课题组成员：

现有教授2人，副教授1人，助理研究员2人，主管技师1人，在读博士后1人，博士研究生3人，硕士研究生2人，八年制医学生科研训练3人，“大学生创新基金”5人

和北京协和医院麻醉科联合成立“麻醉-疼痛联合实验室”

马超课题组：神经科学的转化医学研究 Translational Neuroscience Research

主要研究方向：

1. 慢性痛与瘙痒症的神经机制：

慢性痛是我国乃至全世界范围内严重影响人们健康生活质量的主要问题之一。在医科院基础所原谢益宽教授实验室的基础上，我们已经建立起了一个神经生物学研究实验室和科研梯队，以神经电生理、药理学、影像学、免疫组化和动物行为学为主要手段，以背根神经节在体和离体记录平台为技术特色，重点研究慢性痛的免疫相关机制以及外周感觉神经元的异位放电机理。

在此基础上，课题组还与北京协和医院麻醉科成立了“麻醉-疼痛联合实验室”，并与美国耶鲁大学医学院、约翰霍普金斯医学院等开展合作，将研究范围推广到慢性痛与瘙痒患者的病理改变和治疗。痒觉的研究在世界范围内仍处于起步阶段，而其临床价值越来越受到人们的重视。运用类似的方法和思路，痒觉及瘙痒症的基础与临床研究可以与慢性痛的研究同步开展。

此研究课题已经获得国家自然科学基金、中国医学科学院医学与健康科技创新工程、基础所院所长基金、医科院“协和学者”奖励基金等支持。

2. 人脑组织库的建设和研究、人脑衰老与痴呆的机制：

国家发育和功能人脑组织资源库（中国医学科学院北京协和医学院人脑组织库，简称“协和脑库”）最初成立于2012年，依托单位为中国医学科学院基础医学研究所，是在北京协和医学院遗体志愿捐献接受站基础上设置的专用于人脑组织保存和研究的公益性机构。2019年被科技部正式认可成为国家级科技资源平台：国家发育和功能人脑组织资源库。协和脑库成立至今，已接受并保存了两百八十余例全脑组织样本，成为国内最大的规范化人脑库。在自身开展脑库标准化建设、人脑衰老与痴呆相关的神经病理和多种组学的研究的同时，联合国内十多所院校制定和发表了《中国人脑组织库标准化操作方案》，并为本院校及国内其他单位的多个研究课题组提供了宝贵的人脑组织样本，有力的支持了中国的脑科学与脑疾病研究。作为国家级资源平台，我们将继续以支撑和引领中国的脑科学研究为目标，为维护脑健康、战胜脑疾病做出积极贡献。

目前该研究项目已经获得国家自然科学基金、中国医学科学院医学与健康科技创新工程、中国医学科学院人体组织器官资源库建设项目等支持。

[正在进行的科研课题]

1.         科技创新2030-“脑科学与类脑研究”重大项目2021年度定向委托项目，编号#2021ZD0201100，“人脑组织资源库及地区脑库协作网络平台”及课题1#2021ZD0201101，“北方地区人脑库协作网络平台建设”，2021.12-2026.11，负责人：马超。

2.         中国医学科学院医学科学与健康科技创新工程，编号CIFMS #2021-1-I2M-025，“基于志愿捐献者生前队列的人体组织资源库建设”，2021.10-2025.12，首席专家：马超。

3.         国家自然科学基金原创探索项目，批准号：82050004，“人体组织液界面流动网络的循环功能和结构研究”，2021.1-2023.12，负责人：李宏义（主要参与者）。

[已完成的科研课题]

1.         国家自然科学基金面上项目，批准号：81771205，“伤害性感觉神经元FcεRI在小鼠过敏性结膜炎瘙痒中的作用机制研究”， 2018.1- 2021.12，负责人：马超。

2.         中国医学科学院医学科学与健康科技创新工程，协同创新团队项目，编号CIFMS#2017-I2M-3-008，“基于人体组织器官库的老年人群前瞻性队列研究”，2017.1-2020.12，首席专家：马超。

3.         上海市自然科学基金与基础重大重点研究“人脑认知功能及障碍研究”（16JC1420500），“阿尔茨海默病研究资源库和早期诊断技术研发”子课题（16JC1420502）负责人：马超。2017.1-2019.12。

4.         国家自然科学基金重大研究计划（情感和记忆的神经环路基础）培育项目，批准号：91632113，“基于中国人脑组织库的阿尔茨海默病分子机制研究”， 2017.1- 2019.12 ，负责人：马超。

