（1）中国医学科学院医学与健康科技创新工程，2020-I2M-2-015，武汉 COVID-19 患者及重要康复影响因素纵向研究 ，300万元，2020.1-2021.12，子课题负责人，在研。

（2）新型冠状病毒感染的肺炎疫情项目，2019- nCoV检测试剂研发，2020YFC0841200，30万元，2020/01-2020/12，子课题负责人，已结题。

（3）北京市科委项目， 2019 新型冠状病毒的抗病毒药物筛选研究，Z201100001020005，70万元，2020/01-2021/4，子课题负责人，已结题

（4） 国家科技重大专项课题，2018ZX10734404，急重要呼吸道病毒标准化鉴定关键技术和参比库的建立，171.98万元，2018/01-2020/12，子课题负责人，已结题。

（5）国家科技重大专项课题，2017ZX10204401，突发急性重症呼吸道传染病的免疫特征研究，310.5万元，2017/01-2020/12，子课题负责人。已结题

（6）中国医学科学院医学与健康科技创新工程，2016-I2M-1-014，重要新发突发传染病生物安全基础与防控，200万元，2016.9-2020.12，子课题负责人，已结题。

一、主要代表性论文：

1.     Guo L, Wang Y, Kang L, Hu Y, Wang L, Zhong J, Chen H, Ren L, Gu X, Wang G, WangC, Dong X, Wu C, Han L, Wang Y, Fan G, Zou X, Li H, Xu J, Jin Q, Cao B, Wang J.Cross-reactive antibody against human coronavirus OC43 spike protein correlateswith disease severity in COVID-19 patients：a retrospective study. Emerg Microbes Infect. 2021,10(1):664-676 (Firstauthor)

2.     He Z, Ren L, Yang J, Guo L,Feng L, Ma C, Wang X, Leng Z, Tong X, Zhou W, Wang G, Zhang T, Guo Y, Wu C,Wang Q, Liu M, Wang C, Jia M, Hu X, Wang Y, Zhang X, Hu R, Zhong J, Yang J, DaiJ, Chen L, Zhou X, Wang J, Yang W, Wang C. Seroprevalence and humoral immunedurability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal,population-level, cross-sectional study. Lancet. 2021 Mar20;397(10279):1075-1084. (Co-first author)

3.     Huang CL, Huang LX, Wang YM, Li X,Ren LL, Gu XY, Kang L, Guo L, et al. 6-month consequences of COVID-19 inpatients discharged from hospital: a cohort study. Lancet, 2021 Jan 16;397(10270):220-232. (Co-first author)

4.     Li H, Ren L, Zhang L, Wang Y, GuoL, Wang C, Xiao Y, Wang Y, Rao J, Wang X, Liu Y, Huang C, Gu X, Fan G, LiH, Lu B, Cao B, Wang J. High anal swab viral load predisposes adverse clinicaloutcomes in severe COVID-19 patients. Emerg Microbes Infect. 2020Dec;9(1):2707-2714. (Co-first author)

5.     Guo L, Liu S, Song J, Han L, Zhang H, WuC, Wang C, Zhou H, Wang J. Seroprevalence of Wenzhou virus in China. Biosafetyand Health. 2020, 2(3):152-156. (First author)

6.     Ren LL, Wang YM, Wu ZQ, Xiang ZC, GuoL, Xu T, Yong-Zhong Jiang YZ, Xiong Y, Yong-Jun Li YJ, Li XW, Li H, Fan GH,Gu XY, Xiao Y, Gao H, Jiu-Yang Xu JY, Yang F, Wang XM, Wu C, Chen L, Liu YW,Liu B, Yang J, Xiao-Rui Wang XR, Dong J, Li L, Huang CL, Zhao JP, Hu Y, ChengZS, Liu LL, Qian ZH, Qin C, Jin Q, Cao B, Wang JW. Identification of a novelcoronavirus causing severe pneumonia in human: a descriptive study. Chin Med J(Engl). 2020,133(9):1015-1024. (Co-first author)

