已完成数种原小檗碱型生物碱、苯菲啶生物碱等天然产物等的合成与结构修饰，并进一步开展有关活性化合物的研究。课题组已合成各种先导化合物类似物500多个。承担和参与的科研课题有18项，包括承担国家创新药物重大专项、国家自然科学基金面上项目，参加国家自然科学基金重点项目和国家自然科学基金国际合作项目。

1、Jing Li, Hai-Jing Zhang, An-Jun Deng, Zhi-Hong Li, Ya-Ling Xing,* Lian-Qiu Wu,* and Hai-Lin

. Syntheses and Structure-Activity Relationships in Antibacterial Activity against Clostridium difficile and XBP1 Activation Property of 13-[(N-Alkylamino)methyl]-8-oxodihydrocoptisines, Chemistry  Biodiversity, 2020, 17(7): e2000265

2. Qian Li, An-Jun Deng, Ming Ji, Zhi-Hong Li, Xiao-Guang Chen, Hai-Lin Qin. Racemic 3,4-dihydro-4-naphthyl-naphthalen-1(2H)-ones from Juglans regia flowers, Fitoterapia, 2019, 139:104401

3. Li Song, Hai-Jing Zhang, An-Jun Deng, Jia Li, XiangLi, Zhi-Hong Li, Zhi-Hui Zhang, Lian-Qiu Wu*, Sheng-Qi Wang^*, Hai-LinQin*, Syntheses andstructure-activity relationships on antibacterial and anti-ulcerative colitisproperties of quaternary 13-substituted palmatines and 8-oxo-13-substituteddihydropalmatines, Bioorganic & MedicinalChemistry, 2018, 26(9):2586-2598.

4. HaiJing Zhang, ZhiHui Zhang, GuangMing Song, XiaoNan Tang, HuaChen Song, AnJun Deng, WenJie Wang, LianQiu Wu, Hailin Qin. Development of an XBP1 agonist, HLJ2, as a potential therapeutic agent for ulcerative colitis. European journal of Pharmaceutical Sciences, 2017, 109: 56-64. 

5. An-Jun Deng, Hai-Jing Zhang, Qian Li, Zhi-Hong Li, Zhi-Hui Zhang, Lian-Qiu Wu, Li Li*, Hai-Lin Qin*. Six scalemic mixtures of 6-monosubstituted dihydrobenzophenanthridine alkaloids from Chelidonium majus and optically active structures of enantiomers, Phytochemistry，2017, 144: 159-170.

6. Qian Li, An-Jun Deng, Li Li,* Lian-Qiu Wu, Ming Ji, Hai-Jing Zhang, Zhi-Hong Li, Lin Ma, Zhi-Hui Zhang, Xiao-Guang Chen, and Hai-Lin Qin*. Azacyclo-indoles and Phenolics from the Flowers of Juglans regia. Journal of Natural Products. 2017, 80, 2189-2198.

7.MengXie, Hai-Jing Zhang, An-Jun Deng, Lian-Qiu Wu*, Zhi-Hui Zhang, Zhi-Hong Li,Wen-Jie Wang, and Hai-Lin Qin*. Synthesis and Structure-Activity Relationshipsof N-Dihydrocoptisine-8-ylidene AromaticAmines and N-Dihydrocoptisine-8-ylideneAliphatic Amides as Anti-ulcerative Colitis Agents Targeting XBP1. Journal of Natural Products. 2016, 79,775-783

8. JinRen, Yan-Gai Wang, Ai-Guo Wang, Lian-Qiu Wu, Hai-Jing Zhang, Wen-Jie Wang,Ya-Lun Su, and Hai-Lin Qin. Cembranoidsfrom the Gum Resin of Boswellia carterii as Potential Anti-ulcerative ColitisAgents. Journal of Natural Products. 2015, 78, 2322-2331.

9. Zhi-Hui Zhang, Hai-Jing Zhang, An-Jun Deng, Bo Wang, Zhi-Hong Li, Yang Liu, Lian-Qiu Wu, Wen-Jie Wang, and Hai-Lin Qin. Synthesis and Structure-activity Relationships of Quaternary Coptisine Derivatives as Potential Anti-ulcerative Colitis Agents. Journal of Medicinal Chemistry. 2015, 58, 7557-7571.

10.Zhi-Hui Zhang, An-Jun Deng, Lian-Qiu Wu, Lian-Hua Fang, Jin-Qian Yu, Zhi-Hong Li, Tian-Yi Yuan, Wen-Jie Wang, Guan-Hua Du, Hai-Lin Qin，Syntheses and structure–activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives, European Journal of Medicinal Chemistry, 2014, 86, 542-549.