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现任北京协和医院风湿免疫科主任,国家免疫疾病临床医学研究中心主任,中华医学会风湿病学分会前任主任委员、中国医师协会风湿免疫科医师分会会长;亚太风湿病联盟(APLAR)副主席,中国系统性红斑狼疮研究协作组(CSTAR)&国家风湿病数据中心(CRDC)创始人和负责人。担任《中华风湿病学杂志》、《中华临床免疫与变态反应学杂志》、《中华内科学杂志》、《中国实用内科杂志》4份杂志副主编;国际上担任第18届APLAR大会主席。作为负责人承担“十一五”国家科技支撑计划和“十二五”国家高技术研究发展计划课题、“十三五”国家重点研发计划精准医学项目等;发表SCI文章200余篇、总分超过400分,其中通信作者53篇,SCI总分161.795分;为人民卫生出版社国家卫生健康委员会“十三五”住院医师规范化培训规划教材《内科学·风湿免疫科分册》、全国高等学校医学专业研究生国家级规划教材《风湿内科学》主编,人卫出版社《内科学》教材副主编,主译《哈里森风湿病学》。参与获得国家科技进步奖1项,中华医学科技奖3项,北京市科学技术奖3项,及教育部科学技术进步奖2项,荣获第七届全国优秀科技工作者称号。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg2008.12-2010.12 | 系统性红斑狼疮(SLE)的临床诊断、综合治疗的研究(课题号2008BAI59B02) | “十一五”国家科技重点支撑项目 |
2012.2-2015.12 | SLE分子分型和个体化诊疗技(2012AA02A513) | 十二五”国家高技术研究发展计划(863计划)课题 |
2017.7-2020.12 | 中国常见风湿免疫病临床队列及预后研究 | “十三五”国家重点研发计划精准医学专项 |
1. 我国风湿病免疫学科的领军者:现任北京协和医院风湿免疫科主任,国家皮肤与免疫疾病临床医学研究中心(NCRC-DID)主任,带领团队连续10年蝉联复旦风湿病专科排名榜榜首,连续5年《中国医院科技影响力排行榜》专科第一名。同时担任中华医学会风湿病学分会主任委员、中国医师协会风湿免疫科医师分会会长;亚太风湿病学会联盟副主席。作为负责人承担“十一五”、“十二五”项目,是“十三五”国家重点研发计划精准医学项目的首席科学家等;发表SCI文章200余篇、总分超过500分,其中通信作者77篇,SCI总分182.795分;作为主编主持3本国家级人卫出版社的规划教材撰写,《内科学》教材副主编,还主编和主译了多部专著。参与获得多项国家及省部级奖项,荣获第七届全国优秀科技工作者称号。曾获首届中央人民广播电台“京城好医生”之“优秀好医生”称号,并获北京医学会突出贡献奖、2016年度推动行业前行的力量十大医学贡献专家称号、2019年度改变实践的中国原创研究十大原创研究领衔者称号。为首届“国之名医卓越建树”奖获得者。
2. 我国风湿免疫病多中心数据平台的缔造者:2009年创建中国系统性红斑狼疮研究协作组(CSTAR),后拓展为国家风湿病数据中心(CRDC),并创立中国风湿免疫病医联体联盟。并以此平台为基础,全面推动我国风湿免疫病临床数据库和生物样本库的标准化建设及临床真实世界研究,目前CRDC是世界上最大的风湿病数据库,CSTAR系列研究论文发表了SCI文章近百篇,建立了中国风湿病领域多中心真实世界研究体系,初步摸清了中国风湿病的疾病谱,极大的提高了我国临床研究的国际影响力,并开创了风湿免疫病可持续发展的研究体系,2019年被认定为国家皮肤与免疫疾病临床医学研究中心。
3. 我国风湿免疫学科发展的推动者:为我国风湿病学发展首次制定“一市一科一中心”发展策略,使我国风湿免疫学科在近5年得到飞速发展,目前风湿病学专科数从2012年的1172个增至2019年的3372个,专科医师人数从4515人增至12189人,部分解决了我国风湿免疫专科看病难问题,并积极呼吁和推动卫健委在2019年10月发布《综合医院风湿免疫科建设与管理指南(试行)》和《综合医院风湿免疫科基本标准(试行)》,为我国风湿免疫学科发展做出了突出贡献。
1. Xiaofeng Zeng, Maixing Ai, Xinping Tian, Xiaodan Gan, Yanping Shi, Qinfang Song, Fulin Tang. Diagnostic Value of Anti-Cyclic Citrullinated Peptide Antibody in Patients with Rheumatoid Arthritis. J Rheumatol, 2003; 30: 1451-1455. SCI=2.860
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3. Zhuolong Wang, Mengtao Li, Xiaofeng Zeng, Xinjuan Liu. Hepatitis-B-virus associated antigen deposition in renal tissue from patients with systemic lupus erythematosus. J Rheumatol, 2012; 39(5): 974-978(通讯作者)SCI=3.258
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6. Xiaofang Luo, Limin Zhang, Mengtao Li, Wen Zhang, Xiaomei Leng, Fengchun Zhang, Yan Zhao, Xiaofeng Zeng. The role of miR-125b in T lymphocytes in the pathogenesis of systemic lupus erythematosus. Clin Exp Rheumatol, 2013; 31(2): 263-271(通讯作者)SCI=2.148
