本课题组由研究员1名和助理研究员1名组成，目前有博士研究生3名。

本课题组长期与本所药理毒理中心刘新民教授、天然药物化学中心潘瑞乐教授、制剂中心廖永红教授合作，共同指导研究生课题实施。研究内容主要为从天然植物中寻找抗抑郁、抗老年性痴呆、抗疲劳等神经精神疾病的活性组分，并进行创新中药、保健品、功能食品等健康相关产品的研发。

1.   国家重点研发计划项目“保健食品风险评估及功能评价基础研究”，子课题 “改善记忆和改善睡眠保健食品功能动物与人体评价方法 及体系研究” （主持）

2.  医科院重大协同创新项目“中药资源可持续利用关键技术和新药开发”，任务“中药木豆素抗抑郁新药研发”。（主持）

3.  参与国家重大新药创制专项“基于动物行为实验的抗抑郁药效评价指标体系及参远抗抑郁临床前研究”。（参与）

主要科研项目

1. 中国医学科学院十四五重大协同创新工程项目“ 急性呼吸道感染的抗病毒和宿主个体化干预新策略研究“” （2021/10-2025/12，参与）；

2. 企业横向课题“脱臭蒜提取物保健功能评价”（2021/9-2023/9，主持）；

3.  国家重点研发计划项目“保健食品风险评估及功能评价基础研究”，子课题 “改善学习记忆和改善睡眠障碍保健食品功能动物与人体评价方法及体系研究” （2018/12-2021/12，主持）；

4.  科技部“国家重大新药创制专项“基于动物行为实验的抗抑郁药效评价指标体系及参远苷抗抑郁临床前研究”（2017/1-2020/12，参与）；

5. 中国医学科学院十三五重大协同创新工程项目“中药资源可持续利用关键技术与新药研发” 子课题“木豆素抗抑郁中药新药研发” （2015/1-2020/12，参与）；

6. 中国医学科学院十二五重大协同创新工程项目“中药资源可持续利用关键技术与新药研发” 子课题“中药药代技术平台” （2011/1-2015/12，主持）；

7. 科技部对欧科技合作专项“保健中药风险效益评估合作研究”（2012/1-2013/12，主持）；

8. 欧盟FP7框架 国际合作项目 “植物食品补充剂--摄入水平，风险与效益评估”（2010/6-2015/5，中方主持）；

9. 科技部国际科技合作与交流专项“人参益智药效与基因蛋白表达关联规律合作研究” （2012/1-2014/12，参与）

10. 科技部国家重大新药创制专项 “ 候选药物桑葛降糖组方中药开发研究” （2009/1-2011/12，参与）

迄今共发表论文140余篇；以第一或通行作者身份发表研究论文75篇，其中SCI收录论文60余篇；获国家中药二类新药证书2个；获发明专利6项。

近期发表论文

1.   Wang Z, Jin SW, Xia TJ, Liu YG, Zhou YF, Liu XM, Pan RL, Liao YH, Yan MZ* and Chang Q*. Nelumbinis Stamen Ameliorates Chronic Restraint Stress-InducedMuscle Dysfunction and Fatigue in Mice by Decreasing Serum Corticosterone Levels and Activating Sestrin2. J. Agric. Food Chem. 2022, 70, 16188−16200.

2.   Yan M, Jin S, Liu Y, Wang L, Wang Z, Xia T, Chang Q*. Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control. Front Pharmacol. 2022 Mar8;13:824138. doi: 10.3389/fphar.2022.824138.

3.   Zhou Y, Yan M, Pan R, Wang Z, Tao X, Li C,Xia T, Liu X*, Chang Q*. Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation. J Ethnopharmacol. 2021, 265:113317.

4.   Wang LS, Wang Z, Xia TJ, Cao FR, Ye LH, PanRL, Jin SW, Yan MZ*, Chang Q*. Absorption, Metabolism, and Excretion of Cajaninstilbene Acid. J Agric Food Chem. 2021, 69(7): 2129-2137.

5.   Wang Z, Xia T, Jin S, Liu X, Pan R, Yan M*, Chang Q*. Chronic Restraint Stress-Induced Muscle Atrophy Leads to Fatigue inMice by Inhibiting the AMPK Signaling Pathway. Biomedicines. 2021, 9(10):1321.

6.   Yan M, Wang Z, Xia T, Jin S, Liu Y, Hu H*, Chang Q*. Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice. Biomedicines. 2021,19(8):939.

7.   Tao X, Yan MZ, Wang LS, Zhou YF, Wang Z, Xia TJ, Liu XM, Pan RL and Chang Q*. Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice. Int. J. Mol. Sci. 2020, 21, 1460.

8.   Tao X, Yan M, Wang L, Zhou Y, Wang Z, Xia T, Liu X, Pan R, Chang Q*. Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice. Ann Transl Med. 2020,8(6):356.

9.   Zhang MD, Tao X, Pan RL, Wang LS, Li CC, Zhou YF, Liao YH, Chen SG, Chang Q*, Liu XM*. Antidepressant-like effects of cajaninstilbene acid and its related mechanisms in mice. Fitoterapia. 2020141:104450.

10.  WangLS, Zhang MD, Tao X, Zhou YF, Liu XM, Pan RL, Liao YH, Chang Q*. LC-MS/MS-basedquantification of tryptophan metabolites and neurotransmitters in the serum andbrain of mice. J Chromatogr B Analyt Technol Biomed Life Sci. 2019，1112:24-32.

