巾帼建功标兵