5.         国家自然科学基金面上项目，批准号：81271239，“痛觉神经元 Fc-gamma-I 型受体在慢性痛发生中的作用”， 2013.1- 2016.12 ，负责人：马超。

6.         中国医学科学院神经科学中心科研基金，2014C01，“人脑组织库平台建设和研究”，2014.1-2014.12，负责人：马超。

7.         北京协和医学院，协和青年科研基金，2011C01，“外周感觉神经元Fc受体参与痒觉和瘙痒症的机制”，2012.11-2013.10，负责人：马超。

8.         中国医学科学院基础医学研究所，院所长基金, 2011RC01, “慢性痛的神经机理研究”，2011.12-2013.11，负责人：马超。

9.         NIH/NINDS,2R01NS014624-34A1, Peripheral Neural Mechanisms of Inflammatory Itch and Pain.P.I. Robert H. LaMotte; Co-I. Chao Ma（课题合作人）. 2012.9-2016.6.

10.     NIH/NINDS,1R21NS075706-01A1, In-vivo properties of visualized, molecularly labeledneurons mediating itch. P.I. Robert H. LaMotte; Co-I. Chao Ma（课题合作人）. 2011.12-2013.11.

11.     YaleUniversity School of Medicine, Department of Anesthesiology, Research StartupFund. P.I. Chao Ma（课题负责人）. 2/1/2009-11/30/2011. Immune-relatedmechanisms of chronic pain.

12.     NIH/NINDS,1-R21-NS065091-01, Antigen-specific immune mechanisms of neuronalhyperexcitability and chronic pain. P.I. Chao Ma（课题负责人）. 2/1/2009-7/31/2011.

