目前主要成员： 

韩冰：博士、教授、博士生导师 

陈苗：博士、副教授、硕士生导师 

杨辰：博士、主治医师

研究生团队

基金资助情况：

2020：中国医学科学院中央级公益性科研院所基本科研业务费专项（2019XK320047）

2018：北京市自然科学基金，项目编号：7192168

2016：中国医学科学院医学与健康科技创新工程，项目编号：2016-12M-3-004 

在研课题：

2020：中国医学科学院中央级公益性科研院所基本科研业务费专项（2019XK320047）

2018：北京市自然科学基金，项目编号：7192168

2016：中国医学科学院医学与健康科技创新工程，项目编号：2016-12M-3-004

目前重点研究：

再生障碍性贫血，

骨髓增生异常综合症

阵发性睡眠性血红蛋白尿症

纯红再生障碍

发表文章：

1. Long Z, Li H, Du Y, Chen M, Zhuang J, Han B. Gene mutation profile in patients with acquired pure red cell aplasia. Ann Hematol. 2020 Jun 27.

2. Chen Z, Chen M, Yang C, Han B.Immunosuppression therapy is effective for both acquired tumor-associated and primary pure red cell aplasia: a match pair case-control study. Ann Hematol. 2020 Jul;99(7):1485-1491.

3. Chen M, Zhuang J, Yang C, Zhang L, Wang W, Cai H, Yu Y, Li J, Zhou D, Han B. Rapid response to a single-dose rituximab combined with bortezomib in refractory and relapsed warm autoimmune hemolytic anemia. Ann Hematol. 2020 May;99(5):1141-1143.

4. 张若曦，李红敏，伍洁，韩冰.检验血液参数在常见小细胞性贫血患者诊断鉴别的意义. 基础医学与临床. 2020 Jan.(40)1.105-109.

5. Jiang Ji , Miao Chen, Bing Han. Comparison of Hypomethylator Monotherapy With Hypomethylator Plus Chemotherapy for Intermediate/High-Risk MDS or AML: A Meta-Analysis. J Cancer 2020 Mar 4;11(10):2972-2980.

6. Chen Z, Liu X, Chen M, Yang C, Han B. Successful sirolimus treatment of patients with pure red cell aplasia complicated with renal insufficiency.Ann Hematol. 2020 Apr;99(4):737-741.

7. 韩冰. 我怎样治疗纯红再生障碍.中华血液学杂志. 2020 (1) 14;41(1):5-9.

8. 李红敏，张若曦，龙章彪，杜亚丽，陈苗，庄俊玲，邱正庆，韩冰. 酶替代治疗后22例I型戈谢病患者生活质量调查.中华血液学杂志.2020 Apr 14;41(4):287-29.

9. Geng C, Liu X, Chen M, Yang C1, Han B.Comparison of frontline treatment with intensive immunosuppression therapy and HLA-haploidentical hematopoietic stem cell transplantation for young patients with severe aplastic anemia - A meta analysis.Leuk Res. 2020 Jan;88:106266.

10. Huang Y, Liu X, Chen F, Zhou W, Li H, Long Z, Yang C, Chen M, Han B. Prediction of thrombosis risk in patients with paroxysmal nocturnal hemoglobinuria.Ann Hematol. 2019 Oct;98(10):2283-2291.

11. Yang Z, Cui Q, Zhou W, Qiu L, Han B.Comparison of gene mutation spectrum of thalassemia in different regions of China and Southeast Asia.Mol Genet Genomic Med. 2019 Apr 9:e680.

12. Yang Z, Zhou W, Cui Q, Qiu L, Han B. Gene spectrum analysis of thalassemia for people residing in northern China. BMC Med Genet. 2019 May 22;20(1):86.

13. 高学慧，崔雀玄，张强兴，程歆琦，鲁军，邱玲，韩冰.健康查体人群内因子抗体阳性率和血清维生素B12缺乏率调查. 中华血液学杂志. 2018 Nov 14;39(11):917-920.