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8. Xinjuan Liu, Na Gao, Mengtao Li, Dong Xu, Yong Hou, Qian Wang, Guohua Zhang, Qiuning Sun, Henghui Zhang and Xiaofeng Zeng. Elevated Levels of CD4+CD25+FoxP3+ T Cells in Systemic Sclerosis Patients Contribute to the Secretion of IL-17 and Immunosuppression Dysfunction. PLoS One, 2013; 8(6): e64531(通讯作者)SCI=3.534
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10. M Li, W Zhang, X Leng, Z Li, Z Ye, C Li, X Li, P Zhu, Z Wang, Y Zheng, X Li, M Zhang, F Zhang, Y Zhao, X Zeng and CSTAR co-authors. Chinese SLE Treatment and Research group (CSTAR) registry: I. Major clinical characteristics of Chinese patients with systemic lupus erythematosus. Lupus, 2013; 22(11): 1192-1199(通讯作者)SCI=2.783
11. Tang Y, Xie H, Chen J, Geng L, Chen H, Li X, Hou Y, Lu L, Shi S, Zeng X, Sun L. Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling. Stem Cells Dev, 2013; 22(4): 668-678(通讯作者)SCI=4.202
12. Xu J, Cheng YQ, Chen B, Bai R, Li S, Xu XF, Xu L, Wen JF, Lu ZP, Zeng XF. Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region. Lupus, 2013; 22(10): 1001-1010(通讯作者)SCI=2.783
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15. M Li, Q Wang, J Zhao, Z Li, Z Ye, C Li, X Li, P Zhu, Z Wang, Y Zheng, X Li, M Zhang, Z Tian, Y Liu, J He, F Zhang, Y Zhao, X Zeng and CSTAR co-authors. Chinese SLE Treatment and Research group (CSTAR) registry: II. Prevalence and risk factors of pulmonary arterial hypertension in Chinese patients with systemic lupus erythematosus. Lupus, 2014; 23(10): 1085-1191(通讯作者)SCI=2.481
16. Tian Z, Liu Y, Xu D, Li M, Lai J, Guo X, Wang H, Zhu W, Wang Q, Fang Q, Zeng X. Disease activity is related to acute response to vasodilator in pulmonary artery hypertension associated with systemic lupus erythematosus. Circ J, 2014; 78 (5):1240-1244(通讯作者)SCI=3.685
17. Jing Li, Xiaomei Leng, Zhijun Li, Zhizhong Ye, Caifeng Li, Xiaofeng Li, Ping Zhu, Zhengang Wang, Yi Zheng, Xiangpei Li, Miaojia Zhang, Xin-ping TIAN, Mengtao Li, Jiuliang Zhao, Zhang Feng-chun, Yan Zhao and Xiaofeng Zeng. Chinese SLE Treatment and Research group (CSTAR) registry: III. Association of autoantibodies with clinical manifestations in Chinese patients with systemic lupus erythematosus. J Immunol Research, 2014: 809389. doi: 10.1155(通讯作者)SCI=3.064
18. Jing Huang, Mengtao Li, Zhuang Tian, Evelyn Hsieh, Qian Wang, Yongtai Liu, Dong Xu, Yong Hou, Jiuliang Zhao, Xiaoxiao Guo, Jinzhi Lai, Chaojun Hu, Ning Song, Qiuning Sun, Fengchun Zhang, Yan Zhao, Xiaofeng Zeng. Clinical and laboratory characteristics of systemic sclerosis patients with pulmonary arterial hypertension in China. Clin Exp Rheumatol, 2014; 32 (Suppl. 86): S115-S121(通讯作者)SCI=2.973
