张建民，教授，博士生导师，博士，jzhang42@163.com

     陈慧，副研究员，博士，chenhui_1980@126.com

     胡愉，副主任技师，硕士，huyu12@hotmail.com

     许依，助理研究员，博士，xuyi2207@163.com

    蔡孟华，助理研究员，博士，caimenghua001@163.com

 课题组主要科研项目（提供近5年科研基金项目列表）

   负责：

    参与：

课题组近年代表性论文 2020——2024

1)        Wang Y, Han J, WangD, Cai M, Xu Y, Hu Y, Chen H, He W, Zhang J. Anti-PD-1 antibody armored γδ Tcells enhance anti-tumor efficacy in ovarian cancer. Signal Transduct TargetTher. 2023 Oct 20;8(1):399.

2)     Han J, Liu N, Jin W, Zanvit P, Zhang D, Xu J, Bynum A, Kazmi R, Zhang J*, He W*, Chen W*. TGF-b controls development of CD8aa+ gdT intestinal intraepithelial lymphocytes. Cell Discov. 2023 May 30;9(1):52. 

3）  Wang W*, Xu Y*, WangL, Zhu Z, Aodeng S, Chen H, Cai M, Huang Z, Han J, Wang L, Lin Y, Hu Y, Zhou L,Wang X, Zha Y, Jiang W, Gao Z, He W, Lv W*, Zhang J*. Single-cell profilingidentifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis. NatImmunol. 2022 Oct;23(10):1484-1494.

4）   Chen H, Zhang J, He W*. The role of micro RNA inγδ T cells: a long way to go. Cell Mol Immunol. 2021 Aug;18(8):2071-2072.

5）   Fu Y#, Wang D#, Wang H, Cai M，Li C, Zhang X，Chen H, Hu Y, Zhang X, Ying M, He W *, Zhang J*.TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia,angiogenesis and a growth-promoting metabolic shift toward glycolysis inglioblastoma. Neuro Oncol. 2020 Feb 20;22(2):240-252.

6)      Zhao Y, Dong P, He W, Zhang J, Chen H. γδ T cells: Major advances in basic and clinical research in tumor immunotherapy. Chin Med J (Engl). 2024 Jan 5;137(1):21-33.

7)      Li C, Zhang H, Tong K, Cai M, Gao F, Yang J, Xu Y,Wang H, Chen H, Hu Y, He W, Zhang J. Genetic Deletion of Thorase CausesPurkinje Cell Loss and Impaired Motor Coordination Behavior. Cells. 2023 Aug10;12(16):2032.

8)      Huo T, Yuan X, Han J, Shi J, Xiong Y, Tian F, Xu Z,Cai M, Xu Y, Chen H, Zeng X, He W, Wang Q, Zhang J. Serum metabolomic analysisreveals disorder of steroid hormone biosynthesis in patients with idiopathicinflammatory myopathy. Front Immunol. 2023 Jun 12;14:1188257.

9)      Tian F, Chen H, Zhang J*, He W*. ReprogrammingMetabolism of Macrophages as a Target for Kidney Dysfunction Treatment inAutoimmune Diseases. Int J Mol Sci. 2022 Jul 21;23(14):8024.

10)      Xiong Y, Cai M, Xu Y, Dong P, Chen H, He W* and ZhangJ*. Joint together: The etiology and pathogenesis of ankylosing spondylitis. FrontImmunol. 2022 Oct 17;13:996103.

11）    Gao, F.*; Zhang, H.*; Yang, J.*; Cai, M.*; Yang,Q.;Wang, H.; Xu, Y.; Chen, H.; Hu, Y.; He,W.; Zhang J*. ATPase ThoraseDeficiency Causes-Synucleinopathy and Parkinson’s Disease-like Behavior. Cells.2022 Sep 26;11(19):2990.

12）   Zhang X*, Han J*, Xu Y, Gao F, Han J, Chen H, He W*,Zhang J*. TSPO Deficiency Exacerbates GSDMD-mediated Macrophage Pyroptosis inInflammatory Bowel Disease.  Cells. 2022 Mar 2;11(5):856.

13）   Wang D, Fu Y, Fan J, Wang Y, Li C, Xu Y, Chen H, Hu Y,Cao H, Zhao C*, He W*, Zhang J*. Identification of alpha-enolase (ENO1) as apotential immunogenic molecule during the allogeneic transplantation of humanadipose-derived mesenchymal stromal cells. Cytotherapy. 2022 Apr;24(4):393-404.

 课题组近年专利

1)    基因修饰CDR3δ移植型γδT淋巴细胞及其抑癌用途。专利号：ZL 2010 1 0518490.6。

2)      γδT淋巴细胞中δ1链互补决定域3的优势序列及其TCR受体转染细胞与应用。专利号：ZL 20111 0126369.3。

3)     抗人γδTCR单克隆抗体的重组单链抗体G5-4ScFv及其编码基因与应用。专利号：ZL 201110139150.3。

4)     肿瘤结合特异性gdTCR基因修饰的αβT细胞及其抑癌用途。专利号：ZL 201510846740.1。

5）    基因重组PD-1抗体自分泌型人γδT细胞及其构建方法和应用。专利号：ZL 202010625263.7。

6）     抗人转化生长因子beta 1的纳米抗体B3及其制备方法和应用。专利号：ZL 202010227938.2。

7）     胞外段为Vδ1(GTM)Vγ4的CAR分子及表达该分子的CAR-T细胞及其用途。专利号：ZL 202110188788.3。

8）     一种人源化抗人γδTCR单克隆抗体及其编码基因、制备方法和应用。专利申请号：202211201960.5。

9）     一种人源化抗人Vδ1 TCR单克隆抗体及其在活化扩增Vδ1 T细胞中的应用。专利申请号：202211202016.1。