1.  [科研论文]
2. 1. Chen K, Wang T, Li Y, WuJ, Zhao C-X, Liu S, Sun F, Fang Y, Hu J, Hu J, Zhang C-J*, Yu H*, Ma C*, Yu S-S*. Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain. Acta Pharmaceutica Sinica B 2023. [Accepted Jan 25, 2023]
3. 2. Liu F, Zhang L, Su S, Fang Y, Yin X-S, Cui H, Sun J, Xie Y, Ma C*. Neuronal C-reactive protein/FcγRI positive feedback proinflammatory signaling contributes to nerve injury-induced neuropathic pain. Advanced Science2023, 2205397.
4. https://doi.org/10.1002/advs.202205397
5. 3. He Y, Sun F, Li M, Ji T, Fang Y, Tan G, Ma C*, Huang Y*. A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain.Materials & Design225:111541, 2022. https://doi.org/10.1016/j.matdes.2022.111541
6. 4. Wang W, Wang M, Yang M, Zeng B, Qiu W, Ma Q, Jing X, Zhang Q, Wang B, Yin C, Zhang J, Ge Y, Liu Y, Ji W, Wu Q*, Ma C*, Wang X*. Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans. Cell Res 32:729-743, 2022. https://doi.org/10.1038/s41422-022-00678-y
7. 5. Luo D, Liu H, Liu H, Wu W, Zhu H, Ge W*, Ma C*. Long RNA profiles of human brain extracellular vesicles provide new insights into the pathogenesis of Alzheimer’s disease. Aging & Disease 2022. http://dx.doi.org/10.14336/AD.2022.0607
8. 6. Liu F, Sun J, Wang X, Jin S, Sun F, Wang T, Yuan B, Qiu W, Ma C*. Focal-but not diffuse-type Amyloid  beta plaques are correlated with Alzheimer’s neuropathology, cognitive dysfunction and neuroinflammation in the human hippocampus. Neurosci Bull 38:1125-1138, 2022. http://dx.doi.org/10.1007/s12264-022-00927-5 [Cover Article]
9. 7. Fang Y, Cui H, Liu F, Su S, Wang T, Yuan B, Xie Y, Ma C*. Astrocytic PTEN regulates neuropathic pain by facilitating HMGCR-dependent cholesterol biosynthesis. Pain163(12):p e1192-e1206,2022. https://doi.org/10.1097/j.pain.0000000000002682
10. 8. Guo Z, Shao C, Zhang Y, Qiu W, Li W, Zhu W, Yang Q, Huang Y, Pan L, Dong Y,Sun H, Xiao X, Sun W*, Ma C*, Zhang L*. A Global Multiregional Proteomic Map of the Human Cerebral Cortex. Genomics, Proteomics & Bioinformatics20(4):614-632, 2022. https://doi.org/10.1016/j.gpb.2021.08.008
11. 9. Gao Y, Liu J, Wang J, Liu Y, Zeng LH, Ge W*, Ma C*. Proteomic analysis of human hippocampal subfields provides new insights into the pathogenesis of Alzheimer's disease and the role of glial cells. Brain Pathol32:e13047, 2022.
12. https://doi.org/10.1111/bpa.13047
13. 10. Cui H, Liu F, Fang Y, Wang T, Yuan B, Ma C*. Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis. J Neuroinflammation 19(1):55, 2022.https://doi.org/10.1186/s12974-022-02417-x
14. 11. Su S, Yu N, Zhao H, Wu D, Cui H, Ma C*. Sudan Black B treatment uncovers the distribution of ACE2 in nociceptors. Mol Pain 18:1-4, 2022 https://doi.org/10.1177/17448069221080305
15. 12. Liu P, Yang Q, Yu N, Cao Y, Wang X, Wang Z, Qiu W, Ma C*. Phenylalanine Metabolism Is Dysregulated in Human Hippocampus with Alzheimer's Disease Related Pathological Changes. J Alzheimers Dis 83(2):609-622, 2021.
16. https://doi.org/10.3233/jad-210461
17. 13. Liu S, Hou B, You H, Zhang Y, Zhu Y, Ma C, Zuo Z*, Feng F*. The Association Between Perivascular Spaces and Cerebral Blood Flow, Brain Volume, and Cardiovascular Risk.Font Aging Neurosci 13:599724, 2021.
18. https://doi.org/10.3389/fnagi.2021.599724
19. 14. 王乃利,张翰林,王雪,张迪,仇文颖,马超*.国家发育和功能人脑组织资源库捐献者初步分析. 临床神经外科杂志18(3):242-246, 2021. DOI:10.3969/j.issn.1672-7000.2021.03.002[专家述评文章]
20. 15. Zhang H , Wang H , Gao F , Yang J, Xu Y, Fu Y, Cai M, Zhang X,Yang Q, Tong K, Hu Y, Chen H, Ma C, He W*, Zhang J*. TSPO Deficiency Accelerates Amyloid Pathology and Neuroinflammation by Impairing Microglial Phagocytosis. Neurobio Aging 106:292–303, 2021.https://doi.org/10.1016/j.neurobiolaging.2021.06.020