11.  Zhou YF, Feng L, Liu XM, Tao X, Wang LS, Zhang MD, Wang Z, Chen SG, Chang Q*. Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine. Life Sci. 2019, 234: 116751.

12.  ZhouY, Tao X, Wang Z, Feng L, Wang L, Liu X, Pan R, Liao Y, Chang Q*. Hippocampus Metabolic Disturbance and Autophagy Deficiency in Olfactory Bulbectomized Ratsand the Modulatory Effect of Fluoxetine. Int J Mol Sci. 2019, 20(17). pii:E4282.

13.  Wang LS, Tao X, Liu XM, Zhou YF, Zhang MD, Liao YH, Pan RL, Chang Q*.Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β(1-42) Oligomers. Front Pharmacol. 2019,10:1084.

14.  Ye LH, He XX, You C, Tao X, Wang LS, Zhang MD, Zhou YF, Chang Q*. Pharmacokinetics of Nuciferine and N-Nornuciferine, Two Major Alkaloids From Nelumbo Nucifera Leaves, in Rat Plasma and the Brain. Front Pharmacol. 2018, 29;9:902.

15.  Ye LH, Zhao XQ, Kong LT, Wang LS, Tao X, Wu H, He M, Chang Q*. Inhibitory effectsof Danhong Injection and its major constituents on human cytochrome P450 enzymes in vitro. Biomed Chromatogr. 2018, 32(8):e4250.

16.  Xia F, Li C, Li M, Liao Y, Liu X, Si J, Chang Q* and Pan R*. Antidepressant activity of an aqueous extract from okra seeds. RSC Adv. 2018, 8, 32814.

17.  Cao FR, Xiao BX, Wang LS, Tao X, Yan MZ, Pan RL, Liao YH, Liu XM, Chang Q*. Plasmaand brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC-MS/MS method. J Chromatogr B Analyt Technol Biomed Life Sci.2017,1052:19-26.

18.  Xiao B, Sun Z, Cao F, Wang L, Liao Y, Liu X, Pan R, Chang Q*. Brain Pharmacokinetics and the Pharmacological Effects on Striatal Neurotransmitter Levels of Pueraria lobata Isoflavonoids in Rat. Front Pharmacol. 2017 Sep 5;8:599.doi:10.3389/fphar.2017.00599. eCollection 2017.

19.  Cao FR, Feng L, Ye LH, Wang LS, Xiao BX, Tao X, Chang Q*. Ganoderic Acid A Metabolites and Their Metabolic Kinetics. Front Pharmacol. 2017 Mar 7;8:101.doi:10.3389/fphar.2017.00101.

20.  Wang LS, Tao X, Pan RL, Cao FR, Feng L, Liao YH, Liu XM, Chang Q*. Pharmacokinetics of Cajaninstilbene Acid and Its Main Glucuronide Metabolite in Rats. J Agric FoodChem. 2017, 65(20):4066-4073.

21.  Xiao B, Sun Z, Sun SY, Dong J, Li Y, Gao S, Pang J, Chang Q*. Effect of cortexmorion pharmacokinetic profiles of main isoflavonoids from pueraria lobata in rat plasma. J Ethnopharmacol. 2017, 209:140-146.

22.  Ye LH, Kong LT, Xiao BX, Wang Q, He XX, Liu XM and Chang Q*. Screening of Eleven Commonly Used Traditional Chinese Medicines for Inhibitory Effects on Human Cytochrome P450 Enzymes. Chinese Herbal Medicines. 2017, 9:169-175.

23.  Ye LH, Kong LT, Yan MZ, Cao FR, Wang LS, Liao YH, Pan RL, Chang Q*.  Lotus leaf alkaloid fraction can strongly inhibit CYP2D6 isoenzyme activity. J Ethnopharmacol. 2016, 194:913-917.

24.  Ye LH, Xiao BX, Liao YH, Liu XM, Pan RL, Chang Q*. Metabolism profiles of nuciferine in rats by using ultra fast liquid chromatography with tandem mass spectrometry. Biomed Chromatogr. 2016,30(8):1216-22.

25.  Feng L, Liu XM, Cao FR, Wang LS, Chen YX, Pan RL, Liao YH, Wang Q, Chang Q*. Anti-stresseffects of ginseng total saponins on hindlimb-unloaded rat sassessed by ametabolomics study. J Ethnopharmacol. 2016 21;188: 39-47.

26.  Feng L, Wu HW, Song GQ, Lu C, Li YH, Qu LN, Chen SG, Liu XM, Chang Q*.  Chronical sleep interruption-induced cognitive decline assessed by a metabolomics method. Behav Brain Res. 2016,302(1):60-68.

27.  Feng L, Yue XF, Chen YX, Liu XM, Wang LS, Cao FR, Wang Q, Liao YH, Pan RL, Chang Q*.  LC/MS-based metabolomics strategy toassess the amelioration effects of ginseng total saponins on memory deficiency induced by simulated microgravity. J Pharm Biomed Anal. 2016 125:329-38.

28.  Xiao BX, Feng L, Cao FR, Pan RL, Liao YH, Liu XM, Chang Q*. Pharmacokinetic profiles of the five isoflavonoids from Pueraria lobata roots in the CSF and plasma of rats. J Ethnopharmacol. 2016, 184:22-29.