14. 杨辰，龙章彪，张炎，朱铁楠，韩冰.阵发性睡眠性血红蛋白尿症合并爆发性紫癜一例并文献复习. 中华血液学杂志，2018 Nov 14;39(11):921-926.

15. 李红敏，龙章彪，韩冰.铁稳态和铁相关性疾病.中华血液学杂志，2018，（9）14;39(9):790-792.

16. Long Z, Yu F, Du Y, Li H, Chen M, Zhuang J, Han B. Successful treatment of refractory/relapsed acquired pure red cell aplasia with sirolimus. Ann Hematol. Ann Hematol. 2018 Nov;97(11):2047-2054.

17. Long Z, Li H, Du Y, Han B.Congenital sideroblastic anemia: Advances in gene mutations and pathophysiology. Gene. 2018 Aug 20;668:182-189.

18. 陈苗, 庄俊玲, 段明辉, 张薇,李剑, 朱铁楠, 蔡华聪,曹欣欣,冯俊, 杨辰, 张炎, 张路, 周道斌, 韩冰.泊沙康唑初级预防重型再生障碍性贫血真菌感染的研究. 中华血液学杂志. 2018 Feb 14;39(2):128-131.

19. 杨辰，陈芳菲，龙章彪，杜亚丽，李红敏，陈苗，韩冰.西罗莫司对K562细胞及纯红再生障碍性贫血患者细胞体外生长的研究. 中华血液学杂志.2018 Apr 14;39(4):310-313.

20. Long Z, Du Y, Li H, Han B.CR1 gene polymorphisms in Chinese patients with paroxysmal nocturnal hemoglobinuria. Gene. 2018 Jun 15;659:149-154.

21. Chen M, Ding C, Lu T, Niu N, Han B.Langerhans cell histiocytosis and Erdheim-Chester disease overlap syndrome with bone marrow involvement and type 2 diabetes mellitus. Ann Hematol. 2018 Jan;97(1):189-192.

22. Chen M, Liu C, Qiao X, Zhou D, Zhuang J, Han B.Comparative study of porcine anti-human lymphocyte immunoglobulin and rabbit anti-human thymocyte immunoglobulin as a first-line treatment of acquired severe aplastic anemia. Leuk Res. 2018 Jan 2;65:55-60.Long Z, Du Y, Li H, Han B.Polymorphism of the ABO gene associate with thrombosis risk in patients with paroxysmal nocturnal hemoglobinuria. Oncotarget. 2017 Sep 28;8(54):92411-92419.

23. Li H, Wang L, Wu Y, Su L, Zhao H, Zhang Y, Wang Z, Huang D, Huang Z, Wu X, Li X, Ye F, Yu F, Liu H, Wang JW, Cong J, Sun W, Chen HR, Wang J, Han B. Very-Low-Dose Decitabine Is Effective in Treating Intermediate- or High-Risk Myelodysplastic Syndrome. Acta Haematol. 2017 Oct 19;138(3):168-174.

24. Du Y, Long Z, Chen M, Han B, Hou B, Feng F. Observational Monitoring of Patients with Aplastic Anemia and Low/Intermediate-1 Risk of Myelodysplastic Syndromes Complicated with Iron Overload. Acta Haematol. 2017;138(2):119-128.

25. 龙章彪，杜亚丽，韩冰.获得性铁粒幼细胞性贫血的研究进展.中华血液学杂志.2017 Jan 14;38(1):83-86.

26. 龙章彪，杜亚丽，韩冰. 先天性铁粒幼细胞性贫血的基因突变和发病机制研究进展.中华血液学杂志.2016 Dec 14;37(12):1090-1093.

27. Chen M, Zhuang J, Zhou D, Xu Y, Zhao Y, Wang S, Zhang W, Duan M, Zhu T, Li J, Cai H, Cao X, Han B. Outcome of anti-thymocyte immunoglobulin plus cyclosporine A for severe aplastic anaemia with chronic hepatitis B virus infection. Ann Hematol. 2017 Apr;96(4):581-587.