21. 16. Cui H, Su W, Cao Y, Ma C*, Qiu W*. The altered anatomical distribution of ACE2 in the brain with Alzheimer's Disease pathology. Front Cell Dev Biol 2021. https://doi.org/10.3389/fcell.2021.684874
22. 17. 刘帆,苏思,王涛,袁勃,马超*. 敲除背根神经节Fcgr1减弱类风湿关节炎模型大鼠NF-kB/NLRP3通路活化. 基础医学与临床2021, 41(7):963-969.
23. 18. Jia Y, Wang X, Chen Y,Qiu W, Ge W*, MaC*. Proteomic and Transcriptomic Analyses Reveal Pathological Changes in the Entorhinal Cortex Region that Correlate Well with Dysregulation of Ion Transport in Patients with Alzheimer’s Disease. Mol Neurobiol 58:4007–4027, 2021. https://doi.org/10.1007/s12035-021-02356-3
24. 19. Cui H, Su W, Cao Y, Ma L, Xu G, Mou W, Zhang Hanlin, Yu Jiawen, Ma C*, Zhang X*, Huang Y. Lack of spinal Neuropeptide Y is involved in mechanical itch in aged mice. Font Aging Neurosci 2021.
25. http://dx.doi.org/10.3389/fnagi.2021.654761
26. 20. Su W, Cui H, Wu D, Yu J, Ma L, Zhang X, Huang Y*, Ma C*. Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis. J Neuroinflammation 18:65, 2021.
27. https://doi.org/10.1186/s12974-020-02066-y
28. 21. Wang T, Tao J, Fang Y, Ma C*.The Role of Pruriceptors in Enhancing Sensitivity to Pruritogens in a Murine Chronic Compression Model of Dorsal Root Ganglion. Molecular Brain 14:15, 2021.https://doi.org/10.1186/s13041-021-00730-9
29. 22. Cong C, Zhang W, Qian X, Qiu W*, Ma C*. Significant Overlap of α-Synuclein, Amyloid-β and Phospho-Tau Pathologies in Neuropathological Diagnosis of Lewy-related Pathology: Evidence from China Human Brain Bank. J Alzheimers Dis 80:447-458, 2021. https://doi.org/10.3233/JAD-201548
30. 23. Wang T, Zhang Y, Chen W, Tao J, Xue Q, Ge W, Dou W*, Ma C*.Proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy: effects of topical treatment.Biomedicine & Pharmacotherapy 133:110844, 2021.
31. https://doi.org/10.1016/j.biopha.2020.110844
32. 24. Fang Y, Han S, Li X, Xie Y, Zhu B, Gao X*, Ma C*. Cutaneous Hypersensitivity as an Indicator of Visceral Inflammation via C-Nociceptor’s Axon Bifurcation. Neurosci Bull 37:45-54, 2021.https://doi.org/10.1007/s12264-020-00577-5
33. 25. Liu F, Shen X, Su S, Cui H, Fang Y Wang T, Zhang L, Huang Y, Ma C*.FcγRI-coupled signaling in peripheral nociceptors mediates joint pain in a rat model of rheumatoid arthritis. Arthritis Rheumatol 72(10):1668-78, 2020.
34. https://doi.org/10.1002/art.41386
35. 26. He Y, Qin L, Fang Y, Dan Z, Shen Y, Tan G, Huang Y*, Ma C*. Electrospun PLGA Nanomembrane: A Novel Formulation of Extended- Release Bupivacaine Delivery Reducing Postoperative Pain. Materials & Design 193:108768, 2020.
36. https://doi.org/10.1016/j.matdes.2020.108768
37. 27. Liu Y, Liu H, Li C, Ma C*, Ge W*. Proteome Profiling of Lung Tissues in Chronic Obstructive Pulmonary Disease (COPD): Platelet and Macrophage Dysfunction Contribute to the Pathogenesis of COPD. Int J Chron Obstruct Pulmon Dis 15:973-980，2020. https://doi.org/10.2147/COPD.S246845
38. 28. Zhang W, Zhang Q, Yang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W*, Ma C*. Contribution of Alzheimer’s Disease Neuropathologic Change to the Cognitive Dysfunction in Human Brains with Lewy Body-Related Pathology. Neurobio Aging 91:56-65, 2020.
39. https://doi.org/10.1016/j.neurobiolaging.2020.02.022
40. 29. Qin L, Xu Q, Li Z, Chen L, Li Y, Yang N, Liu Z, Guo J, Shen L, Allen EG, Chen C, Ma C, Wu H, Zhu X*, Jin P*, Tang B*. Ethnicity-specific and overlapping alterations of brain hydroxymethylome inAlzheimer’s disease. Human Molecular Genetics 29(1): 149–158, 2020. https://doi.org/10.1093/hmg/ddz273
41. 30. Zhu J, Chen ZY, Fang Y, Duan W, Xie Y, Ma C*. Injury of the Muscular Nerve but not Cutaneous Nerve Drives Acute Neuropathic Pain. Neurosci Bull 36:453–462, 2020.https://doi.org/10.1007/s12264-019-00462-w
42. [Cover Article]
43. 31. Hu YB, Ren RJ, Zhang YF, Huang Y, Cui HL, Ma C, Qiu WY, Wang H, Cui PJ, Chen HZ, Wang G. Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology.Aging Cell e13001, 2019. https://doi.org/10.1111/acel.13001 PMID: 31287605
