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王志华,现任中国医学科学院阜外医院心血管国家重点实验室研究员/博士生导师。2004年毕业于山东大学生物科学专业,2004-2011年于中国科学院上海生命科学研究院健康科学研究所(现上海营养与健康研究所)攻读博士学位,2011-2017年在美国加州大学洛杉矶分校做博士后研究,2016-2020年在武汉大学人民医院任教授。主要研究方向为病理性心肌肥厚与心脏衰老过程中的基因表达调控。在Nat Med、Circulation、Hypertension、Metabolism等期刊发表论文40余篇。主持国自然优青/面上、国家重大科技专项子任务等科研项目。担任中国生理学会循环生理专业委员会委员、中国病理生理学会心血管青年委员会委员、中国青年科技工作者协会理事等职务。
1. 国家自然科学基金面上项目,“由隐含剪接位点产生的EZH2新亚型的分子功能及其在心肌肥厚中的作用”(82070231),2021-2024,55万元,主持;
2. 国家重点研发计划,“促进心肌组织原位再生修复的机制及新策略研究”(2022YFA1104500),2022-2027,112万元,科研骨干;
3. 中国医学科学院医学与健康科技创新工程-重大协同创新项目,“病理性心脏重构机制解析及逆重构策略研究”(INN_BCOO_202202),2022-2025,216万元,科研骨干;
4. 深圳市科技创新委员会 "优秀科技创新人才培养(杰出青年基础研究)"EZH2可变剪接与心肌肥厚(RCJC20210706091947009),2022-2027,400万元,主持。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1. 国家自然科学基金面上项目,“由隐含剪接位点产生的EZH2新亚型的分子功能及其在心肌肥厚中的作用”(82070231),2021-2024,55万元,主持;
2. 国家重点研发计划,“促进心肌组织原位再生修复的机制及新策略研究”(2022YFA1104500),2022-2027,112万元,科研骨干;
3. 中国医学科学院医学与健康科技创新工程-重大协同创新项目,“病理性心脏重构机制解析及逆重构策略研究”(INN_BCOO_202202),2022-2025,216万元,科研骨干;
4. 深圳市科技创新委员会 "优秀科技创新人才培养(杰出青年基础研究)"EZH2可变剪接与心肌肥厚(RCJC20210706091947009),2022-2027,400万元,主持。
1. Lv J#, Hu Y#*,Li L#, He Y, Wang J, Guo N, Fang Y,Chen Q, Cai C*, Tong J*, Tang L*, Wang Z*. Targeting FABP4 in Elderly MiceRejuvenates Liver Metabolism And Ameliorates Aging-associated MetabolicDisorders. Metabolism-Clinical andExperimental 2023 May;142:155528.
2. Mao S#, Lv J#, Chen M#,Guo N, Fang Y, Tong J, He X*, Wu G*, WangZ*. Serinc2 deficiency causes susceptibility tosepsis-associated acute lung injury. Journalof Inflammation-London 2022 Jul 7;19(1):9.
3. Guo N#, Zheng D#, Sun J#,Lv J, Wang S, Fang Y, Zhao Z, Zeng S, Guo Q, Tong J*, Wang Z*. NAP1L5promotes nucleolar hypertrophy and is required for translation activationduring cardiomyocyte hypertrophy. Frontiersin Cardiovascular Medicine 2021 Dec17;8:791501.
4. Fang Y#, Wang S#, Lv J#,Zhao Z, Guo N, Wu G*, Tong J*, Wang Z*. Slc39a2-mediated ZincHomeostasis Modulates Innate Immune Signaling in Phenylephrine-inducedCardiomyocyte Hypertrophy. Frontiersin Cardiovascular Medicine 2021 Nov1;8:736911.
5. Li S#, Wang S#, He Y, ZhengD, Lv J, Guo N, Guo Y, Li L, Fan M*, Wang Z*. Mouse Strain-specificReponses of Mitochondrial Respiratory Function and Cardiac Hypertrophy toIsoproterenol Treatment. ActaPhysiologica Sinica 2021 Jun 25;73(3):459-470.
6. Tang L*, Li L, Bu L, Guo S, He Y, Liu L, Xing Y,Lou F, Zhang F, Tong J, Lv J, Wang S, Guo N, Xu L, Tang S, Zhu C, Wang Z*.Bigu-style Fasting Affects Metabolic Health by Modulating Taurine, Glucose, andCholesterol Homeostasis in Healthy Young Adults. Journal of Nutrition. 2021 Aug 7;151(8):2175-2187.
7. Li L#, Wang J#, Guo S, XingY, Ke X, Chen Y, He Y, Wang S, Wang J, Cui X*, Wang Z*, Tang L*. Tai ChiExercise Improves Age-associated Decline in Cerebrovascular Function: ACross-sectional Study. BMC Geriatrics. 2021;21:293.