28. Yongwei Wang, Yali Du, Gang Liu, Shanshan Guo, Na Yang, Bo Hou, Xianyong Jiang ,Bing Han, Yanzhong Chang, Guangjun Nie: Contiguous gene deletion in HFE2 region (1q21.1) and pathogenic HFE2 mutations in a Chinese hereditary hemochromatosis patient. Gene Reports 2016:167-170.

29. Wang Y, Du Y, Liu G, Guo S, Hou B, Jiang X, Han B, Chang Y, Nie G. Identification of novel mutations in HFE, HFE2, TfR2, and SLC40A1 genes in Chinese patients affected by hereditary hemochromatosis. Int J Hematol. 2017 Apr;105(4):521-525.

30. Long ZB, Wang YW, Yang C, Liu G, Du YL, Nie GJ, Chang YZ, Han B. Identification of FECH gene multiple variations in two Chinese patients with erythropoietic protoporphyria and a review. J Zhejiang Univ Sci B. 2016 Oct;17(10):813-820.

31. 杜亚丽，龙章彪，韩冰：阵发性睡眠性血红蛋白尿症与血栓发生的研究进展；基础医学与临床.2017;37:128-132.

32. Du Y, Zhang Q, Han B. Genetic variants of C5 and polymorphisms of C3 in Chinese patients with paroxysmal nocturnal hemoglobinuria. Int J Lab Hematol. 2016 Aug;38(4):e84-85.

33. 杜亚丽，龙章彪，庄俊玲，谢海雁，韩冰.阵发性睡眠性血红蛋白尿症血栓的初步研究.中华血液学杂志. 2016 Apr;37(4):318-323.

34. Yu F, Du Y, Han B. A comparative analysis of clinical characteristics of patients with paroxysmal nocturnal hemoglobinuria between Asia and Europe/America. Int J Hematol. 2016 Jun;103(6):649-654.

35. Chen M, Liu C, Zhuang J, Zou N, Xu Y, Zhang W, Li J, Duan M, Zhu T, Cai H, Cao X, Wang S, Zhou D, Han B. Long-term follow-up study of porcine anti-human thymocyte immunoglobulin therapy combined with cyclosporine for severe aplastic anemia. Eur J Haematol. 2016 Mar;96(3):291-296.

36. 张倩，侯波，王璐，杜亚丽，韩冰，冯逢. MRI在铁过载诊断及监测中的意义.中华血液学杂志. 2015 Apr;36(4):302-306. 

37. Liu G, Guo S, Anderson GJ, Camaschella C, Han B*, Nie G. Heterozygous missense mutations in the GLRX5 gene cause sideroblastic anemia in a Chinese patient. Blood. 2014 Oct 23;124(17):2750-2751.

38. 王璐，杨辰，张倩，韩冰*， 庄俊玲，陈苗，邹农，李剑，段明辉，张薇，朱铁楠，许莹，王书杰，周道斌，赵永强，王鹏，徐英春.2010-2012年北京协和医院非骨髓移植血液病房致病细菌的流行病学调查.中国医学科学院学报. 2014 Aug;36(4):439-445.

39. Liu G, Yang F, Han B*, Liu J, Nie G. Identification of four SLC19A2 mutations in four Chinese thiamine responsive megaloblastic anemia patients without diabetes. Blood Cells Mol Dis. 2014 Apr;52(4):203-204.

40. 王璐，张倩，韩冰*， 庄俊玲，陈苗，邹农，李剑，段明辉，张薇，朱铁楠，许莹，王书杰，周道斌，赵永强，王鹏，徐英春.2010-2012年血液病房鲍曼不动杆菌感染的单中心研究. 中华血液学杂志, 2014 Mar;35(3):239-241.

41. Guo S, Wang L, Li X, Nie G, Li M, Han B*.Identification of a novel UROS mutation in a Chinese patient affected by congenital erythropoietic porphyria.Blood Cells Mol Dis. Blood Cells Mol Dis. 2014 Jan;52(1):57-58.