44. 32. Fang Y, Zhu J, Duan W, Xie Y, Ma C*. Inhibition of Muscular Nociceptive Afferents via the Activation of Cutaneous Nociceptors in a Rat Model of Inflammatory Muscle Pain. Neurosci Bull 36:1-10, 2019.
45. https://doi.org/10.1007/s12264-019-00406-4
46. 33. Li H, Yang C, Yin Y, Wang F, Chen M, Xu L, Wang N, Zhang D, Wang X, Kong Y, Li Q, Su S, Cao Y, Liu W, Ao Z, Dai L, Ma C, Shang L, Han D, Ji F, Li H. An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body. Cell Prolif 52(5):e12667, 2019. https://doi.org/10.1111/cpr.12667
47. 34. Chen Z, Wang T, Fang Y, Luo D, Anderson M, Huang Q, He S, Song X, Cui H, Dong X, Xie Y, Guan Y*, Ma C*. Adjacent intact nociceptive neurons drive the acute outburst of pain following peripheral axotomy. Sci Rep 9:7651, 2019.
48. https://doi.org/10.1038/s41598-019-44172-9
49. 35. Jiang H, Cui H, Wang T, Shimada SG, Sun R, Tan Z, Ma C*, LaMotte RH*. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain BehavImmun 80:464–473, 2019.
50. https://doi.org/10.1016/j.bbi.2019.04.026
51. 36. Wang X, Xia W, Li K, Zhang Y, Ge W*, Ma C*. Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse. J Neurol Sci 399:125-139, 2019.
52. 37. Xiong F, Ge W*, Ma C*. Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association15(3):429–440, 2019. doi: 10.1016/j.jalz.2018.10.006.
53. 38. Yang Q, Chen K, Zhang H, Zhang W, Gong C, Zhang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W*, Ma C*. Correlations between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease among Han Chinese. Neurosci Bull 35(2):193-204, 2019 https://doi.org/10.1007/s12264-019-00343-2
54. 39. Zhang Q, Zhang H, Liu F, Yang Q, Chen K, Liu P, Sun T, Ma C, Qiu W, Qian X. Comparison of Reference Genes for Transcriptional Studies in Postmortem Human Brain Tissues under Different Conditions. Neurosci Bull 35(2):225-228, 2019.
55. https://doi.org/10.1007/s12264-018-0309-4
56. 40. Zhang F, Wei J, Li X, Ma C*, Gao Y*. Early candidate urine biomarkers for detecting Alzheimer's disease before beta amyloid plaque deposition in an APP (swe)/PSEN1dE9 transgenic mouse model. J Alzheimers Dis66:613–637, 2018.
57. 41. Zhang H, Chen K, Wang N, Zhang D, Yang Q, Zhang Q, Liu P, Wang M, Gong C, Hong X, Qiu W, Qian X, Chen Y*, Ma C*. Analysis of Brain Donors' Demographic and Medical Characteristics to Facilitate the Construction of a Human Brain Bank in China. J Alzheimers Dis66:1245–1254, 2018.
58. 42. Xu Z, Wang T, Guo X, Li Y, Hu Y, Ma C*, Wang J*. The relationship of serum antigen-specific and total immunoglobulin E with adult cardiovascular diseases. Int J Med Sci 15 (11):1098-1104, 2018.doi: 10.7150/ijms.25857.
59. 43. Wang Z, Liu F, Wei M, Qiu Y, Ma C*, Shen L*, Huang Y*.Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway. J Neuroinflammation 15(1):179, 2018. doi: 10.1186/s12974-018-1215-4.
60. 44. Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C*, LaMotte RH*. Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.Neurosci Lett 668:154–158, 2018.
61. http://doi.org/10.1016/j.neulet.2018.01.031
62. 45. Li J, Zhang W, Wang X, Yuan T, Liu P, Wang T, Shen L, Huang Y, Li N, You H, Xiao T, Feng F*, Ma C*. Functional magnetic resonance imaging reveals differences in brain activation in response to thermal stimuli in diabetic patients with and without diabetic peripheral neuropathy. PLoS One13(1): e0190699, 2018. https://doi.org/10.1371/journal.pone.0190699
63. 46. 贾梓淇,王宇晨,张妙颜,赵森,申新华,曹承刚,马超*. 男性单侧腹直肌罕见缺失变异1例. 解剖学报49 (5): 657-659, 2018.
64. 47. Qiu W, Yang Q, Zhang W, Wang N, Zhang D, Huang Y, Ma C*. The Correlations Between Postmortem Brain Pathologies and Cognitive Dysfunction in Aging and Alzheimer’s Disease. CurrAlz Res15:1-12, 2018.
    
