2. 2022年国家重点研发计划（学术骨干）；

3. 2022年主持国家自然科学基金委面上项目；

4. 2022年主持江苏省杰出青年基金项目；

5. 2019年主持国家自然科学基金委面上项目； 

6. 苏州系统医学研究所启动资金；

重点研究方向如下：

•CD8 T细胞命运决定/代谢重编程的机制;

•肿瘤浸润T细胞功能／代谢衰竭新的分子机制; 

•肿瘤微环境的代谢及表观遗传学调控机制;

•肿瘤抵抗免疫治疗机制；

1. Zhang X†, Wang J†, Tang K†, Yang Y, Liu X, Yuan S, Guo F*, Zhang L*, Ma K*. The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis. Cell Death & Disease, 2024; 15(5): 339.

2. Xu Y†, Ma K†, Zhang L*, Li G*. Supercharging cancer-fighting T cells with lithium carbonate. Cell Metabolism. 2024; 36(3): 463-465.

3. Wang Z†, Shang J†, Qiu Y†, Cheng H, Tao M, Xie E, Pei X, Li W, Zhang L*, Wu A*, Li G*. Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity. Cell Reports. 2024, 43(2).

4. Han C†, Ge M†, Xing P†, Xia T, Zhang C, Ma K, Ma Y, Li S, Li W, Liu X, Zhang B*, Zhang L*, Zhang L*. Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ T cells. Cell Death & Disease, 2024, 15(2): 145.

5. Gao Y†, Li W†, Wang Z†, Zhang C†, He Y, Liu X, Tang K, Zhang W, Long Q, Liu Y, Zhang J, Zhang B and Zhang L*. SEL1L preserves CD8+ T cell survival and homeostasis via fine-tuning PERK signaling and IL-15 receptor mediated mTORC1 axis. Cellular & Molecular Immunology. 2023 Aug 30;20(10):1232-1250.

6. Cheng H†, Qiu Y1†, Xu Y†, Chen L†, Ma K, Tao M1, Frankiw L, Yin H, Xie E, Pan X, Du J, Wang Z, Zhu W, Chen L*, Zhang L* and Li G*. Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness. Nature Metabolism,2023; 5(2): 314–330.

7. Ma K†, Cheng. H†, Li. G*. Zhang L*. cBAF and MYC: decision makers for T cell memory differentiation, Signal Transduction and Targeted Therapy, 2022; 7(1): 389.

8. Moller SH, Hsueh P, Yu YR*, Zhang L*, Ho PC*. Metabolic programs tailor T cell immunity in viral infection, cancer and aging. Cell Metabolism. 2022; 34(3): 378-395.

9. Jiao A, Sun C, Wang X, Lei L, Liu H, Li W, Yang X, Zheng H, Ding R, Zhu K, Su Y, Zhang C, Zhang L*, Zhang B*. DExD/H-box helicase 9 intrinsically controls CD8 + T cell-mediated antiviral response through noncanonical mechanisms. Science Advances. 2022; 8(6): eabk2691.

10. Zhang C†, Lei L†, Yang X†, Ma K, Zheng H, Su Y, Jiao A, Wang X, Liu H, Zou Y, Shi L, Zhou X, Sun C, Hou Y, Xiao Z, Zhang L*and Zhang B*. Single-cell sequencing reveals anti-tumor characteristics of intratumoral immune cells in old mice. Journal for immunotherapy of cancer. 2021; 9(10): e002809.

11. Han C†, Ge M†, Ho PC*, Zhang L*. Fueling T cell anti-tumor immunity: amino acid metabolism revisited. Cancer immunology research, 2021; 9(12): 1373-1382.

12. Li. W†, Cheng. H†, Li. G*. Zhang L*. Mitochondrial Damage and the Road to Exhaustion. Cell Metabolism 2020; 32(1): 906-907. 

13. Duan Q†, Zhang H†, Zheng J*, Zhang L*. Turning cold into hot: firing up the tumor microenvironment. Trends in cancer, 2020; 6(7): 605-618.

14. Dumauthioz N, Tschumi B, Wenes M, Marti B, Wang H, Franco F, Li W, Lopez-Mejia IC, Fajas L, Ho PC, Donda A, Romero P*, Zhang L*. Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and anti-tumor immunity. Cellular & molecular immunology. 2021; 18(7): 1761-1771.