主持及参与的主要科研课题

[1]   国家自然科学基金委员会面上项目（81970417）、HO-1/CO轴调控NLRP3细胞焦亡途径在糖尿病血管内皮损伤中的机制研究、2020.01-2024.12

[2]  北京协和医学院中央高校基本科研业务费（3332019028）、Ang II/MFGE8 信号通路在血管重构及动脉硬化发展中的作用及机制、2019.01-2020.12

[3]  国家自然科学基金面上项目（81470585）、PVAT功能改变影响血管壁骨桥蛋白的表达在糖尿病血管内膜增生中的作用及其机制研究、2015.1-2018.12

[4]   北京自然科学基金面上项目（7172174）、Nrf2-ARE信号通路在糖尿病介导血管氧化损伤及内膜增生中的保护作用及机制、2017.1-2019.12

[5]   北京自然科学基金面上项目（7122145）、血管周脂肪组织转染HO-1基因对于血管抗氧化损伤的保护机制、2012.1~2014.12

[6]   中央保健专项基金（B2009B080）、老年颈动脉狭窄手术安全预警和优化策略研究、2010.1~2013.12

[7]   首都医学发展基金（2009-2001）、糖尿病下肢缺血外科治疗多中心随机对照和临床注册研究、2010.1~2013.7

近五年主要发表文章

1.      Ni L, Weng HL, Zuo Pu, et al. Open surgery versus endovascular approach in treatment of extracranial carotid artery aneurysms. J Vasc Surg. 2018,67(5):1429-37.

2.      Ni L, Pu Z, Zeng R, Zhang R, Zheng YH, Ye W, Liu CW. Endovascular stenting for extracranial carotid artery aneurysms: Experiences and mid-term results. Medicine (Baltimore). 2016; 95(46): e5442. 

3.      Ni L, Wang ZQ, Yang GH, Li TJ, Liu XN, Liu CW. Heme oxygenase-1 alleviates cigarette smoke-induced restenosis after vascular angioplasty by attenuating inflammation in rat model. Toxicol Lett. 2016, 245:99-105. 

4.      Ni L, Tianjia Li, Bao Liu, Xitao Song, Genhuan Yang, Linfang Wang, Shiying Miao，Liu CW. The protective effect of Bcl-xl overexpression against oxidative stress-induced vascular endothelial cell injury and the role of Akt/eNOS pathway. Int J Mol Sci. 2013,14: 22149-22162. 

5.      Ni L, Liu CW, Ricco JB, Dick F, Liu B, Ye W. Role of Thrombophilia in Premature Peripheral Arterial Obstructive Disease-Experience of a Vascular Centre in China. Eur J Vasc Endovasc Surg. 2012,44:158-63. 

6.      Ni L, Di X, Zhang R, Ma BT, Liu CW, Zheng YH. Effect of angiotensin II/milk fat globule epidermal growth factor 8 signaling on matrix remodeling in human umbilical vein endothelial cells and underlying molecular mechanism. Chin J Exp Surg. 2021,38(1):53-56.

7.      Ni L, Li YJ, Zheng YH, Liu B, Ye W, Zeng R, Song XJ, Liu CW. Prevention and treatment of complications for endovascular therapy of aortoiliac artery occlusive disease. Chin J Gen Surg. 2015, 30:440-443.   

8.      Ni L, Liu CW, Cui LY, Liu B, Ye W, Gao S, Hu YH，Lai ZC. Risk analysis of cerebral hyperperfusion syndrome after carotid endarteractomy. Chin J Surg. 2013,51:800-803.

9.      Ni L, Liu CW, Liu B, Ye W, Lai ZC. Shunting during carotid endarteractomy prevent postoperative hyperperfusion syndrome. Natl Med J China.2013,93:1142-1145.

10.    Ni L, Liu CW, Liu B, Song W, Li TJ, Wang LF. Construction and functional identification of recombinant adenovirus B cell Lymphoma/Leukemia-xl. Chin J Exp Surg. 2012,29:618-621.

11.    Ni L, Ye W, Liu CW. Diagnosis and treatment of post-thrombotic syndrome. J Clin Surg. 2012, 20:365-367.

12.    Ni L,  Liu CW, Liu B, Ye W, Wu WW, Song XJ, Guan H. Diagnosis and treatment of 193 cases under 45 years old with peripheral arterial disease. Chin J Surg. 2010,48:15-18.

13.    Ni L,  Liu CW. Surgical management on femoropopliteal occlusive diseases. Int J Surg. 2007,34:841-843.

14.    Wang XB, Li TJ, Ma BT, Zhao ZW, Ni L, Zhang R, Niu S, Liu CW. Melatonin attenuates restenosis after vascular injury in diabetic rats through activation of the Nrf2 signaling pathway. Biochem Biophys Res Commun. 2021; 548:127-133.

15.    Genhuan Yang, Rong Zeng, Xitao Song, Tianjia Li, Changwei Liu, Leng Ni*. Sophocarpine prevents cigarette smoke-induced restenosis in rat carotid arteries after angioplasty. Ann Palliat Med. 2020;9(4):1622-1630.

16.    Baitao Ma, Yunfei Chen, Xuebin Wang, Rui Zhang, Shuai Niu, Leng Ni, Xiao Di, Qin Han, Changwei Liu. Cigarette smoke exposure impairs lipid metabolism by decreasing low-density lipoprotein receptor expression in hepatocytes. Lipid Health Dis. 2020;19(1):88.

17.    Ma BT, Jia J, Wang XB, Zhang R, Nou S, Ni L, Di Xiao, Liu CW. Differential roles of Scavenger receptor class B type I: A protective molecule and a facilitator of atherosclerosis. Mol Med Rep. 2020 Oct;22(4):2599-2604. 