19. Nan Jiang, Mengtao Li, Xiaofeng Zeng. Correlation of Th17 cells and CD4(+)CD25(+) regulatory T cells with clinical parameters in patients with systemic sclerosis. Chin Med J (Engl), 2014; 127 (20): 3557-3561(通讯作者)SCI=1.016
20. Zhen Chen, Meng-Tao Li, Dong Xu, Hong Yang, Jing Li, Jiu-Liang Zhao, Heng-Hui Zhang, Shao-Mei Han, Tao Xu, Xiao-Feng Zeng. Protein-losing enteropathy in systemic lupus erythematosus: 12 years experience from a Chinese academic center. PLoS One; 2014; 9(12): e114684(通讯作者)SCI=3.534
21. Zhuo-Long Wang, Xiao-Fang Luo, Meng-Tao Li, Dong Xu, Shuang Zhou, Hou-Zao Chen, Na Gao, Zhen Chen, Ling-Ling Zhang, Xiao-Feng Zeng. Resveratrol Possesses Protective Effects in a Pristane-induced Lupus Mouse Model. PLoS One, 2014; 9(12): e114792(通讯作者)SCI=3.534
22. Xinping Tian, Mengtao Li, Zhizhong Ye, Xiao Zhang, Shengyun Liu, Lijun Wu, Li Ma, Liqi Bi, Xiaoxia Zuo, Lingyun Sun, Cibo Huang, Jiuliang Zhao, Fengchun Zhang, Yan Zhao, Xiaofeng Zeng and CSTAR co-authors. The related factors of fetal loss in Chinese women with Systemic Lupus Erythematosus: Data from Chinese SLE Treatment and Research group (CSTAR) registry IV. Int J Rheum Dis, 2015; 18(6): 654-660(通讯作者)SCI=1.469
23. Xiaomei Leng, Xiaofeng Zeng. Effectiveness and Safety of Transdermal Buprenorphine versus Sustained-Release Tramadol in Patients with Moderate to Severe Musculoskeletal Pain: An 8-Week, Randomized, Double Blind, Double Dummy, Multi-Center, Active-controlled, Non-inferiority Study. Clin J Pain, 2015; 31: 612-620(通讯作者)SCI=2.527
24. Zhen Chen, Meng-Tao Li, Dong Xu, Xiao-Mei Leng, Qian Wang, Xin-Ping Tian, Shang-Zhu Zhang, Yan Zhao, Xiao-Feng Zeng. Organ damage in patients with incomplete lupus syndromes from a Chinese academic center. Clin Rheumatol, 2015; 34: 1383-1389(通讯作者)SCI=1.696
25. Shuang Zhou, Meng-Tao Li, Yu-Yan Jia, Jin-Jing Liu, Qian Wang, Zhuang Tian, Yong-Tai Liu, Hou-Zao Chen, De-Pei Liu and Xiao-Feng Zeng. Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension. BioMed Res Int, 2015; 762349. doi. 0.1155(通讯作者)SCI=1.579
26. Ziqian Wang, Yanhong Wang, Rongrong Zhu, Xinping Tian, Dong Xu, Qian Wang, Chanyuan Wu, Shangzhu Zhang, Jiuliang Zhao, Yan Zhao, Mengtao Li, Xiaofeng Zeng. Long-term survival and death causes of systemic lupus erythematosus in China: a systemic review of observational studies. Medicine, 2015; 94(17): e794(共同通讯作者)SCI=5.723
27. Li Guo, Mengtao Li, Yi chen, Qian Wang, Zhuang Tian, Shuming Pan, Xiaofeng Zeng, Shuang Y. Anti-endothelin receptor type A autoantibody in systemic lupus erythematosus associated pulmonary arterial hypertension. Arthritis Rheumatol, 2015; 67(9): 2394-2402(共同通讯作者)SCI=7.764