65. 48. Zhang L, Sun C, Jin Y, Gao K, Shi X, Qiu W, Ma C*, Zhang L*. Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis 60 (2) :1-14, 2017.
    
66. 49. Liu X, Guo Z, Liu W, Sun W*, Ma C*.Differential proteome analysis of hippocampus and temporal cortex using label-free based 2D-LC-MS/MS.J Proteomics165:26-34, 2017.
    
67. 50. Qiu W, Guo X, Lin X, Yang Q, Zhang W, Zhang Y, Zuo L, Zhu Y, Li CR, Ma C*, Luo X*. Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease. Neurobio Aging 57:170-177, 2017.
68. 51. Liu F, Wang Z, Qiu Y, Wei M, Li C, Xie Y, Shen L, Huang Y*, Ma C*. Suppression of MyD88-dependent Signaling Alleviates Neuropathic Pain Induced by Peripheral Nerve Injury in the Rat. J Neuroinflammation 14(1):70, 2017.
69. 52. Jiang H, Shen X, Chen Z, Liu F, Wang T, Xie Y, Ma C*. Nociceptive Neuronal Fc-gamma receptor I is involved in IgG immune complex induced pain in the rat. Brain BehavImmun 62:351-361, 2017.
70. 53. Liu F, Xu L, Chen N, Zhou M, Li C, Yang Q, Xie Y, Huang Y, Ma C*. Neuronal Fc-epsilon receptor I contributes to antigen-evoked pruritus in amurine model of ocular allergy. Brain BehavImmun 61:165-175, 2017.
71. 54. Shen XH, Xue HD, Chen Y, Wang M, Mirjalili SA, Zhang ZH*, Ma C*. A Reassessment of Cervical Surface Anatomy Via CT Scan in an Adult Population. Clin Anat 30(3): 330, 2017.
72. 55. Hu X, Hu ZL, Li Z, Ruan CS, Qiu WY, Pan A, Li CQ, Cai Y, Shen L, Chu Y, Tang BS, Cai H, Zhou XF, Ma C, Yan XX. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum. Front Neuroanat 11:45, 2017.
73. 56. Griffith CM, Xie MX, Qiu WY, Sharp AA, Ma C, Pan A, Yan XX, Patrylo PR.Aberrant expression of the pore-forming KATP channel subunit Kir6.2 in hippocampal reactive astrocytes in the 3xTg-AD mouse model and human Alzheimer's disease.Neuroscience 336:81-101, 2016.
74. 57. Zhang XM, Cai Y, Wang F, Wu J, Mo L, Zhang F, Patrylo PR, Pan A, Ma C, Fu J, Yan XX.Sp8 expression in putative neural progenitor cells in guinea pig and human cerebrum.Dev Neurobiol 76(9):939-55, 2016.
75. 58. Xu B, Xiong F, Tian R, Zhan S, Gao Y, Qiu W, Wang R, Ge W*, Ma C*. Temporal Lobe in Human Aging: a Quantitative Protein Profiling Study of Samples from Chinese Human Brain Bank. Exp Gerontol. 73:31-41, 2016.
76. 59. Xu B, Gao Y, Zhan S, Xiong F, Qiu W, Qian X, Wang T, Wang N, Zhang D, Yang Q, Wang R, Bao X, Dou W, Tian R, Meng S, Gai W, Huang Y, Yan X-X, Ge W*, Ma C*. Quantitative Protein Profiling of Hippocampus during Human Aging. Neurobio Aging 39:46-56, 2016.
77. 60. 仇文颖，刘帆，杨倩，刘伟，王乃利，张迪，王涛，袁勃，马超*.人脑组织库样本100例质量及影响因素分析. 解剖学报 47(3):315-320, 2016.
78. 61. Shen XH, Su BY, Liu JJ, Zhang GM, Xue HD, Jing ZY, Mirjalili SA, Ma C*. A Reappraisal of Adult Thoracic and Abdominal Surface Anatomy via CT Scan in Chinese Population. Clin Anat29: 165-174, 2016.
79. 62. Liu Z J, Yi J, Guo W J, Ma C, Huang Y. Comparison of McGrath Series 3 and Macintosh Laryngoscopes for Tracheal Intubation in Patients With Normal Airway by Inexperienced Anesthetists: A Randomized Study. Medicine 95(2):e2514, 2016.
80. 63. Qiu Y, Chen W Y, Wang Z Y, Liu F, Wei M, Ma C, Huang YG. Simvastatin Attenuates Neuropathic Pain by Inhibiting the RhoA/LIMK/Cofilin Pathway. Neurochemical Res 41(9):2457-2469, 2016.
81. 64. Zhao X, Shen L, Xu L, Wang Z, Ma C, Huang Y. Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1. BMC Anesthesiol 16(1):27, 2015.
82. 65. Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically EvokedPain Behavior and the Activity of Cutaneous Nociceptors in Mice. PLoS One 10(9):59-77, 2015.
83. 66. Guo Y, Duan W, Ma C, Jiang C, Xie Y, Hao H, Wang R, Li L. Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model. BioMed EngOnLine 14(1):1-13, 2015
84. 67. Zhu HX, Xue ZQ, Qiu WY, Zeng ZJ, Dai JP, Ma C, Luo XG, Yan XX. Age-related intraneuronal accumulation of αII-spectrin breakdown product SBDP120 in the human cerebrum is enhanced in Alzheimer's disease. Exp Gerontol. 69:43-52. 2015.
85. 68. Xue ZQ, He ZW, Yu JJ, Cai Y, Qiu WY, Pan A, Cai H, Ma C, Yan XX.Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain.BMC Neurol. 15:71,2015
86. 69. 刘帆,李春艳,徐鲁斌,陈纳泽,周末,姜浩武,马超*. Fcγ和Fcε受体在小鼠三叉神经节的表达. 基础医学与临床2015, 35(6): 729-733.
87. 70. Li B, Yang XY, Qian FP, Tang M, Ma C*, Chiang LY*. A novel analgesic approach to optogenetically and specifically inhibit pain transmission using TRPV1 promoter. Brain Res. 1609:12-20. 2015
88. 71. Li H, Huang Y, Ma C, Yu X, Zhang Z, Shen L. MiR-203 Involves in Neuropathic Pain Development and Represses Rap1a Expression in Nerve Growth Factor Differentiated Neuronal PC12 Cells. Clin J Pain. 31(1):36-43. 2015.
89. 72. Li JM, Liu C, Hu X, Cai Y, Ma C, Luo XG, Yan XX. Inverse correlation between Alzheimer’s disease and cancer: implication for a strong impact of regenerative propensity on neurodegeneration? BMC Neurol. 14(1):211. 2014
    