7.     Ren L, Fan G, Wu W, Guo L, Wang Y,Li X, Wang C, Gu X, Li C, Wang Y, Wang G, Zhou F, Liu Z, Ge Q, Zhang Y, Li H,Zhang L, Xu J, Wang C, Wang J, Cao B. Antibody Responses and Clinical Outcomesin Adults Hospitalized with Severe COVID-19: A Post hoc Analysis of LOTUSChina. Clin Infect Dis. 2020; doi:10.1093/cid/ciaa1247 (Co-first author)

8.     Guo L, Ren L, Yang S, Xiao M, ChangD, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y, Zhang L, Han L, Dang S, Xu Y,Yang QW, Xu SY, Zhu HD, Xu YC, Jin Q, Sharma L, Wang L, Wang J. Profiling EarlyHumoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Clin InfectDis 2020. .2020;71(15):778-785. ( First author)

9.     Guo L, Wang D, Zhou H, Wu C, Gao X, Xiao Y, Ren L, Paranhos-Baccalà G, Shu Y,Jin Q, Wang J. Cross-reactivity between avian influenza A (H7N9) virus anddivergent H7 subtypic and heterosubtypic influenza A viruses. Sci. Rep. 2016, 6, 22045. ( First author)

10.  Gao X, Zhou H, Wu C, Xiao Y, Ren L, Paranhos-Baccalà G, Guo L, Wang J. Antibody against nucleocapsid protein predicts susceptibility to human coronavirus infection.J Infect. 2015, 71(5):599-602.(Co-corresponding author)

11.  Chen Z, Wang J, Bao L, Guo L, Zhang W, Xue Y, Zhou H, Xiao Y, Wang J, Wu F, Deng Y, Qin C, Jin Q. Human monoclonal antibodies targeting the haemagglutinin glycoprotein can neutralize H7N9 influenza virus.Nat Commun. 2015, 6:6714. (Co-firstauthor)

12.  Yang J, Zhang T, Guo L, Hu YF,  Li JL, Su HX, Xiao Y, Ren XW, Dong J, Sun LL,Xiao Y, Li Li, Yang F, Wang JW, Yuan H, Jin Q. Mutations of Novel InfluenzaA(H10N8) Virus in Chicken Eggs and MDCK Cells. Emerg  Infect Dis. 2014, 20(9):1541-1543 .(Co-firstauthor)

13.  Zhou Z, Gao X, Wang Y, Zhou H, Wu C,Paranhos-Baccalà G, Vernet G, Guo L, Wang J. Conserved B-Cell Epitopes amongHuman Bocavirus Species Indicate Potential Diagnostic Targets. PLoS One, 2014,9(1): e86960. (Co-corresponding author)

14.  Guo L, Zhang X, Ren L, Yu X, Chen L, ZhouH, Gao X, Teng Z, Li J, Hu J, Wu C, Xiao X, Zhu Y, Wang Q, Pang X, Jin Q, Wu F,Wang J. Human antibody responses to avian influenza A(H7N9) virus. EmergInfect Dis. 2014, 20(2): 192-200. ( First author)

15.  Guo L, Wu C, Zhou H, Wu C,Paranhos-Baccalà G, Vernet G, Jin Q, Wang J, Hung T. Identification of anonstructural DNA-binding protein (DBP) as an antigen with diagnostic potentialfor human adenovirus. PLoS One, 2013, 8(3): e56708. ( First author)

16.  Guo L, Wang Y, Zhou H, WuC, Song J, Li J, Paranhos-Baccalà G, Vernet G, Wang J, Hung T. Differentialseroprevalence of human bocavirus species 1-4 in Beijing, China. PLoS One,2012, 7(6): e39644. ( First author)

17.  Guo L, Gonzalez R, Zhou H,Wu C, Vernet G, Wang Z, Wang J. Detection of three human adenovirus species inadults with acute respiratory infection in China. Eur J Clin MicrobiolInfect Dis. 2012, 31(6): 1051-1058. ( First author)