28. Mengtao Li, Xinping Tian, Wen Zhang, Xiaomei Leng, Xiaofeng Zeng on behalf of CSTAR coauthors. CRDC: Chinese rheumatology research platform. Clin Rheumatol, 2015; 34: 1347-1352(通讯作者)SCI=1.696
29. Xu D, You X, Wang Z, Zeng Q, Xu J, Jiang L, Gong L, Wu F, Gu J, Tao Y, Chen J, Zhao J, Li M, Zhao Y, Zeng X; CSTAR co-authors.Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry VI: Effect of Cigarette Smoking on the Clinical Phenotype of Chinese Patients with Systemic Lupus Erythematosus. PLoS One; 2015; 10(8): e0134451(通讯作者)SCI=3.234
30. S. Zhang, D. Xu, M. Li, Y. Hou, Q. Wang, Z. Tian, Y. Liu, X. Guo, J. Lai, J. Zhao, C. Hu, N. Song, Q. Sun, F. Zhang, Y. Zhao, X. Zeng. Telangiectasia as a potential clinical marker of microvascular lesions in systemic sclerosis patients from EUSTAR data in China. Clin Exp Rheuamtol, 2015; 33 Suppl 91(4): 106-110(通讯作者)SCI=2.724
31. Shangzhu Zhang, Jinmei Su, Xiaofeng Li, Xiao Zhang, Shengyun Liu, Lijun Wu, Li Ma, Liqi Bi, Xiaoxia Zuo, Lingyun Sun, Cibo Huang, Jiuliang Zhao, Mengtao Li, Xiaofeng Zeng and CSTAR co-authors. Chinese SLE Treatment and Research group (CSTAR) registry: V. Gender impact on Chinese patients with systemic lupus erythematosus. Lupus, 2015; 24(12): 1267-1275(通讯作者)SCI=2.197
32. Junyan Qian, Yanhong Wang, Can Huang, Xiaoxi Yana, Jiu Liang Zhao, Qian Wang, Zhuang Tian, Mengtao Li, Xiaofeng Zeng. Survival and prognostic factors of systemic lupus erythematosus-associated pulmonary arterial hypertension: A PRISMA-compliant systematic review and meta-analysis. Autoimmun Rev, 2016; 15(3): 250-257(共同通讯作者)SCI=7.933
33. Ye Y, Ding F, Li M, Yang X, Pang H, Wang Q, Xu D, Kang L, Zeng X, Zhang S. Interarm Blood Pressure Difference in Patients With Systemic Lupus Erythematosus. J Clin Rheumatol, 2015;21(5) :251-255(共同通讯作者)SCI=1.084
34. Ling-ling Zhang, Jie Lu, Meng-tao Li, Qian Wang and Xiao-feng Zeng. Preventive and remedial application of etanercept attenuate monocrotaline-induced pulmonary arterial hypertension. Int J Rheum Dis, 2016; 19: 192-198(通讯作者)SCI=1.469
35. Zhang L, Xu D, Yang H, Tian X, Wang Q, Hou Y, Gao N, Zhang L, Li M, Zeng X. Clinical Features, Morbidity, and Risk Factors of Intestinal Pseudo-obstruction in Systemic Lupus Erythematosus: A Retrospective Case-control Study. J Rheumatol, 2016; 43(3): 559-564(通讯作者)SCI=3.187
36. Huang C, Li M, Liu Y, Wang Q, Guo X, Zhao J, Lai J, Tian Z, Zhao Y, Zeng X. Baseline characteristics and risk factors of pulmonary arterial hypertension in systemic lupus erythematosus patients. Medicine, 2016; 95(10): e2761(通讯作者)SCI=5.723