90. Xue ZJ, Shen L, Wang ZY, Hui SY, Huang YG*, Ma C.STAT3 inhibitor WP1066 as a novel therapeutic agent for bCCI neuropathic pain rats.Brain Res. 1583:79-88. 2014.
    
91. 73. Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, Lamotte RH*. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain.137(Pt 4):1039-5. 2014
    
92. Yan XX*, Ma C, Gai WP, Cai H, Luo XG. Can BACE1 Inhibition Mitigate Early Axonal Pathology in Neurological Diseases? J Alzheimers Dis. 38(4):705-18, 2014.
    
93. 74. 刘克, 段婉茹, 马超, 谢益宽. 经络相关的脊髓前角运动神经元对交感节前神经元的树突投射.针刺研究38(6): 447-452, 2013.
    
94. 75. Han L, Ma C, Liu Q, Weng H-J, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH*, Dong X*. A subpopulation of nociceptors specifically linked to itch. Nat Neurosci. 16(2):174-82. 2013.
    
95. 76. Pan X, Durrett RE, Zhu H, Tanaka Y, Li Y, Zi X, Marjani SL, Euskirchen G, Ma C, LaMotte RH, Park I-H, Snyder M, Mason CE, Weissman SM*. Two methods for full-length RNA-seq for low quantities of cells and single cells. Proc Natl Acad Sci U S A. 110(2):594-9, 2013.
    
96. 77. Li H, Shen L, Ma C, Huang Y*. Differential expression of miRNAs in the nervous system of a rat model of bilateral sciatic nerve chronic constriction injury. Int J Mol Med. 32(1):219-26, 2013.
    
97. 78. Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, and Dong X*. Mechanisms of itch evoked by β-alanine. J Neurosci. 32(42):14532-7, 2012.
    
98. 79. Wang HT, Liu W, Luo AL, Ma C, Huang YG*. Prevalence and risk factors of chronic post-thoracotomy pain in Chinese patients from Peking Union Medical College Hospital. Chin Med J (Engl). 125(17):3033-8, 2012
    
99. 80. Qu L, Li Y, Pan X, Zhang P, LaMotte RH, and Ma C*. Transient Receptor Potential Canonical 3 (TRPC3) Is Required for IgG Immune Complex-Induced Excitation of the Rat Dorsal Root Ganglion Neurons.J Neurosci. 32(28):9554-62, 2012[Focus Article]
    
100. 81. Ma C, Nie H, Gu Q, Sikand P, and LaMotte RH. In-vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans. J Neurophysiol. 107(1):357-63, 2012.
     
101. 82. Qu L, Zhang P, LaMotte RH, and Ma C*. Neuronal Fc-gamma Receptor I Mediated Excitatory Effects of IgG Immune Complex on Rat Dorsal Root Ganglion Neurons. Brain BehavImmun 25:1399-1407, 2011.
     
102. 83. Fan N, Sikand P, Donnelly DF, Ma C, and LaMotte RH*. Increased sodium and potassium currents in small mouse dorsal root ganglion neurons after ganglion compression. J Neurophysiol106(1):211-8, 2011.
     
103. 84. Ma C, Rosenzweig J, Zhang P, Johns DC, and LaMotte RH*. Expression of inwardly rectifying potassium channels by an inducible adenoviral vector reduced the neuronal hyperexcitability and hyperalgesia produced by chronic compression of the spinal ganglion. Mol Pain 6:65, 2010.
     
104. 85. Ma C, Donnelly DF, and LaMotte RH*. In-vivo visualization and functional characterization of primary somatic neurons. J Neurosci Methods 191(1):60-5, 2010.
     
105. 86. Zhang H, Mei X, Zhang P, Ma C, White FA, Donnelly DF, and LaMotte RH. Altered Functional Properties of Satellite Glial Cells in Compressed Spinal Ganglia. Glia 57:1588-99, 2009.
     
106. 87. Ma C, and LaMotte RH*. Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion. J Neurosci27: 14059-68, 2007.
     
107. 88. Sun J, Yang B, Donnelly DF, Ma C, and LaMotte RH*. MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. J Neurophysiol 96: 2189-99, 2006.
     
