承担了参与了国家“十三五”、“十二五”“863”、“国家自然科学基金”和“卫生部临床学科重点项目”等二十余项国家和省部级课题。曾获得“中华医学科技奖三等奖”和“北京市科技进步二等奖”等多项国家省部级科研成果奖。

部分课题：

1.       《老年人颈部动脉迂曲系统性观测及其与脑卒中相关性的研究》中国医学科学院基本科研业务 （2019.1-2019.12）

2.       《数字化脑血管流储备功能诊断评估技术及其应用研究》科学技术部（2016.7-2021.7）

3.       《复合手术治疗多种危险因素并存的复杂性脑血管病的临床研究》北京市科技计划项目（D161100003816005）（2016-2019）

4.       《缺血性脑血管病和脑肿瘤防治关键技术研究》国家科技支撑计划（2015BAI12B04）（2015-1018）

5.       《颈动脉和椎动脉伸长扭曲的血流动力学研究》国家自然科学基金项目（0571915）（2006-2008）

6.       《支架置入技术治疗脑血管病的临床应用研究》卫生部临床学科重点项目（卫规财发[2001]321）（2001-2004）

7.       《脑动静脉畸形供血动脉内压力的测算与出血的临床研究》教育部“留学回国人员科研启动基金”课题（教外司留[2001]498）（2001-2003）

8.       《神经外科学(介入神经放射学)》首都医学发展科研基金项目（首都ZD199802）（2000-2003）

国内首先报告了脑动静脉畸形动物模型的建立和栓塞研究，中国最早获得GDC（电解可脱式弹簧圈）栓塞治疗动脉瘤资格证书的三人之一、在国内首先报告了GDC栓塞治疗颅内动脉瘤、世界上首次报告颅内动脉瘤栓塞标准的专题研究，提出了动脉瘤栓塞标准的建议；首次明确提出并发表了动脉瘤的过度栓塞、世界上首次报告了脉动血流的脑动静脉畸形血液动力学理论模型与临床应用研究、国内首先开展支架置入术治疗颅内动脉粥样硬化性狭窄、国内首先应用脑保护装置(Angioguard和FilterWire)进行颈动脉和椎动脉狭窄的血管内扩张和支架置入术。国外率先开展的工作还包括，颈部动脉扭曲的血流动力学动物模型、体外实验和临床实测研究及其介入治疗、颅内微小动脉瘤的介入治疗、超宽颈或梭形动脉瘤的支架内球囊再塑形栓塞治疗、颅内外动脉狭窄伴颅内动脉瘤的介入治疗、支架成形术治疗颈动脉扭曲伴狭窄等工作。

近五年发表文章：

1.     Association between thrombus density and reperfusion outcomes using different thrombectomy strategies: a single-center study and meta-analysis.Frontiers in Neurology 2019 ;10:843

2.     CT-based Higher Thrombus Density is associated with Secondary Embolism during Mechanical Thrombectomy: A Preliminary Observation    Journal of Stroke & Cerebrovascular Diseases 2019 Oct ;28(10):104311                

3.     A Novel Rat Model for Comprehensive Microvascular Training of End-to-End, End-to-Side, and Side-to-Side Anastomoses. journal of reconstructive microsurgery,2019 Sep ;35(7):499-504

4.     Relationship between cerebrovascular atherosclerotic stenosis and rupture risk of unruptured intracranial aneurysm: A single-center retrospective study Clinical Neurology and Neurosurgery, 2019 Aug ;11(8):740-746

5.     Letter to the Editor Regarding "Endovascular Mechanical Thrombectomy in Large-Vessel Occlusion Ischemic Stroke Presenting with Low National Institutes of Health Stroke Scale: Systematic Review and Meta-Analysis".      World Neurosurg. 2019 Jan 22. pii: S1878-8750(19)30120-2

6.     Firstline a direct aspiration first pass technique versus firstline stent retriever for acute basilar artery occlusion: a systematic review and meta-analysis.  J Neurointerv Surg. 2019 Jan 28. pii: neurintsurg-2018-014573 3.524

7.     Efficacy and safety of drug-eluting stent for the intracranial atherosclerotic disease: a systematic review and meta-analysis J Clin Neurosci. 2019 Jan; 59: 112-118  1.640