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38. Zhao J, Bai W, Zhu P, Zhang X, Liu S, Wu L, Ma L, Bi L, Zuo X, Sun L, Huang C, Tian X, Li M, Zhao Y, Zeng X, CSTAR co-authors. Chinese SLE Treatment and Research group (CSTAR) registry VII: prevalence and clinical significance of serositis in Chinese patients with systemic lupus erythematosus. Lupus, 2016; 25(6): 652-657(通讯作者)SCI=2.197
39. Wang H, Guo X, Lai J, Wang Q, Tian Z, Liu Y, Li M, Zhao J, Zeng X, Fang Q. Predictors of health-related quality of life in patients with systemic lupus erythematosus associated pulmonary arterial hypertension. Clin Exp Rheumatol, 2016; 34(2): 291-295(共同通讯作者)SCI=2.495
40. Hou Y, Li HJ, Li MT, Xu D, Zhou DB, Zeng XF. A successful case of second autologous haematopoietic stem cell transplantation for post-transplant systemic sclerosis relapse. Clin Exp Rheumatol, 2016;34 Suppl 100(5): 207(通讯作者)SCI=2.495
41. Li J, Zhu M, Li M, Zheng W, Zhao J, Tian X, Zeng X. Cause of death in Chinese Takayasu arteritis patients. Medicine (Baltimore), 2016; 95(27): e4069(共同通讯作者)SCI=2.133
42. Xu D, Hou Y, Zheng Y, Zheng Y, Li M, Zeng X. The 2013 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Sclerosis Could Classify Systemic Sclerosis Patients at Earlier Stage: Data from a Chinese EUSTAR Center. PLoS One. 2016; 11(11): e0166629(通讯作者)SCI=3.057
43. Ding FM, Li M, Yang X, Ye Y, Kang L, Pang H, Wang Q, Xu D, Zeng X, Zhang S. Accelerated Age-Related Arterial Stiffness in Systemic Lupus Erythematosus Patients. J Clin Rheumatol, 2016; 22(8):426-433(共同通讯作者)SCI=1.245
44. Li J, Yang Y, Zhao J, Li M, Tian X, Zeng X. The efficacy of Mycophenolate mofetil for the treatment of Chinese Takayasu's arteritis. Sci Rep, 2016; 6: 38687(共同通讯作者)SCI=5.228
45. Liu H, Hou Y, Zhu QL, Xu D, Wang L, Li JC, Jiang YX, Wang Q, Li MT, Zhang FC, Zeng XF. A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter? PLoS One. 2017; 12(3):e0174481(共同通讯作者)SCI=3.057
46. Zhao J, Wang Q, Liu Y, Tian Z, Guo X, Wang H, Lai J, Huang C, Yang X, Li M, Zeng X. Clinical characteristics and survival of pulmonary arterial hypertension associated with three major connective tissue diseases: A cohort study in China. Int J Cardiol. 2017; 236:432-437(共同通讯作者)SCI=4.638
47. Zhou J, Chen Z, Li J, Yang Y, Zhao J, Chen H, Liu M, Sun F, Li M, Tian X, Zeng X. The efficacy of tocilizumab for the treatment of Chinese Takayasu's arteritis. Clin Exp Rheumatol. 2017; 35 Suppl 103(1):171-175(共同通讯作者)SCI=2.495
48. Wu CY, Li CF, Wu QJ, Xu JH, Jiang LD, Gong L, Wu FQ, Gu JR, Zhao JL, Li MT, Zhao Y, Zeng XF; CSTAR Co-authors. Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry IX: Clinical Features and Survival of Childhood-Onset Systemic Lupus Erythematosus in China. Chin Med J (Engl). 2017; 130(11): 1276-1282(通讯作者)SCI=0.957
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