108. 89. Ma C, Greenquist KW, and LaMotte RH*. Inflammatory Mediators Enhance the Excitability of Chronically Compressed Dorsal Root Ganglion Neurons.J Neurophysiol 95: 2098-107, 2006.
     
109. 90. White FA, Sun J, Waters SM, Ma C, Ren D, Ripsch M, Steflik J, Cortright DN, Lamotte RH, and Miller RJ*. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc Natl Acad Sci USA 102: 14092-7, 2005.
     
110. 91. Ma C, and LaMotte RH*. Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat.Pain 113: 106-112. 2005.
     
111. 92. Yao H, Donnelly D, Ma C, and LaMotte RH*. Up-regulation of IH current after chronic compression of the dorsal root ganglion. J Neuroscience 23: 2069-2074, 2003.
     
112. 93. Ma C, Shu Y, Zheng Z, Chen Y, Yao H, Greenquist KW, White FA, and LaMotte RH*. Similar Electrophysiological Changes in Axotomized and Neighboring Intact Dorsal Root Ganglion Neurons.J Neurophysiol89: 1588-1602, 2003.
     
113. 94. Ma C, Zheng Z, and Xie YK*. Meridian-like character of reflex electromyogram activity in longissimus dorsi muscles. Chinese Science Bulletin 46: 57-62, 2001.

 [综述和论著]

    95. Liu F, Yin X-S, Cong C, Wang Y, Ma C*. Human Brain Banking As a Convergence Platform of Neuroscience and Neuropsychiatric Research. Human Brain 1(1), 2022. https://doi.org/10.37819/hb.001.001.0204

[健康科普著作]

协和人说健康：女性身体的真相.金涛马超主编，科学技术文献出版社，2020.【获得“2020年新时代健康科普作品征集大赛”科普图书类优秀作品】

协和人说健康.马超金涛主编，人民卫生出版社，2018.【获得“2018中国医界好书”，2018年度国家卫生健康委管出版单位卫生健康主题宣传激励项目“图书推荐名单”，以及“2019年全国优秀科普作品”】，2022年7月出版增订本。

1. [专利]

1. 中华人民共和国发明专利：一种药物缓释载体、缓释药物组合物及其应用。发明人：贺渝淼，马超，黄宇光。申请号：202111551019. 1，2021年12月18日申请，2023年1月16日授权。

2. 中华人民共和国发明专利：伊曲康唑作为镇痛药物的应用。发明人：马超，王涛，孙丰润，张崇敬。申请号：2022104242983，2022年4月21日申请。

3. 中华人民共和国实用新型专利：脑干模型。穆瑞民，曹承刚，马超。申请号：ZL 202123096141.2，2021年12月10日申请。2022年5月24日授权。

4. 中华人民共和国实用新型专利：分体式面膜。崇煜明，马超，白明，王涛，龙笑。专利号：ZL 202120981152.X，2021年5月10日申请，2021年11月17日授权。

5. 中华人民共和国实用新型专利：可拼接脊柱模型。马超，陆菁菁，张丁月。专利号：ZL 202021723050.X，2020年8月19日申请，2021年4月2日授权。

6. 中华人民共和国发明专利：外周神经电刺激器。发明人：马超，吴永亮，丁孝宇，王子木，郑政。申请号：201910644990.5，2019年7月17日申请。

7. 中华人民共和国实用新型专利：颅骨和脑模型。马超，陆菁菁，陈槺，贾梓淇，耿畅，钱天一，罗瑞。专利号： ZL201821295133.6，2018年8月13日申请，2019年7月19日授权。

8. 中华人民共和国发明专利：一种含有布比卡因的药物组合物及其制备方法和用途。发明人：马超，贺渝淼。申请号：201811308025.2，2018年11月5日申请。

9. 中华人民共和国实用新型专利：脊髓及内脏神经模型。马超，穆瑞民，张迪。专利号：ZL 201721656215.4，2017年12月1日申请，2018年12月5日授权。

10. 中华人民共和国实用新型专利：大脑皮层功能柱模型。马超，穆瑞民，张迪，等。专利号：ZL 2016 2 022438.X，2016年3月23日申请，2017年1月4日授权。

11. 中华人民共和国发明专利：含有布比卡因的药物组合物及其制备方法和用途。发明人：马超，王涛，谢益宽，黄宇光。专利号：ZL 201610329869.X，2016年5月18日申请，2019年1月22日授权。

12. 中华人民共和国实用新型专利：小脑模型。马超，刘克，曹承刚，等。专利号：ZL 2014 2 0561113.4，2014年9月26日申请，2015年2月18日授权。