18.    Zhang R, Wang X, Ni L, Di X, Ma B, Niu S, Liu C, Reiter RJ. COVID-19: Melatonin as a Potential Adjuvant Treatment. Life Sci. 2020 Jun 1;250:117583. 

19.    Di X, Liu CW, Zeng R, Ni L. Endovascular Aortic Repair Is a Viable Strategy for Treatment of Primary Infected Abdominal Aortic Aneurysm. Ann Vasc Surg. 2020;63:117-128. 

20.    Wang X, Bian Y, Zhang R, Liu X, Ni L, Ma B, Zeng R, Zhao Z, Song X, Liu C. Melatonin Alleviates Cigarette Smoke-Induced Endothelial Cell Pyroptosis Through Inhibiting ROS/NLRP3 Axis. Biochem Biophys Res Commun. 2019;519(2):402-408. 

21.    Li T, Ni L, Zhao Z, Liu X, Lai Z, Di X, Xie Z, Song X, Wang X, Zhang R, Liu C. Melatonin attenuates smoking-induced hyperglycemia via preserving insulin secretion and hepatic glycogen synthesis in rats. J Pineal Res. 2018;64(4):e12475.

22.    Wang M, Zhang L, Zhu W, Zhang J, Kim SH, Wang Y, Ni L, Telljohann R, Monticone RE, McGraw K, Liu L, de Cabo R, Lakatta EG. Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype. J Am Heart Assoc. 2018;7(18):e009112. 

23.    Zhao Z, Lu C, Li T, Wang W, Ye W, Zeng R, Ni L, Lai Z, Wang X, Liu C. The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: in vivo assessment and a randomized controlled trial. J Pineal Res. 2018 ;65(4):e12521.

24.    Zeng R, Zhang R, Song X, Ni L, Lai Z, Liu C, Ye W. The long non-coding RNA MALAT1 activates Nrf2 signaling to protect human umbilical vein endothelial cells from hydrogen peroxide. Biochem Biophys Res Commun. 2018 Jan 22;495(4):2532-2538.

25.    Li T, Liu X, Zhao Z, Ni L, Liu C. Sulodexide recovers endothelial function through reconstructing glycocalyx in the balloon-injury rat carotid artery model. Oncotarget. 2017, 8:91350-91361. 

26.    Jiang C, Ni L, Liu C, Jia C, Wu X, Wang J, Liu B. Intravascular Fibrolipoma of the Femoral Vein. Ann Vasc Surg. 2017; 39:287. e7-287.e13. 

27.    Wang ZQ, Ni L, Wang J, Lu CR, Ren M, Han W, Liu CW. The protective effect of melatonin on smoke-induced vascular injury in rats and humans: a randomized controlled trial (RCT). J Pineal Res. 2016; 60:217-27. 

28.    Li T, Ni L, Liu X, Wang Z, Liu C. High glucose induces the expression of osteopontin in blood vessels in vitro and in vivo. Biochem Biophys Res Commun. 2016; 480(2):201-207.

29.    Li T, Liu X, Ni L, Wang Z, Wang W, Shi T, Liu X, Liu C. Perivascular adipose tissue alleviates inflammatory factors and stenosis in diabetic blood vessels. Biochem Biophys Res Commun. 2016; 480(2):147-152.

30.    Xinnong Liu, Zhanqi Wang, Tianjia Li, Leng Ni, Rong Zeng, Changwei Liu. A simplified device for exposing rats to cigarette smoke. Int J Clin Exp Med. 2016; 9(10): 19213-19221. 

31.    Liu Q, Ye W, Liu C, Li Y, Zeng R, Ni L. Outcomes of vascular intervention and use of perioperative medications for nonpulmonary aneurysms in Behçet disease. Surgery. 2016; 159:1422-9.

32.    Song X, Zeng R, Ni L, Liu C. The effect of soy or isoflavones on homocysteine levels: a meta-analysis of randomised controlled trials. J Hum Nutr Diet. 2016; 29(6): 797-804. 

33.    Zeng R, Ye W, Liu C, Wang X, Song X, Ni L, Liu B, Li Y, Zheng Y. Application of physician-modified fenestrated stent graft in urgent endovascular repair of abdominal aortic aneurysm with hostile neck anatomy: Case report. Medicine (Baltimore). 2016; 95(46): e5455. 

获得专利

1.       倪冷；狄潇；蒲佐. 一种动脉瘤栓塞导管和动脉瘤手术辅助装置 （ZL201811205117.8）发明专利

2.       倪冷；曾嵘；刘昌伟；翁慧玲；郑月宏. 一种药物球囊导管和球囊装置（ZL201821243355.3 ）实用新型专利

3.       倪冷.  一种血管腔内活检提取装置（ZL201821720416.0）实用新型专利

4.       倪冷；狄潇；蒲佐. 一种动脉瘤栓塞导管和动脉瘤手术辅助装置（ZL201821681773.0）实用新型专利

荣誉奖励

·  美国血管外科协会（SVS）国际学者奖学金（全球3人）

·  华夏医学科技奖二等奖（主要参与者）

·  香港大学李嘉诚医学院郑裕彤博士奖学金

·  中国医学科学院北京协和医院医疗成果奖三等奖（主要参与者）

·  国家留学基金委公派出国资格

·  中国医学科学院北京协和医院医疗成果奖二等奖（主要参与者）

·  入选北京协和医院第四批“百人计划”

·  美国复杂心血管疾病腔内治疗国际大会“青年学者奖学金”

·  华夏医学科技奖（科普类）（主要参与者）

·  中央保健专项基金优秀课题（主要参与者）