42. Liu G, Guo S, Kang H, Zhang F, Hu Y, Wang L, Li M, Ru Y, Camaschella C, Han B*, Nie G. Mutation spectrum in Chinese patients affected by congenital sideroblastic anemia and a search for a genotype-phenotype relationship.Haematologica. 2013 Dec;98(12):e158-160.

43. 张倩，侯波，王璐，冯逢，江滨，石红霞，马一盖，刘辉，韩冰*，赵永强. 磁共振成像技术定量检测铁过载的临床意义.中华医学杂志.2013，Nov ；93（44）：3506-3509.

44. Yan S, Han B*, Li H, Wu Y, Zhou D, Zhao Y Telomerase gene screening and telomere overhang detection in Chinese patients with myelodysplastic syndrome.Leuk Res. 2013 Oct;37(10):1359-1362.

45. Yan S, Han B, Wu Y, Zhou D, Zhao Y. Telomerase gene mutation screening and telomere overhang detection in Chinese patients with acute myeloid leukemia. Leuk Lymphoma. 2013 Jul;54(7):1437-1441.

46. 邹农，韩冰*，蔡昊，许莹，汪玄，李蓉生，沈悌. 阵发性睡眠性血红蛋白尿症76例临床分析.中华血液学杂志，2012,33(6):471-474.

47. Liu G, Niu S, Dong A, Cai H, Anderson GJ, Han B*, Nie G.A Chinese family carrying novel mutations in SEC23B and HFE2, the genes responsible for congenital dyserythropoietic anaemia II (CDA II) and primary iron overload, respectively. British Journal of Haematol. 2012，158，138-152.

48. 韩冰，严思益，邹农，张薇，李剑，段明辉，焦力，庄俊玲，王书杰，周道斌，朱铁楠，许莹，赵永强，沈悌. 猪抗淋巴细胞免疫球蛋白治疗重型再生障碍性贫血.中华血液学杂志，2011 Apr;32(4):241-244.

49. Ming Yang, Feng-Dan Wang, Bing Han*, Shu-Jie Wang, Dao-Bin Zhou, Hui Pan, Yong-Qiang Zhao, Quan-Cai Cui, Li Ma, Wee-Joo Chng, Ti Shen. Castleman’s Disease Presenting as Prolonged Anemia and Growth Retardation: A Case Report and Literature Review. Acta Haematol 2011;125:125-129. 

50. Han Bing, Yan Siyi, Zhang Wei, Li Jian, Duan Minghui, Jiao Li, Wang Shujie, Zhou Daobin, Zou Nong, Zhu Tienan, Xu Ying, Zhao Yongqiang, Shen Ti. The use of anti-human T lymphocyte porcine immunoglobulin and cyclosporine A to treat patients with acquired severe aplastic anemia. Acta Haematol 2010;124:245-250.

51. Xiao J, Han B*, Wu YJ, Zhong YP, Sun WL. Ex vivo expansion and long-term hematopoietic reconstitution ability of sorted CD34+CD59+ cells from patients with paroxysmal nocturnal hemoglobinuria. Int J Hematol. 2010 Jul;92 (1):58-67.

52. Han B, Liu B, Cui W, Wang X, Lin J, Zhao Y. Telomerase gene mutation screening in Chinese patients with aplastic anemia. Leuk Res. 2010 Feb;34(2):258-260.

主编的专著

1. 崔巍，韩冰；《血液系统疾病的实验室诊断》，北京科学技术出版社，主编，453千字，2014-9.

2. 韩冰，甘佳；《协和实用输血手册》，科学出版社，主编，68千字，2016-12

3. 张凤奎，韩冰：《红细胞疑难病例荟萃》，主编，科学技术文献出版社，214千字，2020.5.

学术奖励

1. 韩冰（2/8）；基于流式细胞术的细胞表型和分子表型的临床系列应用研究，中华医学会，中华医学科技奖，三等奖，2014（崔巍、韩冰、张之南、郭野、黄春梅、陈倩、刘定华、王斐）.