18.  Guo L, Gonzalez R, Xie Z,Zhou H, Liu C, Wu C, Paranhos-Baccalà G, Vernet G, Shen K, Jin Q, Wang J. Bocavirusin children with respiratory tract infections. Emerg Infect Dis. 2011,17(9): 1775-1777. ( First author)

19.  Wang Y, Gonzalez R, Zhou H, Li J, LiY, Paranhos-Baccalà G, Vernet G, Guo L, Wang J. Detection of humanbocavirus 3 in China. Eur J Clin Microbiol Infect Dis. 2011, 30(6):799-805. (Co-corresponding author) ( Co-corresponding author)

20.  Guo L, Gonzalez R, Wang W,Vernet G, Paranhos-Baccalà G, Wang J. Complete genome sequence of humanastrovirus genotype 6. Virol J. 2010, 7: 29. ( First author)

21.  Guo L, Xu X, Song J, WangW, Wang J, Hung T. Molecular Characterization of Astrovirus Infection inChildren with Diarrhea in Beijing, 2005-2007. J Med Virol. 2010, 82(3):415-423. ( First author)

22.  Guo L, Zhou H, Wang M,Song J, Han B, Shu Y, Ren L, Si H, Qu J, Zhao Z, Wang J, Hung T. A recombinantadenovirus prime-virus-like particle boost regimen elicits effective andspecific immunities against norovirus in mice. Vaccine, 2009, 27(38):5233-5238. ( First author)

23.  Guo L, Song J, Xu X, RenL, Li J, Zhou H, Wang M, Qu J, Wang J, Hung T. Genetic analysis of norovirus inchildren affected by acute gastroenteritis in Beijing, 2004-2007. J ClinVirol. 2009, 44(1): 94-98. ( First author)

24.  Guo L, Wang J, Zhou H, SiH, Wang M, Song J, Han B, Shu Y, Ren L, Qu J, Hung T.Intranasal administrationof a recombinant adenovirus expressing the norovirus capsid protein stimulatesspecific humoral, mucosal, and cellular immune responses in mice. Vaccine,2008, 26(4): 460-468. ( First author)

二.、授权发明专利

1. 王健伟，郭丽，周红莉，洪涛。密码子优化的杯状病毒衣壳蛋白的编码核苷酸序列及其应用，授权日：2007.10.10，中国，ZL 200510112914.8。

2.  王健伟，赵荣茂，VERNET GUY，郭丽。一种H1亚型特异性保守表位、抗体及其应用，授权日：2014.8.13, 中国, ZL 201110077459.8。

3. 王健伟，郭丽，吴成君。一种腺病毒非结构蛋白免疫原、抗体及其应用, 授权日：2016.12.14. 中国，专利号：ZL201210033222.4。

4. 王健伟，郭丽，王雅英，G.弗奈特。博卡病毒（HBoV）共有的特异性表位、其应用及其抗体，授权日：2017.11.10，中国，专利号：ZL201310176723.2。

5.王健伟，郭丽，周红莉。H3亚型流感病毒血凝素特异性保守表位、其抗体及其应用。授权日：2021.3.16，中国，专利号：ZL201610862674.1。

三、 获得奖励

1. 王健伟，任丽丽，许文波，郭丽，毛乃颖，相子春，朱贞，肖艳，崔爱利，周红莉，张勇，杨帆，谢正德，李太生，董杰。重要和新发现呼吸道及肠道病毒的病原学研究及其应用，高等学校科学研究优秀成果奖科学技术进步奖，二等奖，2015年。

2. 王健伟，许文波，申昆玲，毛乃颖，李太生，朱贞，郭丽，崔爱利，谢正德，张燕，范洪伟、周红莉、肖艳、于德山、余鹏博。 重要和新发现呼吸道病毒的病原学研究及其应用，科学技术奖，一等奖， 2015年。

3. 金奇，任丽丽，任仙文，肖艳，陈立宏，周红莉，杜江，郭丽，萧燕，李莉，杨莉，卫灿东，苏浩翔，刘博。基于宏基因组学的新型病原体组合筛查鉴定实用技术体系及应用，高等学校科学研究优秀成果奖科学技术进步奖，一等奖，2016年。