8. Hu Y#, Lv J#, Fang Y#,Luo Q, He Y, Li L, Fan M*, Wang Z*. Crtc1 Deficiency Causes ObesityPotentially via Regulating PPARγ Pathway in White Adipose. Frontiers in Cell and Developmental Biology 2021;9:602529.
9. Wang S#, Guo N#, Li S#,He Y, Zheng D, Li L, Wang Z*. EZH2 Dynamically Associates withNon-coding RNAs in Mouse Hearts after Acute Angiotensin II Treatment. Frontiers in Cardiovascular Medicine 2021Feb 25;8:585691.
10. Lv J, He Y, Li L*, Wang Z*.Alternative Splicing Events and Splicing Factors Are Prognostic inAdrenocortical Carcinoma. Frontiers in Genetics. 2020 Sep 3;11:918.
11. Li L, Lv J, He Y, Wang Z*.Gene Network in Pulmonary Tuberculosis Based on Bioinformatic Analysis. BMCInfectious Diseases. 2020 Aug 18;20(1):612.
12. Wang Y#, Xie Y#,Li L#, He Y, Zheng D, Yu P, Yu L, Tang L, Wang Y*, Wang Z*. EZH2RIP-seq Identifies Tissue-specific Long Non-coding RNAs. CurrentGene Therapy. 2018;18(5):275-285.
13. Deng KQ#, Zhao GN#,Wang Z#, Jiang Z, Gong J,Yan FJ, Zhu XY, Zhang P, She ZG, Li H. TargetingTransmembrane BAX Inhibitor Motif Containing 1 Alleviates Pathological CardiacHypertrophy. Circulation. 2018;137(14):1486-1504.
14. Deng KQ, Li J, She ZG, Gong J, Cheng WL, Gong FH,Zhu XY, Zhang Y, Wang Z*, Li H*.Restoration of Circulating MFGE8 (Milk Fat Globule-EGF Factor 8) AttenuatesCardiac Hypertrophy Through Inhibition of Akt Pathway. Hypertension 2017 Oct;70(4):770-779.
15. Wang Z#, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J,Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, VondriskaTM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long non-coding RNA Chaer defines an epigeneticcheckpoint of cardiac hypertrophy. Nature Medicine2016;22(10):1131–1139.
16. Wang ZH#, Liu JL#, Wu L, Yu Z, Yang HT.Concentration-dependent wrestling between detrimental and protective effects ofH2O2 during myocardial ischemia/reperfusion. Cell Death & Disease2014;5:e1297.
17. Wang ZH, CaiXL, Wu L, Yu Z, Liu JL, Zhou ZN, Liu J, Yang HT.Mitochondrial energy metabolism plays a critical role in the cardioprotectionafforded by intermittent hypobaric hypoxia. Experimental Physiology 2012;97(10):1105-18.
18. Wang ZH,Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, Guan Y, Zhou ZN, Yang HT. Intermittenthypobaric hypoxia improves post-ischemic recovery of myocardial contractilefunction via redox signaling during early reperfusion. American Journal of Physiology-Heartand Circulation Physiology 2011;301(4):H1695-705.
1. Wang Z, Xie Y. RIP-seq inepigenetic analysis, Chapter 24 in the book Epigenetics Methods edited byTrygve Tollefsbol. Springer Nature 2020. Pages 495-506.
2. Tong J, Wang Z. Combinatorial ChIP andBisulfite Sequencing (BisChIP-seq), Chapter 19 in the book Epigenetics Methodsedited by Trygve Tollefsbol. Springer Nature 2020. Pages 387-395.
3. Yang HT, Zhang Y, Wang ZH, Zhou ZN. Chapter 4. Protective effects of chronic intermittenthypoxia against myocardial ischemia/reperfusion injury, p47-58 in thebook Intermittent Hypoxia and Human Diseases, edited by Lei Xi &Tatiana V.Serebrovskaya. Springer London, 2012.
1. CILP2在制备改善心脏衰老和心肌肥厚的药物中的应用(ZL202010819200.5),发明人:王志华、汤立许、李丽莉、罗强、胡依萌,获授权时间:2021.07.30;
2. 一种衰老以及健康衰老相关的分子标志物及其在改善健康衰老中的应用(ZL202010819194.3),发明人:王志华、汤立许、李丽莉、胡依萌,获授权时间:2022.01.04;
3. 一种EZH2可变剪切体及其应用(ZL202011179608.7),发明人:王志华、王顺、郭宁宁、李丽莉,获授权时间:2022.05.24;
4. 一种肥胖表型分子标志物及其应用(ZL202011294611.3),发明人:王志华、胡依萌、吕舰、李丽莉,获授权时间:2022.07.22;
5. SLC25A26在制备抑制心肌肥厚的药物中的应用(ZL202110874774.7),发明人:王志华、郭宁宁、吕舰,获授权时间:2022.09.06
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