8.     Antiplatelet agents in acute stroke and TIA (Letter to the Editor)    N Engl J Med. 2018 Oct; 379(17): e29 79.258

9.     Five-year risk of stroke after TIA or minor ischemic stroke (Letter to the Editor)   N Engl J Med. 2018 Oct; 379(16): 1579-1580   79.258

10.   Middle cerebral artery tortuosity associated with aneurysm development (Letter to the Editor) J Neurosurg. 2018 Sep; 1: 1-2    4.318

11.   A clinical study and meta-analysis of carotid stenosis with coexistent intracranial aneurysm      J Clin Neurosci. 2018 Jun; 52: 41-49

12.   Rupture risk of cerebral arteriovenous malformations during pregnancy and puerperium: a single-center experience and pooled data analysis(Letter to the Editor)     World Neurosurg. 2018 Jun; 114: 432-433

13.   Extracranial internal carotid artery tortuosity and body mass index Front Neurol. 2017 Sep; 

14.   Increased levels of soluble cluster of differentiation 40 ligand, matrix metalloproteinase 9, and matrix metalloproteinase 2 are associated with carotid plaque vulnerability in patients with ischemic cerebrovascular disease       World Neurosurg. 2017 Sep; 105: 709-713

15.   Spinal cord ischemia and spontaneous epidural hematoma caused by spinal epidural arteriovenous malformation: a warning    Am J Emerg Med. 2017 Mar; 35(3): 519. e5-519.e9

16.   Hypothermia for convulsive status epilepticus (Letter to the Editor)       N Engl J Med. 2017 Mar; 376(11): 1094-1095

17.   Is carotid revascularization safe for patients with concomitant carotid stenosis and intracranial aneurysms (Letter to the Editor)  World Neurosurg. 2017 Mar; 99: 792-793

18.   Blood flow into basilar tip aneurysms: a predictor for recanalization after coil embolization (Letter to the Editor)   Stroke. 2017 Feb; 48(2): e76

19.   Craniectomy for traumatic intracranial hypertension (Letter to the Editor)    N Engl J Med. 2016 Dec; 375(24): 2401-2404   

20.   Balloon-in-stent assisted coiling for treatment of intracranial overwide and undertall aneurysms     J Clin Neurosci. 2016 Dec; 34: 202–206

21.   Pressure drop in tortuosity/kinking of the internal carotid artery: simulation and clinical investigation     Biomed Res Int, 2016; 2016: 2428970

22.   高龄急性缺血性卒中患者机械再通治疗不良预后的原因分析,中华老年医学杂志

23.   80岁及以上患者行颈动脉支架置入术的临床观察与随访,中华老年医学杂志

24.   大鼠腹主动脉-髂总动脉用于神经外科显微血管吻合术的综合训练      中国脑血管病杂志，2018, 15(2): 77-82

25.   椎动脉颅内段破裂与未破裂梭形动脉瘤的血管内重建治疗    中国脑血管病杂志, 2018, 15(5): 231-235

26.   单纯小球囊血管成形术治疗症状性颅内动脉粥样硬化性狭窄复杂病变的近期疗效分析    中华外科杂志. 2018, 56(6): 458-463

27.   大型与巨大型后循环梭形动脉瘤的血管内重建治疗 中华神经外科杂志. 2018, 34(6): 576-580

28.   颈动脉迂曲与颈动脉粥样硬化性狭窄的相关性研究 中华外科杂志. 2017, 55(8): 608-612

29.   曲克芦丁脑蛋白水解物治疗颅脑创伤的多中心随机对照临床研究 中华神经外科杂志. 2017, 33(7): 669-672

30.   颈动脉迂曲与年龄、性别及颈动脉粥样硬化的相关性    中华老年医学杂志. 2017, 36(5): 528-532

31.   70岁及以上椎动脉狭窄患者介入治疗的随访观察   中华老年医学杂志, 2016, 35(7): 753-755

32.   Advances in endovascular therapy for ischemic cerebrovascular diseases     慢性疾病与转化医学（英文）, 2016, 2(3): 135-139页

33.   血管内治疗颅内微小动脉瘤的研究进展    中华神经外科杂志, 2016, 32(1): 100-103

34.   神经介入新进展略览:希望与问题并存 中华外科杂志, 2016, 54(5): 328-331

35.   血管内多支架套叠伴或不伴弹簧圈栓塞重建治疗椎基底动脉梭形动脉瘤    中华外科杂志, 2016, 54(5): 363-366